Differential effects of Pigment epithelium derived factor and epidermal growth factor on Ischemia-reperfusion injury in rats: a magnetic resonance imaging study at 3 tesla
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
2011
|
| Schlagworte: | |
| Online-Zugang: | kostenfrei Inhaltsverzeichnis |
| Beschreibung: | Zsfassung in dt. und engl. Sprache |
| Beschreibung: | 233 Bl. Ill., graph. Darst. |
Internformat
MARC
| LEADER | 00000nam a2200000 c 4500 | ||
|---|---|---|---|
| 001 | BV041155982 | ||
| 003 | DE-604 | ||
| 005 | 20130801 | ||
| 007 | t | ||
| 008 | 130719s2011 ad|| m||| 00||| eng d | ||
| 035 | |a (OCoLC)856833785 | ||
| 035 | |a (DE-599)BVBBV041155982 | ||
| 040 | |a DE-604 |b ger |e rakwb | ||
| 041 | 0 | |a eng | |
| 049 | |a DE-384 |a DE-473 |a DE-703 |a DE-1051 |a DE-824 |a DE-29 |a DE-12 |a DE-91 |a DE-19 |a DE-1049 |a DE-92 |a DE-739 |a DE-898 |a DE-355 |a DE-706 |a DE-20 |a DE-1102 | ||
| 100 | 1 | |a Pillai, Deepu |d 1971- |e Verfasser |0 (DE-588)103727069X |4 aut | |
| 245 | 1 | 0 | |a Differential effects of Pigment epithelium derived factor and epidermal growth factor on Ischemia-reperfusion injury in rats |b a magnetic resonance imaging study at 3 tesla |c von Deepu Pillai |
| 246 | 1 | 3 | |a Unterschiedlichen Wirkungen von PEDF und EGF auf Ischämie-Reperfusionsschaden bei Ratten - Eine Kernspintomografiestudie bei 3 Tesla |
| 264 | 1 | |c 2011 | |
| 300 | |a 233 Bl. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 500 | |a Zsfassung in dt. und engl. Sprache | ||
| 502 | |a Würzburg, Univ., Diss., 2011 | ||
| 650 | 0 | 7 | |a Epidermaler Wachstumsfaktor |0 (DE-588)4271160-5 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Schlaganfall |0 (DE-588)4052588-0 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Ischämie |0 (DE-588)4162456-7 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Kernspintomografie |0 (DE-588)4120806-7 |2 gnd |9 rswk-swf |
| 655 | 7 | |0 (DE-588)4113937-9 |a Hochschulschrift |2 gnd-content | |
| 689 | 0 | 0 | |a Schlaganfall |0 (DE-588)4052588-0 |D s |
| 689 | 0 | 1 | |a Kernspintomografie |0 (DE-588)4120806-7 |D s |
| 689 | 0 | 2 | |a Ischämie |0 (DE-588)4162456-7 |D s |
| 689 | 0 | 3 | |a Epidermaler Wachstumsfaktor |0 (DE-588)4271160-5 |D s |
| 689 | 0 | |5 DE-604 | |
| 776 | 0 | 8 | |i Erscheint auch als |n Online-Ausgabe |o urn:nbn:de:bvb:20-opus-57341 |
| 856 | 4 | 1 | |u https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-57341 |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 2 | |m DNB Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026131350&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 912 | |a ebook | ||
