Neuropsychological endophenotypes of attention-deficit/hyperactivity disorder:
Gespeichert in:
| 1. Verfasser: | |
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| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online-Zugang: | kostenfrei Inhaltsverzeichnis |
| Beschreibung: | 161 S. Ill., graph. Darst. |
Internformat
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| 245 | 1 | 0 | |a Neuropsychological endophenotypes of attention-deficit/hyperactivity disorder |c von Julia Maria Geissler |
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Datensatz im Suchindex
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|---|---|
| adam_text | TABLE OF CONTENTS
SUMMARY 1
ZUSAMMENFASSUNG 4
PREFACE 7
1 INTRODUCTION TO ATTENTION-DEFICIT/HYPERACTIVITY DISORDER 9
1.1 PHENOMENOLOGY 9
1.2 NEUROPSYCHOLOGY OF ADHD AND THE CONCEPT OF ENDOPHENOTYPES 12
1.3 CANDIDATE GENES 15
1.3.1 CATECHOL-O-METHYL TRANSFERASE (COMT) 16
1.3.2 DOPAMINE TRANSPORTER 1 (DAT) 17
1.3.3 LATROPHILILIN-3 (LPHN3) 19
1.4 CANDIDATE ENDOPHENOTYPES 21
1.4.1 RESPONSE INHIBITION 21
1.4.1.1 BEHAVIOURAL CORRELATES OF RESPONSE INHIBITION 21
1.4.1.2 EEG CORRELATES OF RESPONSE INHIBITION : 22
1.4.1.2.1 EVENT-RELATED POTENTIALS 23
1.4.1.2.2 TOPOGRAPHICAL PARAMETERS: NOGO-ANTERIORIZATION 25
1.4.1.3 GENETIC MODULATION OF RESPONSE INHIBITION 28
1.4.2 WORKING MEMORY 30
1.4.2.1 BEHAVIOURAL CORRELATES OF WORKING MEMORY 31
1.4.2.2 EEG CORRELATES OF WORKING MEMORY 33
1.4.2.2.1 NON-TARGET RELATED ERP COMPONENTS IN ADHD 33
1.4.2.2.2 TARGET ERP COMPONENTS IN ADHD 35
1.4.2.3 GENETIC MODULATION OF WORKING MEMORY 38
1.4.3 SENSORY GATING 40
1.4.4 RESPONSE TIME VARIABILITY 43
1.4.5 OUTLOOK: DEVELOPMENTAL COURSE OF THE CANDIDATE ENDOPHENOTYPES 45
1.5 RESEARCH OBJECTIVES AND HYPOTHESES 52
HTTP://D-NB.INFO/1043950494
2 METHODS 54
2.1 SAMPLE CHARACTERISTICS AND PROCEDURE 54
2.2 ELECTROPHYSIOLOGICAL RECORDING 57
2.3 NEUROPSYCHOLOGICAL TEST BATTERY 57
2.3.1 RESPONSE INHIBITION 57
2.3.1.1 CONTINUOUS PERFORMANCE TEST 57
2.3.1.2 EEG SPECIFICATIONS 58
2.3.2 WORKING MEMORY 58
2.3.2.1 N-BACKTASK 58
2.3.2.2 EEG SPECIFICATIONS ; 59
2.3.3 SENSORY GATING 59
2.3.3.1 DUAL-CLICK PARADIGM 59
2.3.3.2 EEG SPECIFICATIONS 60
2.4 GENOTYPING 60
2.4.1 CATECHOL-O-METHYL-TRANSFERASE 60
2.4.2 DOPAMINE TRANSPORTER 1 61
2.4.3 LATROPHILIN-3 61
2.4.4 HARDY-WEINBERG-EQUILIBRIUM AND GROUP DIFFERENCES 62
2.5 STATISTICAL ANALYSIS 62
3 RESULTS 63
3.1 BEHAVIOURAL PARAMETERS 63
3.2 RESPONSE INHIBITION 64
3.2.1 NOGO-ANTERIORIZATION 64
3.2.3 N200 70
3.2.4 P300 71
3.3 WORKING MEMORY 73
3.3.1 COMT 73
3.3.2 DAT.: 74
3.3.3 LATROPHILIN-3 77
3.4 SENSORY GATING 77
3.5 EXPLORATORY CATAMNESTIC ANALYSIS 79
3.5.1 CHANGES IN RESPONSE INHIBITION FROM T1 TO T2 80
3.5.2 CHANGES IN WORKING MEMORY FROM T1 TO T2 82
3.5.2.1 DEVELOPMENT OF WORKING MEMORY IN INTERACTION WITH COMT 82
3.5.2.2 DEVELOPMENT OF WORKING MEMORY IN INTERACTION WITH DAT 84
3.5.2.3 DEVELOPMENT OF WORKING MEMORY IN INTERACTION WITH LPHN3 86
4 DISCUSSION 89
4.1 RESPONSE INHIBITION 89
4.2 WORKING MEMORY 94
4.3 SENSORY GATING 98
4.4 RESPONSE TIME VARIABILITY 102
4.5 EXPLORATORY CATAMNESTIC ANALYSIS 102
4.6 LIMITATIONS 106
APPENDIX A: INSTRUCTIONS AND QUESTIONNAIRES 108
AL: INFORMATION FOR PARTICIPANTS AND CONFIRMATION OF CONSENT 108
A2: DSM-IV CRITERIA 114
A3: CHILD BEHAVIOUR CHECK LIST (CBCL) 116
A4: TASK INSTRUCTIONS PRESENTED ON A COMPUTER SCREEN BEFORE 118
APPENDIX B: TABLES AND FIGURES 119
