Transcriptional and translational regulation of stem cells:
Gespeichert in:
| Weitere Verfasser: | |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Dordrecht [u.a.]
Springer
2013
|
| Schriftenreihe: | Advances in experimental medicine and biology
786 |
| Schlagworte: | |
| Online-Zugang: | DE-578 Volltext Inhaltsverzeichnis Abstract |
| Beschreibung: | 1 Online-Ressource (X, 371 S.) Ill., graph. Darst. |
| ISBN: | 9789400766211 9789400766204 |
| DOI: | 10.1007/978-94-007-6621-1 |
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Datensatz im Suchindex
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TRANSCRIPTIONAL AND TRANSLATIONAL REGULATION OF STEM CELLS
/
: 2013
TABLE OF CONTENTS / INHALTSVERZEICHNIS
THE STEM CELL STATE
INDUCTION OF PLURIPOTENCY
GERMLINE STEM CELLS AND THEIR REGULATION IN THE NEMATODE CAENORHABDITIS
ELEGANS
TRANSCRIPTIONAL AND POST-TRANSCRIPTIONAL REGULATION OF DROSOPHILA
GERMLINE STEM CELLS AND THEIR DIFFERENTIATING PROGENY
STEM CELLS IN THE DROSOPHILA DIGESTIVE SYSTEM
MECHANISMS OF ASYMMETRIC PROGENITOR DIVISIONS IN THE DROSOPHILA CENTRAL
NERVOUS SYSTEM
TRANSCRIPTIONAL / TRANSLATIONAL REGULATION OF MAMMALIAN SPERMATOGENIC
STEM CELLS
TRANSCRIPTIONAL REGULATION AND SPECIFICATION OF NEURAL STEM CELLS
TRANSCRIPTIONAL CONTROL OF EPIDERMAL STEM CELLS
REGULATION OF INTESTINAL STEM CELLS BY WNT AND NOTCH SIGNALLING
TRANSCRIPTIONAL REGULATION OF HAEMATOPOIETIC STEM CELLS
REGULATION OF MESENCHYMAL STEM CELL DIFFERENTIATION
MOLECULAR FAMILIES IMPLICATED IN STEM CELL REGULATION
THE MUSASHI FAMILY OF RNA BINDING PROTEINS: MASTER REGULATORS OF
MULTIPLE STEM CELL POPULATIONS
JAK-STAT SIGNALLING IN STEM CELLS
MYC IN STEM CELL BEHAVIOUR: INSIGHTS FROM DROSOPHILA
THE ROLE OF NUCLEAR RECEPTORS IN EMBRYONIC STEM CELLS
EPIGENETIC REGULATION OF STEM CELLS.-REGULATION OF STEM CELL
POPULATIONS BY MICRORNAS
MYB AND THE REGULATION OF STEM CELLS IN THE INTESTINE AND BRAIN: A TALE
OF TWO NICHES
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
TRANSCRIPTIONAL AND TRANSLATIONAL REGULATION OF STEM CELLS
/
: 2013
ABSTRACT / INHALTSTEXT
STEM CELLS ARE CENTRAL TO THE DEVELOPMENT AND HOMEOSTASIS OF METAZOAN
TISSUES AND PLAY ROLES AT MULTIPLE TIMES WITHIN A DIVERSITY OF ORGANS
DURING THE LIFETIME OF AN ANIMAL. A KEY GOAL OF REGENERATIVE MEDICINE IS
THE IN VIVO REPAIR OF ORGANS DAMAGED BY DISEASE OR INJURY. IN ORDER TO
FACILITATE THIS GOAL WE NEED TO UNDERSTAND HOW STEM CELLS ARE GENERATED,
WHAT FACTORS MAINTAIN THEM IN THEIR RESPECTIVE TISSUES AND HOW THEIR
DIFFERENTIATION IS REGULATED. IN THIS VOLUME, LEADING RESEARCHERS
DISCUSS THE NATURE OF STEM CELLS AND PLURIPOTENCY AND HOW THIS STATE CAN
BE EXPERIMENTALLY INDUCED. STEM CELL MAINTENANCE, PROLIFERATION AND
DIFFERENTIATION IS UNDER TIGHT REGULATION AS EXCESS STEM CELL
PROLIFERATION COULD FACILITATE TUMOUR FORMATION AND CONVERSELY LOSS OF