| 999 | |a oai:aleph.bib-bvb.de:BVB01-026131350 | ||
Datensatz im Suchindex
| _version_ | 1804150560186695680 |
|---|---|
| adam_text | IMAGE 1
CONTENTS
ACKNOWLEDGEMENTS 1
7,IISAMMENFASSIING 5
SUMMARY 9
1.0. INTRODUCTION. PART I.
1.1. STROKE 13
1.2. THE CASE FOR EXTENDED NEUROPROTECTION 16
1.3. NEUROPROTECTION, A RETROSPECTIVE ANALYSIS 20
1.4. NOVEL THERAPEUTIC APPROACHES AND EMERGING CONCEPTS 24
1.5. THE CONCEPT OF THE NEUROVASCULAR UNIT 28
1.5.1. THE ENDOTHELIUM 29
1.5.2. THE EXTRA-CELLULAR MATRIX 31
1.5.3. PERIVASCULAR ASTROCYTES 32
1.5.4. NEURONS AND AXONS 34
1.5.5. PERICYTES AND MICROGLIA 34
HTTP://D-NB.INFO/1038778476
IMAGE 2
1.6. THE BLOOD BRAIN BARRIER 36
1.6.1. THE BBB PHENOTYPE 38
1.7. NEUROTROPHIC GROWTH FACTORS 42
1.7.1. PROTECTIVE EFFECTS OF NEUROTROPHIC GROWTH FACTORS IN ISCHEMIC
BRAIN
INJURY 47
1.7.2. THE EPIDERMAL GROWTH FACTOR 48
1.7.2.1. NEUROTROPHIC PROPERTIES OF EGF 51
1.7.3. THE PIGMENT EPITHELIUM DERIVED FACTOR 52
1.7.3.1. STRUCTURAL PROPERTIES OF PEDF 54
1.7.3.2. BINDING AND SIGNAL TRANSDUCTION 55
1.7.3.3. TROPHIC PROPERTIES OF PEDF 58
1.7.3.4. NEUROPROTECTIVE PROPERTIES OF PEDF 58
1.7.3.5. PEDF AS A POTENT ANTI-ANGIOGENIC FACTOR 60
2.0. INTRODUCTION. PART II.
2.1. ELEMENTARY CONCEPTS OF NUCLEAR MAGNETIC RESONANCE IMAGING 62
2.1.1. ESTABLISHMENT OF A NET MAGNETIZATION 62
2.1.2. FUNDAMENTAL PRINCIPLES OF NUCLEAR MAGNETIC RESONANCE 69
2.1.3. RELAXATION CHARACTERISTICS 75
IMAGE 3
2.1.3.1. TI RELAXATION 75
2.1.3.2. T2 AND T2* RELAXATION AND SPIN ECHOES 79
2.1.3.3. SPATIAL ALLOCATION OF RESONANT FREQUENCIES 85
3.0. AIM AND OBJECTIVES.
3.1. AIM 93
3.2. OBJECTIVES 93
4.0. MATERIALS AND METHODS.
4.1. ESTABLISHMENT OF SMALL ANIMAL MAGNETIC RESONANCE IMAGING STRATEGIES
ON A 3 TESLA
CLINICAL DEDICATED HEAD MAGNETIC RESONANCE SCANNER 95
4.1.1. THE MR SYSTEM 95
4.1.2. THE PHASED ARRAY RADIO FREQUENCY COIL SYSTEM 96
4.1.3. IN-VIVO MRI 97
4.1.3.1. CONFIGURATION AND OPTIMIZATION OF SEQUENCE PARAMETERS 97
4.1.3.2. DETERMINATION OF TISSUE RELAXATION CHARACTERISTICS 101
4.1.3.3. DETERMINATION OF THE OPTIMAL PARALLEL IMAGING
RECONSTRUCTION ALGORITHM: GRAPPA OR MSENSE? 102
4.1.3.4. ANATOMICAL CHARACTERIZATION OF A RAT BRAIN 102
4.1.3.5. MR IMAGING OF A RAT MODEL OF ISCHEMIC STROKE 103
IMAGE 4
4.3.2.3. DATA ANALYSIS
120
5.0. RESULTS.
5.1. ESTABLISHMENT OF SMALL ANIMAL MAGNETIC RESONANCE IMAGING STRATEGIES
ON A 3 TESLA
CLINICAL DEDICATED HEAD MAGNETIC RESONANCE SCANNER 123
5.1.1. CONFIGURATION AND OPTIMIZATION OF SEQUENCE PARAMETERS 123
5.1.2. 3D-MPRAGE CHARACTERIZATION OF BRAIN ANATOMY 126
5.1.3. THE RAT MODEL OF CEREBRAL ISCHEMIA 128
5.1.4. THE RAT MODEL OF INTRA-CEREBRAL HAEMORRHAGE 130
5.1.5. THE RAT MODEL OF CERVICAL AND THORACIC SPINAL CORD INJURIES 131
5.1.6. THE MOUSE MODEL OF GLIOBLASTOMA 134
5.2. SERIAL MAGNETIC RESONANCE IMAGING TO DETERMINE THE BLOOD BRAIN
BARRIER PERMEABILITY
CHANGES AND THE DYNAMIC FLUXES IN VASOGENIC OEDEMA FORMATION FOLLOWING
ISCHEMIAREPERFUSION INJURY IN RATS 137
5.2.1. BI-PHASIC BBB OPENING AND PROGRESSION OF BRAIN VOLUME WITH LEAKY
BBB
FOLLOWING ISCHEMIA-REPERFUSION INJURY AS INVESTIGATED BY POST-CONTRAST
TISEQUENCES 138
5.2.2. IPSILATERAL AND REMOTE OEDEMA FORMATION AS INVESTIGATED BY THE
TEMPORAL
PROFILE OF TRANSVERSE RELAXATION TIMES 141
IMAGE 5
5.3. TROPHIC PROPERTIES OF EPIDERMAL GROWTH FACTOR AND PIGMENT
EPITHELIUM DERIVED FACTOR
ON SELECTED INDICES OF NEUROVASCULAR INJURY FOLLOWING
ISCHEMIA-REPERFUSION INJURY IN
RATS 144
5.3.1. EVALUATION OF BLOOD-BRAIN BARRIER PERMEABILITY FOR MACROMOLECULES
144
