Genotoxicity assessment: methods and protocols
Gespeichert in:
| Weitere Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
New York [u.a.]
Humana Press
2013
|
| Schriftenreihe: | Methods in molecular biology
1044 |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XV, 463 S. Ill. cm |
Internformat
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Datensatz im Suchindex
| _version_ | 1804150523510652928 |
|---|---|
| adam_text | Titel: Genotoxicity assessment
Autor: Dhawan, Alok
Jahr: 2013
Contents
Preface.......................................................... vii
Acknowledgements..................................................... ix
Contributors...................................................... xiii
Part I Gene Mutation Assays
1 Bacterial Mutation Assays........................................ 3
Errol Zeiger
2 In Vitro Mouse Lymphoma (L5178Y Tk+/~ -3.7.2C) Forward
Mutation Assay................................................ 27
Melissa R. Schisler, Martha M. Moore, and B. Bhaskar Gollapudi
3 Erythrocyte-Based Pig-a Gene Mutation Assay........................ 51
Jeffrey C. Bemis, Nikki E. Hall, and Stephen D. Dertinger
4 Detection of In Vivo Mutation in the Hprt and Pijj-a Genes
of Rat Lymphocytes............................................ 79
Vastly N. Dohrovolsky, Joseph G. Shaddock, Roberta A. Mittelstaedt,
Daishiro Miura, and Robert H. Heflich
5 In Vivo cll,£[pt, and Spi Gene Mutation Assays
in Transgenic Mice and Rats...................................... 97
Mugimane G. Manjanatha, Xuefei Cao, Sharon D. Shelton,
Roberta A. Mittelstaedt, and Robert H. Heflich
Part II Assays for Chromosomal Abnormalities
6 In Vitro Cytogenetic Assays: Chromosomal Aberrations
and Micronucleus Tests.......................................... 123
Pasquale Mosesso, Serena Cinelli, Adyapalam T. Natarajan,
and Fabrizio Palitti
7 Analysis of Chromosome Aberrations in Somatic and Germ Cells
of the Mouse................................................. 147
Francesca Pacchierotti and Valentina Stocchi
8 Chromosomal Aberration Test in Human Lymphocytes................. 165
Christian Johannes and Guenter Obe
9 In Vivo Micronucleus Assay in Mouse Bone Marrow and Peripheral Blood ... 179
Sawako Kasamoto, Shoji Masumori, and Makoto Hayashi
10 Micronucleus Assay in Human Cells: Lymphocytes and Buccal Cells........ 191
Claudia Bolognesi and Michael Fenech
xi
xii
Contents
11 Flow Cytometric Determination of Micronucleus Frequency.............. 209
Azeddine Elhajouji and Magdalena Lukamowicz-Rajska
12 Fluorescence In Situ Hybridization (FISH) Technique
for the Micronucleus Test........................................ 237
Ilse Decordier and Micheline Kirsch-Volders
13 Comparative Genomic Hybridization (CGH) in Geno toxicology.......... 245
Adolf Baumgartner
14 The In Vitro Micronucleus Assay and Kinetochore Staining:
Methodology and Criteria for the Accurate Assessment
of Genotoxicity and Cytotoxicity................................... 269
Bella B. Manshian, Neenu Singh, and Shareen H. Doak
Part III Tests for Primary DNA Damage
15 y-H2AX Detection in Somatic and Germ Cells of Mice.................. 293
Eugenia Cordelli and Lorena Paris
16 Multicolor Laser Scanning Confocal Immunofluorescence
Microscopy of DNA Damage Response Biomarkers..................... 311
Julian Laubenthal, Michal R. Gdula, Alok Dhawan,
and Diana Anderson
17 The Comet Assay: Assessment of In Vitro and In Vivo DNA Damage....... 325
Mahima Bajpayee, Ashutosh Kumar, and Alok Dhawan
18 The Comet Assay in Human Biomonitoring.......................... 347
Diana Anderson, Alok Dhawan, and Julian Laubenthal
19 The Comet Assay in Marine Animals................................ 363
Giada Frenzilli and Brett P. Lyons
20 Unscheduled DNA Synthesis (UDS) Test with Mammalian Liver Cells In Vivo 373
Fabrice Nesslany
21 32P-Postlabeling Analysis of DNA Adducts........................... 389
Heinz H. Schmeiser, Marie Stiborova, and Volker M. Arlt
Part IV Assays in Plants and Alternate Animal Models
22 Micronucleus Assay with Tetrad Cells of Tradescantia................... 405
Miroslav Miïîk, Clemens Pichler, Bernhard Rainer,
Armen Nersesyan, and Siegfried Knasmueller
23 The Wing-Spot and the Comet Tests as Useful Assays Detecting
Genotoxicity in Drosophila....................................... 417
Ricard Marcos and Erico R. Carmona
Part V Guidelines
24 Genotoxicity Guidelines Recommended by International Conference
of Harmonization (ICH)........................................ 431
Gireesh H. Kamath and K.S. Rao
Index........................................................... 459
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| indexdate | 2024-07-10T00:40:17Z |
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| spelling | Genotoxicity assessment methods and protocols Ed. by Alok Dhawan ... New York [u.a.] Humana Press 2013 XV, 463 S. Ill. cm txt rdacontent n rdamedia nc rdacarrier Methods in molecular biology 1044 Springer protocols Dhawan, Alok edt Methods in molecular biology 1044 (DE-604)BV035362695 1044 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026106149&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Genotoxicity assessment methods and protocols Methods in molecular biology |
| title | Genotoxicity assessment methods and protocols |
| title_auth | Genotoxicity assessment methods and protocols |
| title_exact_search | Genotoxicity assessment methods and protocols |
| title_full | Genotoxicity assessment methods and protocols Ed. by Alok Dhawan ... |
| title_fullStr | Genotoxicity assessment methods and protocols Ed. by Alok Dhawan ... |
| title_full_unstemmed | Genotoxicity assessment methods and protocols Ed. by Alok Dhawan ... |
| title_short | Genotoxicity assessment |
| title_sort | genotoxicity assessment methods and protocols |
| title_sub | methods and protocols |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026106149&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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