Regenerative biology and medicine:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Amsterdam [u.a.]
Elsevier
2012
|
| Ausgabe: | 2. ed. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Includes bibliographical references and index |
| Beschreibung: | xi, 461 pages illustrations (chiefly color) |
| ISBN: | 9780123848604 |
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Datensatz im Suchindex
| _version_ | 1804150706605654016 |
|---|---|
| adam_text | Contents
Preface
χι
Part I
Regenerative Biology
1.
An Overview of Regenerative Biology
I.
li.
III.
IV.
V.
VI.
Introduction
A Brief History of Regenerative Biology
Regeneration Occurs at All Levels of
Biological Organization
Mechanisms of Vertebrate Regeneration
A. Cellular Re-Growth
B. Regeneration from Pre-Existing Parent Cells
C.
Transdifferentiation
D.
Activation of Adult Stem Cells (ASCs)
E. The Regeneration of Many Tissues Involves
More than One Mechanism
The Niche Concept in Tissue Repair
A. Niche Signaling Molecules
B. Signal Transduction Pathways
Approaches to the Study of Regeneration
A. Animal Models
B. Determining the Cellular Origins
of Regenerated Tissues
C. Analyzing the Niche Regulation of Cell
9
9
9
10
15
15
15
III.
Activities
16
D. Cell Imaging and Identification
16
E. Comparative Analysis of Regeneration
and Fibrosis
17
Summary
17
References
18
air of Skin by Fibrosis
Introduction
21
Structure of Adult Mammalian Skin
21
A. Epidermis
21
B.
Dermis
21
Phases of Repair By Fibrosis
23
A. Hemostasis
23
B. Inflammation
25
С
Structural Repair
26
D. The Role of Wound Contraction
in Dermal Repair
32
IV.
Tattoos and Fetal Skin Have a Minimal
Immune Response to Wounding
32
A. Tattoos Heal Without Scarring
32
B. Fetal Skin Heals Without Scarring
33
V.
Comparative Molecular Analysis
of Wound Repair
36
Summary
36
References
37
Regeneration of Epidermal Structures
1.
Introduction
43
II.
Maintenance Regeneration of Interfollicular
Epidermis and Hair
43
A. Interfollicular Epidermis
43
B. Hair Follicles
44
III.
Regeneration of Nails
48
IV.
Regeneration of Cornea
49
A. General Structure of the Eye
49
B. Structure of the Cornea
49
С
Regeneration of
Corneal
Epithelium
50
D. The
Corneal
Stroma
Does Not Regenerate,
But Harbors Stem Cells
51
E. Injury-Induced
Corneal
Regeneration Is
Regulated By Epithelial-Stromal
Interaction
51
V.
Regeneration of the Lens
51
A. Structure of the Lens
51
B. Lens Regeneration
51
VI.
Regeneration of Avian and Mammalian
Auditory Sensory Cells
56
A. Structure of the Inner Ear
56
B. Regeneration of Sensory Hair Cells
56
C. Niche Signals Regulating Hair Cell
Regeneration
58
D. Mammals Have Some Capacity for
Hair Cell Regeneration
58
Summary
59
References
61
VI
Contents
4. Regeneration
of Neural Tissues
I. Introduction
67
II. Structure of the Nervous System
67
A. Basic Organization
67
B. Cell Types
67
C. Nerve Structure
68
III. Regeneration of
Axons
68
A. Peripheral (Spinal) Nerve
Axons
69
Β. Αχοη
Regeneration in the CNS: Injured
Spinal Cord
72
C. Regeneration of the Optic Nerve
77
IV. Neurogenesis in the Adult CNS
78
A. Mammalian Brain and Spinal Cord
78
B. Fish Brain and Spinal Cord
82
C. Caudally Transected Amphibian
Spinal Cord
82
D. Caudally Transected Lizard Spinal Cord
85
E. Fish, Amphibians and Lizards are Good
Comparative Models of Adult Neurogenesis
and Axon Regeneration
85
F. Regeneration of the Neural Retina
85
Summary
90
References
91
5.