5.3.2. TROPHIC PROPERTIES OF EGF AND FEDF ON ISCHEMIA-REPERFUSION INJURY
144
5.3.2.1. EFFECT OF EGF AND PEDF ON THE INFARCT VOLUME 145
5.3.2.2. EFFECT OF EGF AND PEDF ON THE T2-VALUES WITHIN THE INFARCT
REGION 147
5.3.2.3. EFFECT OF EGF AND PEDF ON THE T2-VALUE X INFARCT VOLUME PRODUCT
(T2VOI) UP TO 48 HOURS 148
5.3.2.4. EFFECT OF EGF AND PEDF ON THE T2-VALUES AT THE IPSILATERAL
CORTEX 149
5.3.2.5. EFFECT OF EGF AND PEDF ON THE T2-VALUES AT THE CONTRALATERAL
STRIATUM 150
5.3.2.6. EFFECT OF EGF AND PEDF ON THE SUSCEPTIBILITY WEIGHTED
T2*-VALUES AT
THE INFARCT REGION 152
5.3.2.7. EFFECT OF EGF AND PEDF ON THE SUSCEPTIBILITY WEIGHTED T2*-
VALUES
AT THE CONTRALATERAL REGION 153
5.3.2.8. EFFECT OF EGF AND PEDF ON THE TISIDIFF VALUES AT THE
IPSILATERAL
STRIATUM 155
IMAGE 6
5.3.2.9. EFFECT OF EGF AND PEDF ON THE TISIDIFF VALUES AT THE
CONTRALATERAL
STRIATUM 156
6.0. DISCUSSION.
6.1. ESTABLISHMENT OF SMALL ANIMAL MAGNETIC RESONANCE IMAGING STRATEGIES
ON A 3 TESLA
CLINICAL DEDICATED HEAD MAGNETIC RESONANCE SCANNER 158
6.1.1. IMAGING OF THE RODENT MODEL OF CEREBRAL ISCHEMIA 161
6.1.2. IMAGING OF THE RODENT MODEL OF INTRA-CEREBRAL HAEMORRHAGE 163
6.1.3. IMAGING OF THE RODENT MODEL OF SPINAL CORD INJURIES 164
6.1.4. IMAGING OF THE MOUSE GLIOBLASTOMA MODEL 166
6.2. SERIAL MAGNETIC RESONANCE IMAGING TO DETERMINE THE BLOOD BRAIN
BARRIER PERMEABILITY
CHANGES AND THE DYNAMIC FLUXES IN VASOGENIC OEDEMA FORMATION FOLLOWING
ISCHEMIAREPERFUSION INJURY IN RATS 168
6.2.1. MR IMAGING OF BBB PERMEABILITY CHARACTERISTICS 169
6.2.2. OEDEMA DEVELOPMENT IN RELATION TO BBB PERMEABILITY 172
6.2.3. BIPHASIC BBB PERMEABILITY; A SURROGATE MARKER FOR THE NEW
PENUMBRA ?.. 175
6.2.4. SUMMARY 176
6.3. TROPHIC PROPERTIES OF EPIDERMAL GROWTH FACTOR AND PIGMENT
EPITHELIUM DERIVED FACTOR
ON SELECTED INDICES OF NEUROVASCULAR INJURY FOLLOWING
ISCHEMIA-REPERFUSION INJURY IN
RATS 178
6.3.1. EFFECT OF EGF AND PEDF ON THE INFARCT VOLUME 178
IMAGE 7
6.3.2. EFFECT OF EGF AND PEDF ON OEDEMA FORMATION AND RESORPTION AT THE
INFARCT
REGION 182
6.3.3. EFFECT OF EGF AND PEDF ON OEDEMA FORMATION AND RESORPTION AT
DISTANT SITES
REMOTE FROM INFARCTED REGION 184
6.3.4. ALTERED METABOLIC STATE AT THE INFARCT SITE AS MAPPED BY
SUSCEPTIBILITY WEIGHTED
(T2*) SEQUENCES 186
6.3.5. ALTERED METABOLIC STATE AT THE CONTRALATERAL STRIATUM AS MAPPED
BY
SUSCEPTIBILITY WEIGHTED (T2*) SEQUENCES 188
6.3.6. TEMPORAL PROFILE OF BLOOD BRAIN BARRIER PERMEABILITY
CHARACTERISTICS AT THE
IPSILATERAL STRIATUM AS DETECTED BY POST-CONTRAST TI IMAGING 189
6.3.7. TEMPORAL PROFILE OF TISW CHANGES AT THE CONTRALATERAL STRIATUM
192
6.3.8. CONCLUDING REMARKS AND FUTURE DIRECTIVES 194
REFERENCES 196
LIST OF ABBREVIATIONS 225
LIST OF PUBLICATIONS 230
CURRICULUM VITAE 232
DECLARATION 233
|
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| indexdate | 2024-07-10T00:40:52Z |
| institution | BVB |
| language | English |
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| spelling | Pillai, Deepu 1971- Verfasser (DE-588)103727069X aut Differential effects of Pigment epithelium derived factor and epidermal growth factor on Ischemia-reperfusion injury in rats a magnetic resonance imaging study at 3 tesla von Deepu Pillai Unterschiedlichen Wirkungen von PEDF und EGF auf Ischämie-Reperfusionsschaden bei Ratten - Eine Kernspintomografiestudie bei 3 Tesla 2011 233 Bl. