Multidisciplinary breast management:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Philadelphia, Pa.
Elsevier
2013
|
| Schriftenreihe: | Surgical clinics of North America
93,2 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Includes bibliographical references and index Benign breast disease -- Screening, imaging, and image-guided biopsy techniques for breast cancer -- Surgical management of high-risk breast lesions -- Genetic predisposition syndromes and their management -- Pathology of invasive breast disease -- Ductal carcinoma in situ -- Surgical management of the breast: breast conservation therapy and mastectomy -- Management of the axilla -- Breast reconstruction -- Radiation therapy in the management of breast cancer -- Adjuvant systemic therapies in breast cancer -- Neoadjuvant chemotherapy in the treatment of breast cancer -- Landmark trials affecting the surgical management of invasive breast cancer -- Miscellaneous syndromes and their management: occult breast cancer, breast cancer in pregnancy, male breast cancer, surgery in stage IV disease |
| Beschreibung: | XVIII S., S. 299 - 548 Ill. 24 cm |
| ISBN: | 9781455773343 1455773344 |
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| 245 | 1 | 0 | |a Multidisciplinary breast management |c ed. George M. Fuhrman ; Tari A. King |
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| 490 | 1 | |a Surgical clinics of North America |v 93,2 | |
| 490 | 0 | |a Clinics review articles | |
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| 650 | 4 | |a Breast / Cancer / Treatment | |
| 650 | 4 | |a Breast / Diseases / Treatment | |
| 650 | 4 | |a Breast neoplasms / therapy | |
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Datensatz im Suchindex
| _version_ | 1804150271281987584 |
|---|---|
| adam_text | Titel: Multidisciplinary breast management
Autor: Fuhrman, George M
Jahr: 2013
Multidisciplinary Breast Management
Contents
Foreword: Multidisciplinary Breast Management xiii
Ronald F. Martin
Preface: Multidisciplinary Breast Management xvii
George M. Fuhrman and Tari A. King
Benign Breast Disease 299
Amanda L. Amin, Anna C. Purdy, Joanne D. Mattingly, Amanda L. Kong, and
Paula M. Termuhlen
This article presents an overview of the benign conditions that affect the
breast for the practicing surgeon. The authors discuss the diagnosis and
management of a variety of breast pathologic conditions, including those
associated with infection and inflammation as well as proliferative and
nonproliferative disorders. The authors also offer their experience with
the integration of nurse practitioners in the care of patients with benign
breast disease.
Screening, Imaging, and Image-Guided Biopsy Techniques for Breast Cancer 309
Dana H. Smetherman
Mammography remains the primary modality for breast cancer diagnosis.
Other imaging studies, most commonly ultrasonography and magnetic
resonance imaging, are also used to characterize breast lesions, stage
breast cancer, and aid in surgical planning. Although mammography is
the only screening examination demonstrated to decrease breast cancer
mortality in the general population, other imaging studies have been
shown to be beneficial for screening high-risk patients. In the future,
new technologies may also improve the sensitivity and specificity of breast
cancer screening and detection.
Surgical Management of High-Risk Breast Lesions 329
Amy C. Degnim and Tari A. King
High-risk lesions of the breast are lesions that confer an increased risk of
breast cancer, either because of an increased probability of finding can-
cer associated with percutaneous biopsy findings or because of an in-
creased probability of developing breast cancer over the long term.
Atypical ductal hyperplasia found on percutaneous biopsy is generally ex-
cised, whereas lobular neoplasia lesions, including both atypical lobular
hyperplasia and lobular carcinoma in situ, may be observed if radiologic
and pathologic findings are concordant and there is no other high-risk
lesion present.
viii Contents
Genetic Predisposition Syndromes and Their Management 341
David M. Euhus and Linda Robinson
Apart from BRCA1, BRCA2, and TP53, more than a dozen breast cancer
susceptibility genes have been identified. Recognizing affected individuals
depends on evaluation of cancer family history and recognition of certain
phenotypic markers on physical examination. Genetic testing provides
a powerful tool for individualized risk stratification. Mutation carriers have
several options for managing risk, including lifestyle alterations, enhanced
surveillance, chemoprevention, and prophylactic surgery. Genetic counsel-
ing and testing should be considered in the initial evaluation of patients with
newly diagnosed breast cancer because this information contributes to sur-
gical decisions, radiation therapy options, and systemic therapy choices.
Pathology of Invasive Breast Disease 363
Adriana D. Corben
Invasive breast cancers constitute a heterogeneous group of lesions.
Although the most common types are ductal and lobular, this distinction
is not meant to indicate the site of origin within the mammary ductal system.