Regeneration of Digestive, Respiratory
and Urinary Tissues
I. Introduction
99
II. Regeneration of the Intestinal Epithelium
99
A. Structure of the Intestine
99
B. Intestinal Stem Cells and their Niche
Regulation
99
С
Regulation of Proliferation, Migration and
Differentiation of Transit Amplifying Cells
102
D. Regeneration of Transected Amphibian
Intestine
103
III. Regeneration of the Liver
103
A. Function and Structure of the Liver
103
B. The Liver Has An Enormous Capacity
for Regeneration
104
С
The Primary Mode of Liver Regeneration
Is Compensatory Hyperplasia
105
D. The Liver Has a Secondary Stem Cell
System for Regeneration
109
IV. Regeneration of the Pancreas
11
о
A. Structure and Function of the Pancreas
110
B. Models for Pancreatic Regeneration
111
С
Beta Cells of the Pancreas are
Regenerated from Differentiated Parent
Cells After Partial Pancreatectomy
11
1
D. Regeneration of 3-Cells from Stem
Cells and Non-0 Cells
112
V Regeneration of Respiratory Epithelium
115
A. Structure and Function of the Lung
115
B. Distinct Populations of Cells Regenerate
Epithelia in Different Parts of the
Respi ratory Tract
116
С
Niche Signals Regulating Epithelial
Regeneration
116
D.
A Multi
potent Mesenchymal Stem
Cell Population Resides in Human
Lung Tissue
117
VI. Regeneration of Kidney Tubule Epithelium
117
A. Nephron Structure and Function
117
B. Epithelial Cells are Regenerated
byEMT/MET
118
С
Some Fish Can Regenerate Nephrons
via Stem Cells
120
Summary
120
References
121
6.
Regeneration of Musculoskeletal
Tissues
127
127
127
127
129
I. Introduction
II. Regeneration of Skeletal Muscle
A. Structure of Skeletal Muscle
B. Injured Muscle is Regenerated
by Satellite Cells
С
Muscle Contains a Heterogeneous
Array of Stem Cells
D. Satellite Cells are Necessary and
Sufficient for Muscle Regeneration
130
E. Cellular Events of Muscle Regeneration
130
F. Signals that Regulate Satellite Cell Activity
131
G. Tension and
Innervation
are Requirements
for Normal Muscle Regeneration
134
III. Regeneration of Bone
135
A. Structure of Bone
135
B. Maintenance Regeneration
136
С
Fracture Repair in Endochondral Bones
142
IV. Regeneration of Articular Cartilage,
Meniscus, Tendon and Ligament
145
A. Articular Cartilage I45
B. Meniscus I46
С
Tendon and Ligament
146
V. Regeneration of Dental Tissues
148
A. Regeneration of Mammalian Tooth
and Periodontal Structures
148
B. Regeneration of
Urodele
Amphibian
Jaws and Teeth
1
50
Summary
152
References
1
54
7.
Regeneration of Cardiac Muscle
and Hematopoietic Tissues
Introduction
Regeneration of Cardiac Muscle
161
161
Contents
vn
A. Structure
of Cardiac
Muscle
161
B.
Amphibian and Zebrafish Cardiomyocytes
Regenerate from Pre-Existing
Cardiomyocytes
162
C. Mammalian Cardiomyocytes Can
Self-Replicate
166
D. Mammalian Cardiac Muscle Harbors
Cardiac Stem Cells
167
III. Regeneration of Hematopoietic Cells
169
A. Origin of Hematopoietic Stem Cells
169
B. Characteristics of Adult Hematopoietic
Stem Cells
171
C. Lineage Maps of HSCs
171
D. Niche Factors for Hematopoiesis
172
Summary
177
References
178
8.
