Neurale Korrelate von Wortgenerierungsaufgaben bei ketamininduzierten Modellpsychosen: eine fMRT-Studie
Gespeichert in:
| 1. Verfasser: | |
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| Format: | Abschlussarbeit Buch |
| Sprache: | German English |
| Veröffentlicht: |
2011
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Text teilw. dt., teilw. engl. |
| Beschreibung: | 145 S. Ill., graph. Darst. |
Internformat
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Datensatz im Suchindex
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| adam_text | Inhaltsverzeichnis
1. EINLEITUNG.....................................................................................1
2. ÜBERSICHT......................................................................................2
2.1. Wortgenerierungsaufgaben: phonologische, lexikalische
und semantische Wortflüssigkeit.........................................2
2.2. Schizophrenie und Wortflüssigkeit.....................................6
2.3. Modelipsychoseforschung.................................................13
2.3.1. Experimentelle Vorarbeiten von Kraepelin..........................13
2.3.2.
Meskalin.........
.........................................................................17
2.3.3. LSD..........................................................................................18
2.3.4. Ketamin...................................................................................20
2.4. Ziele und Hypothesen.........................................................24
2.4.1. Experiment 1.......................................................................... 24
2.4.2. Experiment 2..........................................................................25
2.4.3. Experiment 3..........................................................................25
3. EXPERIMENTE...............................................................................27
4. EXPERIMENT 1..............................................................................28
4.1.
Abstract
................................................................................29
4.2.
Introduction
.........................................................................
ЗО
4.3. Materials
and Methods
........................................................35
4.3.1.
Subjects
..................................................................................35
4.3.2.
Tasks and stimuli
...................................................................36
4.3.3.
Procedure
...............................................................................37
4.3.4.
fMRI image acquisition
..........................................................38
4.3.5.
fMRI data analysis.
.................................................................38
4.4.
Results
..................................................................................39
4.4.1
Behavioral results
..................................................................39
4.4.2.
fMRI data
.................................................................................40
4.5.
Discussion
...........................................................................42
4.6.
Conclusion
...........................................................................45
4.7.
References
...........................................................................46
5.
EXPERIMENT
2............................................................................„53
5.1.
Abstract
................................................................................54
5.2.
Introduction
.........................................................................55
5.3.
Materials and methods
.......................................................57
5.3.1.
Subjects
..................................................................................57
6.3.2.
Tasks and stimuli.
..................................................................57
5.3.3.
Procedure
...............................................................................58
5.3.4.
Speech recordings....
.............................................................59
5.3.5.
fMRI image acquisition
..........................................................60
5.3.6.
fMRI data analysis
..................................................................60
5.3.7.
S-ketamine and placebo infusions
.......................................61
5.3.8.
Psychopathological data
.......................................................61
5.4.
Results
..................................................................................62
5.4.1.
Behavioural data
....................................................................62
5.4.2.
Psychopathofogical data.
......................................................62
5.4.3.
Neuroimaging data
................................................................63
5.4.3.1.
Task and condition specific effects
..............................63
5.4.3.2.
Task specific complex contrasts..
.................................64
5.4.3.2.1.
Phonological verbal fluency.
.................................... 64
5.4.3.2.2.
Lexical verbal fluency
...............................................64
5.4.3.2.3.
Semantic verbal fluency
...........-............................... 64
5.5.
Discussion
...........................................................................67
5.5.1.
Effects on task performance
.................................................67
5.5.2.
FMRI....
....................................................................................68
5.6.
Conclusions
.........................................................................70
5.7.
Acknowledgments
...............................................................70
5.8.
References
...........................................................................71
6. EXPERIMENT 3..............................................................................78
6.1.
Abstract
................................................................................79
6.2.
Introduction
.........................................................................80
6.3.
Methods
..................................................,.............................83
6.3.1.
Subjects
..................................................................................83
6.3.2.
Tasks and stimuli..
.................................................................83
6.3.3.
Procedure
...............................................................................84
6.3.4.
Speech recordings
.................................................................84
6.3.5.
fMRI image acquisition
..........................................................85
6.3.6.
fMRI data analysis
..................................................................85
6.3.7.
S-ketamine and placebo infusions....
...................................86
6.3.8.
Psychopathological data...
....................................................87
6.4.
Results
..................................................................................87
6.4.1.
Psychopathology
...................................................................87
6.4.2.
Behavioural data
....................................................................88
6.4.3.
Imaging data
...........................................................................88
6.4.3.1.
