Pirfenidone, an inhibitor of TGF-beta expression in malignant glioma cell lines:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | 50 S. Ill., graph. Darst. |
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Datensatz im Suchindex
| _version_ | 1804150493263429632 |
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| adam_text | IMAGE 1
TABLE OF CONTENTS
1. INTRODUCTION 6
1.1. GLIOMA BIOLOGY
1.1.1. CHARACTERISTICS A N D THERAPY 6
1.1.2. T H E IMMUNE PRIVILEGE OF GLIOBLASTOMA 7
1.1.3. METALLOPROTEINASES IN GLIOBLASTOMA 9
1. 2. TRANSFORMING GROWTH FACTOR BETA (TGF-SS) 11
1.2.1. PROCESSING, TARGETING A N D ACTIVATION 11
1.2.2. CELLULAR R E S P O N S E S INDUCED BY THE TGF-SS SIGNALING C A S C
A D E 1 3
1. 3. PIRFENIDONE (PFD) - A REGULATOR OF TGF-SS ACTIVITY 1 5
1.4. AIMS OF THE INVESTIGATION 1 7
2. MATERIAL A N D METHODS 19
3. RESULTS 2 2
3.1. PFD C A U S E S CELL GROWTH ARREST 2 2
3.2. PFD REDUCES TGF-SS ACTIVITY BY AFFECTING TGF-SS2 MRNA
EXPRESSION A N D PROCESSING OF PRO-TGF-SS 2 3
3.3. PFD INHIBITS T H E ACTIVITY OF RECOMBINANT FURIN A N D
DOWNREGULATES T H E EXPRESSION OF MMP-11 A TGF-SS TARGET G E N E
A N D FURIN SUBSTRATE 2 8
4. DISCUSSION 31
5. SUMMARY 3 4
6. REFERENCES 3 5
7. ZUSAMMENFASSUNG 4 3
8. VEROEFFENTLICHUNG 4 5
ERKLAERUNG ZUM EIGENANTEIL 4 6
DANKSAGUNG 4 7
CURRICULUM VITAE 4 8
4
HTTP://D-NB.INFO/1036664562
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| title | Pirfenidone, an inhibitor of TGF-beta expression in malignant glioma cell lines |
| title_auth | Pirfenidone, an inhibitor of TGF-beta expression in malignant glioma cell lines |
| title_exact_search | Pirfenidone, an inhibitor of TGF-beta expression in malignant glioma cell lines |
| title_full | Pirfenidone, an inhibitor of TGF-beta expression in malignant glioma cell lines vorgelegt von Isabel Tritschler, geb. Burghardt |
| title_fullStr | Pirfenidone, an inhibitor of TGF-beta expression in malignant glioma cell lines vorgelegt von Isabel Tritschler, geb. Burghardt |
| title_full_unstemmed | Pirfenidone, an inhibitor of TGF-beta expression in malignant glioma cell lines vorgelegt von Isabel Tritschler, geb. Burghardt |
| title_short | Pirfenidone, an inhibitor of TGF-beta expression in malignant glioma cell lines |
| title_sort | pirfenidone an inhibitor of tgf beta expression in malignant glioma cell lines |
| topic_facet | Hochschulschrift |
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