Regeneration of Appendages
I. Introduction
183
II. Urodele
Limb Regeneration
183
A. Stages of Limb Regeneration
183
B. Origin of Blastema Cells
184
C. Mechanisms of Blastema Formation
186
D. Blastema Cell Proliferation: Role of the
Nerve and Wound Epidermis
190
E. Mechanisms of Blastema Patterning
196
III. What Inhibits Limb Regeneration in Adult
Frogs, Birds and Mammals?
205
A. Loss of Limb Regeneration in Anuran
Tadpoles is Associated with Spatial
Deficiencies in Patterning Gene
Expression
205
B. Hypotheses to Explain Loss of Anuran
Tadpole Regeneration
207
IV. Regeneration of Mammalian Appendages
208
A. Ear Tissue of Rabbits and Rodents
208
B. Deer Antlers
210
C. Mouse and Human Digit Tips
211
V. Stimulation of Regeneration in Anuran
and Mammalian Appendages
213
A. Frog Limbs
213
B. Mouse Digit Tips
215
VI. Comparative Analysis as a Tool to
Understand Limb Regeneration
216
Summary
217
References
218
Partii
Regenerative Medicine
9.
Strategies of Regenerative Medicine
I. Introduction
229
II. Biomimetic Devices and Organ Transplant
229
III. Cell Transplants
230
A. Characteristics of the Ideal Cell for
Transplant
230
B. Are Adult Stem Cells Pluripotent?
230
С
Effects of Age on Adult
Regeneration-Competent Cells
234
D. Embryonic Stem Cells (ESCs)
239
E. Induced Pluripotent Stem Cells (iPSCs)
243
F. ESC-like Cells Derived from Long-term
in vitro Cultures
247
IV. Bioartificial Tissue Construction
248
A. Types of Bioartificial Tissues
248
B. Challenges to Bioartificial Tissue
Construction
248
V. Chemical Induction of Regeneration in situ
251
Summary
251
References
253
10.
Regenerative Medicine of Epidermal
Structures
Introduction
261
Repair of Skin Wounds and Burns
261
A. Acute Wounds
261
B. Chronic Wounds
269
C. Future Research
273
Stimulation of Hair Regeneration
274
A. Pattern Baldness
274
B. Treatments for Pattern Baldness
274
Limbai
Cell Transplants to Regenerate
the Cornea
275
Summary
278
References
279
IV.
11.
Regenerative Medicine of Neural
Tissues
I. Introduction
285
II. Therapies for Regeneration of Peripheral
Nerves
285
A. Nerve
Autografe
285
B. Biomaterial
Conduits
286
C.
Cell Transplants
287
D.
Infra-Red Light and
LEDs 288
III. Therapies for Trauma to the Mammalian
Central Nervous System
288
A. Injured Spinal Cord
288
B. Therapies for Stroke and Traumatic
Brain Injury
299
IV. Therapies for
Neurodegenerative
Diseases
301
A. Parkinson s Disease
302
B.
Huntington^
Disease
306
C. Amyotrophic Lateral Sclerosis
308
D. Prospects for Deeper Understanding
of
Neurodegenerative
Diseases
311
VIII
Contents
Summary
References
312
315
12.
Regenerative Therapies for Digestive,
Respiratory and Urinary Tissues
I. Introduction
325
II. Regenerative Therapies for the Liver
325
A. Drug Treatments
325
B. HepatocyteTransplants
325
C. New Sources of Hepatocytes
for Transplant
326
D. Bioartificial Liver
328
III. Regenerative Therapies for the Pancreas
330
A. Suppression of Autoimmunity
and Regeneration from Remaining
rt-Cells in Diabetic Mice
331
B. Clinical Islet Transplants
332
C. Beta Cell Transplants in Experimental
Animals
333
D. Gene Therapy and
Transdifferentiation
of Acinar Cells in situ
334
E. Bioartificial Pancreas
335
IV. Regenerative Therapies for the Esophagus
and Intestine
337
A. Esophagus
337
B. Intestine
337
V. Regenerative Therapies for the Respiratory
System
339
A. Trachea
339
B. Distal Lung
340
VI. Regenerative Therapies for the Urinary
System
343
A. Kidney
343
B. Urinary Conduit Tissues
344
Summary
347
References
348
13.
