Sialo-xenoantigenic glycobiology: Molecular glycobiology of sialylglycan-xenoantigenic determinants in pig to human xenotransplantation
<p>Carbohydrate antigens on glycoconjugates of mammalian cells play crucial roles in various biological processes and are epitopes recognized by the immune system, as glycobiology has hugely been progressed during the past two decades. The book focuses on sialic acid–based xenoantigenes. In pi...
Gespeichert in:
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| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Berlin [u.a.]
Springer
2013
|
| Schriftenreihe: | Sungkyunkwan University outstanding research
1 |
| Schlagworte: | |
| Online-Zugang: | BTU01 FHA01 FHI01 FHN01 FHR01 FKE01 FWS01 UBY01 Volltext Inhaltsverzeichnis Abstract |
| Zusammenfassung: | <p>Carbohydrate antigens on glycoconjugates of mammalian cells play crucial roles in various biological processes and are epitopes recognized by the immune system, as glycobiology has hugely been progressed during the past two decades. The book focuses on sialic acid–based xenoantigenes. In pig to human xenotransplantation, exposure of pig organs to human blood results in hyper acute rejection (HAR), caused by differences in carbohydrate epitopes between human and pig vascular endothelia. Although Gal-antigen as major antigen was eliminated, the remaining non-Gal antigens are considered to be xenoantigens. Sialosyl-Tn or Hanganutziu-Deicher (HD), are non-Gal antigens specific to natural antibodies in human. To overcome rejection responses such as HAR, studies of genes involved in carbohydrate antigens, causing xenoantigenicity, are necessary. Knowledge of pig glycosyltransferases are also useful to apply to xenoantigen masking or identification of the xenoantigenic sialylglycan(s). In the first chapter the screening for pig glycosyltransferase genes for xenoantigens is presented. In the chapter II to IV the cloning, characterization, and investigation of the regulatory mechanism of the pig CMAH gene in NeuGc biosynthesis is shown. Lastly, the effects of an alteration of pig glycosylation patterns on human serum-mediated cytotoxicity, caused by human sialyltransferases including hST6GalNAc IV is presented.</p><p> </p> |
| Beschreibung: | Screening of pig glycosyltransferase genes related to xenoantigens and their masking -- Cloning and tissue specific expression of pcmah and its alternative transcripts -- Functional characterization of pCMAH in the synthesis of N-glycolylneuraminic acid as the xenoantigenic determinant in pig-to-human xenotransplantation -- Identification of two alternative promoters of the pig CMP-N-acetylneuraminic acid hydroxylase gene -- Screening for xenoantigenic determinants formed by sialyltransferases |
| Beschreibung: | 1 Online-Ressource (XVI, 63 p. 34 illus) |
| ISBN: | 9783642340949 |
| DOI: | 10.1007/978-3-642-34094-9 |
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| adam_text | SIALO-XENOANTIGENIC GLYCOBIOLOGY
/ SONG, KWON-HO
: 2013
TABLE OF CONTENTS / INHALTSVERZEICHNIS
SCREENING OF PIG GLYCOSYLTRANSFERASE GENES RELATED TO XENOANTIGENS AND
THEIR MASKING
CLONING AND TISSUE SPECIFIC EXPRESSION OF PCMAH AND ITS ALTERNATIVE
TRANSCRIPTS
FUNCTIONAL CHARACTERIZATION OF PCMAH IN THE SYNTHESIS OF
N-GLYCOLYLNEURAMINIC ACID AS THE XENOANTIGENIC DETERMINANT IN
PIG-TO-HUMAN XENOTRANSPLANTATION
IDENTIFICATION OF TWO ALTERNATIVE PROMOTERS OF THE PIG
CMP-N-ACETYLNEURAMINIC ACID HYDROXYLASE GENE
SCREENING FOR XENOANTIGENIC DETERMINANTS FORMED BY SIALYLTRANSFERASES
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
SIALO-XENOANTIGENIC GLYCOBIOLOGY
/ SONG, KWON-HO
: 2013
ABSTRACT / INHALTSTEXT
CARBOHYDRATE ANTIGENS ON GLYCOCONJUGATES OF MAMMALIAN CELLS PLAY CRUCIAL
ROLES IN VARIOUS BIOLOGICAL PROCESSES AND ARE EPITOPES RECOGNIZED BY THE
IMMUNE SYSTEM, AS GLYCOBIOLOGY HAS HUGELY BEEN PROGRESSED DURING THE
PAST TWO DECADES. THE BOOK FOCUSES ON SIALIC ACID–BASED XENOANTIGENES.
