Biomaterials surface science:
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| Format: | Buch |
| Sprache: | English |
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Weinheim
Wiley-VCH
2013
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| Online-Zugang: | Inhaltstext Inhaltsverzeichnis |
| Beschreibung: | XXXII, 581 S. Ill., graph. Darst. |
| ISBN: | 3527330313 9783527330317 9783527649600 |
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IMAGE 1
CONTENTS
PREFACE XVII LIST OF CONTRIBUTORS XXI
PART I POLYMER SURFACES 1
1 PROTEINS FOR SURFACE STRUCTURING 3
ALEXANDER SCHULZ, STEPHANIE HILTL, PATRICK VAN RIJN, AND ALEXANDER BOKER
1.1 INTRODUCTION 3
1.2 STRUCTURING AND MODIFICATION OF INTERFACES BY SELF-ASSEMBLING
PROTEINS 3 1.2.1 FORMATION AND MODIFICATION OF PROTEIN STRUCTURES AT
LIQUID INTERFACES 4
1.2.1.1 SILAFFINS 4
1.2.1.2 HYDROPHOBINS 5 1.2.2 FORMATION AND MODIFICATION OF PROTEIN
STRUCTURES AT SOLID INTERFACES 8 1.2.2.1 SILICATEINS 8 1.3 STRUCTURING
AND MODIFICATION OF SOLID SURFACES VIA PRINTING OF
BIOMOLECULES 11
1.3.1 INTAGLIO PRINTING USING NANOSTRUCTURED WRINKLE SUBSTRATES 11
1.3.1.1 WRINKLING: NANOSTRUCTURED TEMPLATES 11 1.3.1.2 ASSEMBLY OF
BIONANOPARTICLES ON WRINKLES 12 1.3.1.3 INTAGLIO PRINTING OF TOBACCO
MOSAIC VIRUS 14
1.3.2 MICROCONTACT PRINTING FOR BIOINSPIRED SURFACE MODIFICATION 16
1.3.2.1 MICROCONTACT PRINTING ONTO SELF-ASSEMBLED MONOLAYERS 16 1.3.2.2
MICROCONTACT PRINTING WITH WRINKLE STAMPS 16 1.3.2.3 MICROCONTACT
PRINTING WITH POROUS STAMPS 18
1.3.2.4 ENHANCED MICROCONTACT PRINTING 20 . 1.4 CONCLUSION AND OUTLOOK
22
REFERENCES 22
HTTP://D-NB.INFO/1033099759
IMAGE 2
VI | CONTENTS
2 SURFACE-GRAFTED POLYMER BRUSHES 27
SZCZEPAN ZAPOTOCZNY 2.1 INTRODUCTION 27
2.2 SYNTHESIS OF POLYMER BRUSHES 28
2.3 STIMULI-RESPONSIVE POLYMER BRUSHES 30 2.4 POLYELECTROLYTE BRUSHES 33
2.5 BIO-FUNCTIONALIZED POLYMER BRUSHES 35 ACKNOWLEDGMENT 3 7 REFERENCES
37
3 INHIBITING NONSPECIFIC PROTEIN ADSORPTION: MECHANISMS, METHODS, AND
MATERIALS 45 MOJTABA BINAZADEH, HONGBO ZENG, AND LARRY D. UNSWORTH 3.1
INTRODUCTION 45
3.2 UNDERLYING FORCES RESPONSIBLE FOR NONSPECIFIC PROTEIN ADSORPTION 46
3.2.1 PROTEIN STRUCTURE EFFECTS ON ADSORPTION AND ADSORBED FILM
PROPERTIES 47 3.3 POLY(ETHYLENE GLYCOL) 48
3.4 SURFACE FORCES APPARATUS (SFA) 50 3.5 APPLICATIONS OF POLY(ETHYLENE
GLYCOL) 53 SUMMARY 55 REFERENCES 55
4 STIMULI-RESPONSIVE SURFACES FOR BIOMEDICAL APPLICATIONS 63 RUI R.
COSTA, NAT&LIA M. ALVES, J. CARLOS RODRFGUEZ-CABELLO, AND JOAO F. MARIO
4.1 INTRODUCTION 63
4.2 SURFACE MODIFICATION METHODOLOGIES: HOW TO RENDER SUBSTRATES WITH
STIMULI RESPONSIVENESS 64 4.2.1 SELF-ASSEMBLED MONOLAYERS 64 4.2.2 THIN
POLYMER NETWORK FILMS 65 4.2.3 GRAFTING 66
4.2.4 LAYER-BY-LAYER 68 4.3 EXPLOITABLE STIMULI AND MODEL SMART