Regenerative Therapies for
Musculoskeletal Tissues
I. Introduction
355
II. Therapies for Skeletal Muscle
355
A. Muscle Injured by Trauma
355
B. Duchenne Muscular Dystrophy
355
С
Bioartificial Muscle
358
III. Regenerative Therapies for Articular
Cartilage
359
A. Types of Cartilage Defects
359
B. Surgical Repair
359
С
Induction of Regeneration by Growth
Factors, Acellular
Biomaterial
Scaffolds
and Combinations
360
D. Cell Transplants
361
E. Bioartificial Articular Cartilage
364
IV. Regenerative Therapies for Meniscus
365
A. Meniscal Allografts
365
B. Acellular Scaffolds and Bioartificial
Meniscus
365
V. Regenerative Therapies for
Non-Union
Fractures and Critical Size Gaps in Bone
367
A. Non-Union
Fractures and Osteotomies
367
B. Critical Size Defects
368
С
Ilizarov Distraction Technique
for Lengthening Bones
374
D. Use of the Body as a Bioreactor
to Regenerate Skeletal Structures
375
VI. Regenerative Therapies for Teeth
and Periodontium
376
A. Growth Factors
376
B. Dental Stem Cells
377
С
Scaffolds for Periodontal Regeneration
378
VII.
Regenerative Therapies for Tendon
and Ligament
380
A. Tendon
381
B. Ligament
382
Summary
383
References
385
14.
Regenerative Therapies for
Hematopoietic and Cardiovascular
Tissues
I. Introduction
393
II. Therapies for Hematopoietic Disorders
393
A. General Strategies
393
B. Myeloablative Therapy
394
С
Non-Myeloablative Therapy
397
D. Gene Therapy for Genetic Deficiency
Diseases
399
III. Therapies for Damaged Blood Vessels
401
A. General Strategies 401
B. Decellularized Matrix
402
С
Bioartificial Bloodvessels
403
D. Progenitor and Stem Cell Transplants
405
E. Soluble Factors 407
IV. Therapies for Infarcted Myocardium
408
A. Stem Cell Transplants 408
B.
Transdifferentiation 412
С
Soluble Factors 412
D. Bioartificial Cardiac Muscle 415
Summary
417
References 42°
Partili
Perspective
15.
Retrospect and Prospect
I. Introduction
II. Achievements and Challenges
429
429
Contents
IX
IV.
A. Biology of Regeneration
B. Regenerative Medicine
Bioethics in Regenerative Medicine
A. In vitro Fertilization
B. Reproductive Cloning
C. Human ESCs and Therapeutic Cloning
436
D. The Ethical Controversy Over Human
ESC Research
E. The Specter of
Interspecies
Grafting
F. Resolving Unresolvable Dilemmas
439
Exciting Future Prospects for Regenerative
Biology and Medicine
441
429
A. Cell Transplants to Replace Tissues
430
and Identification of Raracrine Factors
441
434
B. Using iPSCs to Investigate Disease and
435
for Drug Discovery
441
436
С
Bioartificial Tissues and Organs
442
436
D. Chemical and Physical Induction of
Regeneration
443
436
V. Concluding Remarks
446
438
References
447
Index
451
|
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| id | DE-604.BV041251597 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T00:43:11Z |
| institution | BVB |
| isbn | 9780123848604 |
| language | English |
| lccn | 2012540054 |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-026225628 |
| oclc_num | 826940758 |
| open_access_boolean | |
| owner | DE-703 |
| owner_facet | DE-703 |
| physical | xi, 461 pages illustrations (chiefly color) |
| publishDate | 2012 |
| publishDateSearch | 2012 |
| publishDateSort | 2012 |
| publisher | Elsevier |
| record_format | marc |
