Management of chemical and biological samples for screening applications:
Gespeichert in:
| Weitere Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
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Weinheim
Wiley-VCH-Verl.
2012
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| Online-Zugang: | Inhaltstext Inhaltsverzeichnis |
| Beschreibung: | Literaturangaben |
| Beschreibung: | XXVI, 406 S. Ill., graph. Darst. 25 cm |
| ISBN: | 9783527328222 352732822X |
Internformat
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| 245 | 1 | 0 | |a Management of chemical and biological samples for screening applications |c ed. by Mark Wigglesworth and Terry Wood |
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| 300 | |a XXVI, 406 S. |b Ill., graph. Darst. |c 25 cm | ||
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IMAGE 1
CONTENTS
PREFACE X I X
LIST O F CONTRIBUTORS X X I I I
1 INTRODUCTION T O SAMPLE M A N A G E M E N T 1
WILLIAM P. J A N Z E N A N D A N D Y ZAAYENGA REFERENCES 6
2 GENERATING A HIGH-QUALITY C O M P O U N D COLLECTION 9
PHILIP B. COX A N D ANIL VASUDEVAN
2.1 DEFINING C U R R E N T SCREENING COLLECTIONS 9
2.2 DESIGN CRITERIA FOR ENRICHING A C O M P O U N D COLLECTION W I T H
DRUG-LIKE
C O M P O U N D S 10
2.2.1 PHYSICOCHEMICAL TAILORING O F A C O M P O U N D COLLECTION 10
2.2.2 LIPOPHILICITY DESIGN CONSIDERATIONS 11
2.2.3 O T H E R PHYSICOCHEMICAL ROADBLOCKS 14
2.2.4 ASSESSING RISK - F R O M RULE O F 5 TO RULE O F 3/75 18
2.2.5 TOOLS ENABLING D E S K T O P IN SILICO DESIGN 19
2.3 C O N C L U D I N G R E M A R K S 20
REFERENCES 2 0
3 ASSESSING C O M P O U N D QUALITY 23
IOANA POPA-BURKE, STEPHEN BESLEY, A N D ZOE BLAXILL
3.1 I N T R O D U C T I O N 2 3
3.2 PROCESS QUALITY A N D ANALYTICAL QUALITY I N C O M P O U N D
M A N A G E M E N T 24
3.2.1 PROCESS QUALITY (QA) 2 5
3.2.2 ANALYTICAL QUALITY (SAMPLE QC) 2 7
3.3 IDENTITY 28
3.4 PURITY/STABILITY 3 2
3.4.1 M E A S U R I N G PURITY 3 2
3.4.2 D E T E R M I N I N G T H E M O S T APPROPRIATE PURITY CUT-OFF FOR
SOLUTIONS 3 7
3.4.3 STABILITY O F SOLUTIONS 38
HTTP://D-NB.INFO/1013615468
IMAGE 2
V I I I C O N T E N T S
3.5 CONCENTRATION/SOLUBILITY 39
3.6 CONCLUSIONS 41
A C K N O W L E D G M E N T S 41 REFERENCES 4 2
F U R T H E R READING 44
4 DELIVERING A N D MAINTAINING QUALITY WITHIN C O M P O U N D
M A N A G E M E N T 45
ISABEL CHARLES
4.1 INTRODUCTION 4 5
4.2 W H A T IS QUALITY F R O M A C O M P O U N D M A N A G E M E N T
PERSPECTIVE? 46
4.3 STORAGE A N D DELIVERY O F SAMPLES I N SOLUTION 4 7
4.4 INTERCEPTING LOW PURITY 4 9
4.5 STORAGE A N D DELIVERY O F SOLIDS 51
4.6 A U T O M A T I O N QUALITY CONTROL A N D RELIABILITY 5 2
4.7 HIGH-QUALITY DATA M A N A G E M E N T 54
4.8 CONCLUSION 5 5
ACKNOWLEDGMENTS 5 6 REFERENCES 5 6
5 OBTAINING A N D MAINTAINING HIGH-QUALITY TISSUE SAMPLES: SCIENTIFIC A
N D
TECHNICAL CONSIDERATIONS T O PROMOTE EVIDENCE-BASED BIOBANKING PRACTICE
(EBBP) 5 9 LISA B. MIRANDA 5.1 I N T R O D U C T I O N 5 9
5.1.1 C U R R E N T ISSUES A N D I M P E D I M E N T S TO B E N C H M A
R K LEVEL BIOSPECIMEN RESEARCH 5 9
5.1.2 T H E ROLE O F T H E RESEARCH PROTOCOL I N PRESERVING BIOSPECIMEN
QUALITY 6 0
5.1.3 RATIONALE FOR BEST PRACTICE INTEGRATION INTO S A M P L E M A N A G
