Developmental biology:
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| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Sunderland, MA
Sinauer
2014
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| Ausgabe: | 10. ed. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Hier auch später erschienene, unveränderte Nachdrucke |
| Beschreibung: | Getr. Zählung zahlr. Ill., graph. Darst. |
| ISBN: | 9781605351735 9780878939787 |
Internformat
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Datensatz im Suchindex
| _version_ | 1804150251662082048 |
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| adam_text | Titel: Developmental biology
Autor: Gilbert, Scott F
Jahr: 2014
Brief Contents
PART ONE ¦ QUESTIONS Introducing Developmental Biology 1
chapter 1 Comprehending Development: Generating New Cells
and Organs 5
chapter 2 Differential Gene Expression in Development 31
chapter 3 Cell-Cell Communication in Development 69
PART TWO ¦ SPECIFICATION Introducing Cell Commitment and Early
Embryonic Development 107
chapter 4 Fertilization: Beginning a New Organism 117
chapter 5 Early Development: Rapid Specification in Snails
and Nematodes 153
chapter 6 The Genetics of Axis Specification in Drosophila 179
chapter 7 Sea Urchins and Tunicates: Deuterostome Invertebrates 217
chapter 8 Early Development in Vertebrates: Amphibians and Fish 241
chapter 9 Early Development in Vertebrates: Birds and Mammals 285
PARTTHREE ¦ THE STEM CELL CONCEPT Introducing Organogenesis 319
chapter 10 The Emergence of the Ectoderm: Central Nervous System
and Epidermis 333
chapter 11 Neural Crest Cells and Axonal Specificity 375
chapter 12 Paraxial and Intermediate Mesoderm 415
chapter 13 Lateral Plate Mesoderm and the Endoderm 449
chapter 14 Development of the Tetrapod Limb 489
chapter 15 Sex Determination 519
chapter 16 Postembryonic Development: Metamorphosis, Regeneration,
and Aging 549
chapter 17 The Saga of the Germ Line 591
PART FOUR ¦ SYSTEMS BIOLOGY Expanding Developmental Biology to
Medicine, Ecology, and Evolution 627
chapter 18 Birth Defects, Endocrine Disruptors, and Cancer 635
chapter 19 Ecological Developmental Biology: Biotic, Abiotic, and Symbiotic
Regulation of Development 663
chapter 20 Developmental Mechanisms of Evolutionär/ Change 689
Contents
PART ONE QUESTIONS
Introducing Developmental Biology 1
CHAPTER 1 ¦ SIDELIGHTS SPECULATIONS The Basic Tools of
Comprehending Development Developmental Genetics 32
,.. . ¦ m /-T i a- 1- Differential Gene Iranscription 34
Generating New Cells and Organs 5 . , ,iU Ai j ,
° a Anatomy of the gene: Active and repressed
The Cycle of Life 6 chromatin 35
A Frog s Life 6 Anatomy of the gene: Exons and introns 35
Gametogenesis and fertilization 6 Anatomy of the gene: Promoters and enhancers 37
Cleavage and gastrulation 7 Enhancer functioning 39
Organogenesis 10 Transcription factor function 43
Metamorphosis and gametogenesis 11 Keeping the right genes on or off 45
How Are You? 12 ¦ SIDELIGHTS SPECULATIONS Reprogramming
Comparative embryology 12 Cells: Changing Cell Differentiation through
Epigenesis and preformation 12 Embryonic Transcription Factors 46
Naming the parts: The primary germ layers and early Mechanisms of Differential Gene Transcription 47
organs 14 Finding DNA regulatory sequences 48
The four principles of Karl Ernst von Baer 15 Differentiated proteins from high and low CpG-
Keeping Track of Moving Cells: Fate Maps and content promoters 48
Cell Lineages 17 DNA methylation, another key on/off switch of
Fate maps 19 ^ transcription 49
Direct Observation of living embryos 19 Poised chromatin 51
Dye marking 19 ¦ SIDELIGHTS SPECULATIONS Genomic
Genetic labeling 19 Imprinting and DNA Methylation 52
Transgenic DNA chimeras 23 Differential RNA Processing 53
Evolutionary Embryology 23 ¦ SIDELIGHTS SPECULATIONS X Chromosome
Embryonic homologies 25 Inactivation: Noncoding RNAs in Transcriptional
