Homocysteine in protein structure/function and human disease: chemical biology of homocysteine-containing proteins
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Vienna
Springer
2013
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| Schlagworte: | |
| Online-Zugang: | FAN01 UBT01 Volltext Inhaltsverzeichnis Abstract |
| Beschreibung: | 1 Online-Ressource |
| ISBN: | 9783709114094 9783709114100 |
| DOI: | 10.1007/978-3-7091-1410-0 |
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Datensatz im Suchindex
| _version_ | 1804150508600950784 |
|---|---|
| adam_text | HOMOCYSTEINE IN PROTEIN STRUCTURE/FUNCTION AND HUMAN DISEASE
/ JAKUBOWSKI, HIERONIM
: 2013
TABLE OF CONTENTS / INHALTSVERZEICHNIS
1. INTRODUCTION
2. HOMOCYSTEINE. CHEMICAL SYNTHESIS
PHYSICOCHEMICAL PROPERTIES
QUANTIFICATION METHODS
METABOLIC PATHWAYS
CLINICAL SIGNIFICANCE
3. HOMOCYSTEINE THIOLACTONE
CHEMICAL SYNTHESIS
PHYSICOCHEMICAL PROPERTIES
QUANTIFICATION METHODS
BIOLOGICAL FORMATION AND TURNOVER
CLINICAL SIGNIFICANCE
4. N-HOMOCYSTEINYLATED PROTEINS
FUNCTIONAL CONSEQUENCES
ALBUMIN
FIBRINOGEN
CYTOCHROME C
OTHER PROTEINS
QUANTIFICATION METHODS
TOTAL N-HOMOCYSTEINYLATION ASSAYS
SITE-SPECIFIC N-HOMOCYSTEINYLATION ASSAYS
FORMATION IN VIVO
TURNOVER TO NΕ-HOMOCYSTEINYL-LYSINE
BIOLOGICAL CONSEQUENCES AND CLINICAL SIGNIFICANCE
5. S-HOMOCYSTEINYLATED PROTEINS
FORMATION IN VITRO
FUNCTIONAL CONSEQUENCES
ANNEXIN
METALLOTHIONEIN
FIBRILIN, FIBRONECTIN, TROPOELASTIN
DETECTION IN VIVO
BIOLOGICAL CONSEQUENCES
CONCLUSIONS
REFERENCES
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
HOMOCYSTEINE IN PROTEIN STRUCTURE/FUNCTION AND HUMAN DISEASE
/ JAKUBOWSKI, HIERONIM
: 2013
ABSTRACT / INHALTSTEXT
EXCESS OF HOMOCYSTEINE, A PRODUCT OF THE METABOLISM OF THE ESSENTIAL
AMINO ACID METHIONINE, IS ASSOCIATED WITH POOR HEALTH, IS LINKED TO
HEART AND BRAIN DISEASES IN GENERAL HUMAN POPULATIONS, AND ACCELERATES
MORTALITY IN HEART DISEASE PATIENTS. NEUROLOGICAL AND CARDIOVASCULAR
ABNORMALITIES OCCUR IN PATIENTS WITH SEVERE GENETIC HYPERHOMOCYSTEINEMIA
AND LEAD TO PREMATURE DEATH DUE TO VASCULAR COMPLICATIONS. ALTHOUGH IT
IS CONSIDERED A NON-PROTEIN AMINO ACID, STUDIES OVER THE PAST DOZEN
YEARS HAVE DISCOVERED MECHANISMS BY WHICH HOMOCYSTEINE BECOMES A
COMPONENT OF PROTEINS. HOMOCYSTEINE-CONTAINING PROTEINS LOSE THEIR
NORMAL BIOLOGICAL FUNCTION AND BECOME AUTO-IMMUNOGENIC AND
PRO-THROMBOTIC. IN THIS BOOK, THE AUTHOR, A PIONEER AND A LEADING
CONTRIBUTOR TO THE FIELD, DESCRIBES UP-TO DATE STUDIES OF THE BIOLOGICAL
CHEMISTRY OF HOMOCYSTEINE-CONTAINING PROTEINS, AS WELL AS PATHOLOGICAL
CONSEQUENCES AND CLINICAL IMPLICATIONS OF THEIR FORMATION. THIS IS A
COMPREHENSIVE ACCOUNT OF THE BROAD RANGE OF BASIC SCIENCE AND MEDICAL
IMPLICATIONS OF HOMOCYSTEINE-CONTAINING PROTEINS FOR HEALTH AND DISEASE
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
|
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| isbn | 9783709114094 9783709114100 |
| language | English |
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| spelling | Jakubowski, Hieronim Verfasser aut Homocysteine in protein structure/function and human disease chemical biology of homocysteine-containing proteins Hieronim Jakubowski Vienna Springer 2013 1 Online-Ressource txt rdacontent c rdamedia cr rdacarrier Biowissenschaften Life sciences Metabolic diseases Biochemistry https://doi.org/10.1007/978-3-7091-1410-0 Verlag Volltext Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026094373&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026094373&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Abstract |
| spellingShingle | Jakubowski, Hieronim Homocysteine in protein structure/function and human disease chemical biology of homocysteine-containing proteins Biowissenschaften Life sciences Metabolic diseases Biochemistry |
| title | Homocysteine in protein structure/function and human disease chemical biology of homocysteine-containing proteins |
| title_auth | Homocysteine in protein structure/function and human disease chemical biology of homocysteine-containing proteins |
| title_exact_search | Homocysteine in protein structure/function and human disease chemical biology of homocysteine-containing proteins |
| title_full | Homocysteine in protein structure/function and human disease chemical biology of homocysteine-containing proteins Hieronim Jakubowski |
| title_fullStr | Homocysteine in protein structure/function and human disease chemical biology of homocysteine-containing proteins Hieronim Jakubowski |
| title_full_unstemmed | Homocysteine in protein structure/function and human disease chemical biology of homocysteine-containing proteins Hieronim Jakubowski |
| title_short | Homocysteine in protein structure/function and human disease |
| title_sort | homocysteine in protein structure function and human disease chemical biology of homocysteine containing proteins |
| title_sub | chemical biology of homocysteine-containing proteins |
| topic | Biowissenschaften Life sciences Metabolic diseases Biochemistry |
| topic_facet | Biowissenschaften Life sciences Metabolic diseases Biochemistry |
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