E M E N T
PROCEDURES A N D PROTOCOLS 61 5.2 T H E P A T H TOWARD INTEGRATION O F
EVIDENCE-BASED BIOBANKING
PRACTICE 62
5.2.1 CONCEPTUAL F O U N D A T I O N S O F EVIDENCE-BASED BIOBANKING
PRACTICE 62 5.2.2 T H E PRE- A N D POST-ACQUISITION ANALYTIC VARIABLE
RELATIONSHIP T O EBBP 63
5.2.3 T H E BIOSPECIMEN LIFECYCLE CONCEPT: A F R A M E W O R K TO AID
EBBP PROTOCOL DESIGN 64
5.3 INTEGRATING EVIDENCE-BASED BIOBANKING PRACTICE INTO S A M P L E
PROTOCOLS 66
5.3.1 PROTOCOL P L A N N I N G FOR EBBP-BASED S A M P L E M A N A G E M
E N T 66
5.3.2 CRUCIAL SCIENTIFIC A N D TECHNICAL CONSIDERATIONS FOR EBBP
PROTOCOL DESIGN 6 8
5.3.3 UTILIZING PUBLICATION REPORTING GUIDELINES TO G U I D E EBBP
PROTOCOL DESIGN 73
IMAGE 3
C O N T E N T S IX
5.4 FINAL T H O U G H T S A N D R E C O M M E N D A T I O N S 74
5.4.1 PROPOSED STAGING SYSTEM TO QUALIFY EBBP RELATED DATA 74 ,
5.4.2 REVISITING CRUCIAL CONSIDERATIONS RELATED TO I M P L E M E N T A T
I O N OF EBBP 7 7
5.4.3 STRATEGIES TO O P T I M I Z E REAL-TIME I M P L E M E N T A T I O
N O F EBBP 78
REFERENCES 79
6 THINKING LEAN IN C O M P O U N D M A N A G E M E N T LABORATORIES 83
MICHAEL ALLEN
6.1 T H E E M E R G E N C E O F ' L E A N T H I N K I N G ' 83
6.2 T H E APPLICATION O F ' L E A N T H I N K I N G ' 83
6.3 LEAN T H I N K I N G I N D R U G DISCOVERY 8 6
6.4 A LEAN LABORATORY TOOLBOX 8 7
6.4.1 DEFINING VALUE 87
6.4.2 U N D E R S T A N D I N G T H E C U R R E N T PROCESS - PROCESS M
A P P I N G 88
6.4.3 IDENTIFYING W A S T E 8 8
6.4.4 STANDARDIZED WORK, F U T U R E STATE MAPPING, A N D C O N T I N U
O U S
I M P R O V E M E N T 8 9
6.4.5 BATCH SIZE REDUCTION, CHANGEOVER T I M E REDUCTION, A N D WORKLOAD
S M O O T H I N G 90
6.4.6 5S A N D K A N B A N 92
6.4.7 LEAN LAYOUTS A N D FLOW 95
6.4.8 TOTAL PRODUCTIVE M A I N T E N A N C E 96
6.4.9 THEORY O F CONSTRAINTS (TOC) 99
6.4.10 T H E VISUAL WORKPLACE 100
6.4.11 ENGAGING STAFF 100
6.5 STREAMLINING C O M P O U N D PROCESSING - A N EXAMPLE 101
6.6 S U M M A R Y 103
REFERENCES 105
7 APPLICATION O F SUPPLY M A N A G E M E N T PRINCIPLES IN S A M P L E
M A N A G E M E N T 107 PAUL A. GOSNELL
7.1 INTRODUCTION 107
1.1 C O M M O N PITFALLS O F S A M P L E M A N A G E M E N T 107
7.2.1 O N E SIZE DOES N O T FIT ALL 108
7.3 S A M P L E M A N A G E M E N T A N D SUPPLY C H A I N CONCEPTS
7.3.1 GOODS A N D SERVICES - CLASSIFICATION A N D STRATEGY
7.4 I M P L E M E N T I N G T H E S A M P L E M A N A G E M E N T
STRATEGY
7.5 S A M P L E M A N A G E M E N T O R G A N I Z A T I O N 111
7.6 S A M P L E M A N A G E M E N T INFORMATICS 113
7.7 AVOID MONOLITHIC SILOS O F EXCELLENCE 114
7.8 POSITION A N D SYNCHRONIZE INVENTORY 115
7.9 EXPAND T H E S A M P L E M A N A G E M E N T BOUNDARY 117
7.10 M E A S U R I N G A N D ASSESSING EFFECTIVENESS A N D QUALITY 118
108 109 1 1 1
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X I CONTENTS
7.11
8
8 . 1
8.1.1
8 . 1 . 2
8.1.3
8.1.4
8.1.5 8.2 8 . 2 . 1
8.2.2
8.2.3
8.2.3.1 8.2.3.2 8.2.3.3 8.2.4
8.2.5 8.2.5.1 8.2.6 8.2.7
9
9.1
9.2 9.3
9.4
9.4.1 9.4.2 9.4.3 9.4.4
9.4.5 9.4.6 9.4.7 9.4.8
9.4.9 9.4.10
CONCLUSIONS 119
REFERENCES 120
SOLID SAMPLE WEIGHING A N D DISTRIBUTION 121 MICHAEL GRAY AND SNEHAL
