Structural and functional characterization of the yeast Ski2-Ski3-Ski8 complex:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online-Zugang: | https://nbn-resolving.org/urn:nbn:de:bvb:19-160779 http://d-nb.info/1041584709/34 kostenfrei Inhaltsverzeichnis |
| Beschreibung: | XIV, 112 S. Ill., graph. Darst. |
| Format: | Langzeitarchivierung gewährleistet, LZA |
Internformat
MARC
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| 245 | 1 | 0 | |a Structural and functional characterization of the yeast Ski2-Ski3-Ski8 complex |c Felix Johannes Halbach |
| 264 | 1 | |c 2013 | |
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Datensatz im Suchindex
| _version_ | 1804151440948592640 |
|---|---|
| adam_text | IMAGE 1
CONTENTS
SUMMARY XIII
1 PREFACE 1
2 INTRODUCTION 3
2.1 MRNA DEGRADATION IN EUKARYOTES 3
2.1.1 CANONICAL MRNA DECAY IS INITIATED BY THE DEADENYLATION MACHINERY
AND DRIVEN BY EXONUCLEASES 4
2.1.2 ALTERNATIVE DECAY PATHWAYS 6
2.1.3 RELATIVE CONTRIBUTIONS OF 5 AND 3 DECAY ROUTES 6
2.2 THE EXOSOME IS THE MAJOR EUKARYOTIC 3 TO 5 RIBONUCLEASE COMPLEX 7
2.2.1 FUNCTIONS OF THE EUKARYOTIC EXOSOME: FROM MATURATION TO
DEGRADATION 7
2.2.2 THE ARCHITECTURE OF THE CORE EXOSOME AND ITS CONSERVATION THROUGH
ALL DOMAINS OF LIFE 9
2.2.3 RRP44 AND RRP6 CONFER ACTIVITY TO THE EUKARYOTIC EXOSOME 11
2.2.4 THE INACTIVE EUKARYOTIC EXOSOME CORE RETAINS FUNCTIONALITY 12
2.3 EXOSOME COFACTORS 14
2.3.1 GENERAL COFACTORS OF THE EXOSOME 14
2.3.2 SPECIFIC EXOSOME COFACTORS 17
2.4 THE SKI COMPLEX IS A GENERAL COFACTOR OF THE CYTOPLASMIC EXOSOME 18
2.4.1 FUNCTIONS OF THE SKI2-SKI3-SKI8 COMPLEX 18
2.4.2 TOWARDS THE ARCHITECTURE OF THE S. CEREVISIAE SKI2-SKI3-SKI8
COMPLEX 20
2.4.3 CONSERVATION OF THE SKI2-SKI3-SKI8 COMPLEX AND SKI7 IN HIGHER EU
KARYOTES 25
2.5 SCOPE OF THIS WORK 26
HTTP://D-NB.INFO/1042583463
IMAGE 2
VI CONTENTS
3 RESULTS 27
3.1 CRYSTAL STRUCTURE OF THE S. CEREVISIAE SKI2 HELICASE 27
3.2 THE SKI COMPLEX: CRYSTAL STRUCTURE AND SUBSTRATE CHANNELING TO THE
EXOSOME 42
4 DISCUSSION 65
4.1 SKI2 CONTAINS A CONSERVED DEXH BOX CORE AND A VARIABLE INSERTION
DOMAIN . 65 4.2 THE STRUCTURE OF THE SKI COMPLEX: A FRAMEWORK FOR SKI2
TO FUNCTION IN CONCERT WITH THE EXOSOME 67
4.3 THE SKI3 TPR SCAFFOLD ORGANIZES THE SKI COMPLEX 68
4.4 SKI8 IS A VERSATILE ADAPTER PROTEIN WITH MULTIPLE ROLES 71
4.5 THE SKI COMPLEX REGULATES EXOSOME FUNCTION 76
4.6 MAJOR CONCLUSIONS 80
5 OUTLOOK 81
A APPENDIX 83
BIBLIOGRAPHY 95
ACKNOWLEDGEMENTS 110
CURRICULUM VITAE 113
|
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| spelling | Halbach, Felix Johannes 1981- Verfasser (DE-588)1042583358 aut Structural and functional characterization of the yeast Ski2-Ski3-Ski8 complex Felix Johannes Halbach 2013 XIV, 112 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Langzeitarchivierung gewährleistet, LZA (DE-588)4113937-9 Hochschulschrift gnd-content Erscheint auch als Online-Ausgabe urn:nbn:de:bvb:19-160779 https://nbn-resolving.org/urn:nbn:de:bvb:19-160779 Resolving-System http://d-nb.info/1041584709/34 Langzeitarchivierung Nationalbibliothek http://edoc.ub.uni-muenchen.de/16077/ Verlag kostenfrei DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026806709&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Halbach, Felix Johannes 1981- Structural and functional characterization of the yeast Ski2-Ski3-Ski8 complex |
| subject_GND | (DE-588)4113937-9 |
| title | Structural and functional characterization of the yeast Ski2-Ski3-Ski8 complex |
| title_auth | Structural and functional characterization of the yeast Ski2-Ski3-Ski8 complex |
| title_exact_search | Structural and functional characterization of the yeast Ski2-Ski3-Ski8 complex |
| title_full | Structural and functional characterization of the yeast Ski2-Ski3-Ski8 complex Felix Johannes Halbach |
| title_fullStr | Structural and functional characterization of the yeast Ski2-Ski3-Ski8 complex Felix Johannes Halbach |
| title_full_unstemmed | Structural and functional characterization of the yeast Ski2-Ski3-Ski8 complex Felix Johannes Halbach |
| title_short | Structural and functional characterization of the yeast Ski2-Ski3-Ski8 complex |
| title_sort | structural and functional characterization of the yeast ski2 ski3 ski8 complex |
| topic_facet | Hochschulschrift |
| url | https://nbn-resolving.org/urn:nbn:de:bvb:19-160779 http://d-nb.info/1041584709/34 http://edoc.ub.uni-muenchen.de/16077/ http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026806709&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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