Medical Embryology and Teratology 27 Gene Regulation 54
Genetic malformations and Syndromes 27 ^^S farVilies of proteins through differential
Disruptions and teratogens 27
CHAPTER 2
nRNAsplicing 56
Splicing enhancers and recognition factors 57
Control of Gene Expression at the Level of
Translation 59
Differential Gene Expression in Differential mRNA longevity 59
evelopment 31
Evidence for Genomic Equivalence 32
Development 31 Stored oocyte mRNAs: Selective inhibition of mRNA
translation 59
Ribosomal selectiviry: Selective activation of mRNA
translation 61
viii Contents
microRNAs: Specific regulation of mRNA translation Paracrine Factors: Inducer Molecules 84
and transcription 61 Signal transduction cascades: The response to
Control of RNA expression by cytoplasmic inducers 84
localization 64 Fibroblast growth factors and the RTK pathway 84
Posttranslational Regulation of Gene The JAK-STAT pathway 86
Expression 65 The Hedgehog family 88
Coda 65 The Wnt family 90
TheTGF-ßsuperfamily 92
CHAPTER 3 B SIDELIGHTS SPECULATIONS Cell Death
Cell-Cell Communication in Pathways 94
Development 69 Other paracrine factors 96
CellAdhesion 70
Juxtacrine Signaling 96
The thermodynamic model of cell interactions 71
Cadherins and cell adhesion 72
^.rr . , ,.,.. n The Notch pathway: Juxtaposed lieands and
Differential cell affiniry 70........ ^ receptors 96
¦ SIDELIGHTS SPECULATIONS Juxtacrine
Signaling and Cell Patterning 97
¦ SIDELIGHTS SPECULATIONS Shape Change The Extracellular Matrix as a Source of
and Epithelial Morphogenesis: The Force Is Strong Developmental Signals 99
Integrins: Receptors for extracellular matrix
Cell Migration 78 molecules 100
Cell Signaling 79 Tne Epithelial-Mesenchymal Transition 101
Induction and competence 79 The Ceh Bjology of Paracrine Signaling 102
Reciprocal induction 81 Coda 104
Epithelial-mesenchymal interactions 82
PART TWO SPECIFICATION
Introducing Cell Commitment and Early Embryonic
Development 107
Levels of Commitment 107 Morphogen Gradients and Conditional
Autonomous Specification 109 Specification 113
Conditional Specification 110 Syncytial Specification 114
Summary 115
CHAPTER 4 The fast block to polyspermy 129
Fertilization The slow block to polyspermy 130
Beginning a New Organism 117 ^t^on ^nitiatOT °f the cortical ®anule
Structure of the Gametes 117 Activation of Egg Metabolism in Sea Urchins 134
Sperm 117 Release of intracellular calcium ions 134
Sperm anatomy 118
The egg 120 «Find lt, Lose It, Move It 136
Recognition of egg and sperm 123 Effects of calcium release 137
External Fertilization in Sea Urchins 124 Fusion of Genetic Material in Sea Urchins 139
Sperm attraction: Action at a distance 124 Internal Fertilization in Mammals 140
The acrosome reaction 125 Getting the gametes into the oviduct: Translocation
Recognition of the egg s extracellular coat 126 and capacitation 141
Fusion of the egg and sperm cell membranes 128 In the vicinity of the oocyte: Hyperactivation,
One egg, one sperm 128 thermotaxis, and Chemotaxis 143
SIDELIGHTS SPECULATIONS Rules of Evidence:
Contents ix
The acrosome reaction and recognition at the zona GENES THAT PATTERN THE DROSOPHILA BODY
pellucida 143 PLAN 185
Gamete fusion and the prevention of polyspermy 145 Primary Axis Formation during Oogenesis 186
Fusion of genetic material 146 Anterior-posterior polarity in the oocyte 186
Activation of the mammalian egg 146 Dorsal-ventral patterning in the oocyte 186
¦ SIDELIGHTS SPECULATIONS The Generating the Dorsal-Ventral Pattern in the
Nonequivalence of Mammalian Pronuclei 148 Embryo 190
Coda 149 Dorsal, the ventral morphogen 190
Establishing a nuclear Dorsal gradient 190
CHAPTER 5 Effects of the Dorsal protein gradient 191
Early Development Rapid Specification in ¦ sidelights speculations The Left-Right and
r~ i ki _l i -* r-r insiQ©~uut axös lyj
Snails and Nematodes 153 _, , . . .
