Introduction to biomaterials: basic theory with engineering applications
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Cambridge [u.a.]
Cambridge Univ. Press
2014
|
| Ausgabe: | 1. publ. |
| Schriftenreihe: | Cambridge texts in biomedical engineering
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Klappentext |
| Beschreibung: | XVIII, 402 S. Ill., graph. Darst. |
| ISBN: | 9780521116909 0521116902 |
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Datensatz im Suchindex
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|---|---|
| adam_text | Contents
Preface page
xvii
1
5
7
7
7
8
9
10
11
11
12
14
14
15
16
17
17
18
19
20
21
26
27
27
28
30
32
Introduction
1.1
Definitions
1.2
Changing focus
1.3
Types
of bonds in materials
1.3.1
Ionic bonds
1.3.2
Metallic bonds
1.3.3
Covalent bonds
1.3.4
Secondary bonds
1.4
Types
of materials
1.4.1
Ceramics
1.4.2
Metals
1.4.3
Polymers
1.4.4
Composites
1.5
Impaci
:
of
biomaterials
1.6
Future
of
biomaterials
1.7
Summary
References
Problems
Basic properties of materials
2.1
Mechanical properties
2.1.1
Tensile testing
2.1.2
Compressive
testing
2.1.3
Shear testing
2.1.4
Bend or flexural tests
2.1.5
Viscoelastic behavior
2.1.6
Ductile and brittle fracture
2.1.7
Stress concentration
Contents
2.1.8
Fracture toughness
33
2.1.9
Fatigue
34
2.2
Electrochemical properties
35
2.2.1
Corrosion
35
2.2.2
Types of corrosion
37
2.3
Surface properties
43
2.3.1
Contact angle
44
2.3.2
Hardness
44
2.4
Summary
45
Suggested reading
45
Problems
46
Biological systems
48
3.1
The biological environment
48
3.2
Genetic regulation and control systems
51
3.3
The plasma membrane
51
3.3.1
Membranes are phospholipid layers
52
3.4
Cytoskeleton and motility
53
3.5
Cell to cell communication pathways
55
3.6
Cell junctions
57
3.6.1
Tight junctions
57
3.6.2
Gap junctions
59
3.6.3
Adherens and desmosomes
61
3.7
Cell signaling pathways
62
3.7.1
Receptors as signaling sensors
63
3.7.2
Receptor classes
64
3.7.3
Second messengers and their activation/
deactivation
66
3.8
Biological testing techniques
68
3.8.1
Probe and labeling technologies
68
3.8.2
Examination of gene expression
69
3.8.3
The plasma membrane
69
3.8.4
Cytoskeleton and motility
70
3.8.5
Communication between cells
71
3.8.6
Mapping intracellular signaling
72
3.9
Summary
72
Suggested reading
73
Problems
73
Contents
4 Characterization
of biomaterials
74
4.1
Contact angle
75
4.2
Infrared spectroscopy
80
4.2.1
Attenuated total reflection (ATR)
83
4.2.2
Specular reflectance
85
4.2.3
Infrared reflection absorption spectroscopy
(IRRAS)
85
4.2.4
Diffuse reflectance infrared Fourier transform
spectroscopy (DRIFTS)
85
4.3
X-ray photoelectron spectroscopy
87
4.4
Secondary ion mass spectrometry
91
4.5
Atomic force microscopy
94
4.6
Scanning electron microscopy
98
4.7
Transmission electron microscopy
100
4.8
X-ray diffraction (XRD)
103
4.9
Chromatography
106
4.9.1
High performance liquid chromatography (HPLC)
106
4.9.2
Gel permeation chromatography (GPC)
108
4.10
Summary
110
Suggested reading
110
References
111
Problems
111
5
Metals: structure and properties
113
5.1
Titanium and its alloys
114
5.1.1
Classification of
Ti
and its alloys based on
crystallographic forms
116
5.1.2
Surface properties
119
5.1.3
Applications
119
5.2
Stainless steel
119
5.2.1
Martensitic stainless steels
120
5.2.2
Ferritic stainless steels
120
5.2.3
Austenitic stainless steels
120
5.2.4
Duplex stainless steels
122
5.2.5
Recent developments in stainless steel alloys
122
5.3
Cobalt-chromium alloys
123
5.3.1
ASTMF75
123
5.3.2
ASTM F799
125
5.3.3
ASTM F90
125
5.3.4
ASTM F562
126
5.4
Nitinol
126
5.5
Tantalum
128
Contents
5.6 Magnesium 129