BIOMATERIALS 69 4.3.1 PHYSICAL STIMULI 69
4.3.1.1 TEMPERATURE 69 4.3.1.2 LIGHT 71
4.3.2 CHEMICAL STIMULI 72
4.3.2.1 PH 72
4.3.2.2 IONIC STRENGTH 73 4.3.3 BIOCHEMICAL STIMULI 73 4.3.3.1 ANTIGENS
73 4.3.3.2 ENZYMES 73
4.3.3.3 GLUCOSE 74
4.3.4 MULTIPLE-RESPONSIVE SURFACES 74
IMAGE 3
CONTENTS IVII
4.4 BIOMEDICAL APPLICATIONS OF SMART SURFACES 75
4.4.1 SMART COATINGS FOR TISSUE ENGINEERING, REGENERATIVE MEDICINE, AND
DRUG DELIVERY APPLICATIONS 75 4.4.2 SMART BIOMINERALIZATION 77 4.4.3
CELL SHEET ENGINEERING 78 4.5 CONCLUSIONS 79
ACKNOWLEDGMENTS 79 REFERENCES 80
5 SURFACE MODIFICATION OF POLYMERIC BIOMATERIALS 89 AYSUN GUNEY, FILIZ
KARA, OZGE OZGEN, EDA AYSE AKSOY, VASIF HASIRCI, AND NESRIN HASIRCI 5.1
INTRODUCTION 89
5.2 EFFECT OF MATERIAL SURFACES ON INTERACTIONS WITH BIOLOGICAL ENTITIES
90 5.2.1 FUNDAMENTAL ASPECTS OF BIOLOGICAL RESPONSES TO BIOMATERIALS 90
5.2.2 SURFACE PROPERTIES OF POLYMERIC BIOMATERIALS 92 5.3 SURFACE
MORPHOLOGY OF POLYMERIC BIOMATERIALS 96 5.3.1 PHYSICAL METHODS 97
5.3.1.1 PHYSICAL ADSORPTION 97 5.3.1.2 SURFACE MICRO- AND NANOPATTERNING
99 5.3.1.3 LANGMUIR-BLODGETT (LB) FILM DEPOSITION 100 5.3.2 CHEMICAL
METHODS 102
5.3.2.1 OZONE TREATMENT 102 5.3.2.2 SILANIZATION 103 5.3.2.3
FLUORINATION 104 5.3.2.4 WET TREATMENTS 104 5.3.2.5 FLAME TREATMENT 105
5.3.2.6 INCORPORATION OF FUNCTIONAL GROUPS 105
5.3.3 BIOLOGICAL METHODS 106 5.3.3.1 PROTEIN-ENZYME IMMOBILIZATION 107
5.3.4 RADIATION METHODS 109 5.3.4.1 PLASMA RADIATION 110 5.3.4.2
MICROWAVE AND CORONA DISCHARGE 113
5.3.4.3 PHOTOACTIVATION BY UV 114 5.3.4.4 LASER 115
5.3.4.5 ION BEAM 115 5.3.4.6 GAMMA IRRADIATION 115 5.3.5 IMPROVEMENT OF
HYDROPHILICITY 115 5.4 SURFACE MODIFICATIONS TO IMPROVE BIOCOMPATIBILITY
OF BIOMATERIALS 118
5.4.1 ADSORPTION OF PROTEINS 118 5.4.1.1 PATTERNING OF THE SURFACES 120
5.5. SURFACE MODIFICATIONS TO IMPROVE HEMOCOMPATIBILITY OF BIOMATERIALS
126
5.5.1 BLOOD-MATERIAL INTERACTION 126 5.5.2 FACTORS INFLUENCING
HEMOCOMPATIBILITY 129
IMAGE 4
VIII | CONTENTS
5.5.3 MODIFICATION TECHNIQUES FOR HEMOCOMPATIBLE SURFACES 131
5.6 SURFACE MODIFICATIONS TO IMPROVE ANTIBACTERIAL PROPERTIES OF
BIOMATERIALS 134 5.6.1 BACTERIAL INFECTIONS ASSOCIATED WITH BIOMATERIALS
134 5.6.2 BACTERIA AND MATERIAL INTERACTION 135 5.6.3 MODIFICATION
TECHNIQUES FOR OBTAINING ANTIBACTERIAL SURFACES 137 5.6.3.1 SURFACE
COATINGS WITH ANTIBIOTICS 138 5.6.3.2 SURFACE COATINGS WITH SILVER 139
5.6.3.3 SURFACE MODIFICATIONS WITH ANTIBACTERIAL AGENTS 140 5.7
NANOPARTICLES 142
REFERENCES 143
6 POLYMER VESICLES ON SURFACES 159
AGNIESZKA JAGODA, JUSTYNA KOWAL, MIHAELA DELCEA, CORNELIA G. PALIVAN,
AND WOLFGANG MEIER 6.1 INTRODUCTION 159
6.2 POLYMER VESICLES 160
6.2.1 POLYMER VESICLES IN SOLUTION 160 6.2.1.1 SELF-ASSEMBLY 160 6.2.1.2