The main purpose of the identification of specific types of invasive breast
carcinoma is to refine the prediction of likely behavior and response to treat-
ment also offered by the other major prognostic factors, including lymph
node stage, histologic grade, tumor size, and lymphovascular invasion.
Ductal Carcinoma in Situ 393
Richard J. Bleicher
Management of ductal carcinoma in situ (DCIS) has evolved from radical
surgery to the option of a more minimally invasive approach. Data show
that breast conservation surgery performed with administration of radiother-
apy, like mastectomy, is feasible and safe. Because efforts to find a safe
group for elimination of radiotherapy have resulted in data that conflict, ra-
diotherapy still remains standard of care as a part of breast conservation
for DCIS. Tamoxifen has also shown a significant recurrence benefit and
has become standard in the treatment of receptor-positive disease. Inves-
tigation of other agents, such as anastrazole and trastuzumab, are ongoing.
Surgical Management of the Breast: Breast Conservation Therapy and Mastectomy 411
Sarah A. McLaughlin
The twentieth century has witnessed dramatic changes in the surgical
management of breast cancer. Herein we focus on the evolution of breast
conservation surgery and current surgical trends of lumpectomy, mastec-
tomy and contralateral prophylactic mastectomy. Margin analysis, speci-
men localization and processing, and the benefits of magnetic
resonance imaging remain controversial. Neoadjuvant chemotherapy
can offer prognostic information and aid in surgical planning while radia-
tion therapy continues to reduce the risk of local recurrence after breast
conserving surgery. Despite these advances, mastectomy remains a pop-
ular choice for many women and the use of nipple sparing procedures is
increasing. Overall the low rates of local recurrence are attributed to the
combination of surgery and targeted adjuvant and radiation therapies.
Contents ix
Management of the Axilla 429
Barbara Zarebczan Dull and Heather B. Neuman
Status of the axillary lymph nodes is one ofthe most important factors impact-
ing overall prognosis and treatment for breast cancer. The sentinel lymph
node (SLN) concept for breast cancer has been validated and SLN biopsy
should be considered standard of care for axillary staging in patients with clin-
ically node-negative axilla given the decreased morbidity when compared
with axillary lymph node dissection. Ongoing controversy includes use of
SLN in patients with ductal carcinoma in situ, prior axillary surgery, multicen-
tric breast cancer, and large breast cancers. Determining the optimal timing
of SLN in patients undergoing neoadjuvant chemotherapy and the prognostic
and clinical significance of micrometastases remain areas of research.
Breast Reconstruction 445
Frank J. DellaCroce and Emily T. Wolfe
As diagnostic technology has progressed and the understanding of the
disease process has evolved, the number of mastectomies performed in
the United States has increased. Breast reconstructive techniques have
commensurately become more sophisticated along the same timeline.
The result is that those facing mastectomy have the potential to simulta-
neously retain physical beauty and wholeness. Only 33% of women who
are otherwise candidates for immediate reconstruction at the time of mas-
tectomy choose reconstruction. Patients generally have a high level of sat-
isfaction with the option they choose, contributing to a feeling of overall
recovery and physical and emotional wholeness.
Radiation Therapy in the Management of Breast Cancer 455
T. Jonathan Yang and Alice Y. Ho
Radiation therapy (RT) plays an essential role in the management of breast
cancer by eradicating subclinical disease after surgical removal of grossly
evident tumor. Radiation reduces local recurrence rates and increases
breast cancer-specific survival in patients with early-stage breast cancer
after breast-conserving surgery and in node-positive patients who have
undergone mastectomy. This article reviews the following topics: (1) the
rationale for adjuvant RT and the evidence for its use in noninvasive and
invasive breast cancer, (2) RT delivery techniques for breast-conserving
therapy such as hypofractionated RT, partial breast irradiation, and prone
irradiation, and (3) indications for PMRT.
Adjuvant Systemic Therapies in Breast Cancer 473
Leonel F. Hernandez-Aya and Ana M. Gonzalez-Angulo
Although some women with early breast cancer (BC) may be cured with
loco-regional treatment alone, up to 20% of patients with early-stage BC
will ultimately experience treatment failure and recurrence. A substantial
portion of the success in improving clinical outcomes of patients with
BC is related to the standardized use of adjuvant therapies. The identifica-
tion of tumor subtypes with prognostic value has contributed to the idea of
tailoring treatments using biologic predictive factors to identify the patients
who will most likely respond to therapy and minimize the exposure of non-
responders to the side effects of the treatment.
x Contents
Neoadjuvant Chemotherapy in the Treatment of Breast Cancer 493
Meredith H. Redden and George M. Fuhrman
Randomized prospective trials have demonstrated that patients with early-
stage breast cancer preferring breast conservation can benefit from neo-
adjuvant chemotherapy, achieving about a 25% complete and greater
than 80% partial pathologic response. These responses do not translate
into a survival advantage. For earlier stage patients, neoadjuvant chemo-
therapy s primary advantage is the ability to increase the use of breast
conservation. Patients who opt for neoadjuvant chemotherapy should
have a clinical and radiographic assessment of the axilla. The inability to
predict the extent and pattern of response to chemotherapy requires
that surgeons monitor patient response during neoadjuvant chemotherapy
to provide optimal surgical planning.
