Early diagnosis and intervention in predementia Alzheimer's disease:
Gespeichert in:
| Weitere Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Philadelphia, Pa.
Elsevier
2013
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| Schriftenreihe: | Medical clinics of North America
97,3 |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XV S., S. 363 - 501 Ill., graph. Darst. |
| ISBN: | 9781455771172 |
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Datensatz im Suchindex
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| adam_text | Titel: Early diagnosis and intervention in predementia Alzheimer s disease
Autor: Molinuevo, José L
Jahr: 2013
Early Diagnosis and Intervention in Predementia Alzheimer s Disease
Contents
Preface xiii
José L. Molinuevo, Jeffrey L. Cummings, Bruno Dubois, and Philip Scheltens
International Work Group Criteria for the Diagnosis of Alzheimer Disease 363
Jeffrey L. Cummings, Bruno Dubois, José L. Molinuevo, and Philip Scheltens
Alzheimer-type biomarker changes are identifiable in asymptomatic and
mildly symptomatic predementia phases of Alzheimer disease (AD) and
AD dementia. The International Work Group (IWG) guidelines for diagnosis
identify a unified spectrum of 3 phases. The classic clinical feature that
indicates AD is an episodic memory defect of the amnestic type. IWG cri-
teria require biomarker support for the diagnoses of AD at any clinical
stage. Pathophysiologic and topographic biomarkers are recognized.
These criteria are proposed to allow highly specific diagnosis of AD and
assist in identifying patients for clinical trials of AD-related treatments
and other types of AD research.
The Application of Cerebrospinal Fluid Biomarkers in Early Diagnosis of Alzheimer
Disease 369
Kaj Klennow and Henrik Zetterberg
This article gives an updated account of the clinical application of cerebro-
spinal fluid (CSF) biomarkers for Alzheimer disease (AD). The clinically
most relevant biomarkers, total tau, phospho-tau and Aß42 are discussed,
and how they may be used, together with other diagnostic investigations,
to make a predementia diagnosis of AD. Recent findings in sporadic and
genetic preclinical AD are also discussed and, more specifically, what
the biomarkers have taught us on the sequence of events in the patho-
genic process underlying AD.
Amyloid Imaging with PET in Early Alzheimer Disease Diagnosis 377
Christopher C. Rowe and Victor L. Villemagne
In vivo imaging of amyloid-ß (Aß) with positron emission tomography has
moved from the research arena into clinical practice. Clinicians working
with cognitive decline and dementia must become familiar with its benefits
and limitations. Amyloid imaging allows earlier diagnosis of Alzheimer dis-
ease and better differential diagnosis of dementia and provides prognostic
information for mild cognitive impairment. It also has an increasingly
important role in therapeutic trial recruitment and for evaluation of anti-
Aß treatments. Longitudinal observations are required to elucidate the
role of Aß deposition in the course of Alzheimer disease and provide infor-
mation needed to fully use the prognostic power of this investigation.
x Contents
Relevance of Magnetic Resonance Imaging for Early Detection and Diagnosis of
Alzheimer Disease 399
Stefan J. Teipel, Michel Grothe, Simone Lista, Nicola Toschi,
Francesco G. Garaci, and Harald Hampel
Magnetic resonance imaging (MRI)-based indicators of regional and global
brain atrophy and more advanced measures of cortical functional and
structural connectivity are among the most promising imaging biomarkers
for the characterization of preclinical and prodromal stages of Alzheimer
disease (AD). This review presents the current status of available and
evolving MRI-based technologies for the early asymptomatic and prede-
mentia diagnosis of AD, including high-resolution structural MRI of global
and regional brain atrophy, diffusion tensor imaging of structural cortical
connectivity, and functional MRI during rest and task performance. The
selection of an appropriate technique needs to consider its suitability for
specific applications.
Cognitive Approaches to Early Alzheimer s Disease Diagnosis 425
John Harrison
In this article, cognitive measures in the screening of individuals at risk for
Alzheimer disease (AD) are reviewed. Use of cognitive tasks in identifying
clinical cases of AD is considered, as well as methods for detecting those
in the prodromal stages of the disease, including cognitive screening
instruments. Traditional assessments, such as the mini-mental state
examination, as well as contemporary computerized screening instru-
ments, are examined. Areas of cognition for investigation in the detection
of prodromal AD are recommended. The prospects for general cognitive
screening are reviewed, and more engaging technologies to tests individ-
uals at risk for developing AD are recommended.