AMPHIPHILIC COPOLYMERS 161 6.2.1.3 PREPARATION OF POLYMER VESICLES 161
6.2.1.4 PROPERTIES OF POLYMER VESICLES 162 6.2.2 POLYMER VESICLES
TETHERED TO SURFACES 164 6.2.2.1 SURFACE PREPARATION 165
6.2.2.2 IMMOBILIZATION PROCEDURES 166 6.2.3 CHARACTERIZATION OF
VESICLES, SURFACES, AND VESICLES ON SURFACES 168 6.2.4 CHARACTERIZATION
OF VESICLES IN SOLUTION 169 6.2.4.1 SCATTERING METHODS 169
6.2.4.2 MICROSCOPIC TECHNIQUES 173 6.2.5 SOLID SUPPORT CHARACTERIZATION
176 6.2.6 VESICLES ON SURFACES 177 6.3 APPLICATIONS OF POLYMER MEMBRANES
AND VESICLES AS SMART AND ACTIVE
SURFACES 180
6.3.1 SURFACE FUNCTIONALIZATION OF POLYMERIC MEMBRANES AND VESICLES 182
6.3.1.1 INSERTION OF MEMBRANE PROTEINS IN POLYMERIC VESICLES 182 6.3.1.2
FUNCTIONALIZATION OF POLYMERIC MEMBRANES AND VESICLES WITH ANTIBODIES,
PEPTIDES, AND OTHER LIGANDS 183 6.3.2 POLYMER MEMBRANES AND VESICLES AS
(BIO)SENSORS 184
6.3.3 POLYMER VESICLES AS NANOREACTORS FOR DIAGNOSTICS AND THERAPY 185
6.3.3.1 ENCAPSULATION OF FLUORESCENT MOLECULES 186 6.3.3.2 ENCAPSULATION
OF NANOPARTICLES 186
6.3.3.3 POLYMER VESICLES AS NANOREACTORS 186 6.4 CURRENT LIMITATIONS OF
POLYMER VESICLES AND EMERGING TRENDS 187 6.4.1 REPRODUCIBILITY AND
STABILITY OF POLYMER VESICLES 187 6.4.2 LOADING EFFICIENCY OF POLYMER
VESICLES 188
IMAGE 5
CONTENTS I I X
6.4.3 CYTOTOXICITY OF POLYMER VESICLES 188
6.4.4 NEXT GENERATION OF POLYMER VESICLES 189 6.5 CONCLUSIONS 190
ABBREVIATIONS AND SYMBOLS 191 REFERENCES 193
PART II HYDROGEL SURFACES 205
7 PROTEIN-ENGINEERED HYDROGELS 207 JORDAN RAPHEL, ANDREINA PARISI-AMON,
AND SARAH C. HEILSHORN 7.1 INTRODUCTION TO PROTEIN ENGINEERING FOR
MATERIALS DESIGN 207 7.2 HISTORY AND DEVELOPMENT OF PROTEIN-ENGINEERED
MATERIALS 207 7.3 MODULAR DESIGN AND RECOMBINANT SYNTHESIS STRATEGY 210
7.3.1 MODULE DESIGN 210
7.3.2 LINKER DESIGN 212
7.3.3 RECOMBINANT PROTEIN EXPRESSION 214 7.4 PROCESSING
PROTEIN-ENGINEERED MATERIALS 216 7.4.1 CROSS-LINKING MECHANISMS 216
7.4.1.1 EFFECTS OF CROSS-LINK DENSITY 217 7.4.1.2 CHEMICAL HYDROGELS 219
7.4.1.3 PHYSICAL HYDROGELS 220 7.4.1.4 SELF-ASSEMBLING HYDROGEL TRIGGERS
222 7.4.2 PROTEIN-ENGINEERED HYDROGEL PROCESSING TECHNIQUES 222 7.4.2.1
THIN FILM TECHNIQUES 223 7.4.2.2 BULK PROTEIN TECHNIQUES 224 7.4.2.3
SURFACE PATTERNING TECHNIQUES 226 7.5 CONCLUSION 228
REFERENCES 229
8 BIOACTIVE AND SMART HYDROGEL SURFACES 239 J. CARLOS RODRIGUEZ-CABELLO,
A. FEMDNDEZ-COLINO, M.J. PITTA, M. ALONSO, M. SANTOS, AND A.M. TESTERA
8.1 INTRODUCTION 239
8.2 MIMICKING THE EXTRACELLULAR MATRIX 240 8.2.1 IMPORTANCE OF MIMICKING
ECM STRUCTURE: FROM 2D TO 3D CULTURE 240 8.2.2 PATTERNED SURFACES 242
8.2.2.1 LITHOGRAPHY 242
8.2.2.2 MICROMOLDING 243 8.2.2.3 NANO-MICROFLUIDICS 243 8.2.2.4