Landmark Trials Affecting the Surgical Management of Invasive Breast Cancer 501
Daliiah M. Black and Elizabeth A. Mittendorf
Significant progress has been made in the surgical management of breast
cancer. Most women diagnosed with early stage invasive breast cancer
can now be managed with breast-conserving therapy to include a segmen-
tal mastectomy followed by radiation. Axillary lymph nodes are routinely
assessed by sentinel lymph node biopsy. Axillary lymph node dissection
is reserved for patients with documented nodal metastasis; however,
here too progress has been made because a population of low-risk
patients has been identified in whom a complete dissection is not required
even in the setting of a positive sentinel lymph node. This article details the
landmark clinical trials that have guided the surgical management of breast
cancer.
Miscellaneous Syndromes and Their Management: Occult Breast Cancer,
Breast Cancer in Pregnancy, Male Breast Cancer, Surgery in Stage IV Disease 519
Alfred John Colfry III
Surgical therapy for occult breast cancer has traditionally centered on mas-
tectomy; however, breast conservation with whole breast radiotherapy fol-
lowed by axillary lymph node dissection has shown equivalent results.
Patients with breast cancer in pregnancy can be safely and effectively
treated; given a patient s pregnancy trimester and stage of breast cancer,
a clinician must be able to guide therapy accordingly. Male breast cancer
risk factors show strong association with BRCA2 mutations, as well as
Klinefelter syndrome. Several retrospective trials of surgical therapy in
stage IV breast cancer have associated a survival advantage with primary
site tumor extirpation.
Index
533
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| physical | XVIII S., S. 299 - 548 Ill. 24 cm |
| publishDate | 2013 |
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| publisher | Elsevier |
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| series | Surgical clinics of North America |
| series2 | Surgical clinics of North America Clinics review articles |
| spelling | Multidisciplinary breast management ed. George M. Fuhrman ; Tari A. King Philadelphia, Pa. Elsevier 2013 XVIII S., S. 299 - 548 Ill. 24 cm txt rdacontent n rdamedia nc rdacarrier Surgical clinics of North America 93,2 Clinics review articles Includes bibliographical references and index Benign breast disease -- Screening, imaging, and image-guided biopsy techniques for breast cancer -- Surgical management of high-risk breast lesions -- Genetic predisposition syndromes and their management -- Pathology of invasive breast disease -- Ductal carcinoma in situ -- Surgical management of the breast: breast conservation therapy and mastectomy -- Management of the axilla -- Breast reconstruction -- Radiation therapy in the management of breast cancer -- Adjuvant systemic therapies in breast cancer -- Neoadjuvant chemotherapy in the treatment of breast cancer -- Landmark trials affecting the surgical management of invasive breast cancer -- Miscellaneous syndromes and their management: occult breast cancer, breast cancer in pregnancy, male breast cancer, surgery in stage IV disease Breast / Cancer / Treatment Breast / Diseases / Treatment Breast neoplasms / therapy Breast Diseases / therapy Fuhrman, George M. Sonstige (DE-588)1016272510 oth King, Tari A. Sonstige (DE-588)1037134028 oth Surgical clinics of North America 93,2 (DE-604)BV000003239 93,2 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025939179&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Multidisciplinary breast management Surgical clinics of North America Breast / Cancer / Treatment Breast / Diseases / Treatment Breast neoplasms / therapy Breast Diseases / therapy |
| title | Multidisciplinary breast management |
| title_auth | Multidisciplinary breast management |
| title_exact_search | Multidisciplinary breast management |
| title_full | Multidisciplinary breast management ed. George M. Fuhrman ; Tari A. King |
| title_fullStr | Multidisciplinary breast management ed. George M. Fuhrman ; Tari A. King |
| title_full_unstemmed | Multidisciplinary breast management ed. George M. Fuhrman ; Tari A. King |
| title_short | Multidisciplinary breast management |
| title_sort | multidisciplinary breast management |
| topic | Breast / Cancer / Treatment Breast / Diseases / Treatment Breast neoplasms / therapy Breast Diseases / therapy |
| topic_facet | Breast / Cancer / Treatment Breast / Diseases / Treatment Breast neoplasms / therapy Breast Diseases / therapy |
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