BHATT T H E PRACTICALITIES A N D TECHNOLOGY O F W E I G H I N G SOLID C
O M P O U N D S 121
INTRODUCTION 121 M A N U A L W E I G H I N G 122 A U T O M A T E D W E I
G H I N G 123 VOLATILE SOLVENT TRANSFER 125
S A M P L E W E I G H I N G - S U M M A R Y A N D CONCLUSIONS 126
LOGISTICAL CHALLENGES O F TRANSPORTATION O F SMALL MOLECULES 127
INTRODUCTION TO TRANSPORTATION 127 COMPLEXITY O F LOGISTICS A N D
COMPLIANCE CHALLENGES O F SUPPLY C H A I N 129
REGULATIONS A N D PROCEDURES FOR SHIPPING H A Z A R D O U S MATERIALS, H
A Z A R D O U S MATERIAL I N SMALL, LIMITED QUANTITY, W I T H DRY ICE
131 DOMESTIC REGULATIONS 131 G E N E R A L S H I P P I N G PROCEDURES A
N D ASSOCIATED REGULATIONS 132
INTERNATIONAL REGULATIONS 134 COLD SUPPLY C H A I N CHALLENGES 136
COLLABORATION W I T H SUBJECT EXPERTS 137 PROCESS D E V E L O P M E N T
A N D STANDARDIZATION 138
SOFTWARE SOLUTIONS 140 CONCLUSION 141 REFERENCES 142
MANAGING A GLOBAL BIOLOGICAL RESOURCE O F CELLS A N D CELLULAR
DERIVATIVES 143 FRANK P. SIMIONE AND RAYMOND H . CYPESS INTRODUCTION 143
DIVERSITY O F COLLECTIONS 144 SOURCING A N D ACQUISITION 148
AUTHENTICATION A N D CHARACTERIZATION 149 VIABILITY 151
CELLULAR MORPHOLOGY 151 MICROBIAL C O N T A M I N A T I O N 151
MYCOPLASMA DETECTION 151
VIRUS TESTING 151
SHORT T A N D E M REPEAT (STR) PROFILING 152 I S O E N Z Y M E ANALYSIS
152 COX 1 A N D C O L 152
KARYOTYPING 152
I M M U N O P H E N O T Y P I N G A N D I M M U N O C H E M I S T R Y
153
IMAGE 5
C O N T E N T S X I
9.4.11 PICO G R E E N A N D PI 153
9.5 CRYOPRESERVATION, STORAGE, A N D PRODUCTION 153
9.6 DATA M A N A G E M E N T 154
9.7 QUALITY A N D STANDARDS 155
9.8 O R D E R FULFILLMENT A N D DISTRIBUTION 157
9.9 OFFSITE BIOREPOSITORY M A N A G E M E N T 158
9.10 REGULATORY A N D LEGAL C O M P L I A N C E 159
9.11 O W N E R S H I P A N D INTELLECTUAL PROPERTY M A N A G E M E N T
160
9.12 COLLABORATIONS 161
9.13 CONCLUSION 162
REFERENCES 163
10 DEVELOPMENT O F AUTOMATION IN S A M P L E M A N A G E M E N T 165
GREGORY J. WENDEL
10.1 INTRODUCTION 165
10.2 HISTORICAL BACKGROUND 165
10.3 A U T O M A T I O N O F S A M P L E M A N A G E M E N T TODAY 167
10.4 SYSTEM BUILDING BLOCKS 169
10.4.1 STORAGE SYSTEMS 169
10.4.2 LIQUID H A N D L I N G 169
10.4.3 ACCESSORIES 170
10.4.4 PLATE H A N D L I N G , INTEGRATION 170
10.4.5 DATA M A N A G E M E N T 171
10.5 STORAGE SYSTEMS 171
10.5.1 FEATURES 171
10.5.1.1 SIZE 171
10.5.1.2 F O R M A T 172
10.5.1.3 T E M P E R A T U R E 172
10.5.1.4 E N V I R O N M E N T 172
10.5.1.5 INTERNAL MANIPULATION 172
10.5.1.6 ROBOTIC INTERFACE 172
10.5.2 EXAMPLE H A R D W A R E 173
10.6 LIQUID H A N D L E R 175
10.6.1 FEATURES 175
10.6.1.1 DECK SIZE 176
10.6.1.2 H E A D F O R M A T 176
10.6.1.3 H E A D V O L U M E RANGE 176
10.6.1.4 INDIVIDUAL C H A N N E L S 176
10.6.1.5 G R I P P E R 177
10.6.1.6 T I P LOADING 177
10.6.1.7 BARCODE READER 177
10.6.1.8 TUBE/VIAL G R I P P I N G 177
10.6.1.9 INTEGRATION OPTIONS 177
10.6.1.10 ON-DECK ACCESSORIES 177
10.6.2 EXAMPLE H A R D W A R E 178
IMAGE 6
XII C O N T E N T S
10.7 ACCESSORIES ISO
10.7.1 C O M M O N DEVICES 180
10.7.1.1 PLATE S E A L / U N S E A L 180
10.7.1.2 PLATE LABEL 181
10.7.1.3 T U B E SORTING 181
