Holdings: TGF-beta in human disease

TGF-beta in human disease:

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Bibliographic Details
Format:	Electronic eBook
Language:	English
Published:	Tokyo Springer 2013
Subjects:	Transforming growth factors-beta Cell proliferation Cell differentiation
Online Access:	FAN01 UBT01 Volltext Inhaltsverzeichnis Abstract
Physical Description:	1 Online-Ressource
ISBN:	9784431544081 9784431544098
DOI:	10.1007/978-4-431-54409-8

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MARC


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adam_text	TGF-Β IN HUMAN DISEASE / : 2013 TABLE OF CONTENTS / INHALTSVERZEICHNIS PART I INTRODUCTION 1 TRANSFORMING GROWTH FACTOR-Β SIGNALING 2 TGF-Β SIGNALING IN STEM CELL FATE DETERMINATION 3 EMERGING ROLES OF TGF-Β CO-RECEPTORS IN HUMAN DISEASE PART II CANCER, FIBROSIS, AND INFLAMMATION 4 TGF-Β IN CANCER STEM CELLS 5 TGF-Β AS TUMOR SUPPRESSOR: IN VITRO MECHANISTIC ASPECTS OF GROWTH INHIBITION 6 TGF-Β AS TUMOR SUPPRESSOR: LESSONS FROM MOUSE MODELS 7 THE MULTIFUNCTIONAL ROLES OF TGF-Β IN NAVIGATING THE METASTATIC CASCADE 8 TGF-Β SIGNALING IN LEUKEMOGENESIS 9 TGF-Β IN SKIN CANCER AND FIBROSIS 10 THE ROLE OF TGF-Β IN CUTANEOUS MELANOMA BIOLOGY 11 THE TRANSFORMING GROWTH FACTOR-BETA (TGF-Β) IN LIVER FIBROSIS 12 TGF-Β AND INHIBITORY SMADS IN INFLAMMATION PART III CARDIOVASCULAR DISEASES 13 TGF-Β AND CARDIOVASCULAR DISORDERS 14 TGF-Β SIGNALING IN PHYSIOLOGICAL AND PATHOLOGICAL ANGIOGENESIS 15 TGF-Β SIGNALING PATHWAY AND MICRORNAS IN CARDIOVASCULAR DISEASE PART IV OTHER DISEASES 16 TGF-Β AND GENETIC SKELETAL DISEASES 17 TGF-Β IN BRAIN DISORDERS 18 TGF-Β AND METABOLIC HOMEOSTASIS PART V DISEASE PROGNOSIS AND THERAPY. 19 TARGETING PRO-ANGIOGENIC TGF-Β SIGNALING IN THE TUMOR MICROENVIRONMENT DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT. TGF-Β IN HUMAN DISEASE / : 2013 ABSTRACT / INHALTSTEXT TRANSFORMING GROWTH FACTOR-Β (TGF-Β) IS A SECRETED POLYPEPTIDE WITH MULTIFUNCTIONAL PROPERTIES MANIFESTED DURING EMBRYONIC DEVELOPMENT, ADULT ORGAN PHYSIOLOGY, AND PATHOBIOLOGY OF MAJOR DISEASES, INCLUDING CANCER AND FIBROTIC AND CARDIOVASCULAR DISEASES. THE SIGNALING PATHWAY OF TGF-Β NOW IS RATHER WELL UNDERSTOOD. CONTINUING REVELATIONS IN THE MECHANISMS OF ACTION OF TGF-Β PROVIDE SPECIFIC MECHANISTIC EXAMPLES OF HOW HUMAN CELLS LOSE THEIR CONTROLLED FUNCTION AND BEHAVE WRONGLY DURING THE DEVELOPMENT OF DIVERSE DISEASES. EQUALLY IMPORTANT, HOWEVER, IS THE CURRENT PROMISE OF EXPLOITING THE TGF-Β PATHWAY IN COMBATING HUMAN DISEASE. THIS BOOK COMPREHENSIVELY COVERS MAJOR AREAS OF HUMAN DISEASE WHERE THE INVOLVEMENT OF TGF-Β IS FIRMLY ESTABLISHED. SIMULTANEOUSLY, THE BOOK HIGHLIGHTS MAJOR GAPS IN KNOWLEDGE AND THE FUTURE DIRECTIONS OF RESEARCH THAT CAN BENEFIT HUMAN MEDICAL SCIENCE. THE CORE SET OF DISEASES WHERE TGF-Β ACTION IS WELL DOCUMENTED AND ARE INCLUDED IN THE BOOK ARE CANCER AND CARDIOVASCULAR AND FIBROTIC DISORDERS. THE CENTRAL AIM OF THE BOOK IS TO STIMULATE YOUNG SCIENTISTS TO ENTER THE PROLIFIC TGF-Β FIELD AND FIND NEW SOLUTIONS TO THE PROBLEMS REMAINING IN THIS AREA OF STUDY. FOR THIS PURPOSE THE BOOK PROVIDES AUTHORITATIVE EDUCATIONAL CHAPTERS THAT FURNISH A GOOD INTRODUCTION TO THE FIELD FOR YOUNG DOCTORAL STUDENTS, POSTDOCS, AND CLINICAL FELLOWS. THE BOOK ALSO SERVES AS A VALUABLE REFERENCE FOR THE AFICIONADOS IN THE FIELD, WHO CAN FIND ACCESSIBLE AND WELL-ILLUSTRATED MATERIAL FOR THEIR TEACHING AND LECTURING ACTIVITIES, VIA WHICH THE IMPORTANCE OF TGF-Β BIOLOGY IS DISSEMINATED TO THE WORLD OF SCIENCE AND TO THE PUBLIC DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
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spelling	TGF-beta in human disease Aristidis Moustakas ..., ed. Tokyo Springer 2013 1 Online-Ressource txt rdacontent c rdamedia cr rdacarrier Transforming growth factors-beta Cell proliferation Cell differentiation Moustakas, Aristides 1976- Sonstige (DE-588)13239331X oth https://doi.org/10.1007/978-4-431-54409-8 Verlag Volltext Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026092724&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026092724&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Abstract
spellingShingle	TGF-beta in human disease Transforming growth factors-beta Cell proliferation Cell differentiation
title	TGF-beta in human disease
title_auth	TGF-beta in human disease
title_exact_search	TGF-beta in human disease
title_full	TGF-beta in human disease Aristidis Moustakas ..., ed.
title_fullStr	TGF-beta in human disease Aristidis Moustakas ..., ed.
title_full_unstemmed	TGF-beta in human disease Aristidis Moustakas ..., ed.
title_short	TGF-beta in human disease
title_sort	tgf beta in human disease
topic	Transforming growth factors-beta Cell proliferation Cell differentiation
topic_facet	Transforming growth factors-beta Cell proliferation Cell differentiation
url	https://doi.org/10.1007/978-4-431-54409-8 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026092724&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026092724&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA
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