5.7
Summary
130
References
131
Suggested reading
132
Problems
132
Polymers
134
6.1
Molecular structure of polymers
135
6.1.1
Molecular weight
139
6.2
Ty pes
of polymerization
141
6.3
Physical states of polymers
142
6.3.1
Amorphous phase
142
6.3.2
Crystalline phase
144
6.4
Common polymeric
biomaterials
146
6.4.1
Polyethylene
146
6.4.2
Polymethylmethacrylate (PMMA)
147
6.4.3
Polylactic acid
(PLA)
and
polyglycolic
acid (PGA)
150
6.4.4
Polycaprolactone
(PCL) 152
6.4.5
Other biodegradable polymers
153
6.4.6
Polyurethanes
153
6.4.7
Silicones
154
6.5
Hydrogels
155
6.5.1
Synthesis of
hydrogels
159
6.5.2
Properties of
hydrogels
160
6.5.3
Applications
160
6.6
Nanopoly
mers
161
6.7
Summary
162
References
163
Suggested reading
163
Problems
163
Ceramics
165
ΊΛ
General properties
166
7.2
Classifications
167
7.2.1
Classification based on form
167
7.2.2
Classification based on composition
168
7.2.3
Classification based on reactivity
169
7.3
Bioceramics
169
7.3.1
Silicate glass
170
7.3.2
Alumina (A12O3)
174
Contents
7.3.3 Zirconia
(7Ю2)
177
7.3.4 Carbon 179
7.3.5
Calcium
phosphates (CaP)
180
7.3.6 Hydroxyapatite
(HA)
183
7.3.7
Tricalcium
phosphate
(TCP) 186
7.3.8
Calcium sulfate (CaSO4H2O)
187
7.3.9
Bioactive
glass
188
7.4
Nanoceramics
189
7.5
Summary
195
References
196
Suggested reading
196
Problems
196
8
Natural
biomaterials
198
8.1
Collagen
199
8.2
Elastin
204
8.3
Silk
207
8.4
Chitosan
210
8.5
Cellulose
213
8.6
Alginate
217
8.7
Hyaluronan
223
8.8
Chondroitin
sulfate
226
8.9
Coral
228
8.10
Summary
231
References
231
Suggested reading
231
Problems
232
9
Surface modification
233
9.1
Abrasive blasting
234
9.2
Plasma glow discharge treatments
237
9.2.1
Direct current glow discharge
239
9.2.2
Alternating current glow discharge
240
9.2.3
Capacitiveiy coupled radiofrequency glow discharge
241
9.2.4
Inductively coupled radiofrequency glow discharge
242
9.3
Thermal spraying
243
9.4
Physical vapor deposition (PVD)
251
9.4.1
Evaporative deposition
252
9.4.2
Pulsed laser deposition
253
9.4.3
Sputter deposition
254
Contents
9.5 Chemical
vapor deposition
(CVD)
261
9.6
Grafting
264
9.7
Self-assembled monolayer (SAM)
266
9.7.1
Patterning of self-assembled monolayers
271
9.8
Layer-by-lay
er (LbL)
assembly
274
9.8.1
Different layer-by-layer (LbL) assembly techniques
277
9.9
Summary
279
References
279
Suggested reading
280
Problems
280
10
Sterilization of
biomedical
implants
282
10.1
Common terminology
282
10.2
Steam sterilization
283
10.3
Ethylene
oxide sterilization
285
10.4
Gamma radiation sterilization
287
10.5
Other sterilization methods
289
10.5.1
Dry heat sterilization
289
10.5.2
Formaldehyde and glutaraldehyde treatments
290
10.5.3
Phenolic and hypochloride solution treatments
290
10.5.4
Ultraviolet (UV) radiation
290
10.5.5
Electron beam sterilization
291
10.6
Recently developed methods
291
10.6.1
Low temperature gas plasma treatment
291
10.6.2
Gaseous chlorine dioxide treatment
292
10.7
Summary
292
References
293
Suggested reading
293
Problems
294
11
Cell-biomaterial
interactions
295
11.1
The extracellular environment
297
11.2
Extracellular matrix mimics
309
11.3
Cell interactions with non-cellular substrates
309
11.4
Biocompatibility testing and techniques
314
11.4.1
Immunostaining techniques for studying cell-ECM
interactions
316
11.4.2
Profiling a cell line for its ECM binding
characteristics
317
11.4.3
Immunoprecipitation and Western blotting
318
Contents
11.5
Summary
319
Reference
319
Suggested reading
319
Problems
320
12
Drug delivery systems
321
12.1
Diffusion controlled drug delivery systems
323
12.1.1
Membrane controlled reservoir systems
323
12.1.2
Monolithic matrix systems