IN PIG TO HUMAN XENOTRANSPLANTATION, EXPOSURE OF PIG ORGANS TO HUMAN
BLOOD RESULTS IN HYPER ACUTE REJECTION (HAR), CAUSED BY DIFFERENCES IN
CARBOHYDRATE EPITOPES BETWEEN HUMAN AND PIG VASCULAR ENDOTHELIA.
ALTHOUGH GAL-ANTIGEN AS MAJOR ANTIGEN WAS ELIMINATED, THE REMAINING
NON-GAL ANTIGENS ARE CONSIDERED TO BE XENOANTIGENS. SIALOSYL-TN OR
HANGANUTZIU-DEICHER (HD), ARE NON-GAL ANTIGENS SPECIFIC TO NATURAL
ANTIBODIES IN HUMAN. TO OVERCOME REJECTION RESPONSES SUCH AS HAR,
STUDIES OF GENES INVOLVED IN CARBOHYDRATE ANTIGENS, CAUSING
XENOANTIGENICITY, ARE NECESSARY. KNOWLEDGE OF PIG GLYCOSYLTRANSFERASES
ARE ALSO USEFUL TO APPLY TO XENOANTIGEN MASKING OR IDENTIFICATION OF THE
XENOANTIGENIC SIALYLGLYCAN(S). IN THE FIRST CHAPTER THE SCREENING FOR
PIG GLYCOSYLTRANSFERASE GENES FOR XENOANTIGENS IS PRESENTED. IN THE
CHAPTER II TO IV THE CLONING, CHARACTERIZATION, AND INVESTIGATION OF THE
REGULATORY MECHANISM OF THE PIG CMAH GENE IN NEUGC BIOSYNTHESIS IS
SHOWN. LASTLY, THE EFFECTS OF AN ALTERATION OF PIG GLYCOSYLATION
PATTERNS ON HUMAN SERUM-MEDIATED CYTOTOXICITY, CAUSED BY HUMAN
SIALYLTRANSFERASES INCLUDING HST6GALNAC IV IS PRESENTED.
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
|
| any_adam_object | 1 |
| author | Song, Kwon-Ho |
| author_facet | Song, Kwon-Ho |
| author_role | aut |
| author_sort | Song, Kwon-Ho |
| author_variant | k h s khs |
| building | Verbundindex |
| bvnumber | BV040957133 |
| collection | ZDB-2-ENG |
| ctrlnum | (OCoLC)824651281 (DE-599)BVBBV040957133 |
| dewey-full | 610.28 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 610 - Medicine and health |
| dewey-raw | 610.28 |
| dewey-search | 610.28 |
| dewey-sort | 3610.28 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| doi_str_mv | 10.1007/978-3-642-34094-9 |
| format | Electronic eBook |
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| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV040957133 |
| illustrated | Not Illustrated |
| indexdate | 2024-08-01T16:14:51Z |
| institution | BVB |
| isbn | 9783642340949 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-025935555 |
| oclc_num | 824651281 |
| open_access_boolean | |
| owner | DE-898 DE-BY-UBR DE-634 DE-573 DE-92 DE-Aug4 DE-859 DE-706 DE-863 DE-BY-FWS |
| owner_facet | DE-898 DE-BY-UBR DE-634 DE-573 DE-92 DE-Aug4 DE-859 DE-706 DE-863 DE-BY-FWS |
| physical | 1 Online-Ressource (XVI, 63 p. 34 illus) |
| psigel | ZDB-2-ENG |
| publishDate | 2013 |
| publishDateSearch | 2013 |
| publishDateSort | 2013 |
| publisher | Springer |
| record_format | marc |
| series | Sungkyunkwan University outstanding research |
| series2 | Sungkyunkwan University outstanding research |