BIOPATTERNING 243 8.2.2.5 RESPONSE OF CELLS TO PATTERNED SURFACES 244
8.3 HYDROGELS: WHY ARE THEY SO SPECIAL? 245 8.3.1 CHEMICAL VERSUS
PHYSICAL HYDROGELS 247 8.3.1.1 CHEMICAL CROSS-LINKING 247 8.3.1.2
BIOINSPIRED PEPTIDIC MOTIFS FOR PHYSICAL CROSS-LINKING 250
IMAGE 6
X | CONTENTS
8.3.2 INJECTABLE HYDROGELS 251
8.3.3 NATURAL VERSUS ARTIFICIAL POLYMERS 251 8.3.3.1 NATURAL POLYMERS
251 8.3.3.2 ARTIFICIAL POLYMERS 254 8.4 ELASTIN-LIKE RECOMBINAMERS AS
BIOINSPIRED PROTEINS 255
8.4.1 ELR CHEMICAL HYDROGELS 258 8.4.2 ELR PHYSICAL HYDROGELS 259 8.4.3
ADDING BIOFUNCTIONALITY 260 8.4.4 COMPOSITES 260
8.5 PERSPECTIVES 261
ACKNOWLEDGMENTS 261 REFERENCES 261
9 BIORESPONSIVE SURFACES AND STEM CELL NICHES 269 MIGUEL ANGEL
MATEOS-TIMONEDA, MELBA NAVARRO, AND JOSEP ANTON PLANELL 9.1 GENERAL
INTRODUCTION 269
9.2 STEM CELL NICHES 271
9.2.1 HEMATOPOIETIC STEM CELL NICHE 271 9.2.2 EPITHELIAL STEM CELL NICHE
271 9.2.3 NEURAL STEM CELL NICHE 272 9.3 SURFACES AS STEM CELL NICHES
274
9.3.1 TOPOGRAPHY EFFECT ON STEM CELL BEHAVIOR 275 9.3.2 IMPORTANCE OF
MECHANICAL PROPERTIES ON STEM CELLS 276 9.3.3 ENGINEERING CHEMICAL
MICROENVIRONMENTS FOR STEM CELLS 277
9.4 CONCLUSIONS 279
REFERENCES 279
PART III HYBRID & INORGANIC SURFACES 285
10 MICRO- AND NANOPATTERNING OF BIOMATERIAL SURFACES 287 DANIEL
BRODOCEANU AND TOBIAS KRAUS 10.1 INTRODUCTION 287
10.2 PHOTOLITHOGRAPHY 287
10.3 ELECTRON BEAM LITHOGRAPHY 290 10.4 FOCUSED ION BEAM 292
10.5 SOFT LITHOGRAPHY 292
10.6 DIP-PEN NANOLITHOGRAPHY 294 10.7 NANOIMPRINT LITHOGRAPHY 295 10.8
SANDBLASTING AND ACID ETCHING 298 10.9 LASER-INDUCED SURFACE PATTERNING
298
10.10 COLLOIDAL LITHOGRAPHY 301 10.11 CONCLUSIONS AND PERSPECTIVES 303
ACKNOWLEDGMENTS 305 REFERENCES 306
IMAGE 7
CONTENTS I XI
11 ORGANIC/INORGANIC HYBRID SURFACES 311
TOBIAS MAI, KATRIN BLEEK, AND ANDREAS TAUBERT 11.1 INTRODUCTION 311
11.2 CALCIUM CARBONATE SURFACES AND INTERFACES 314 11.3 CALCIUM
PHOSPHATE SURFACES AND INTERFACES 319 11.4 SILICA SURFACES AND
INTERFACES 326 11.5 CONCLUSION AND OUTLOOK 327
ACKNOWLEDGMENTS 328 REFERENCES 328
12 BIOACTIVE CERAMIC AND METALLIC SURFACES FOR BONE ENGINEERING 337
CARLOS MAS-MORUNO, MONTSERRAT ESPANOL, EDGAR B. MONTUFAR, GEMMA MESTRES,
CONRADO APARICIO, FRANCISCO JAVIER GIL, AND MARIA-PAU. GINEBRA 12.1
INTRODUCTION 337
12.2 CERAMICS FOR BONE REPLACEMENT AND REGENERATION 338 12.2.1 THE
CONCEPT OF BIOACTIVITY IN CERAMICS: GENESIS AND EVOLUTION 339
12.2.2 BIOACTIVITY AS A SURFACE PROPERTY: SURFACE REACTIONS IN GLASSES
AND CERAMICS 340 12.2.3 IN VITRO EVALUATION OF BIOACTIVITY 344 12.2.4
BIOACTIVITY VIA FUNCTIONALIZATION OF SURFACES 345
12.3 METALLIC SURFACES FOR BONE REPLACEMENT AND REGENERATION 346 12.3.1
PHYSICAL SURFACE MODIFICATIONS TO CONFER FUNCTIONALITY TO METALLIC
IMPLANTS 348