10.7.1.4 CENTRIFUGE 182
10.7.1.5 MIXING 182
10.7.1.6 BULK REAGENT ADDITION 183
10.7.1.7 T U B E INSPECTION 184
10.8 PLATE HANDLING, INTEGRATION 184
10.9 CASE STUDY: EVOLUTION O F A C O M P O U N D M A N A G E M E N T G R
O U P 186
10.9.1 BACKGROUND 186
10.9.2 STARTING CONDITION 187
10.9.3 R O A D M A P TO EVOLUTION 188
10.9.4 C U R R E N T H O L D I N G S INTEGRITY 188
10.9.5 A U T O M A T E D SOLUTIONS 189
10.9.5.1 STORAGE F O R M A T 190
10.9.5.2 STORAGE SYSTEMS 190
10.9.5.3 LIQUID H A N D L I N G 190
10.9.5.4 ACCESSORIES 191
10.9.5.5 SYSTEM INTEGRATION 191
10.9.5.6 INTEGRATED VS WALK-UP 192
10.9.6 WORKFLOW STANDARDIZATION 193
10.9.6.1 SCREENING PLATES 193
10.9.6.2 CHERRY-PICKS 194
10.9.6.3 C O M P O U N D REGISTRATION 195
10.10 RESULTS 196
REFERENCES 197
11 APPLICATIONS O F ACOUSTIC TECHNOLOGY 199
ERIC TANG, COLIN BATH, A N D SUE HOLLAND-CRIMMIN 11.1 INTRODUCTION 199
11.2 C O M P O U N D - H A N D L I N G CHALLENGES I N D R U G DISCOVERY
201
11.3 ACOUSTIC DROP EJECTION - P E R F O R M A N C E , QUALITY ASSURANCE,
A N D
PLATFORM VALIDATION 203 11.3.1 PRECISION 203
11.3.2 QUALITY A S S U R A N C E - NON-INVASIVE D M S O HYDRATION M O N
I T O R 203 11.3.3 PLATFORM VALIDATION 205
11.4 ACOUSTIC-ASSISTED C O M P O U N D SOLUBILIZATION A N D MIXING 206
11.4.1 SONICATION 207
11.4.2 ULTRASONIC MIXING 207
11.5 ACOUSTIC APPLICATIONS I N D R U G DISCOVERY 209
11.5.1 H T S A N D ASSAY-READY PLATES - C O M P O U N D REFORMATTING A N
D G E N E R I C DOSE RESPONSE STUDIES 209 11.5.2 C O M P O U N D DOSING
I N CELL-BASED SCREENING APPLICATIONS 211
IMAGE 7
C O N T E N T S X I I I
11.5.3
11.6 11.6.1 11.6.2 11.6.3
12
1 2 . 1
1 2 . 1 . 1
1 2 . 1 . 2
12.1.3
12.1.3.1 12.1.3.2 12.1.3.3 12.1.4
12.1.5
12.2 1 2 . 2 . 1
1 2 . 2 . 2
12.2.3
12.2.3.1 12.2.3.2 12.2.4
12.2.4.1 12.2.4.2 12.2.4.3 12.2.4.4
12.2.4.5 12.2.4.6 12.3
12.3.1 12.3.1.1 12.3.1.2 12.3.1.3
12.3.2 12.3.2.1 12.3.2.2 12.4
CELL-BASED C O M B I N A T I O N SCREENING 215 E M E R G I N G
APPLICATIONS 216 ACOUSTIC T R A N S F E R O F A Q U E O U S REAGENTS A N
D BIOLOGIES 216 CELL S U S P E N S I O N T R A N S F E R 217
MATRIX DEPOSITION FOR MALDI I M A G I N G MASS SPECTROMETRY 217
REFERENCES 218
ENHANCING BIOREPOSITORY SAMPLE INTEGRITY WITH AUTOMATED STORAGE A N D
RETRIEVAL 221 J O H A N N V A N NIEKERK T H E E M E R G I N G G R O W T
H O F BIOBANKING 221 T H E N E W FACE O F A N OLD PRACTICE 221
SOURCE MATERIAL FOR POST-GENOMIC AGE RESEARCH 221 DIFFERENT OPERATIONAL
MODELS I N BIOBANKING 222 POPULATION BIOBANKS 222 DISEASE-ORIENTED
BIOBANKS FOR EPIDEMIOLOGY 223 DISEASE-ORIENTED G E N E R A L BIOBANKS
223 W H Y ARE M O D E R N BIOBANKS NEEDED? 223
T H E Q U E S T FOR BIOSPECIMEN QUALITY I N BIOREPOSITORIES 223 A U T O
M A T E D STORAGE A N D RETRIEVAL I N A BIOREPOSITORY 225 INVENTORY M A
N A G E M E N T 225 A U T O M A T I O N - SELF-CONTROLLING PROCESSES 225
M A I N T A I N I N G BIOSPECIMEN VALUE 226 BIOSPECIMEN INTEGRITY 226
DATA INTEGRITY 228
ADVANTAGES O F A U T O M A T E D BIOSPECIMEN M A N A G E M E N T 2 3 2
STABLE STORAGE CONDITIONS 232 OPERATIONAL RELIABILITY 232 EFFICIENCY A N
D CONVENIENCE O F OPERATION 234
RESTRICTED PHYSICAL ACCESS TO STORED C O N T E N T 235 REDEPLOYMENT O R