Segmentation and the Anterior-Posterior Body
Developmental Patterns among the Metazoa 153 Plan 194
Sponges and the diploblastic animals 154 Maternal gradients: Polarity regulation by oocyte
The triploblastic animals: Protostomes and cytoplasm 194
deuterostomes 155 The molecular model: Protein gradients in the early
EARLY DEVELOPMENTAL PROCESSES: AN
embryo 194
OVERVIEW 155 The anterior organizing center: The Bicoid and
_. .,_,_ Hunchback gradients 199
tj c -•!• -•*. i 1Ci The terminal gene group 201
From fertilization to cleavage 156 ... .
™ ,11,1 , • ,.,. ,. Summanzing early antenor-postenor axis
The cytoskeletal mechamsms of mitosis 157 specification in Drosophüa 201
Patterns of embryonic cleavage 158 Segmentation Genes 202
Gastrulation and Axis Formation 158 Segments and parasegments 202
EARLY DEVELOPMENT IN SNAILS 161 The gap genes 203
Cleavage in Snail Embryos 161 The pair-rule genes 204
The snail fate map 164 The segment polarity genes 206
Autonomous cell specification and the polar lobe 164 The Homeotic Selector Genes 209
¦ SIDELIGHTS SPECULATIONS Adaptation by Initiating and maintaining the patterns of homeotic
Modifying Embryonic Cleavage 167 gene expression 211
Gastrulation in Snails 169 Realisator genes 211
Tuc MCMATnnc r n f/^aiq ito Axes and 0r9an Pr mord a: The Cartesian
THE NEMATODE C. ELEGANS 170 Coordinate Model 212
Cleavage and Axis Formation in C. elegans 171 Coda 213
Rotational cleavage of the egg 171
Anterior-posterior axis formation 171
Dorsal-ventral and right-left axis formation 172
CHAPTER 7
Controiofbiastomere identity 173 Sea Urchins and Tunicates
Gastrulation in C. elegans 176 Deuterostome Invertebrates 217
_ . _,__ fi EARLY DEVELOPMENT IN SEA URCHINS 217
UMArTcK O _ ,, .. _, _._
Sea Urchin Cleavage 217
The Genetics of Axis Specification in Biastuia formation 219
DrOSOphlla 179 Fate maps and the determination of sea urchin
blastomeres 219
EARLY DROSOPHILA DEVELOPMENT 179 , . . , , , , , .
Gene regulatory networks and skeletogemc
Fertilization 180 mesenchyme specification 221
Cleavage 180 Specification of the vegetal cells 224
The mid-blastula transition 182 Axis specification 225
x Contents
Sea Urchin Gastrulation 225 Gastrulation and Formation of the Germ
Ingression of the skeletogenic mesenchyme 226 Layers 275
Invagination of the archenteron 229
EARLY DEVELOPMENT IN TUNICATES 232
Tunicate Cleavage 232
The tunicate fate map 233
Autonomous and conditional specification of tunicate
blastomeres 234
Specification of the embryonic axes 236
Gastrulation in Tunicates 237
Coda 238 Early Development in Vertebrates
Birds and Mammals 285
CHAPTER 8
v^rw-i t o EARLY DEVELOPMENT IN BIRDS 286
Early Development in Vertebrates Cleavage 286
Axis Formation 277
Dorsal-ventral axis formation 278
The fish Nieuwkoop center 279
Anterior-posterior axis formation 280
Left-right axis formation 280
Coda 282
CHAPTER 9
Gastrulation of the Avian Embryo 287
Amphibians and Fish 241
EARLY AMPHIBIAN DEVELOPMENT 241 The typoblast 287
Fertilization, Cortical Rotation, and Cleavage 242 The Primitive streak 287
Unequal radial holoblastic cleavage 242 Molecular mechanisms of migration through the
_, .,,,.,. ..... c primitive streak 291
The mid-blastula transition: Prepanng for r
gastrulation 245 Regression of the primitive streak and epiboly of the
Amphibian Gastrulation 245
ectoderm 292
Axis Specification and the Avian Organizer 293
Veeetal rotation and the invagination of the bottle m , ,
*ells 245 The role of gravity and the PMZ 293
Epiboly of the prospective ectoderm 250 The chick//organizer and the role of fibroblast growth