Task and condition specific effects
..............................88
6.4.3.2.
Conceptual disorganization (CD)
..................................89
6.4.3.3.
Difficulty in abstract thinking (AT)
................................ 91
6.4.3.4.
Lack of spontaneity and flow of conversation (SP)
.....92
6.5.
Discussion
...........................................................................93
6.5.1.
Association of psychopathological items with
hemodynamic responses
.................................................................93
6.5.1.1.
Conceptual disorganization (CD)
..................................93
6.5.1.2.
Difficulty in abstract thinking
(АЂ
................................94
6.5.1.3.
Lack of spontaneity and flow of conversation (SP)
.....96
6.6.
Limitations..
.........................................................................96
6.7.
Conclusions
...................,.....................................................97
6.8.
Acknowledgements
.............................................................97
6.9.
Bibliography
........................................................................98
7. ZUSAMMENFASSUNG UND AUSBLICK....................................105
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11. ZUSAMMENFASSUNG (DEUTSCH)............................................141
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| indexdate | 2024-07-10T00:54:33Z |
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| language | German English |
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| spelling | Nagels, Arne 1980-2024 Verfasser (DE-588)143520601 aut Neurale Korrelate von Wortgenerierungsaufgaben bei ketamininduzierten Modellpsychosen eine fMRT-Studie vorgelegt von Arne Nagels 2011 145 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Text teilw. dt., teilw. engl. Marburg an der Lahn, Univ., Diss., 2011 Modellpsychose (DE-588)4170299-2 gnd rswk-swf Funktionelle Kernspintomografie (DE-588)7618675-1 gnd rswk-swf Sprachstörung (DE-588)4056500-2 gnd rswk-swf Neuropsychologischer Test (DE-588)4397354-1 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Funktionelle Kernspintomografie (DE-588)7618675-1 s Modellpsychose (DE-588)4170299-2 s Sprachstörung (DE-588)4056500-2 s Neuropsychologischer Test (DE-588)4397354-1 s DE-604 Digitalisierung UB Augsburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026794817&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Nagels, Arne 1980-2024 Neurale Korrelate von Wortgenerierungsaufgaben bei ketamininduzierten Modellpsychosen eine fMRT-Studie Modellpsychose (DE-588)4170299-2 gnd Funktionelle Kernspintomografie (DE-588)7618675-1 gnd Sprachstörung (DE-588)4056500-2 gnd Neuropsychologischer Test (DE-588)4397354-1 gnd |
| subject_GND | (DE-588)4170299-2 (DE-588)7618675-1 (DE-588)4056500-2 (DE-588)4397354-1 (DE-588)4113937-9 |
| title | Neurale Korrelate von Wortgenerierungsaufgaben bei ketamininduzierten Modellpsychosen eine fMRT-Studie |
| title_auth | Neurale Korrelate von Wortgenerierungsaufgaben bei ketamininduzierten Modellpsychosen eine fMRT-Studie |
| title_exact_search | Neurale Korrelate von Wortgenerierungsaufgaben bei ketamininduzierten Modellpsychosen eine fMRT-Studie |
| title_full | Neurale Korrelate von Wortgenerierungsaufgaben bei ketamininduzierten Modellpsychosen eine fMRT-Studie vorgelegt von Arne Nagels |
| title_fullStr | Neurale Korrelate von Wortgenerierungsaufgaben bei ketamininduzierten Modellpsychosen eine fMRT-Studie vorgelegt von Arne Nagels |
| title_full_unstemmed | Neurale Korrelate von Wortgenerierungsaufgaben bei ketamininduzierten Modellpsychosen eine fMRT-Studie vorgelegt von Arne Nagels |
| title_short | Neurale Korrelate von Wortgenerierungsaufgaben bei ketamininduzierten Modellpsychosen |
| title_sort | neurale korrelate von wortgenerierungsaufgaben bei ketamininduzierten modellpsychosen eine fmrt studie |
| title_sub | eine fMRT-Studie |
| topic | Modellpsychose (DE-588)4170299-2 gnd Funktionelle Kernspintomografie (DE-588)7618675-1 gnd Sprachstörung (DE-588)4056500-2 gnd Neuropsychologischer Test (DE-588)4397354-1 gnd |
| topic_facet | Modellpsychose Funktionelle Kernspintomografie Sprachstörung Neuropsychologischer Test Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026794817&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT nagelsarne neuralekorrelatevonwortgenerierungsaufgabenbeiketamininduziertenmodellpsychoseneinefmrtstudie |