Generation, maintenance and fate of T follicular helper cells:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online-Zugang: | Volltext Inhaltsverzeichnis |
| Beschreibung: | Nebentitel: Generierung, Aufrechterhaltung und Schicksal follikulärer T-Helferzellen |
| Beschreibung: | VI, 71 S. Ill., graph. Darst. |
Internformat
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| 245 | 1 | 0 | |a Generation, maintenance and fate of T follicular helper cells |c by Jan Phillip Weber |
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| 264 | 1 | |c 2013 | |
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Datensatz im Suchindex
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| adam_text | TABLE OF CONTENTS
TABLE OF CONTENTS
1. ABSTRACT/ZUSAMMENFASSUNG 1
1.1 ABSTRACT 1
1.2 ZUSAMMENFASSUNG 3
2. INTRODUCTION 5
2.1 THE ADAPTIVE IMMUNE SYSTEM 5
2.2 T CELL CO-STIMULATION 5
2.3 T FOLLICULAR HELPER CELLS IN THE GERMINAL CENTRE REACTION 7
2.4 CD4
+
T CELL MEMORY 8
2.5 OBJECTIVE 9
3. MATERIALS AND METHODS 11
3.1 MICE 11
3.2 ADOPTIVE TRANSFER EXPERIMENTS 11
3.3 IN VIVO BLOCKADE 12
3.4 FLOW CYTOMETRY 12
3.5 ANALYSIS OF CYTOKINE PRODUCTION 13
3.6 HISTOLOGY 14
3.7 STATISTICAL ANALYSIS 14
4. RESULTS 15
4.1 ACTIVATED EFFECTOR T CELLS EXPRESS TFH HALLMARK PROTEINS BEFORE THE
EMERGENCE OF TFH CELLS 15
4.2 SIGNALLING VIA CD28 AND ITS FAMILY MEMBER ICOS IS ESSENTIAL FOR THE
DEVELOPMENT OF A TFH CELL POPULATION 17
4.3 THE DEFECT IN THE GENERATION OF A TFH POPULATION IS T CELL*INTRINSIC
IN
CD28 KO AND ICOS KO T CELLS 18
4.4 ICOS, IN CONTRAST TO CD28, IS NOT ESSENTIAL FOR THE INDUCTION OF
BCL-6
AND MOLECULES CHARACTERISTIC FOR B CELL HELP 20
4.5 BLOCKING OF ICOS AND CD28 SIGNALLING VIA MIL-5733 AND CTLA-4-IG
IS AS EFFECTIVE AS USING KNOCKOUT MOUSE STRAINS 22
V
HTTP://D-NB.INFO/1044247657
TABLE OF CONTENTS
4.6 BLOCKING ICOS SIGNALLING REDUCES THE FREQUENCY OF TRANSGENIC T CELLS
WITH THE TFH PHENOTYPE 24
4.7 ESTABLISHMENT OF THE RE-TRANSFER OF IN VIVO GENERATED TRANSGENIC
T FOLLICULAR HELPER CELLS 26
4.8 DISTRIBUTION OF RE-TRANSFERRED T EFFECTOR CELLS IN PRE-IMMUNISED
HOSTS 27
4.9 RE-TRANSFERRED TFH AND NON-TFH EFFECTOR CELLS DIFFER IN
PHENOTYPE AND PROLIFERATION 28
4.10 RE-TRANSFERRED TFH CELLS MAINTAIN FUNCTIONAL CHARACTERISTICS OF TFH
CELLS ... 30
4.11 BLOCKING OF ICOS SIGNALLING CAUSES REVERSION OF THE TFH PHENOTYPE
31
4.12 BLOCKING OF ICOS SIGNALLING DOES NOT INTERFERE WITH CELL
PROLIFERATION .32
4.13 TFH MEMORY CELLS CAN PERSIST IN THE ABSENCE OF ANTIGEN 33
4.14 TFH AND NON-TFH MEMORY CELLS HAVE DISTINCTIVE PHENOTYPES 35
4.15 RE-ACTIVATION OF TFH MEMORY CELLS SHOWS THEIR SUPERIOR
POTENTIAL FOR B CELL HELP 37
5. DISCUSSION 41
5.1 MERITS AND DEARTHS OF THE ADOPTIVE TRANSFER SYSTEM 41
5.2 THOU CANST BE PLACED IN A NEW HOME, TFH! 43
5.3 THY COMING OF AGE 44
5.4 THY TRUTHFUL FACE: ARE THOU THE ONLY GIVER OF IL-21, AND DO THOU
DIVIDE? .... 45
5.5 THY NEEDED FRIENDS CD28 AND ICOS 47
5.5.1 THY CHILDHOOD FRIEND CD28 47
5.5.2 THOU CANST NOT THRIVE WITHOUT THINE ICOS 48
5.5.3 ONE FRIEND S DUSK IS ANOTHER FRIEND S DAWN 49
5.6 THOU LOOKEST DIFFERENT, OLDE FRIEND! 50
5-7 THY STRENGTH WAS NEVER ANY GREATER THAN NOW 52
6. BIBLIOGRAPHY 55
A ACKNOWLEDGMENTS 65
B LIST OF PUBLICATIONS 67
C ABBREVIATIONS 69
D TABLE OF FIGURES 71
VI
|
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| spelling | Weber, Jan Phillip Verfasser aut Generation, maintenance and fate of T follicular helper cells by Jan Phillip Weber Generierung, Aufrechterhaltung und Schicksal follikulärer T-Helferzellen 2013 VI, 71 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Nebentitel: Generierung, Aufrechterhaltung und Schicksal follikulärer T-Helferzellen Berlin, Freie Univ., Diss., 2013 (DE-588)4113937-9 Hochschulschrift gnd-content Erscheint auch als Online-Ausgabe urn:nbn:de:kobv:188-fudissthesis000000095282-6 http://www.diss.fu-berlin.de/diss/receive/FUDISS_thesis_000000095282 kostenfrei Volltext DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026809797&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Weber, Jan Phillip Generation, maintenance and fate of T follicular helper cells |
| subject_GND | (DE-588)4113937-9 |
| title | Generation, maintenance and fate of T follicular helper cells |
| title_alt | Generierung, Aufrechterhaltung und Schicksal follikulärer T-Helferzellen |
| title_auth | Generation, maintenance and fate of T follicular helper cells |
| title_exact_search | Generation, maintenance and fate of T follicular helper cells |
| title_full | Generation, maintenance and fate of T follicular helper cells by Jan Phillip Weber |
| title_fullStr | Generation, maintenance and fate of T follicular helper cells by Jan Phillip Weber |
| title_full_unstemmed | Generation, maintenance and fate of T follicular helper cells by Jan Phillip Weber |
| title_short | Generation, maintenance and fate of T follicular helper cells |
| title_sort | generation maintenance and fate of t follicular helper cells |
| topic_facet | Hochschulschrift |
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