r J v r factors 294
Progressive Determination of the Amphibian
Axes 251
Anterior-posterior patterning 296
Specification of the germ layers 251 Left-right axis formation 297
The dorsal-ventral and anterior-posterior axes 251 EARLY MAMMALIAN DEVELOPMENT 298
The Work of Hans Spemann and Hilde Cleavage 298
Mangold 252 The unique nature of mammalian cleavage 299
Autonomous specification versus inductive B SIDELIGHTS SPECULATIONS The Decisions That
interactions 252 Real|y Shape Your Ufe 3QQ
Primary embryonic induction 254 Compaction 301
Molecular Mechanisms of Amphibian Axis
Formation 256
How does the Organizer form? 256
Escape from the zona pellucida 303
Mammalian Gastrulation 303
ril . .,.. Modifications for development inside another
Functions of the Organizer 261 organism 303
Induction of neural ectoderm and dorsal mesoderm:
BMP inhibitors 262 ¦ SIDELIGHTS SPECULATIONS Twins and
Epidermal inducers: The BMPs 264
¦ SIDELIGHTS SPECULATIONS BMP4 and
Geoffroy s Lobster 266
Chimeras 304
Formation of the chorion 308
Mammalian Axis Formation 309
The Regional Specificity of Neural Induction 266 ^lente^m^^ *** ^ ^^
The head inducer: Wnt antagonists 266 Anterior-posterior patterning by FGF and retinoic
Trunk patterning: Wnt signals and retinoic acid 269 acid gradients 310
Specifying the Left-Right Axis 270 Anterior-posterior patterning: The Hox code
EARLY ZEBRAFISH DEVELOPMENT 271 hypothesis 311
Cleavage 273 The dorsa-l ventral and left-right axes 314
Coda 314
Contents xi
PART THREE THE STEM CELL CONCEPT
Introducing Organogenesis 319
The Stern Cell Concept 319 Mesenchymal Stern Cells: Multipotent Adult
Stern Cell Vocabulary 321 stem Cells 326
Adult Stem Cells 322 Pluripotent Embryonic Stem Cells 327
Stem Cell Niches 322 Stem Ce Therapy 328
A New Perspective on Organogenesis 331
CHAPTER 10
Emergence of the Ectoderm CHAPTER 11
Central Nervous System and Epidermis 333 Neural Crest Cells and Axonal
Specificity 375
NEURAL PLATE AND CENTRAL NERVOUS K J
NEURAL PLATE AND CENTRAL NERVOUS THE NEURAL CREST 375
SYSTEM 333
Formation of the Neural Tube 334
Specification of Neural Crest Cells 376
Regionalization of the Neural Crest 379
Primary neurulation334^ Tmnk Neura, Crest ^
_ Migration pathways of trunk neural crest cells 380
Building the Brain 340
Mechanisms of trunk neural crest migration 380
The anterior-posterior axis 341 The yentral pamway 3g2
The dorsal-ventral axis 343 The dorsolateral migration pathway 384
Differentiation of Neurons in the Brain 345 Cranja| Neura| Crest 386
Tissue Architecture of the Central Nervous
Intramembranous ossification: Neural crest-derived
System 347 head skeleton 388
Neural stem cell differentiation 347 Coordination of face and brain growth 390
Spinal cord and medulla Organization 349 Tooth formation 391
Cerebellar Organization 350 Cardiac Neural Crest 391
Cerebral Organization 351 Cranja| p|acodes 392
Adult Neural Stem Cells 354
NEURON SPECIFICATION AND AXON
¦ SIDELIGHTS SPECULATIONS The Unique SPECIFICITY 394
Development of the Human Brain 356
¦ SIDELIGHTS SPECULATIONS The Growth
THE DYNAMICS OF OPTIC DEVELOPMENT: THE Cone 394
VERTEBRATE EYE 359
The Generation of Neuronal Diversity 396
The Lens-Retina Induction Cascade 362
Lens and cornea differentiation 364
F°rStainan360the ^ Fie d: ^ Be9innin9S °f the Pattern Generation in the Nervous System 398
Cell adhesion and contact guidance by attraction and
repulsion 399
Membrane proteins: The ephrins and
Neural retina differentiation 364 semaphorins 399
