Targeted delivery of the theranostic sodium iodide symporter (NIS) for cancer gene therapy:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online-Zugang: | Volltext http://d-nb.info/1038151805/34 https://nbn-resolving.org/urn:nbn:de:bvb:19-158988 Inhaltsverzeichnis |
| Beschreibung: | 134 S. Ill., graph. Darst. |
Internformat
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Datensatz im Suchindex
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|---|---|
| adam_text | IMAGE 1
TABLE OF CONTENTS
TABLE OF CONTENTS
1. INTRODUCTION 1
1.1 CANCER AND CANCER THERAPY 1
1.1.1 CANCER 1
1.1.2 GENE THERAPY 1
1.2 THE SODIUM IODIDE SYMPORTER (NIS) 2
1.2.1 THE PHYSIOLOGICAL ROLE OF NIS 2
1.2.2 NIS-MEDIATED RADIOIODINE THERAPY 3
1.2.3 NIS AND ITS ROLE AS REPORTER GENE 3
1.2.4 NIS AS NOVEL THERAPEUTIC GENE 5
1.3 GENE DELIVERY CONCEPTS 7
1.3.1 GENE TRANSFER 7
1.3.2 NON-VIRAL GENE DELIVERY VECTORS 7
1.3.3 NON-VIRAL NIS GENE DELIVERY 9
1.3.4 VIRAL GENE DELIVERY VECTORS 10
1.3.5 ADENOVIRUS-MEDIATED GENE TRANSFER 11
1.4 ADENOVIRUS-MEDIATED NIS GENE THERAPY 12
1.4.1 INTRATUMORAL ADENOVIRAL NIS GENE DELIVERY 12
1.4.2 RADIOVIROTHERAPY 13
1.4.3 SYSTEMIC ADENOVIRAL GENE DELIVERY 14
1.4.4 DENDRIMER COATING OF ADENOVIRUS VECTORS FOR SYSTEMIC NIS GENE
DELIVERY 15
1.5 AIM OF THE THESIS 18
2. CHAPTER 1 SODIUM IODIDE SYMPORTER (NLS)-MEDIATED RADIOVIROTHERAPY OF
HEPATOCELLULAR CANCER USING A CONDITIONALLY REPLICATING ADENOVIRUS 20
2.1 ABSTRACT 21
2.2 INTRODUCTION 22
2.3 MATERIALS AND METHODS 24
2.4 RESULTS 29
2.5 DISCUSSION 38
2.6 ACKNOWLEDGMENTS 44
3. CHAPTER 2 SYSTEMIC IMAGE-GUIDED LIVER CANCER RADIOVIROTHERAPY USING
DENDRIMER-COATED ADENOVIRUS ENCODING THE SODIUM IODIDE SYMPORTER (NIS)
AS THERANOSTIC GENE 45
3.1 ABSTRACT 46
HTTP://D-NB.INFO/1042582963
IMAGE 2
TABLE OF CONTENTS
3.2 INTRODUCTION 47
3.3 MATERIALS AND METHODS 49
3.4 RESULTS 52
3.5 DISCUSSION 61
3.6 ACKNOWLEDGMENTS 65
4. CHAPTER 3 EGFR-TARGETED ADENOVIRUS DENDRIMER COATING FOR IMPROVED
SYSTEMIC DELIVERY OF THE THERANOSTIC NIS GENE 66
4.1 ABSTRACT 67
4.2 INTRODUCTION 68
4.3 MATERIALS AND METHODS 70
4.4 RESULTS 73
4.5 DISCUSSION 81
4.6 ACKNOWLEDGMENTS 86
5. CHAPTER 4 SYSTEMIC EPIDERMAL GROWTH FACTOR RECEPTOR-TARGETED SODIUM
IODIDE SYMPORTER (NIS) GENE THERAPY IN A GENETICALLY ENGINEERED MOUSE
MODEL OF PANCREATIC DUCTAL ADENOCARCINOMA 87
5.1 ABSTRACT 88
5.2 INTRODUCTION 90
5.3 MATERIALS AND METHODS 92
5.4 RESULTS 96
5.5 DISCUSSION 102
5.6 ACKNOWLEDGMENTS 106
6. SUMMARY 107
7. PUBLICATIONS 111
7.1 ORIGINAL PAPERS 111
7.2 MANUSCRIPTS IN PREPARATION 111
7.3 ORAL PRESENTATIONS 112
7.4 POSTER PRESENTATIONS 113
7.5 AWARDS 115
8. REFERENCES 116
9. ACKNOWLEDGMENTS 131
10. CURRICULUM VITAE 133
|
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| spelling | Grünwald, Geoffrey K. 1982- Verfasser (DE-588)1042582874 aut Targeted delivery of the theranostic sodium iodide symporter (NIS) for cancer gene therapy Geoffrey K. Grünwald 2013 134 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier München, Univ., Diss., 2013 (DE-588)4113937-9 Hochschulschrift gnd-content Erscheint auch als Online-Ausgabe urn:nbn:de:bvb:19-158988 http://edoc.ub.uni-muenchen.de/15898/ Verlag kostenfrei Volltext http://d-nb.info/1038151805/34 Langzeitarchivierung Nationalbibliothek https://nbn-resolving.org/urn:nbn:de:bvb:19-158988 Resolving-System DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026798793&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Grünwald, Geoffrey K. 1982- Targeted delivery of the theranostic sodium iodide symporter (NIS) for cancer gene therapy |
| subject_GND | (DE-588)4113937-9 |
| title | Targeted delivery of the theranostic sodium iodide symporter (NIS) for cancer gene therapy |
| title_auth | Targeted delivery of the theranostic sodium iodide symporter (NIS) for cancer gene therapy |
| title_exact_search | Targeted delivery of the theranostic sodium iodide symporter (NIS) for cancer gene therapy |
| title_full | Targeted delivery of the theranostic sodium iodide symporter (NIS) for cancer gene therapy Geoffrey K. Grünwald |
| title_fullStr | Targeted delivery of the theranostic sodium iodide symporter (NIS) for cancer gene therapy Geoffrey K. Grünwald |
| title_full_unstemmed | Targeted delivery of the theranostic sodium iodide symporter (NIS) for cancer gene therapy Geoffrey K. Grünwald |
| title_short | Targeted delivery of the theranostic sodium iodide symporter (NIS) for cancer gene therapy |
| title_sort | targeted delivery of the theranostic sodium iodide symporter nis for cancer gene therapy |
| topic_facet | Hochschulschrift |
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