Hippocampal oscillations in a model of temporal lobe epilepsy:
Gespeichert in:
| 1. Verfasser: | |
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| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | 100 Bl. Ill., graph. Darst. 30 cm |
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| 245 | 1 | 0 | |a Hippocampal oscillations in a model of temporal lobe epilepsy |c von Ulrich Paul Froriep |
| 264 | 1 | |c 2012 | |
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Datensatz im Suchindex
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| adam_text | IMAGE 1
CONTENTS
1 INTRODUCTION 1 3
1.1 OSCILLATIONS IN THE BRAIN 13
1.2 EPILEPSY 14
1.3 HIPPOCAMPAL FORMATION 15
1.4 MESIAL TEMPORAL LOBE EPILEPSY 17
1.5 ANIMAL MODELS OF MTLE 19
1.6 STRATEGY AND ORGANIZATION 21
2 MATERIALS A N D M E T H O D S 2 2
2.1 ANIMALS 22
2.2 INJECTION OF KA AND NACL 22
2.3 ELECTRODE IMPLANTATION 24
2.3.1 EVALUATION OF OPTIMAL MEC ELECTRODE POSITION 24
2.3.2 IMPLANTATION 24
2.3.3 CHOICE OF POSITION FOR REFERENCE ELECTRODES 27
2.4 RECORDINGS 28
2.5 HISTOLOGICAL PROCEDURES 29
2.5.1 PERFUSION 29
2.5.2 SLICING 29
2.5.3 NISSL STAINING 30
2.5.4 FLUORO-JADE STAINING 30
2.5.5 IMMUNOHISTOCHEMISTRY FOR REELIN DETECTION 31
2.5.6 MICROSCOPY 31
2.6 D A T A ANALYSIS 32
2.6.1 CELL LOSS : 32
2.6.2 CHARACTERIZATION OF EA AND EA-FREE ACTIVITY 32
2.6.3 CORRELATION ANALYSES 32
9
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IMAGE 2
CONTENTS
2.6.4 THETA-GAMMA COUPLING 34
2.7 COMPUTER SIMULATIONS 34
2.7.1 ASYMMETRY 34
2.7.2 POPULATION MODEL OF COUPLED POPULATIONS 35
3 RESULTS 36
3.1 INITIAL TESTING 36
3.1.1 CELL LOSS IN MOST HIPPOCAMPAL STRUCTURES, BUT NOT IN THE MEC . . .
37
3.1.2 THE MEC IS INVOLVED IN EA 39
3.1.3 EA-FREE ACTIVITY IS COMPARABLE TO ONGOING ACTIVITY FROM HEALTHY
CONTROLS 41
3.2 ALTERED COUPLING BETWEEN MEC AND DG 42
3.2.1 SHIFTED THETA COUPLING IN EPILEPTIC MICE 42
3.2.2 FREQUENCY DEPENDENCE OF THE SHIFT 46
3.2.3 ASYMMETRY OF THETA SIGNALS DOES NOT EXPLAIN DELAYED THETA COUPLING
48
3.2.4 IMBALANCED COUPLING LEADS TO THE SHIFT 50
3.3 CROSS-FREQUENCY COUPLING BETWEEN THETA AND GAMMA OSCILLATIONS 52
3.3.1 THETA-GAMMA COUPLING IS WIDELY PRESERVED IN THE MEC 53
3.3.2 THETA-GAMMA COUPLING IN THE DG IS SHIFTED 54
3.4 MULTI-ELECTRODE SILICON PROBES FOR SIMULTANEOUS LFP AND SPIKE
RECORDINGS . 63
3.4.1 INITIAL DESIGN 63
3.4.2 SIMULTANEOUS LFP AND SPIKE RECORDINGS IN FREELY BEHAVING MICE . .
66
3.4.3 THETA-SPIKE COUPLING IN EPILEPTIC MICE 66
4 DISCUSSION 7 0
4.1 CELL LOSS IN THE SUB BUT NOT IN THE MEC 71
4.2 EA OCCURRED A T ALL RECORDING SITES 72
4.3 COUPLING OF MEC AND DG 73
4.3.1 INVERSION OF MEC VS. DG SIGNALS 73
4.3.2 DELAYED SYNCHRONY IN EPILEPTIC MICE 74
4.3.3 ORIGIN OF THE DELAY BETWEEN MEC AND HC 75
4.4 LOCAL CHANGES IN THETA-GAMMA COUPLING 77
4.5 MULTI-ELECTRODE SILICON PROBES 80
4.6 IMPLICATIONS OF THE FINDINGS FOR MTLE 80
4.7 CONCLUSION AND OUTLOOK 81
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BIBLIOGRAPHY
LIST O F FIGURES
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| author | Froriep, Ulrich Paul 1980- |
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| ctrlnum | (OCoLC)824734582 (DE-599)DNB1029109613 |
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| dewey-ones | 570 - Biology 610 - Medicine and health |
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| dewey-tens | 570 - Biology 610 - Medicine and health |
| discipline | Biologie Medizin |
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| spelling | Froriep, Ulrich Paul 1980- Verfasser (DE-588)1027541283 aut Hippocampal oscillations in a model of temporal lobe epilepsy von Ulrich Paul Froriep 2012 100 Bl. Ill., graph. Darst. 30 cm txt rdacontent n rdamedia nc rdacarrier Freiburg (Breisgau), Univ., Diss., 2012 (DE-588)4113937-9 Hochschulschrift gnd-content DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026112340&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Froriep, Ulrich Paul 1980- Hippocampal oscillations in a model of temporal lobe epilepsy |
| subject_GND | (DE-588)4113937-9 |
| title | Hippocampal oscillations in a model of temporal lobe epilepsy |
| title_auth | Hippocampal oscillations in a model of temporal lobe epilepsy |
| title_exact_search | Hippocampal oscillations in a model of temporal lobe epilepsy |
| title_full | Hippocampal oscillations in a model of temporal lobe epilepsy von Ulrich Paul Froriep |
| title_fullStr | Hippocampal oscillations in a model of temporal lobe epilepsy von Ulrich Paul Froriep |
| title_full_unstemmed | Hippocampal oscillations in a model of temporal lobe epilepsy von Ulrich Paul Froriep |
| title_short | Hippocampal oscillations in a model of temporal lobe epilepsy |
| title_sort | hippocampal oscillations in a model of temporal lobe epilepsy |
| topic_facet | Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026112340&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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