REDUCTION O F FULL-TIME EMPLOYEES 236 CONFIGURATION FLEXIBILITY - FIT
FOR P U R P O S E 236 CONFIGURATION O F A N A U T O M A T E D
BIOREPOSITORY 236
MODULARITY 236 STORAGE C H A M B E R 237
ROBOTIC OBJECT H A N D L I N G 237 FUNCTIONAL MODULES - EXECUTION O F
SPECIFIC TASKS 238
SCALABILITY 239
EXPANSION O F STORAGE CAPACITY 240 INCREASED STORAGE SYSTEM P E R F O R
M A N C E 240 CONCLUSIONS 241
REFERENCES 241
IMAGE 8
X I V C O N T E N T S
13 INFORMATION TECHNOLOGY SYSTEMS FOR SAMPLE M A N A G E M E N T 243
BRIAN BROOKS
13.1 S A M P L E REGISTRATION 243
13.1.1 W H Y T H E N E E D FOR REGISTRATION? 243
13.1.2 ASSIGNING A N D U S I N G IDENTIFIERS A T DIFFERENT LEVELS 245
13.1.3 PREPARATION N U M B E R I N G 246
13.1.4 SAMPLE N U M B E R I N G 246
13.1.5 M E T H O D S FOR N A M I N G C O M P O U N D S 246
13.1.6 S O M E HISTORY TO C O M P O U N D REGISTRATION 247
13.1.7 BUSINESS RULES FOR C O M P O U N D REGISTRATION 247
13.1.7.1 N U M B E R F O R M A T 248
13.1.7.2 C O M P O U N D N U M B E R PREFIX 248
13.1.7.3 PURITY 248
13.1.7.4 SALTS 249
13.1.7.5 STEREOCHEMISTRY 249
13.1.7.6 E N A N T I O M E R S A N D RACEMIC MIXTURES 250
13.1.7.7 STANDARDIZATION O F C H A R G E F O R M 250
13.1.7.8 T A U T O M E R I S M 250
13.1.7.9 RADIOACTIVITY 250
13.1.7.10 PROJECT CODES, SITE CODES, C O U N T R Y CODES 251 13.1.7.11
LARGER MOLECULES - O F K N O W N STRUCTURE 251 13.1.7.12 LARGER
MOLECULES - O F U N K N O W N STRUCTURE 252
13.1.7.13 COMBINATORIAL MIXTURES 2 5 2 13.1.7.14 INORGANIC C O M P O U N
D S 252
13.1.7.15 DEVELOPMENT C O M P O U N D S , O U T S I D E PUBLICATIONS,
GENERIC, A N D T R A D E N A M E S 252
13.1.8 T H E ROLE O F T H E CHEMICAL REGISTRAR 253
13.2 INTELLECTUAL PROPERTY A N D LABORATORY NOTEBOOKS 253
13.3 S O M E OBSERVATIONS O N I N F O R M A T I O N TECHNOLOGY 254
13.4 BIOLOGICAL DATA M A N A G E M E N T 2 5 5
13.4.1 T H E CORPORATE BIOLOGICAL SCREENING DATABASE (CBSD) 2 5 5 13.4.2
DATA ENTRY TOOLS 2 5 7
13.4.3 DATABASE Q U E R Y I N G 2 5 8
13.4.4 SPECIAL DATA TYPES 261
13.4.5 DATABASE DESIGNS 261
DEDICATION A N D A C K N O W L E D G M E N T S 263
14 KEY FEATURES O F A C O M P O U N D M A N A G E M E N T SYSTEM 2 6 5
CLIVE BATTLE
14.1 W H Y DO W E N E E D C O M P O U N D M A N A G E M E N T I N F O R
M A T I O N TECHNOLOGY SYSTEMS? 2 6 5
14.2 C O M P O U N D M A N A G E M E N T SOFTWARE 266
14.2.1 INVENTORY M A N A G E M E N T 266
14.2.1.1 DATA STORAGE 2 6 7
14.2.1.2 INVENTORY TRACKING 2 6 7
IMAGE 9
C O N T E N T S X V
14.2.1.3 INVENTORY BROWSING 2 6 7
14.2.1.4 I M P O R T I N G INVENTORY I T E M S 2 6 7
14.2.1.5 EDITING INVENTORY I T E M S 2 6 7
14.2.1.6 ORGANIZING T H E INVENTORY 2 6 7
14.2.2 O R D E R I N G 2 6 8
14.2.2.1 WEB-BASED O R D E R I N G 268
14.2.2.2 SAMPLE N A M I N G 2 6 8
14.2.2.3 DEFINITION O F A N O R D E R 268
14.2.2.4 O R D E R VALIDATION 268
14.2.2.5 O R D E R APPROVAL 269
14.2.2.6 RESTRICTIONS 2 6 9
14.2.2.7 Q U E R I E S 2 6 9
14.2.2.8 O R D E R STATUS NOTIFICATIONS 269
14.2.3 WORKFLOW M A N A G E M E N T 269
14.2.3.1 WORKFLOW STEPS 2 6 9
14.2.4 FULFILLMENT 270
14.2.4.1 OFFLINE I N S T R U M E N T INTEGRATION 270
14.2.4.2 O N L I N E I N S T R U M E N T INTEGRATION 270
14.2.4.3 OFFLINE VS O N L I N E 271