THE EPIDERMIS AND ITS CUTANEOUS Guidance by diffusible molecules 400
APPENDAGES 367 Target selection 404
Origin of the Epidermis 367 Synapse formation: Activiry-dependent
The Cutaneous Appendages: Mammalian Hair 368 development 405
Hair follicles and hair generation in mammals 368 Differential survival after Innervation: The role of
Adult stem cells and hair regeneration 369
Paths to Glory: The Travels of the Retinal Ganglion
Coda 372
Axons 407
¦ SIDELIGHTS SPECULATIONS The Brainbow 409
xii Contents
CHAPTER 12 Heart cell differentiation 455
Fusion of the heart rudiments and initial
Paraxial and Intermediate
Mesoderm 415
heartbeats 456
¦ SIDELIGHTS SPECULATIONS A Minimalist
PARAXIAL MESODERM: THE SOMITES AND Heart 457
THEIR DERIVATIVES 416 Looping and formation of heart Chambers 457
Formation of the Somites 417 Blood Vessel Formation 460
Where somites form: The Notch pathway 418 Constraints on the construction of blood vessels 460
Separation of somites from the presomitic m SIDELIGHTS SPECULATIONS Redirecting Blood
mesoderm 420 Row jn the Newborn Mammal 461
Periodicity of somite formation 420 Vasculogenesis: The initial formation of blood
¦ SIDELIGHTS SPECULATIONS Coordinating vessels 463
Waves and Clocks in Somite Formation 421 Angiogenesis: Sprouting of blood vessels and
Epithelialization of the somites 423 remodeling of vascular beds 467
Specification of the somites along the anterior- Arterial and venous differentiation 467
posterior axis 423 Organ-specific capillary formation 468
Differentiation of the somites 423 Anti-angiogenesis in normal and abnormal
Determination of the sclerotome 426 development 470
Determination of the central dermamyotome 427 The lymphatic vessels 471
Determination of the myotome 428 Hematopoiesis: The Stem Cell Concept 472
Myoblasts and myofibers 429 Sites of hematopoiesis 472
Satellite cells: Unfused muscle progenitor cells 431 The bone marrow HSC niche 474
Osteogenesis: The Development of Bones 432 Hematopoietic inductive microenvironments 475
Endochondral ossification 432 In conclusion 475
Vertebrae formation 434 ENDODERM 476
¦ SIDELIGHTS SPECULATIONS Mechanotrans- The Pharynx 478
duction in the Musculoskeletal System 435 The Digestive Tube and Its Derivatives 478
Tendon Formation: The Syndetome 436 Specification of the gut tissue 479
Formation of the Dorsal Aorta 436 Liver, pancreas, and gallbladder 481
INTERMEDIATE MESODERM: THE UROGENITAL ¦ SIDELIGHTS SPECULATIONS Specification of
SYSTEM 436 Liver and Pancreas 481
The Progression of Kidney Types 438 The Respiratory Tube 484
Specification of the Intermediate Mesoderm: Coda 486
Pax2/8 and Lim1 439
Reciprocal Interactions of Developing Kidney CHAPTER 14
Tissues 440
Mechanisms of reciprocal induction 441 Development of the Tetrapod
Coda 447 Limb 489
Formation of the Limb Bud 490
CHAPTER 13 Specification of the limb fields 490
Lateral Plate Mesoderm and the Indlcti°M °lthe e*A ^ b!± Wnt proteins and
_ , , AACk Fibroblast growth factors 492
Endoderm 449 Specification of forelimb or hindlimb 492
FORMATION AND DEVELOPMENT OF THE Generating the Proximal-Distal Axis of the
CIRCULATORY SYSTEM 450 Limb 495
Heart Development 450 Tne aPical ectodermal ridge 495
Formation of the heart fields 450 FGFs in the induction of the AER 496
Specification of the cardiogenic mesoderm 451 Specifying the limb mesoderm: Determining the
Migration of the cardiac precursor cells 453 proximal-distal polarity of the limb skeleton 497
The dual-gradient model of limb patterning 497
Postembryonic Development
Contents xiii
¦ SIDELIGHTS SPECULATIONS A Reaction- Dosage Compensation 541
