TGF-beta in human disease:
Gespeichert in:
| Format: | Elektronisch E-Book |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Tokyo
Springer
2013
|
| Schlagworte: | |
| Online-Zugang: | FAN01 UBT01 Volltext Inhaltsverzeichnis Abstract |
| Beschreibung: | 1 Online-Ressource |
| ISBN: | 9784431544081 9784431544098 |
| DOI: | 10.1007/978-4-431-54409-8 |
Internformat
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Datensatz im Suchindex
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| adam_text | TGF-Β IN HUMAN DISEASE
/
: 2013
TABLE OF CONTENTS / INHALTSVERZEICHNIS
PART I INTRODUCTION
1 TRANSFORMING GROWTH FACTOR-Β SIGNALING
2 TGF-Β SIGNALING IN STEM CELL FATE DETERMINATION
3 EMERGING ROLES OF TGF-Β CO-RECEPTORS IN HUMAN DISEASE
PART II CANCER, FIBROSIS, AND INFLAMMATION
4 TGF-Β IN CANCER STEM CELLS
5 TGF-Β AS TUMOR SUPPRESSOR: IN VITRO MECHANISTIC ASPECTS OF GROWTH
INHIBITION
6 TGF-Β AS TUMOR SUPPRESSOR: LESSONS FROM MOUSE MODELS
7 THE MULTIFUNCTIONAL ROLES OF TGF-Β IN NAVIGATING THE METASTATIC
CASCADE
8 TGF-Β SIGNALING IN LEUKEMOGENESIS
9 TGF-Β IN SKIN CANCER AND FIBROSIS
10 THE ROLE OF TGF-Β IN CUTANEOUS MELANOMA BIOLOGY
11 THE TRANSFORMING GROWTH FACTOR-BETA (TGF-Β) IN LIVER FIBROSIS
12 TGF-Β AND INHIBITORY SMADS IN INFLAMMATION
PART III CARDIOVASCULAR DISEASES
13 TGF-Β AND CARDIOVASCULAR DISORDERS
14 TGF-Β SIGNALING IN PHYSIOLOGICAL AND PATHOLOGICAL ANGIOGENESIS
15 TGF-Β SIGNALING PATHWAY AND MICRORNAS IN CARDIOVASCULAR DISEASE
PART IV OTHER DISEASES
16 TGF-Β AND GENETIC SKELETAL DISEASES
17 TGF-Β IN BRAIN DISORDERS
18 TGF-Β AND METABOLIC HOMEOSTASIS
PART V DISEASE PROGNOSIS AND THERAPY. 19 TARGETING PRO-ANGIOGENIC TGF-Β
SIGNALING IN THE TUMOR MICROENVIRONMENT
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
TGF-Β IN HUMAN DISEASE
/
: 2013
ABSTRACT / INHALTSTEXT
TRANSFORMING GROWTH FACTOR-Β (TGF-Β) IS A SECRETED POLYPEPTIDE WITH
MULTIFUNCTIONAL PROPERTIES MANIFESTED DURING EMBRYONIC DEVELOPMENT,
ADULT ORGAN PHYSIOLOGY, AND PATHOBIOLOGY OF MAJOR DISEASES, INCLUDING
CANCER AND FIBROTIC AND CARDIOVASCULAR DISEASES. THE SIGNALING PATHWAY
OF TGF-Β NOW IS RATHER WELL UNDERSTOOD. CONTINUING REVELATIONS IN THE
MECHANISMS OF ACTION OF TGF-Β PROVIDE SPECIFIC MECHANISTIC EXAMPLES OF
HOW HUMAN CELLS LOSE THEIR CONTROLLED FUNCTION AND BEHAVE WRONGLY DURING
THE DEVELOPMENT OF DIVERSE DISEASES. EQUALLY IMPORTANT, HOWEVER, IS THE
CURRENT PROMISE OF EXPLOITING THE TGF-Β PATHWAY IN COMBATING HUMAN
DISEASE. THIS BOOK COMPREHENSIVELY COVERS MAJOR AREAS OF HUMAN DISEASE
WHERE THE INVOLVEMENT OF TGF-Β IS FIRMLY ESTABLISHED. SIMULTANEOUSLY,
THE BOOK HIGHLIGHTS MAJOR GAPS IN KNOWLEDGE AND THE FUTURE DIRECTIONS OF
RESEARCH THAT CAN BENEFIT HUMAN MEDICAL SCIENCE. THE CORE SET OF
DISEASES WHERE TGF-Β ACTION IS WELL DOCUMENTED AND ARE INCLUDED IN THE
BOOK ARE CANCER AND CARDIOVASCULAR AND FIBROTIC DISORDERS. THE CENTRAL
AIM OF THE BOOK IS TO STIMULATE YOUNG SCIENTISTS TO ENTER THE PROLIFIC
TGF-Β FIELD AND FIND NEW SOLUTIONS TO THE PROBLEMS REMAINING IN THIS
AREA OF STUDY. FOR THIS PURPOSE THE BOOK PROVIDES AUTHORITATIVE
EDUCATIONAL CHAPTERS THAT FURNISH A GOOD INTRODUCTION TO THE FIELD FOR
YOUNG DOCTORAL STUDENTS, POSTDOCS, AND CLINICAL FELLOWS. THE BOOK ALSO
SERVES AS A VALUABLE REFERENCE FOR THE AFICIONADOS IN THE FIELD, WHO CAN
FIND ACCESSIBLE AND WELL-ILLUSTRATED MATERIAL FOR THEIR TEACHING AND
LECTURING ACTIVITIES, VIA WHICH THE IMPORTANCE OF TGF-Β BIOLOGY IS
DISSEMINATED TO THE WORLD OF SCIENCE AND TO THE PUBLIC
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
|
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| illustrated | Not Illustrated |
| indexdate | 2024-07-10T00:40:01Z |
| institution | BVB |
| isbn | 9784431544081 9784431544098 |
| language | English |
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| spelling | TGF-beta in human disease Aristidis Moustakas ..., ed. Tokyo Springer 2013 1 Online-Ressource txt rdacontent c rdamedia cr rdacarrier Transforming growth factors-beta Cell proliferation Cell differentiation Moustakas, Aristides 1976- Sonstige (DE-588)13239331X oth https://doi.org/10.1007/978-4-431-54409-8 Verlag Volltext Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026092724&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026092724&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Abstract |
| spellingShingle | TGF-beta in human disease Transforming growth factors-beta Cell proliferation Cell differentiation |
| title | TGF-beta in human disease |
| title_auth | TGF-beta in human disease |
| title_exact_search | TGF-beta in human disease |
| title_full | TGF-beta in human disease Aristidis Moustakas ..., ed. |
| title_fullStr | TGF-beta in human disease Aristidis Moustakas ..., ed. |
| title_full_unstemmed | TGF-beta in human disease Aristidis Moustakas ..., ed. |
| title_short | TGF-beta in human disease |
| title_sort | tgf beta in human disease |
| topic | Transforming growth factors-beta Cell proliferation Cell differentiation |
| topic_facet | Transforming growth factors-beta Cell proliferation Cell differentiation |
| url | https://doi.org/10.1007/978-4-431-54409-8 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026092724&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026092724&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA |
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