324
12.2
Water penetration controlled drug delivery systems
325
12.2.1
Osmotic pressure controlled drug delivery systems
326
12.2.2
Swelling controlled drug delivery system
327
12.3
Chemically controlled drug delivery systems
328
12.3.1
Polymer-drug dispersion systems
328
12.3.2
Polymer-drug conjugate systems
329
12.4
Responsive drug delivery systems
331
12.4.1
Temperature-responsive drag delivery systems
331
12.4.2
pH-responsive drug delivery systems
332
12.4.3
Solvent-responsive drug delivery systems
333
12
A A Ultrasound-responsive drug delivery systems
333
12.4.5
Electrically responsive drug delivery systems
334
12.4.6
Magnetic-sensitive drug delivery systems
334
12.5
Particulate systems
335
12.5.1
Polymeric microparticles
335
12.5.2
Polymeric micelles
336
12.5.3
Liposomes
336
12.6
Summary
337
References
339
Suggested reading
339
Problems
340
13
Tissue engineering
341
13.1
Tissue engineering approaches
342
13.1.1
Assessment of medical need
342
13.1.2
Selecting a tissue engineering strategy
343
13.2
Cells
344
13.2.1
Stem cells
345
13.2.2
Biopreservation of cells
347
13.3
Scaffold properties
349
13.4
Fabrication techniques for polymeric scaffolds
350
Contents
13.4.1 Solvent
casting and particulate leaching
350
13.4.2 Electrospinning 350
13.4.3 Solid
free form fabrication (SFFF)
351
13.5
Fabrication of natural polymer scaffolds
354
13.6
Fabrication techniques for ceramic scaffolds
357
13.6.1
Template sponge coating
357
13.6.2
Non-sintering techniques
357
13.7
Assessment of scaffold architecture
358
13.8
Cell seeded scaffolds
361
13.8.1
Cell culture bioreactors
361
13.8.2
Cell seeding
363
13.8.3
Growth factors
364
13.8.4
Mechanical modulation
366
13.9
Assessment of cell and tissue properties
367
13.9.1
Cellular properties
367
13.9.2
Tissue properties
371
13.10
Challenges in tissue engineering
372
13.11
Summary
373
References
373
Suggested reading
373
Problems
374
14
Clinical applications
375
14.1
Cardiovascular assist devices
376
14.2
Cardiovascular stents
378
14.3
Dental restoration
381
14.4
Dental implants
384
14.5
Neural
prostheses
386
14.6
Opthalmology
387
14.7
Orthopedic implants
390
14.8
Renal
393
14.9
Skin applications
394
14.10
Summary
397
Additional reading
397
Problems
397
Index
399
Introduction
to Biomaterials
This textbook gives students the perfect introduction to the world of
biomaterials,
linking the fundamental properties of metals, polymers, ceramics, and natural
biomaterials
to the unique advantages and limitations surrounding their
biomedical
applications.
•
Clinical concerns such as sterilization, surface modification, cell-biomaterial
interactions, drug delivery systems, and tissue engineering are discussed in
detail, giving students practical insight into the real-world challenges associ¬
ated with
biomaterials
engineering.
•
Key definitions, equations and concepts are concisely summarized alongside
the text, allowing students to quickly and easily identify the most important
information.
•
Bringing together elements from across the book, the final chapter discusses
modern commercial implants, challenging students to consider future indus¬
trial possibilities.
Concise enough to be taught in a single semester, and requiring only a basic
understanding of biology, this balanced and accessible textbook is the ideal
introduction to
biomaterials
for students of engineering, materials science, and
medicine.
С
Maulì
Agrawal is the Vice President for Research at the University of Texas at
San Antonio
(UTSA),
and the Peter Flawn Professor of
Biomedical
Engineering.
Previously, he served as the Dean of the College of Engineering at
UTSA.