12.3.1.1 MICROROUGH AND NANOROUGH SURFACES 348 12.3.1.2 SUPERHYDROPHILIC
SURFACES 349 12.3.2 INORGANIC AND HYBRID BIOACTIVE COATINGS TO IMPROVE
BONE - IMPLANT INTERACTIONS 350
12.3.2.1 BIOMIMETIC CALCIUM PHOSPHATE COATINGS 351 12.3.2.2 OTHER
INORGANIC SURFACE MODIFICATIONS 352 12.3.2.3 HYBRID COATINGS 352 12.3.3
FUNCTIONALIZATION OF METALLIC MATERIALS WITH BIOMOLECULES 353 12.3.3.1
COATING WITH FULL-LENGTH PROTEINS OR LINEAR PEPTIDES 354 12.3.3.2
COATING WITH PEPTIDE MIXTURES AND MULTIPLE PEPTIDE MOTIFS 358 12.3.3.3
COATING WITH ENGINEERED PROTEIN FRAGMENTS 360 12.3.3.4 COATING WITH
CYCLIC PEPTIDES 360 12.3.3.5 COATING WITH PEPTIDOMIMETICS 361 12.3.4
DESIGN OF A COATING MOLECULE AND IMMOBILIZATION
METHODS 362
12.3.4.1 THE COATING SYSTEM 362 12.3.4.2 IMMOBILIZATION METHODS 363 12.4
CONCLUSIONS 364
REFERENCES 365
IMAGE 8
CONTENTS
13 PLASMA-ASSISTED SURFACE TREATMENTS AND MODIFICATIONS FOR BIOMEDICAL
APPLICATIONS 375 SANJAY MATHUR, TRILOK SINGH, MAHBOUBEH MALEKI, AND
THOMAS FISCHER 13.1 INTRODUCTION 375
13.2 SURFACE REQUISITES FOR BIOMEDICAL APPLICATIONS 377 13.2.1
TECHNIQUES OF SURFACE MODIFICATION 378 13.2.2 PLASMA-ASSISTED
MODIFICATION OF BIOMATERIALS 379 13.3 SURFACE FUNCTIONALIZATION OF
INORGANIC SURFACES BY PLASMA
TECHNIQUES 383
13.3.1 PLASMA-ENHANCED CHEMICAL VAPOR DEPOSITION (PECVD) 384 13.3.2
PLASMA-ASSISTED ETCHING (PAE) 385 13.3.3 PLASMA-ASSISTED MODIFICATIONS
(PAM) 385 13.4 APPLICATIONS OF PLASMA-MODIFIED SURFACES IN BIOLOGY AND
BIOMEDICINE 386
13.4.1 SURFACE MODIFICATION FOR IMPROVED BLOOD COMPATIBILITY 386 13.4.2
SURFACE MODIFICATION FOR PROMOTING CELL ADHESION AND GROWTH 389 13.4.3
SURFACE MODIFICATION FOR IMPROVING WEAR AND CORROSION RESISTANCE 395
13.4.4 SURFACE MODIFICATION FOR TARGETED DRUG DELIVERY 399 13.5
CONCLUSIONS AND OUTLOOK 401 ACKNOWLEDGMENTS 402 REFERENCES 402
14 BIOLOGICAL AND BIOINSPIRED MICRO- AND NANOSTRUCTURED ADHESIVES 409
LONGJIAN XUE, MARTIN STEINHART, AND STANISLAV N. GORB 14.1 INTRODUCTION:
ADHESION IN BIOLOGICAL SYSTEMS 409 14.2 FIBRILLAR CONTACT ELEMENTS 410
14.2.1 ORIGIN 410
14.2.2 HIERARCHY 411 14.2.3 SLANTED FIBRILS 412 14.2.4 TIP SHAPE OF
FIBRILS 413 14.3 BASIC PHYSICAL FORCES CONTRIBUTING TO ADHESION 414
14.4 CONTACT MECHANICS 415
14.5 LARGER ANIMALS RELY ON FINER FIBERS 416 14.6 PEELING THEORY 416
14.7 ARTIFICIAL ADHESIVE SYSTEMS 419 14.7.1 ARRAYS OF MICRO- AND
NANO-FIBRILS 419 14.7.2 TIP SHAPE 424
14.7.3 SLANTED ANGLE 430 14.7.4 HIERARCHY 432
14.7.5 COMBINATION OF SEVERAL FEATURES 436 14.8 TOWARD SMART ADHESIVES
436 ACKNOWLEDGMENT 436 REFERENCES 437
IMAGE 9
CONTENTS I XIII
PART IV CELL-SURFACE INTERACTIONS 441
15 GENERIC METHODS OF SURFACE MODIFICATION TO CONTROL ADHESION OF CELLS
AND BEYOND 443 MARCUS NIEPEL, ALEXANDER KDWITSCH, YUAN YANG, NING MA,