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Zsfassung in dt. und engl. Sprache Würzburg, Univ., Diss., 2011 Epidermaler Wachstumsfaktor (DE-588)4271160-5 gnd rswk-swf Schlaganfall (DE-588)4052588-0 gnd rswk-swf Ischämie (DE-588)4162456-7 gnd rswk-swf Kernspintomografie (DE-588)4120806-7 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Schlaganfall (DE-588)4052588-0 s Kernspintomografie (DE-588)4120806-7 s Ischämie (DE-588)4162456-7 s Epidermaler Wachstumsfaktor (DE-588)4271160-5 s DE-604 Erscheint auch als Online-Ausgabe urn:nbn:de:bvb:20-opus-57341 https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-57341 Resolving-System kostenfrei Volltext DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026131350&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Pillai, Deepu 1971- Differential effects of Pigment epithelium derived factor and epidermal growth factor on Ischemia-reperfusion injury in rats a magnetic resonance imaging study at 3 tesla Epidermaler Wachstumsfaktor (DE-588)4271160-5 gnd Schlaganfall (DE-588)4052588-0 gnd Ischämie (DE-588)4162456-7 gnd Kernspintomografie (DE-588)4120806-7 gnd |
| subject_GND | (DE-588)4271160-5 (DE-588)4052588-0 (DE-588)4162456-7 (DE-588)4120806-7 (DE-588)4113937-9 |
| title | Differential effects of Pigment epithelium derived factor and epidermal growth factor on Ischemia-reperfusion injury in rats a magnetic resonance imaging study at 3 tesla |
| title_alt | Unterschiedlichen Wirkungen von PEDF und EGF auf Ischämie-Reperfusionsschaden bei Ratten - Eine Kernspintomografiestudie bei 3 Tesla |
| title_auth | Differential effects of Pigment epithelium derived factor and epidermal growth factor on Ischemia-reperfusion injury in rats a magnetic resonance imaging study at 3 tesla |
| title_exact_search | Differential effects of Pigment epithelium derived factor and epidermal growth factor on Ischemia-reperfusion injury in rats a magnetic resonance imaging study at 3 tesla |
| title_full | Differential effects of Pigment epithelium derived factor and epidermal growth factor on Ischemia-reperfusion injury in rats a magnetic resonance imaging study at 3 tesla von Deepu Pillai |
| title_fullStr | Differential effects of Pigment epithelium derived factor and epidermal growth factor on Ischemia-reperfusion injury in rats a magnetic resonance imaging study at 3 tesla von Deepu Pillai |
| title_full_unstemmed | Differential effects of Pigment epithelium derived factor and epidermal growth factor on Ischemia-reperfusion injury in rats a magnetic resonance imaging study at 3 tesla von Deepu Pillai |
| title_short | Differential effects of Pigment epithelium derived factor and epidermal growth factor on Ischemia-reperfusion injury in rats |
| title_sort | differential effects of pigment epithelium derived factor and epidermal growth factor on ischemia reperfusion injury in rats a magnetic resonance imaging study at 3 tesla |
| title_sub | a magnetic resonance imaging study at 3 tesla |
| topic | Epidermaler Wachstumsfaktor (DE-588)4271160-5 gnd Schlaganfall (DE-588)4052588-0 gnd Ischämie (DE-588)4162456-7 gnd Kernspintomografie (DE-588)4120806-7 gnd |
| topic_facet | Epidermaler Wachstumsfaktor Schlaganfall Ischämie Kernspintomografie Hochschulschrift |
| url | https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-57341 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026131350&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT pillaideepu differentialeffectsofpigmentepitheliumderivedfactorandepidermalgrowthfactoronischemiareperfusioninjuryinratsamagneticresonanceimagingstudyat3tesla AT pillaideepu unterschiedlichenwirkungenvonpedfundegfaufischamiereperfusionsschadenbeiratteneinekernspintomografiestudiebei3tesla |