STEM CELLS OR FAILURE OF DIFFERENTIATION COULD DISRUPT TISSUE
HOMEOSTASIS OR REPAIR.HENCE, STEM CELLS ARE REGULATED BY MULTIPLE
LAYERS OF MOLECULAR CONTROL AND THIS VOLUME DISCUSSES TRANSCRIPTIONAL,
TRANSLATIONAL, EPIGENETIC, CELL SIGNALLING AND MICRORNA MODALITIES THAT
AFFECT STEM CELL BEHAVIOUR. MANY OF THE UNDERLYING KEY PRINCIPLES OF
STEM CELL BIOLOGY WERE DISCOVERED BY GENETIC ANALYSIS OF INVERTEBRATE
SYSTEMS AND CHAPTERS IN THIS VOLUME DESCRIBE REGULATION OF THE GERMLINE
IN C. ELEGANS AND IN THE DIGESTIVE SYSTEM, CENTRAL NERVOUS SYSTEM AND
GERMLINE OF DROSOPHILA. THE MOLECULAR PROCESSES THAT REGULATE
REGENERATIVE ORGAN SYSTEMS FROM ALL THREE OF THE VERTEBRATE GERM LAYERS
ARE DESCRIBED WITH EMPHASIS ON THE MALE GERMLINE, NERVOUS SYSTEM,
EPIDERMIS, INTESTINE, HAEMATOPOIETIC SYSTEM AND DERIVATIVES OF THE
MESODERM.SEVERAL CHAPTERS ALSO FOCUS ON MOLECULAR FAMILIES THAT HAVE
BEEN IMPLICATED IN CONTROLLING A RANGE OF STEM CELL TYPES INCLUDING THE
JAK-STAT, WNT AND NOTCH SIGNALLING PATHWAYS; MYC, MYB AND NUCLEAR
RECEPTOR TRANSCRIPTIONAL REGULATORS; THE MUSASHI FAMILY OF RNA-BINDING
PROTEINS; MICRORNAS AND EPIGENETIC REGULATORS. THIS VOLUME WILL PROVIDE
ACCESS TO THE CURRENT STATE OF RESEARCH IN THESE RAPIDLY EVOLVING AREAS
OF STEM CELL BIOLOGY TO THE STUDENT, EDUCATOR OR RESEARCHER
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT. |
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| spellingShingle | Transcriptional and translational regulation of stem cells Advances in experimental medicine and biology Medizin Medicine Cytology Stem cells Developmental biology Translation Genetik (DE-588)4185909-1 gnd Stammzelle (DE-588)4665329-6 gnd Transkription Genetik (DE-588)4185906-6 gnd |
| subject_GND | (DE-588)4185909-1 (DE-588)4665329-6 (DE-588)4185906-6 |
| title | Transcriptional and translational regulation of stem cells |
| title_auth | Transcriptional and translational regulation of stem cells |
| title_exact_search | Transcriptional and translational regulation of stem cells |
| title_full | Transcriptional and translational regulation of stem cells Gary Hime ..., ed. |
| title_fullStr | Transcriptional and translational regulation of stem cells Gary Hime ..., ed. |
| title_full_unstemmed | Transcriptional and translational regulation of stem cells Gary Hime ..., ed. |
| title_short | Transcriptional and translational regulation of stem cells |
| title_sort | transcriptional and translational regulation of stem cells |
| topic | Medizin Medicine Cytology Stem cells Developmental biology Translation Genetik (DE-588)4185909-1 gnd Stammzelle (DE-588)4665329-6 gnd Transkription Genetik (DE-588)4185906-6 gnd |
| topic_facet | Medizin Medicine Cytology Stem cells Developmental biology Translation Genetik Stammzelle Transkription Genetik |
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