NEHA AGGARWAL, DEEPAK GUDURU, AND THOMAS GROTH
15.1 GENERAL INTRODUCTION 443 15.2 SURVEY ON GENERIC METHODS TO MODIFY
MATERIAL SURFACES 444 15.2.1 METHODS FOR PREPARATION OF NANOSTRUCTURED
SURFACES 444 15.2.2 LAYER-BY-LAYER TECHNIQUE 445 15.2.3 SELF-ASSEMBLED
MONOLAYERS 446 15.2.4 COVALENT MODIFICATION BY WET CHEMICAL METHODS 448
15.3 RESULTS AND DISCUSSION 44 9 15.3.1 CELL ADHESION ON NANOSTRUCTURED
SURFACES 449
15.3.2 CELL ADHESION ON PEM-MODIFIED SURFACES 451 15.3.3 CELL ADHESION
ON SAMS 454 15.3.4 CHEMICAL MODIFICATION WITH GLYCANS 457 15.4 SUMMARY
AND CONCLUSIONS 461
ACKNOWLEDGMENTS 462 REFERENCES 462
16 SEVERE DEFORMATIONS OF MALIGNANT BONE AND SKIN CELLS, AS WELL AS AGED
CELLS, ON MICROPATTERNED SURFACES 469 PATRICIA M. DAVIDSON, TOKUKO
HARAGUCHI, TAKAKO KOUJIN, THORSTEN STEINBERG, PASCAL TOMAKIDI, YASUSHI
HIRAOKA, KARINE ANSELME,
AND GIINTER REITER
16.1 INTRODUCTION 469
16.2 EXPERIMENTAL METHODS 470 16.2.1 SUBSTRATE PREPARATION 470 16.2.1.1
SILICON TEMPLATES 470 16.2.1.2 PDMS REPLICAS 471 16.2.1.3 HOT EMBOSSING
471 16.2.2 CELL CULTURE 471
16.2.2.1 BONE CELLS 471 16.2.2.2 KERATINOCYTES 472 16.2.2.3 TIG-1 CELLS
472 16.2.2.4 SAMPLE PREPARATION FOR CELL SEEDING 472 16.2.2.5
IMMUNOHISTOCHEMICAL STAINING AND IMAGING 472
16.3 THE INTERACTION OF BONE CELLS WITH MICROPILLARS 473 16.3.1 THE
BEHAVIOR OF CANCEROUS CELLS ON MICROPATTERNED SURFACES 474 16.3.2 THE
DEFORMATION OF BONE CELLS AS A FUNCTION OF THEIR MALIGNANCY 477 16.4 THE
DEFORMATION OF SKIN CELLS AS A FUNCTION OF THEIR MALIGNANCY 480 16.5 THE
DEFORMATION OF FIBROBLASTS OF DIFFERENT CELLULAR AGES 481 16.6
DISCUSSION 484
16.6.1 COMPARISON OF BONE CELLS AND SKIN CELLS 485
IMAGE 10
XIV | CONTENTS
16.6.2 COMPARISON WITH AGING CELLS 485
16.7 CONCLUSIONS 48 6
ACKNOWLEDGMENTS 487 REFERENCES 487
17 THERMORESPONSIVE CELL CULTURE SURFACES DESIGNED FOR CELL-SHEET-BASED
TISSUE ENGINEERING AND REGENERATIVE MEDICINE 491 JUN KOBAYASHI AND TERUO
OKANO 17.1 INTRODUCTION 491
17.2 CHARACTERISTICS OF PIPAAM-GRAFTED CELL CULTURE SURFACES 493 17.3
MECHANISMS OF CELL DETACHMENT FROM THE THERMORESPONSIVE CELL CULTURE
DISH 495 17.4 CELL-SHEET-BASED TISSUE ENGINEERING AND ITS CLINICAL
APPLICATIONS 495
17.5 NEXT-GENERATION THERMORESPONSIVE CELL CULTURE DISHES 498 17.5.1
FUNCTIONAL THERMORESPONSIVE CELL CULTURE DISHES 499 17.5.2 AFFINITY
REGULATION BETWEEN CELLS AND SURFACE-IMMOBILIZED LIGANDS ON
THERMORESPONSIVE CELL CULTURE DISHES 500
17.5.3 COCULTURED CELL SHEETS USING MICROPATTERNED THERMORESPONSIVE
SURFACES 501 17.5.4 PREVASCULARIZED CELL SHEETS 502 17.5.5
THERMORESPONSIVE MICROCARRIERS FOR LARGE-SCALE CULTIVATION 502 17.6
CONCLUSIONS 503
REFERENCES 504
18 CELL MECHANICS ON SURFACES 511
JESSICA H. WEN, HERMES TAYLOR-WEINER, ALEXANDER FUHRMANN, AND ADAM J.
