Computational neuroscience: simulated demyelinating neuropathies and neuronopathies
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Boca Raton, Fla.
CRC Press
2013
|
| Schlagworte: | |
| Beschreibung: | "Science publishers book." Includes bibliographical references "Preface Preface v vi Computational Neuroscience Simulated Demyelinating Neuropathies and Neuronopathies (PISD) are specifi c indicators for CIDP and its subtypes; (3) the severe focal demyelinations, each of them internodal and paranodal, paranodalinternodal (IFD and PFD, PIFD), are specifi c indicators for acquired demyelinating neuropathies such as GBS and MMN; (4) the simulated progressively greater degrees of axonal dysfunctions termed ALS1, ALS2 and ALS3 are specifi c indicators for the motor neuron disease ALS Type1, Tape2 and Type3; and (5) the obtained excitability properties in the simulated demyelinating neuropathies are quite different from those in the simulated ALS subtypes, because of the different fi bre electrogenesis. The results show that the abnormalities in the axonal excitability properties in the ALS1 subtype are near normal. The results also show that in the simulated hereditary, chronic and acquired demyelinating neuropathies, the slowing of action potential propagation, based on the myelin sheath dysfunctions, is larger than this, based on the progressively increased uniform axonal dysfunctions in the simulated ALS2 and ALS3 subtypes. Conversely, the abnormalities in the accommodative and adaptive processes are larger in the ALS2 and ALS3 subtypes than in the demyelinating neuropathies. The increased axonal superexcitability in the ALS2 and ALS3 subtypes leads to repetitive discharges (action potential generation) in the nodal and internodal axolemma beneath the myelin sheath along the fi bre length in response to the applied long-duration subthreshold polarizing current stimuli (accommodative processes) and to the applied long-duration suprathreshold depolarizing current stimuli (adaptive processes)"-- |
| Beschreibung: | 1 Online-Ressource (x, 133 p.) |
| ISBN: | 9781466578326 9781466578364 |
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| 100 | 1 | |a Stephanova, Diana Ivanova |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Computational neuroscience |b simulated demyelinating neuropathies and neuronopathies |c Diana I. Stephanova and Bozhidar Dimitrov |
| 264 | 1 | |a Boca Raton, Fla. |b CRC Press |c 2013 | |
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| 500 | |a "Science publishers book." | ||
| 500 | |a Includes bibliographical references | ||
| 500 | |a "Preface Preface v vi Computational Neuroscience Simulated Demyelinating Neuropathies and Neuronopathies (PISD) are specifi c indicators for CIDP and its subtypes; (3) the severe focal demyelinations, each of them internodal and paranodal, paranodalinternodal (IFD and PFD, PIFD), are specifi c indicators for acquired demyelinating neuropathies such as GBS and MMN; (4) the simulated progressively greater degrees of axonal dysfunctions termed ALS1, ALS2 and ALS3 are specifi c indicators for the motor neuron disease ALS Type1, Tape2 and Type3; and (5) the obtained excitability properties in the simulated demyelinating neuropathies are quite different from those in the simulated ALS subtypes, because of the different fi bre electrogenesis. The results show that the abnormalities in the axonal excitability properties in the ALS1 subtype are near normal. The results also show that in the simulated hereditary, chronic and acquired demyelinating neuropathies, the slowing of action potential propagation, based on the myelin sheath dysfunctions, is larger than this, based on the progressively increased uniform axonal dysfunctions in the simulated ALS2 and ALS3 subtypes. Conversely, the abnormalities in the accommodative and adaptive processes are larger in the ALS2 and ALS3 subtypes than in the demyelinating neuropathies. The increased axonal superexcitability in the ALS2 and ALS3 subtypes leads to repetitive discharges (action potential generation) in the nodal and internodal axolemma beneath the myelin sheath along the fi bre length in response to the applied long-duration subthreshold polarizing current stimuli (accommodative processes) and to the applied long-duration suprathreshold depolarizing current stimuli (adaptive processes)"-- | ||
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Datensatz im Suchindex
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| author | Stephanova, Diana Ivanova |
| author_facet | Stephanova, Diana Ivanova |
| author_role | aut |
| author_sort | Stephanova, Diana Ivanova |
| author_variant | d i s di dis |
| building | Verbundindex |
| bvnumber | BV041134999 |
| collection | ZDB-38-EBR |
| ctrlnum | (OCoLC)874345932 (DE-599)BVBBV041134999 |