51 GENOTYPE AND ALLELE FREQUENCIES (TL) 121
52 BEHAVIOURAL PARAMETERS (TL) 122
53 RESPONSE INHIBITION: AMPLITUDES AND LATENCIES (TL) 124
54 WORKING MEMORY: AMPLITUDES AND LATENCIES (TL) 127
55 SENSORY GATING 130
56 CATAMNESTIC RE-EXAMINATION OF SUB-SAMPLE 131
56.1 BEHAVIOURAL PARAMETERS (T2) 132
56.2 RESPONSE INHIBITION AT T2 134
56.3 WORKING MEMORY AT T2 137
REFERENCES 141
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| author | Geissler, Julia 1981- |
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| discipline | Psychologie |
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| spelling | Geissler, Julia 1981- Verfasser (DE-588)1042026289 aut Neuropsychological endophenotypes of attention-deficit/hyperactivity disorder von Julia Maria Geissler Neuropsychologische Endophänotypen des Aufmerksamkeitsdefizit-/Hyperaktivitätssyndroms 2013 161 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Würzburg, Univ., Diss., 2013 Zsfassung in dt. und engl. Sprache Arbeitsgedächtnis (DE-588)4332959-7 gnd rswk-swf Aufmerksamkeitsdefizit-Syndrom (DE-588)4525885-5 gnd rswk-swf Elektroencephalographie (DE-588)4014254-1 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Aufmerksamkeitsdefizit-Syndrom (DE-588)4525885-5 s Arbeitsgedächtnis (DE-588)4332959-7 s Elektroencephalographie (DE-588)4014254-1 s DE-604 Erscheint auch als Online-Ausgabe urn:nbn:de:bvb:20-opus-79221 https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-79221 Resolving-System kostenfrei Volltext DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026252992&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Geissler, Julia 1981- Neuropsychological endophenotypes of attention-deficit/hyperactivity disorder Arbeitsgedächtnis (DE-588)4332959-7 gnd Aufmerksamkeitsdefizit-Syndrom (DE-588)4525885-5 gnd Elektroencephalographie (DE-588)4014254-1 gnd |
| subject_GND | (DE-588)4332959-7 (DE-588)4525885-5 (DE-588)4014254-1 (DE-588)4113937-9 |
| title | Neuropsychological endophenotypes of attention-deficit/hyperactivity disorder |
| title_alt | Neuropsychologische Endophänotypen des Aufmerksamkeitsdefizit-/Hyperaktivitätssyndroms |
| title_auth | Neuropsychological endophenotypes of attention-deficit/hyperactivity disorder |
| title_exact_search | Neuropsychological endophenotypes of attention-deficit/hyperactivity disorder |
| title_full | Neuropsychological endophenotypes of attention-deficit/hyperactivity disorder von Julia Maria Geissler |
| title_fullStr | Neuropsychological endophenotypes of attention-deficit/hyperactivity disorder von Julia Maria Geissler |
| title_full_unstemmed | Neuropsychological endophenotypes of attention-deficit/hyperactivity disorder von Julia Maria Geissler |
| title_short | Neuropsychological endophenotypes of attention-deficit/hyperactivity disorder |
| title_sort | neuropsychological endophenotypes of attention deficit hyperactivity disorder |
| topic | Arbeitsgedächtnis (DE-588)4332959-7 gnd Aufmerksamkeitsdefizit-Syndrom (DE-588)4525885-5 gnd Elektroencephalographie (DE-588)4014254-1 gnd |
| topic_facet | Arbeitsgedächtnis Aufmerksamkeitsdefizit-Syndrom Elektroencephalographie Hochschulschrift |
| url | https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-79221 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026252992&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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