| spellingShingle | Song, Kwon-Ho Sialo-xenoantigenic glycobiology Molecular glycobiology of sialylglycan-xenoantigenic determinants in pig to human xenotransplantation Sungkyunkwan University outstanding research Ingenieurwissenschaften Medizin Engineering Human genetics Medicine Biochemistry Biomedical engineering Antigen (DE-588)4002272-9 gnd Heterotransplantation (DE-588)4133067-5 gnd Transplantatabstoßung (DE-588)4137807-6 gnd Sialoglykoproteine (DE-588)7626540-7 gnd Schwein (DE-588)4053848-5 gnd |
| subject_GND | (DE-588)4002272-9 (DE-588)4133067-5 (DE-588)4137807-6 (DE-588)7626540-7 (DE-588)4053848-5 (DE-588)4143413-4 |
| title | Sialo-xenoantigenic glycobiology Molecular glycobiology of sialylglycan-xenoantigenic determinants in pig to human xenotransplantation |
| title_auth | Sialo-xenoantigenic glycobiology Molecular glycobiology of sialylglycan-xenoantigenic determinants in pig to human xenotransplantation |
| title_exact_search | Sialo-xenoantigenic glycobiology Molecular glycobiology of sialylglycan-xenoantigenic determinants in pig to human xenotransplantation |
| title_full | Sialo-xenoantigenic glycobiology Molecular glycobiology of sialylglycan-xenoantigenic determinants in pig to human xenotransplantation Kwon-Ho Song and Cheorl-Ho Kim |
| title_fullStr | Sialo-xenoantigenic glycobiology Molecular glycobiology of sialylglycan-xenoantigenic determinants in pig to human xenotransplantation Kwon-Ho Song and Cheorl-Ho Kim |
| title_full_unstemmed | Sialo-xenoantigenic glycobiology Molecular glycobiology of sialylglycan-xenoantigenic determinants in pig to human xenotransplantation Kwon-Ho Song and Cheorl-Ho Kim |
| title_short | Sialo-xenoantigenic glycobiology |
| title_sort | sialo xenoantigenic glycobiology molecular glycobiology of sialylglycan xenoantigenic determinants in pig to human xenotransplantation |
| title_sub | Molecular glycobiology of sialylglycan-xenoantigenic determinants in pig to human xenotransplantation |
| topic | Ingenieurwissenschaften Medizin Engineering Human genetics Medicine Biochemistry Biomedical engineering Antigen (DE-588)4002272-9 gnd Heterotransplantation (DE-588)4133067-5 gnd Transplantatabstoßung (DE-588)4137807-6 gnd Sialoglykoproteine (DE-588)7626540-7 gnd Schwein (DE-588)4053848-5 gnd |
| topic_facet | Ingenieurwissenschaften Medizin Engineering Human genetics Medicine Biochemistry Biomedical engineering Antigen Heterotransplantation Transplantatabstoßung Sialoglykoproteine Schwein Aufsatzsammlung |
| url | https://doi.org/10.1007/978-3-642-34094-9 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025935555&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025935555&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV040957111 |
| work_keys_str_mv | AT songkwonho sialoxenoantigenicglycobiologymolecularglycobiologyofsialylglycanxenoantigenicdeterminantsinpigtohumanxenotransplantation AT kimcheorlho sialoxenoantigenicglycobiologymolecularglycobiologyofsialylglycanxenoantigenicdeterminantsinpigtohumanxenotransplantation |