14.2.4.4 DESPATCH 271
14.2.4.5 REPORTS A N D METRICS 271
14.2.5 INTERFACES WITH EXTERNAL SYSTEMS 271
14.2.5.1 CHEMICAL REGISTRATION SYSTEM 271
14.2.5.2 EXTERNAL O R D E R I N G SYSTEM 272
14.2.5.3 RESULTS ANALYSIS 272
14.3 BENEFITS O F COMMERCIALLY AVAILABLE C O M P O U N D M A N A G E M E
N T SYSTEMS 272
REFERENCES 273
15 W H A T DOES A N HTS FILE O F T H E FUTURE LOOK LIKE? 2 7 5
FRANCOIS BERTELLI
15.1 INTRODUCTION 2 7 5
15.2 HISTORY O F C O M P O U N D S COLLECTION FOR H T S 276
15.3 I M P A C T O F H I G H - T H R O U G H P U T C H E M I S T R Y O N
CORPORATE FILES 2 7 7
15.4 CHEMICAL LIBRARY M A N A G E M E N T 278
15.5 T H E CONCEPT O F DRUG-LIKENESS A N D T H E LIPINSKI RULES 279
15.5.1 DRUG-LIKE 280
15.5.2 LEAD-LIKE 282
15.6 QUALITY VERSUS QUANTITY 283
15.7 T H E E M E R G E N C E O F T H E SUBSETS: F R A G M E N T ,
G-PROTEIN-COUPLED
RECEPTOR (GPCR), I O N C H A N N E L , KINASE, P R O T E I N - P R O T E
I N INTERACTION, C H E M O G E N O M I C S , LIBRARY O F
PHARMACOLOGICALLY ACTIVE C O M P O U N D S (LOPAC), CENTRAL NERVOUS
SYSTEM (CNS), A N D DIVERSITY 285 15.7.1 'CHERRY PICKING' F R O M
VIRTUAL SPACE 286
15.7.2 DIVERSE SUBSETS 2 8 7
IMAGE 10
XVI C O N T E N T S
15.7.3 CREATION O F T H E GLOBAL DIVERSITY REPRESENTATIVE S U B S E T
(GDRS) 288
15.7.4 PLATE-BASED DIVERSITY SET (PBDS) 290
15.8 RE-DESIGNING T H E CORPORATE FILE FOR T H E F U T U R E 291
15.8.1 POOLING C O M P O U N D S MOVING FORWARD 291
15.8.2 RE-DESIGNING T H E F U T U R E FILE 296
15.9 F U T U R E ROUTES FOR H I T IDENTIFICATION 299
REFERENCES 301
16 N E W ENABLING TECHNOLOGY 3 0 5
NEIL HARDY, J I YI KHOO, SHOUFENG YANG, HOLGER EICKHOFF, JOE OLECHNO, A
N D RICHARD ELLSON 16.1 INTRODUCTION 3 0 5
16.2 A D R O P - O N - D E M A N D P R I N T E R FOR DRY P O W D E R D I
S P E N S I N G 3 0 7
16.2.1 DISPENSING DEVICE SETUP 308
16.2.2 EFFECT O F P O W D E R D I S P E N S I N G P A R A M E T E R S O
N MICRO-FEEDING 309 16.3 PIEZO D I S P E N S E PENS: INTEGRATED STORAGE
A N D D I S P E N S I N G DEVICES A N D
THEIR POTENTIAL I N SECONDARY SCREENING A N D DIAGNOSTIC M A N U F A C T
U R I N G 3 1 2 16.3.1 A N INTRODUCTION TO PIEZO DISPENSERS 312
16.3.2 P D P M O D E O F OPERATION A N D ITS ADVANTAGES 313
16.3.3 P D P S I N T H E H I G H - T H R O U G H P U T SCREENING E N V I
R O N M E N T 3 1 7
16.3.4 T H E I N S T R U M E N T TO O P E R A T E P D P S I N A
PHARMACEUTICAL LABORATORY: SCISWIFTER 319 16.3.5 PDPS FOR T H E STERILE
A N D CONTAMINATION-FREE P R O D U C T I O N O F I N VITRO DIAGNOSTICS
321 16.3.6 S U M M A R Y A N D OUTLOOK 3 2 2
16.4 FUTURE DIRECTIONS I N ACOUSTIC DROPLET EJECTION TECHNOLOGY 323
16.4.1 INTRODUCTION 323
16.4.2 STRETCHING T H E BOUNDARIES O F C U R R E N T ADE U S E S 323
16.4.2.1 HIGH-VISCOSITY FLUIDS 324
16.4.2.2 LOW-SURFACE-TENSION FLUIDS 326 16.4.2.3 LAYERED, BI-PHASIC
FLUIDS 329
16.4.2.4 COMBINATORIAL C H E M I S T R Y 331
16.4.2.5 PARTICLE F O R M A T I O N 332
16.4.2.6 PRECISION COATING 3 3 2
16.4.2.7 T O U C H L E S S T R A N S F E R O F D A N G E R O U S
MATERIALS 3 3 3 16.4.2.8 ASSAY MINIATURIZATION 334
16.4.2.9 TRANSFECTION VIA SONOPORATION 336
16.4.2.10 EXPANDED REPORTING CAPABILITIES 336 16.4.2.11 T R A N S F E R