ENGLER 18.1 INTRODUCTION 511
18.2 WHAT IS ELASTICITY AND STIFFNESS? 511 18.3 MEASURING AND
QUANTIFYING STIFFNESS 514 18.3.1 MEASURING LINEARLY ELASTIC PROPERTIES
515 18.3.2 MEASURING NONLINEARLY ELASTIC PROPERTIES 518 18.4 CONTROLLING
SUBSTRATE STIFFNESS 519
18.4.1 MATERIAL PROPERTIES THAT DETERMINE STIFFNESS 519 18.5 NATURALLY
DERIVED SCAFFOLDS 520 18.5.1 COLLAGEN TYPE I 521 18.5.2 HYALURONIC ACID
523 18.5.3 CELL-DERIVED EXTRACELLULAR MATRIX 524
18.6 SYNTHETIC SCAFFOLDS 525 18.6.1 POLYACRYLAMIDE HYDROGELS 525 18.6.2
POLY(ETHYLENE GLYCOL) 527
18.6.3 POLYDIMETHYLSILOXANE 528 18.7 SUBSTRATE STIFFNESS' IMPACT ON CELL
BEHAVIOR 528 18.8 WHEN STIFFNESS IN VIVO GOES AWRY: THE IMPACT OF
FIBROSIS ON FUNCTION 530
IMAGE 11
CONTENTS I XV
18.9 NOVEL SURFACE FABRICATION TECHNIQUES TO IMPROVE BIOMIMICRY 531
18.10 CONCLUSION 532
ACKNOWLEDGMENT 533 ABBREVIATIONS 533 REFERENCES 533
19 ELECTRODE-NEURAL TISSUE INTERACTIONS: IMMUNE RESPONSES, CURRENT
TECHNOLOGIES, AND FUTURE DIRECTIONS 539 GLORIA BORA KIM, POURIA FATTAHI,
AND MOHAMMAD REZA ABIDIAN
19.1 INTRODUCTION 539
19.2 IMMUNE RESPONSE TO NEURAL IMPLANTS 540 19.2.1 CELLS INVOLVED IN THE
IMMUNE RESPONSE OF CNS 540 19.2.2 ACUTE RESPONSE TO IMPLANTED ELECTRODES
542 19.2.3 CHRONIC RESPONSE TO IMPLANTED ELECTRODES 542 19.3 PAST AND
CURRENT NEURAL INTERFACES 543 19.3.1 ELECTRODE TYPES 544 19.3.1.1
MICROWIRES 544
19.3.1.2 SILICON ELECTRODES 544 19.3.2 SHAPE, SIZE, AND TEXTURE OF
ELECTRODES 545 19.3.3 MATERIALS USED FOR THE INSULATING LAYER 547 19.3.4
MATERIALS USED AS ELECTRODE CONNECTORS 547 19.4 METHODS FOR IMPROVEMENT
OF THE ELECTRODE-TISSUE INTERFACE 548
19.4.1 IMPROVEMENT OF ELECTRICAL AND MECHANICAL PROPERTIES 548 19.4.1.1
CONDUCTING POLYMERS 548 19.4.1.2 CARBON NANOTUBES 549 19.4.1.3 HYDROGELS
552 19.4.2 METHODS OF ANCHORING ELECTRODES 555 19.4.3 ELECTRODE
INSERTION AND IMPLANTATION PROCEDURE 555 19.5 CONCLUSIONS AND FUTURE
DIRECTIONS 557
REFERENCES 558
INDEX 567 |
| any_adam_object | 1 |
| author2 | Taubert, Andreas 1972- |
| author2_role | edt |
| author2_variant | a t at |
| author_GND | (DE-588)122449134 |
| author_facet | Taubert, Andreas 1972- |
| building | Verbundindex |
| bvnumber | BV041270787 |
| classification_rvk | UP 7500 VE 7000 VX 5650 YI 3200 ZM 7070 ZM 7600 |
| ctrlnum | (OCoLC)859398657 (DE-599)DNB1033099759 |
| dewey-full | 610.28 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 610 - Medicine and health |
| dewey-raw | 610.28 |
| dewey-search | 610.28 |
| dewey-sort | 3610.28 |
| dewey-tens | 610 - Medicine and health |
| discipline | Chemie / Pharmazie Physik Werkstoffwissenschaften / Fertigungstechnik Medizin |
| format | Book |
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| id | DE-604.BV041270787 |
| illustrated | Illustrated |
| indexdate | 2024-08-03T00:55:37Z |
| institution | BVB |