| dewey-full | 612.8 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 612 - Human physiology |
| dewey-raw | 612.8 |
| dewey-search | 612.8 |
| dewey-sort | 3612.8 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| format | Electronic eBook |
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| id | DE-604.BV041134999 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-10T00:40:23Z |
| institution | BVB |
| isbn | 9781466578326 9781466578364 |
| language | English |
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| publishDate | 2013 |
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| publisher | CRC Press |
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| spelling | Stephanova, Diana Ivanova Verfasser aut Computational neuroscience simulated demyelinating neuropathies and neuronopathies Diana I. Stephanova and Bozhidar Dimitrov Boca Raton, Fla. CRC Press 2013 1 Online-Ressource (x, 133 p.) txt rdacontent c rdamedia cr rdacarrier "Science publishers book." Includes bibliographical references "Preface Preface v vi Computational Neuroscience Simulated Demyelinating Neuropathies and Neuronopathies (PISD) are specifi c indicators for CIDP and its subtypes; (3) the severe focal demyelinations, each of them internodal and paranodal, paranodalinternodal (IFD and PFD, PIFD), are specifi c indicators for acquired demyelinating neuropathies such as GBS and MMN; (4) the simulated progressively greater degrees of axonal dysfunctions termed ALS1, ALS2 and ALS3 are specifi c indicators for the motor neuron disease ALS Type1, Tape2 and Type3; and (5) the obtained excitability properties in the simulated demyelinating neuropathies are quite different from those in the simulated ALS subtypes, because of the different fi bre electrogenesis. The results show that the abnormalities in the axonal excitability properties in the ALS1 subtype are near normal. The results also show that in the simulated hereditary, chronic and acquired demyelinating neuropathies, the slowing of action potential propagation, based on the myelin sheath dysfunctions, is larger than this, based on the progressively increased uniform axonal dysfunctions in the simulated ALS2 and ALS3 subtypes. Conversely, the abnormalities in the accommodative and adaptive processes are larger in the ALS2 and ALS3 subtypes than in the demyelinating neuropathies. The increased axonal superexcitability in the ALS2 and ALS3 subtypes leads to repetitive discharges (action potential generation) in the nodal and internodal axolemma beneath the myelin sheath along the fi bre length in response to the applied long-duration subthreshold polarizing current stimuli (accommodative processes) and to the applied long-duration suprathreshold depolarizing current stimuli (adaptive processes)"-- Computational neuroscience Neurogenetics / Computer simulation Computersimulation (DE-588)4148259-1 gnd rswk-swf Neurowissenschaften (DE-588)7555119-6 gnd rswk-swf Neurowissenschaften (DE-588)7555119-6 s Computersimulation (DE-588)4148259-1 s 1\p DE-604 Dimitrov, Bozhidar Sonstige oth 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Stephanova, Diana Ivanova Computational neuroscience simulated demyelinating neuropathies and neuronopathies Computational neuroscience Neurogenetics / Computer simulation Computersimulation (DE-588)4148259-1 gnd Neurowissenschaften (DE-588)7555119-6 gnd |
| subject_GND | (DE-588)4148259-1 (DE-588)7555119-6 |
| title | Computational neuroscience simulated demyelinating neuropathies and neuronopathies |
| title_auth | Computational neuroscience simulated demyelinating neuropathies and neuronopathies |
| title_exact_search | Computational neuroscience simulated demyelinating neuropathies and neuronopathies |
| title_full | Computational neuroscience simulated demyelinating neuropathies and neuronopathies Diana I. Stephanova and Bozhidar Dimitrov |
| title_fullStr | Computational neuroscience simulated demyelinating neuropathies and neuronopathies Diana I. Stephanova and Bozhidar Dimitrov |
| title_full_unstemmed | Computational neuroscience simulated demyelinating neuropathies and neuronopathies Diana I. Stephanova and Bozhidar Dimitrov |
| title_short | Computational neuroscience |
| title_sort | computational neuroscience simulated demyelinating neuropathies and neuronopathies |
| title_sub | simulated demyelinating neuropathies and neuronopathies |
| topic | Computational neuroscience Neurogenetics / Computer simulation Computersimulation (DE-588)4148259-1 gnd Neurowissenschaften (DE-588)7555119-6 gnd |
| topic_facet | Computational neuroscience Neurogenetics / Computer simulation Computersimulation Neurowissenschaften |
| work_keys_str_mv | AT stephanovadianaivanova computationalneurosciencesimulateddemyelinatingneuropathiesandneuronopathies AT dimitrovbozhidar computationalneurosciencesimulateddemyelinatingneuropathiesandneuronopathies |