O F DROPLETS O F DIFFERENT V O L U M E - SMALLER DROPLETS 3 3 7
16.4.2.12 T R A N S F E R O F DROPLETS O F DIFFERENT V O L U M E -
LARGER DROPLETS 338 16.4.3 EXPANDED A U D I T I N G CAPABILITIES 338
16.4.3.1 AUDITING FOR V O L U M E 339
16.4.3.2 A U D I T I N G FOR RESTORATION 340
16.4.3.3 AUDITING FOR SOLUTE I N F O R M A T I O N 342
IMAGE 11
C O N T E N T S X V I I
16.4.3.4
16.4.3.5 16.4.3.6 16.4.4 16.4.4.1 16.4.5 16.5
17
17.1 17.2 17.2.1
17.2.2
17.2.3
17.3 17.3.1 17.3.2 17.3.3
17.4
17.4.1 17.4.2 17.4.3 17.4.4 17.4.5 17.4.6 17.4.7
17.5
17.6
18
18.1 18.1.1 1 8 . 1 . 2 18.1.3
18.1.4
AUDITING BI-PHASIC SOLUTIONS 3 4 2 AUDITING FOR S A M P L E QUALITY 3 4
2 FREQUENCY-DOMAIN ANALYSIS 343 N E W SOFTWARE ADVANCES 344
I M P R O V E D M E N I S C U S SCAN 344 ADE S U M M A R Y 344
CLOSING R E M A R K S 347 REFERENCES 347
T H E IMPACT O F FUTURE TECHNOLOGIES WITHIN BIOBANKING 351 MANUEL M .
MORENTE, LAURA CERECEDA, A N D MARIA J. ARTIGA I N T R O D U C T I O N
351
T H E ROLE O F BIOBANKS I N BIOMEDICAL RESEARCH 351
BIOBANKING ACTIVITY IS BASED O N C O M M I T M E N T S 351 SCIENTIFIC C
O M M I T M E N T : BIOBANKS M U S T BE O P E N TO U P D A T I N G A N D
REDEFINITION ACCORDING TO T H E EVER-CHANGING SCIENTIFIC R E Q U I R E M
E N T S 352
PERSONALIZED MEDICINE O N T H E HORIZON: BIOBANKS FOR BETTER H E A L T H
353
T H E INCREASING COMPLEXITY O F BIOBANKING 354 BIOBANKS VERSUS S A M P L
E COLLECTIONS 354 BIOBANK DIVERSITY 3 5 5 BIOBANKING, A Y O U N G
DISCIPLINE 356 F U T U R E TECHNOLOGIES A N D BIOBANKING: H O W C O U L
D N E W TECHNOLOGIES AFFECT T H E DAILY ACTIVITIES O F BIOBANKS? 356
IT SOLUTIONS A N D CHALLENGES 357 STORAGE MECHANIZATION 359 VIRTUAL
MICROSCOPY 360 NANOTECHNOLOGY A N D QUALITY CONTROL 3 6 0
T I S S U E MICROARRAYS 361 N E W FIXATIVES 3 6 2 ROBOTIZED R N A / D N
A / P R O T E I N EXTRACTION 363 T H E F U T U R E O F BIOBANKING DOES N
O T D E P E N D O N TECHNOLOGICAL
DEVELOPMENTS ALONE 363 CONCLUSIONS 364
A C K N O W L E D G M E N T S 3 6 4 REFERENCES 364
O U T S O U R C I N G S A M P L E M A N A G E M E N T 3 6 7 SYLVIANE
BOUCHARENS A N D AMELIA WALL WARNER O U T S O U R C I N G I N T H E
PHARMACEUTICAL I N D U S T R Y 3 6 7 ECONOMIC A N D ORGANIZATIONAL
ADVANTAGE O F O U T S O U R C I N G 368
SOURCING T H E RIGHT P A R T N E R 368
C O M P O U N D INVENTORY - COST O F O W N E R S H I P 369 AREAS O F O U
T S O U R C I N G I N C O M P O U N D M A N A G E M E N T 371
IMAGE 12
X V I I I | C O N T E N T S
18.1.5 O U T S O U R C I N G TO EXPLOIT A KEY ASSET 371
18.1.6 F U T U R E DEVELOPMENTS 3 7 3
18.2 O U T S O U R C I N G BIOLOGICAL S P E C I M E N COLLECTIONS 3 7 4
18.2.1 O U T S O U R C I N G T H E BIOREPOSITORY: D E T E R M I N I N G
T H E MODEL 3 7 5
18.2.2 KEY COMPETENCIES FOR O U T S O U R C E D BIOREPOSITORY V E N D O
R S 376 18.2.3 INTERNAL OVERSIGHT FOR O U T S O U R C E D BIOREPOSITORY
VENDORS 3 7 7 18.2.4 LESSONS LEARNED 3 7 7
18.3 CONCLUSIONS 3 7 8
ACKNOWLEDGMENTS 378 REFERENCES 378
19 SAMPLE M A N A G E M E N T YESTERDAY A N D TOMORROW 381
TERRY WOOD A N D MARK WIGGLESWORTH 19.1 T H E ROLE O F S A M P L E M A N
A G E M E N T 381
19.2 A U T O M A T I O N O F C O M P O U N D M A N A G E M E N T 3 8 2
19.3 C O M P O U N D INTEGRITY 384