| spelling | Stocum, David L. Verfasser aut Regenerative biology and medicine David L. Stocum 2. ed. Amsterdam [u.a.] Elsevier 2012 xi, 461 pages illustrations (chiefly color) txt rdacontent n rdamedia nc rdacarrier Includes bibliographical references and index Regenerative medicine Tissue engineering Regenerationsfähigkeit (DE-588)4177387-1 gnd rswk-swf Tissue Engineering (DE-588)4646061-5 gnd rswk-swf Regenerative Medizin (DE-588)7652075-4 gnd rswk-swf Gewebetransplantation (DE-588)4157246-4 gnd rswk-swf Regeneration (DE-588)4048983-8 gnd rswk-swf Stammzelle (DE-588)4665329-6 gnd rswk-swf Zelltransplantation (DE-588)4516953-6 gnd rswk-swf Organismus (DE-588)4043831-4 gnd rswk-swf Transplantation (DE-588)4060675-2 gnd rswk-swf Regenerationsfähigkeit (DE-588)4177387-1 s Organismus (DE-588)4043831-4 s DE-604 Tissue Engineering (DE-588)4646061-5 s Regenerative Medizin (DE-588)7652075-4 s Stammzelle (DE-588)4665329-6 s Transplantation (DE-588)4060675-2 s Regeneration (DE-588)4048983-8 s 1\p DE-604 Gewebetransplantation (DE-588)4157246-4 s 2\p DE-604 Zelltransplantation (DE-588)4516953-6 s 3\p DE-604 Digitalisierung UB Bayreuth application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026225628&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 2\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 3\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Stocum, David L. Regenerative biology and medicine Regenerative medicine Tissue engineering Regenerationsfähigkeit (DE-588)4177387-1 gnd Tissue Engineering (DE-588)4646061-5 gnd Regenerative Medizin (DE-588)7652075-4 gnd Gewebetransplantation (DE-588)4157246-4 gnd Regeneration (DE-588)4048983-8 gnd Stammzelle (DE-588)4665329-6 gnd Zelltransplantation (DE-588)4516953-6 gnd Organismus (DE-588)4043831-4 gnd Transplantation (DE-588)4060675-2 gnd |
| subject_GND | (DE-588)4177387-1 (DE-588)4646061-5 (DE-588)7652075-4 (DE-588)4157246-4 (DE-588)4048983-8 (DE-588)4665329-6 (DE-588)4516953-6 (DE-588)4043831-4 (DE-588)4060675-2 |
| title | Regenerative biology and medicine |
| title_auth | Regenerative biology and medicine |
| title_exact_search | Regenerative biology and medicine |
| title_full | Regenerative biology and medicine David L. Stocum |
| title_fullStr | Regenerative biology and medicine David L. Stocum |
| title_full_unstemmed | Regenerative biology and medicine David L. Stocum |
| title_short | Regenerative biology and medicine |
| title_sort | regenerative biology and medicine |
| topic | Regenerative medicine Tissue engineering Regenerationsfähigkeit (DE-588)4177387-1 gnd Tissue Engineering (DE-588)4646061-5 gnd Regenerative Medizin (DE-588)7652075-4 gnd Gewebetransplantation (DE-588)4157246-4 gnd Regeneration (DE-588)4048983-8 gnd Stammzelle (DE-588)4665329-6 gnd Zelltransplantation (DE-588)4516953-6 gnd Organismus (DE-588)4043831-4 gnd Transplantation (DE-588)4060675-2 gnd |
| topic_facet | Regenerative medicine Tissue engineering Regenerationsfähigkeit Tissue Engineering Regenerative Medizin Gewebetransplantation Regeneration Stammzelle Zelltransplantation Organismus Transplantation |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026225628&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT stocumdavidl regenerativebiologyandmedicine |