| isbn | 3527330313 9783527330317 9783527649600 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-026244396 |
| oclc_num | 859398657 |
| open_access_boolean | |
| owner | DE-29T DE-11 DE-703 DE-83 |
| owner_facet | DE-29T DE-11 DE-703 DE-83 |
| physical | XXXII, 581 S. Ill., graph. Darst. |
| publishDate | 2013 |
| publishDateSearch | 2013 |
| publishDateSort | 2013 |
| publisher | Wiley-VCH |
| record_format | marc |
| spelling | Biomaterials surface science ed. by Andreas Taubert ... Weinheim Wiley-VCH 2013 XXXII, 581 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Dünne Schicht (DE-588)4136925-7 gnd rswk-swf Physikalische Eigenschaft (DE-588)4134738-9 gnd rswk-swf Grenzfläche (DE-588)4021991-4 gnd rswk-swf Oberflächenchemie (DE-588)4126166-5 gnd rswk-swf Biomaterial (DE-588)4267769-5 gnd rswk-swf Biomaterial (DE-588)4267769-5 s Oberflächenchemie (DE-588)4126166-5 s DE-604 Grenzfläche (DE-588)4021991-4 s Physikalische Eigenschaft (DE-588)4134738-9 s Dünne Schicht (DE-588)4136925-7 s Taubert, Andreas 1972- (DE-588)122449134 edt Erscheint auch als Online-Ausgabe, EPUB 978-3-527-64962-4 Erscheint auch als Online-Ausgabe, MOBI 978-3-527-64961-7 Erscheint auch als Online-Ausgabe, PDF 978-3-527-64963-1 X:MVB text/html http://deposit.dnb.de/cgi-bin/dokserv?id=4289654&prov=M&dok_var=1&dok_ext=htm Inhaltstext DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026244396&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Biomaterials surface science Dünne Schicht (DE-588)4136925-7 gnd Physikalische Eigenschaft (DE-588)4134738-9 gnd Grenzfläche (DE-588)4021991-4 gnd Oberflächenchemie (DE-588)4126166-5 gnd Biomaterial (DE-588)4267769-5 gnd |
| subject_GND | (DE-588)4136925-7 (DE-588)4134738-9 (DE-588)4021991-4 (DE-588)4126166-5 (DE-588)4267769-5 |
| title | Biomaterials surface science |
| title_auth | Biomaterials surface science |
| title_exact_search | Biomaterials surface science |
| title_full | Biomaterials surface science ed. by Andreas Taubert ... |
| title_fullStr | Biomaterials surface science ed. by Andreas Taubert ... |
| title_full_unstemmed | Biomaterials surface science ed. by Andreas Taubert ... |
| title_short | Biomaterials surface science |
| title_sort | biomaterials surface science |
| topic | Dünne Schicht (DE-588)4136925-7 gnd Physikalische Eigenschaft (DE-588)4134738-9 gnd Grenzfläche (DE-588)4021991-4 gnd Oberflächenchemie (DE-588)4126166-5 gnd Biomaterial (DE-588)4267769-5 gnd |
| topic_facet | Dünne Schicht Physikalische Eigenschaft Grenzfläche Oberflächenchemie Biomaterial |
| url | http://deposit.dnb.de/cgi-bin/dokserv?id=4289654&prov=M&dok_var=1&dok_ext=htm http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026244396&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT taubertandreas biomaterialssurfacescience |