Analysis of the role of the microtubule associated protein tau and the amyloid precursor protein APP in transgenic mouse models of Alzheimer's disease:
Gespeichert in:
| 1. Verfasser: | |
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| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Enth. 3 Sonderabdr. aus verschieden Zeitschr. |
| Beschreibung: | II, 117 S. Ill., graph. Darst. 30 cm |
Internformat
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Datensatz im Suchindex
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| adam_text | IMAGE 1
CONTENTS
TABLE OF CONTENTS
1. ABSTRACT 1
2. INTRODUCTION 2
2.1. ALZHEIMER S DISEASE 2
2.2. AMYLOID PRECURSOR PROTEIN (APP) AND AMYLOID BETA (AP) 2
2.3. TAU PROTEIN AND PSEUDOHYPERPHOSPHORYLATION O F TAU (PHP-TAU) 5
2.4. MOUSE MODELS O F ALZHEIMER S DISEASE 7
2.5. SYNAPTIC CONNECTIVITY AND DENDRITIC SPINES 8
2.6. METHODS TO VISUALIZE NEURONAL MORPHOLOGY 10
2.6.1. GOLGI - SILVER IMPREGNATION METHOD 10
2.6.2. CLSM O F BRAIN SLICES FROM EGFP EXPRESSING MICE 11
2.7. PHARMACOLOGICAL APPROACHES TO MODULATE SYNAPTIC CONNECTIVITY 13
2.8. AIM O F THE THESIS 14
3. RESULTS: PUBLICATIONS 15
3.1. M. HUNDELT, T. FATH, K. SELLE. K. OESTERWIND, J. JORDAN, C.
SCHULTZ, 16 J. GOTZ, J. VON ENGELHARDT, H. MONYER, L. LEWEJOHANN, N.
SACHSER, L. BAKOTA, R. BRANDT (2011); ALTERED PHOSPHORYLATION BUT NO
NEURODEGENERATION IN A MOUSE MODEL
O F TAU HYPERPHOSPHORYLATION. NEUROBIOLOGY O F AGING 32:991-1006
3.2. K. SELLE. N. GOLOVYASHKINA, L. PENAZZI, F. SUNDERMANN, W. ABELS. 33
. T. PRIESNITZ, L. LEWEJOHANN, N. SACHSER, R. BRANDT, L. BAKOTA;
CHRONIC PRESENCE O F AP DIFFERENTIALLY MODULATES SYNAPTIC CONNECTIVITY
IN HIPPOCAMPAL AND CORTICAL NEURONS, REDUCES DENDRITIC ARBORIZATION AND
^ CAUSES ERK1/2 ACTIVATION
3.3. P. FANARA, K.H. HUSTED, K. SELLE. P.-Y. A. WONG, J. BANERJEE, R.
BRANDT 86 AND M.K. HELLERSTEIN (2010); CHANGES IN MICROTUBULE TURNOVER
ACCOMPANY SYNAPTIC PLASTICITY AND MEMORY FORMATION IN RESPONSE TO
CONTEXTUAL FEAR CONDITIONING IN MICE. NEUROSCIENCE 168:167-178
4. CONCLUSIONS AND OUTLOOK 99
5. LITERATURE 103
6. ABBREVIATIONS 111
7. CURRICULUM VITAE 113
HTTP://D-NB.INFO/1027276202
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| spelling | Selle, Karolin 1981- Verfasser (DE-588)1027275958 aut Analysis of the role of the microtubule associated protein tau and the amyloid precursor protein APP in transgenic mouse models of Alzheimer's disease von Karolin Selle 2012 II, 117 S. Ill., graph. Darst. 30 cm txt rdacontent n rdamedia nc rdacarrier Enth. 3 Sonderabdr. aus verschieden Zeitschr. Osnabrück, Univ., Diss., 2012 Tau-Protein (DE-588)4328997-6 gnd rswk-swf Alzheimerkrankheit (DE-588)4112510-1 gnd rswk-swf Mikrotubulus (DE-588)4169864-2 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Alzheimerkrankheit (DE-588)4112510-1 s Tau-Protein (DE-588)4328997-6 s Mikrotubulus (DE-588)4169864-2 s DE-604 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026142690&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Selle, Karolin 1981- Analysis of the role of the microtubule associated protein tau and the amyloid precursor protein APP in transgenic mouse models of Alzheimer's disease Tau-Protein (DE-588)4328997-6 gnd Alzheimerkrankheit (DE-588)4112510-1 gnd Mikrotubulus (DE-588)4169864-2 gnd |
| subject_GND | (DE-588)4328997-6 (DE-588)4112510-1 (DE-588)4169864-2 (DE-588)4113937-9 |
| title | Analysis of the role of the microtubule associated protein tau and the amyloid precursor protein APP in transgenic mouse models of Alzheimer's disease |
| title_auth | Analysis of the role of the microtubule associated protein tau and the amyloid precursor protein APP in transgenic mouse models of Alzheimer's disease |
| title_exact_search | Analysis of the role of the microtubule associated protein tau and the amyloid precursor protein APP in transgenic mouse models of Alzheimer's disease |
| title_full | Analysis of the role of the microtubule associated protein tau and the amyloid precursor protein APP in transgenic mouse models of Alzheimer's disease von Karolin Selle |
| title_fullStr | Analysis of the role of the microtubule associated protein tau and the amyloid precursor protein APP in transgenic mouse models of Alzheimer's disease von Karolin Selle |
| title_full_unstemmed | Analysis of the role of the microtubule associated protein tau and the amyloid precursor protein APP in transgenic mouse models of Alzheimer's disease von Karolin Selle |
| title_short | Analysis of the role of the microtubule associated protein tau and the amyloid precursor protein APP in transgenic mouse models of Alzheimer's disease |
| title_sort | analysis of the role of the microtubule associated protein tau and the amyloid precursor protein app in transgenic mouse models of alzheimer s disease |
| topic | Tau-Protein (DE-588)4328997-6 gnd Alzheimerkrankheit (DE-588)4112510-1 gnd Mikrotubulus (DE-588)4169864-2 gnd |
| topic_facet | Tau-Protein Alzheimerkrankheit Mikrotubulus Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026142690&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT sellekarolin analysisoftheroleofthemicrotubuleassociatedproteintauandtheamyloidprecursorproteinappintransgenicmousemodelsofalzheimersdisease |