Clinical Trials in Predementia Stages of Alzheimer Disease 439
Jagan A. Pillai and Jeffrey L. Cummings
Effective treatments of Alzheimer disease (AD) dementia are an urgent
necessity. There is a growing consensus that effective disease-modifying
treatment before the onset of clinical dementia and slowing the progres-
sion of mild symptoms are needed after recent setbacks in AD therapeu-
tics. The identification of at-risk and preclinical AD populations is
becoming important for targeting primary and secondary prevention clini-
cal trials in AD. This article reviews the strategies and challenges in target-
ing at-risk and preclinical AD populations for a new generation of AD
clinical trials. Design, outcome measures, and complexities in successfully
completing a clinical trial targeting this population are reviewed.
Emotional and Psychological Implications of Early AD Diagnosis 459
Pascal Antoine and Florence Pasquier
This article reviews the current recommendations in early diagnosis and
the desires of the patients and their relatives, put in perspective with the
reality of the clinical practices. More specific situations covered are:
(1) the issue of young diseased patients, taking into account the psycho-
logical implications of the early occurrence of the disease in life and of
Contents xi
the longer delay for these patients between the first observable signs and
the diagnosis and (2) the issue of genetic testing, taking into account the
implications of this extremely early form of bad news on the individual s
existence and on the family structure.
Applying the IWG Research Criteria in Clinical Practice: Feasibility and Ethical Issues 477
José L. Molinuevo and Lorena Rami
In 2007, new International Working Group research criteria introduced
a new conceptualization of Alzheimer disease and created a framework
for earlier diagnosis. There is increasing consensus to understand Alzheimer
disease as a clinical-biologic entity, in which biomarkers, especially patho-
physiologic markers revealing underlying pathology, represent the biologic
counterpart of the diagnosis, and specific symptoms, such as episodic
memory deficits, account for the clinical one. This article advances and
moves forward on this.
FDG-PET in Early AD Diagnosis 485
Jessica Chew and Daniel H.S. Silverman
18F-fludeoxyglucose positron emission tomography (FDG-PET) is an
important tool for detecting the early stages of Alzheimer disease (AD).
This article discusses the multiple roles FDG-PET plays in helping to diag-
nose AD, including detecting the disease in the prodromal and early
dementia stages, differential diagnosis of dementia, documenting and
quantifying cognitive decline, and predicting progression from mild cogni-
tive impairment to AD. In addition, the role of structural magnetic resonance
imaging, underutilization of FDG-PET, and a suggested multimodal
approach for early AD diagnosis are discussed.
Index
495
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| spelling | Early diagnosis and intervention in predementia Alzheimer's disease ed. José L. Molinuevo ... Philadelphia, Pa. Elsevier 2013 XV S., S. 363 - 501 Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Medical clinics of North America 97,3 Clinics review articles Molinuevo, José L. (DE-588)1036490858 edt Medical clinics of North America 97,3 (DE-604)BV000003310 97,3 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026086402&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Early diagnosis and intervention in predementia Alzheimer's disease Medical clinics of North America |
| title | Early diagnosis and intervention in predementia Alzheimer's disease |
| title_auth | Early diagnosis and intervention in predementia Alzheimer's disease |
| title_exact_search | Early diagnosis and intervention in predementia Alzheimer's disease |
| title_full | Early diagnosis and intervention in predementia Alzheimer's disease ed. José L. Molinuevo ... |
| title_fullStr | Early diagnosis and intervention in predementia Alzheimer's disease ed. José L. Molinuevo ... |
| title_full_unstemmed | Early diagnosis and intervention in predementia Alzheimer's disease ed. José L. Molinuevo ... |
| title_short | Early diagnosis and intervention in predementia Alzheimer's disease |
| title_sort | early diagnosis and intervention in predementia alzheimer s disease |
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