19.4 REDUCTION O F R E D U N D A N C Y 386
19.5 T H E F U T U R E O F S A M P L E M A N A G E M E N T ? 3 8 7
19.5.1 I N T R O D U C T I O N 3 8 7
19.5.2 T H E COST O F D R U G DISCOVERY 388
19.5.3 I N D E P E N D E N T SERVICE PROVIDERS 388
19.5.4 ALTERNATIVE MODELS O F D R U G DISCOVERY 389
19.6 C O N C L U D I N G R E M A R K S 3 9 0
REFERENCES 391
INDEX 393 |
| any_adam_object | 1 |
| author2 | Wigglesworth, Mark |
| author2_role | edt |
| author2_variant | m w mw |
| author_facet | Wigglesworth, Mark |
| building | Verbundindex |
| bvnumber | BV040998989 |
| ctrlnum | (OCoLC)794523455 (DE-599)DNB1013615468 |
| dewey-full | 615.19 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 615 - Pharmacology and therapeutics |
| dewey-raw | 615.19 |
| dewey-search | 615.19 |
| dewey-sort | 3615.19 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| format | Book |
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| id | DE-604.BV040998989 |
| illustrated | Illustrated |
| indexdate | 2024-08-03T00:39:26Z |
| institution | BVB |
| isbn | 9783527328222 352732822X |
| language | English |
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| physical | XXVI, 406 S. Ill., graph. Darst. 25 cm |
| publishDate | 2012 |
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| publisher | Wiley-VCH-Verl. |
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| spelling | Management of chemical and biological samples for screening applications ed. by Mark Wigglesworth and Terry Wood Weinheim Wiley-VCH-Verl. 2012 XXVI, 406 S. Ill., graph. Darst. 25 cm txt rdacontent n rdamedia nc rdacarrier Literaturangaben Probe (DE-588)4258863-7 gnd rswk-swf Reihenuntersuchung (DE-588)4277596-6 gnd rswk-swf Reihenuntersuchung (DE-588)4277596-6 s Probe (DE-588)4258863-7 s DE-604 Wigglesworth, Mark edt X:MVB text/html http://deposit.dnb.de/cgi-bin/dokserv?id=3855503&prov=M&dok_var=1&dok_ext=htm Inhaltstext DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025976632&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
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| subject_GND | (DE-588)4258863-7 (DE-588)4277596-6 |
| title | Management of chemical and biological samples for screening applications |
| title_auth | Management of chemical and biological samples for screening applications |
| title_exact_search | Management of chemical and biological samples for screening applications |
| title_full | Management of chemical and biological samples for screening applications ed. by Mark Wigglesworth and Terry Wood |
| title_fullStr | Management of chemical and biological samples for screening applications ed. by Mark Wigglesworth and Terry Wood |
| title_full_unstemmed | Management of chemical and biological samples for screening applications ed. by Mark Wigglesworth and Terry Wood |
| title_short | Management of chemical and biological samples for screening applications |
| title_sort | management of chemical and biological samples for screening applications |
| topic | Probe (DE-588)4258863-7 gnd Reihenuntersuchung (DE-588)4277596-6 gnd |
| topic_facet | Probe Reihenuntersuchung |
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