Design, synthesis and pharmacological studies of novel multivalent and -functional Anti-Alzheimer's disease agents:
Gespeichert in:
| 1. Verfasser: | |
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| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | getr. Zählung Ill., graph. Darst. |
Internformat
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Datensatz im Suchindex
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| adam_text | IMAGE 1
TABLE OF CONTENTS
1 INTRODUCTION INTO ALZHEIMER S DISEASE 3
1.1 ALZHEIMER S DISEASE 3
1.2 BIOCHEMISTRY OF AD 5
1.3 AMYLOID HYPOTHESIS 5
1.4 TAU ( T ) HYPOTHESIS 8
1.5 CHOLINERGIC HYPOTHESIS 10
1.6 THERAPEUTIC APPROACHES 13
1.7 REFERENCES 16
2 BUTYRYLCHOLINESTERASE SELECTIVE INHIBITORS 21
2.1 ACETYL- AND BUTYRYLCHOLINESTERASE INHIBITORS 21
2.2 BCHE AND ITS SELECTIVE INHIBITORS 21
2.3 COMPOUND DESIGN 23
2.4 CONCLUSION 25
2.5 REFERENCES 26
3 THE MULTI-TARGET DIRECTED LIGANDS APPROACH USING NATURAL PRODUCTS 30
3.1 NATURAL ALKALOIDS AS NOVEL LEADS FOR CHES INHIBITORS 30
3.2 INTRODUCTION INTO TACRINE AND SILIBININ 32
3.3 COMPOUND DESIGN OF TACRINE-SILIBININ CODRUG 33
3.4 SYNTHESIS OF THE CODRUG 35
3.5 PHARMACOLOGICAL RESULTS 40
3.6 METABOLISM 41
3.7 EXPERIMENTAL SECTION 43
3.8 REFERENCES 48
4 POTENT ACETYLCHOLINESTERASE INHIBITORS WITH PHOTOSWITCHABLE INHIBITION
OF P-AMYLOID
AGGREGATION 53
4.1 TACRINE AND PHOTOCHROMIC COMPOUNDS 53
4.2 CHEMISTRY 53
4.3 RESULTS AND DISCUSSION 54
4.3.1 CHES INHIBITION AND KINETIC STUDIES 54
4.3.2 ACHE INDUCED P-AMYLOID AGGREGATION 58
4.4 CONCLUSION 59
4.5 REFERENCES 60
1
HTTP://D-NB.INFO/1036119408
IMAGE 2
5 NOVEL AGONISTS FOR THE MUSCARINIC RECEPTOR SUBTYPE 1 (MI) 63
5.1 MUSCARINIC RECEPTORS AND AD 63
5.2 ORTHOSTERIC ACTIVATION AND ALLOSTERIC MODULATION OF MI RECEPTORS 66
5.3 BITOPIC MI RECEPTOR AGONISTS 68
5.4 SYNTHESIS OF MI SELECTIVE BITOPIC AGONISTS 70
5.5 RESULTS AND DISCUSSION 76
5.6 EXPERIMENTAL SECTION 78
5.6.1 CHEMISTRY 78
5.6.2 RADIOLIGAND BINDING STUDIES 105
5.7 REFERENCES 107
2
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| any_adam_object | 1 |
| author | Chen, Xinyu |
| author_facet | Chen, Xinyu |
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| author_sort | Chen, Xinyu |
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| bvnumber | BV040991560 |
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| ctrlnum | (OCoLC)844104608 (DE-599)BVBBV040991560 |
| dewey-full | 540 610 |
| dewey-hundreds | 500 - Natural sciences and mathematics 600 - Technology (Applied sciences) |
| dewey-ones | 540 - Chemistry and allied sciences 610 - Medicine and health |
| dewey-raw | 540 610 |
| dewey-search | 540 610 |
| dewey-sort | 3540 |
| dewey-tens | 540 - Chemistry and allied sciences 610 - Medicine and health |
| discipline | Chemie / Pharmazie Medizin |
| format | Thesis Book |
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| language | English |
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| physical | getr. Zählung Ill., graph. Darst. |
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| spelling | Chen, Xinyu Verfasser aut Design, synthesis and pharmacological studies of novel multivalent and -functional Anti-Alzheimer's disease agents vorgelegt von Xinyu Chen 2013 getr. Zählung Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Regensburg, Univ., Diss., 2013 Chemische Synthese (DE-588)4133806-6 gnd rswk-swf Alzheimerkrankheit (DE-588)4112510-1 gnd rswk-swf Arzneimittel (DE-588)4003115-9 gnd rswk-swf Muscarinrezeptor (DE-588)4170773-4 gnd rswk-swf Cholinerges System (DE-588)4147867-8 gnd rswk-swf Arzneimitteldesign (DE-588)4278218-1 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Alzheimerkrankheit (DE-588)4112510-1 s Cholinerges System (DE-588)4147867-8 s Arzneimitteldesign (DE-588)4278218-1 s Arzneimittel (DE-588)4003115-9 s Chemische Synthese (DE-588)4133806-6 s DE-604 Muscarinrezeptor (DE-588)4170773-4 s DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025969361&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Chen, Xinyu Design, synthesis and pharmacological studies of novel multivalent and -functional Anti-Alzheimer's disease agents Chemische Synthese (DE-588)4133806-6 gnd Alzheimerkrankheit (DE-588)4112510-1 gnd Arzneimittel (DE-588)4003115-9 gnd Muscarinrezeptor (DE-588)4170773-4 gnd Cholinerges System (DE-588)4147867-8 gnd Arzneimitteldesign (DE-588)4278218-1 gnd |
| subject_GND | (DE-588)4133806-6 (DE-588)4112510-1 (DE-588)4003115-9 (DE-588)4170773-4 (DE-588)4147867-8 (DE-588)4278218-1 (DE-588)4113937-9 |
| title | Design, synthesis and pharmacological studies of novel multivalent and -functional Anti-Alzheimer's disease agents |
| title_auth | Design, synthesis and pharmacological studies of novel multivalent and -functional Anti-Alzheimer's disease agents |
| title_exact_search | Design, synthesis and pharmacological studies of novel multivalent and -functional Anti-Alzheimer's disease agents |
| title_full | Design, synthesis and pharmacological studies of novel multivalent and -functional Anti-Alzheimer's disease agents vorgelegt von Xinyu Chen |
| title_fullStr | Design, synthesis and pharmacological studies of novel multivalent and -functional Anti-Alzheimer's disease agents vorgelegt von Xinyu Chen |
| title_full_unstemmed | Design, synthesis and pharmacological studies of novel multivalent and -functional Anti-Alzheimer's disease agents vorgelegt von Xinyu Chen |
| title_short | Design, synthesis and pharmacological studies of novel multivalent and -functional Anti-Alzheimer's disease agents |
| title_sort | design synthesis and pharmacological studies of novel multivalent and functional anti alzheimer s disease agents |
| topic | Chemische Synthese (DE-588)4133806-6 gnd Alzheimerkrankheit (DE-588)4112510-1 gnd Arzneimittel (DE-588)4003115-9 gnd Muscarinrezeptor (DE-588)4170773-4 gnd Cholinerges System (DE-588)4147867-8 gnd Arzneimitteldesign (DE-588)4278218-1 gnd |
| topic_facet | Chemische Synthese Alzheimerkrankheit Arzneimittel Muscarinrezeptor Cholinerges System Arzneimitteldesign Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025969361&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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