He
specializes in orthopedic and cardiovascular
biomaterials
and implants and his
inventions have been licensed to various companies. He is a member of the
International College of Fellows of
Biomaterials
Science and Engineering, a
Fellow of the American Institute for Medical and Biological Engineering, a former
President of the Society for
Biomaterials,
and was awarded the
2010
Julio Palmaz
Award for Innovation in Healthcare and the
Biosciences.
|
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| ctrlnum | (OCoLC)868344075 (DE-599)BVBBV041215908 |
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| edition | 1. publ. |
| format | Book |
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| genre | (DE-588)4151278-9 Einführung gnd-content |
| genre_facet | Einführung |
| id | DE-604.BV041215908 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T00:42:18Z |
| institution | BVB |
| isbn | 9780521116909 0521116902 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-026190544 |
| oclc_num | 868344075 |
| open_access_boolean | |
| owner | DE-703 DE-1102 DE-11 DE-355 DE-BY-UBR DE-29 DE-83 |
| owner_facet | DE-703 DE-1102 DE-11 DE-355 DE-BY-UBR DE-29 DE-83 |
| physical | XVIII, 402 S. Ill., graph. Darst. |
| publishDate | 2014 |
| publishDateSearch | 2014 |
| publishDateSort | 2014 |
| publisher | Cambridge Univ. Press |
| record_format | marc |
| series2 | Cambridge texts in biomedical engineering |
| spelling | Introduction to biomaterials basic theory with engineering applications C. Mauli Agrawal ... 1. publ. Cambridge [u.a.] Cambridge Univ. Press 2014 XVIII, 402 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Cambridge texts in biomedical engineering Biomaterial (DE-588)4267769-5 gnd rswk-swf Werkstoff (DE-588)4065579-9 gnd rswk-swf Biologischer Abbau (DE-588)4145625-7 gnd rswk-swf Biomedizinische Technik (DE-588)4006882-1 gnd rswk-swf Medizintechnik (DE-588)4074676-8 gnd rswk-swf Biotechnologie (DE-588)4069491-4 gnd rswk-swf (DE-588)4151278-9 Einführung gnd-content Biomaterial (DE-588)4267769-5 s DE-604 Werkstoff (DE-588)4065579-9 s Biomedizinische Technik (DE-588)4006882-1 s Biotechnologie (DE-588)4069491-4 s Biologischer Abbau (DE-588)4145625-7 s Medizintechnik (DE-588)4074676-8 s Agrawal, Chandra Mauli Sonstige oth Digitalisierung UB Bayreuth - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026190544&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Bayreuth - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026190544&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
| spellingShingle | Introduction to biomaterials basic theory with engineering applications Biomaterial (DE-588)4267769-5 gnd Werkstoff (DE-588)4065579-9 gnd Biologischer Abbau (DE-588)4145625-7 gnd Biomedizinische Technik (DE-588)4006882-1 gnd Medizintechnik (DE-588)4074676-8 gnd Biotechnologie (DE-588)4069491-4 gnd |
| subject_GND | (DE-588)4267769-5 (DE-588)4065579-9 (DE-588)4145625-7 (DE-588)4006882-1 (DE-588)4074676-8 (DE-588)4069491-4 (DE-588)4151278-9 |
| title | Introduction to biomaterials basic theory with engineering applications |
| title_auth | Introduction to biomaterials basic theory with engineering applications |
| title_exact_search | Introduction to biomaterials basic theory with engineering applications |
| title_full | Introduction to biomaterials basic theory with engineering applications C. Mauli Agrawal ... |
| title_fullStr | Introduction to biomaterials basic theory with engineering applications C. Mauli Agrawal ... |
| title_full_unstemmed | Introduction to biomaterials basic theory with engineering applications C. Mauli Agrawal ... |
| title_short | Introduction to biomaterials |
| title_sort | introduction to biomaterials basic theory with engineering applications |
| title_sub | basic theory with engineering applications |
| topic | Biomaterial (DE-588)4267769-5 gnd Werkstoff (DE-588)4065579-9 gnd Biologischer Abbau (DE-588)4145625-7 gnd Biomedizinische Technik (DE-588)4006882-1 gnd Medizintechnik (DE-588)4074676-8 gnd Biotechnologie (DE-588)4069491-4 gnd |
| topic_facet | Biomaterial Werkstoff Biologischer Abbau Biomedizinische Technik Medizintechnik Biotechnologie Einführung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026190544&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026190544&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA |
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