Diffusion Mechanism for Building the Limb Skeletal ENVIRONMENTAL SEX DETERMINATION 541
Pattern 499
_ ., . . A . A . . . ,.« Temperature-Dependent Sex Determination in
Specifying the Anterior-Posterior Axis 502 ReDtiles 541
The zone of polarizing activity 502 The aromatase hypothesis for environmental sex
Sonic hedgehog defines the ZPA 502 determination 542
Specifying digit identity by Sonic hedgehog 504 Estrogens, aromatase, sex reversal, and conservation
¦ SIDELIGHTS SPECULATIONS Hox Gene Changes biology 542
during Limb Development 506 Location-Dependent Sex Determination 544
Generation of the Dorsal-Ventral Axis 508 Coda 545
Coordinating the Three Axes 509
Cell Death and the Formation of Digits and CHAPTER 16
Joints 510
Sculpting the autopod 510
Forming the joints 510 Metamorphosis, Regeneration, and Aging 549
¦ SIDELIGHTS SPECULATIONS Evolution by METAMORPHOSIS: THE HORMONAL
Altering Limb Signaling Centers 512 REACTIVATION OF DEVELOPMENT 549
Continued Limb Growth: Epiphyseal Plates 514 Amphibian Metamorphosis 550
Fibroblast growth factor receptors: Dwarfism 514 Morphological changes associated with amphibian
Growth hormone and estrogen receptors 515 metamorphosis 550
Parathyroid hormone-related peptide and Indian Hormonal control of amphibian metamorphosis 553
hedgehog 516 Regionally specific developmental programs 555
Coda 516 ¦ SIDELIGHTS SPECULATIONS Variations on the
Theme of Amphibian Metamorphosis 556
CHAPTER 15 Metamorphosis in Insects 558
Sex Determination 519 imaginai discs 559
Determination of the wing imaginai discs 562
CHROMOSOMAL SEX DETERMINATION 519 Hormonal control of insect metamorphosis 564
The Mammalian Pattern 519 The molecular biology of 20-hydroxyecdysone
Primary Sex Determination in Mammals 522 activity 565
Thedevelopinggonads 522 REGENERATION 568
Genetic mechanisms of primary sex determination: Stem-Cell Mediated Regeneration in
Making decisions 524 Flatworms 569
The ovary pathway: Wnt4 and R-spondinl 525 Epimorphic Regeneration of Salamander
The testis pathway 525 Limbs 571
The right time and the right place 529 Formation of the apical ectodermal cap and
Secondary Sex Determination in Mammals: regeneration blastema 571
Hormonal Regulation of the Sexual Proliferation of the blastema cells: The requirement
Phenotype 530 for nerves and the AEC 572
The genetic analysis of secondary sex Regeneration in Hydra: Morphallaxis and
determination 531 Epimorphosis 574
Chromosomal Sex Determination in The head activator 575
Drosophila 532 The head inhibition gradients 577
¦ SIDELIGHTS SPECULATIONS Brain Sex: Compensatory Regeneration in the Mammalian
Secondary Sex Determination through Multiple Liver 578
Pathways 533 AGING: THE BIOLOGY OF SENESCENCE 579
The Sex-lethal gene 537 _ ... __^
t- ui tu -i. u t Genes and Aging 579
Doublesex: The switch gene for sex
determination 539 DNA repair enzymes 581
Brain sex in Drosophila 540
xiv Contents
¦ SIDELIGHTS SPECULATIONS Exceptions to the
Aging Rule 581 Germ cell determination in frogs and fish 596
Aging and the insulin signaling cascade 582 Germ cell determination in mammals 596
The mTOR pathway 583 The inert genome hypothesis 597
Chromatin modification 583 B SIDELIGHTS SPECULATIONS Pluripotency, Germ
Integrating the conserved aging pathways 584 CellSj and Embryonic Stem Cells 598
¦ SIDELIGHTS SPECULATIONS Young Blood: Germ Cell Migration 601
Serum Factors and Progenitor Cells 585 Germ cell migration in Drosophila 601
Environmental and Epigenetic Causes of Germ cell migration in vertebrates 603
Aging 586 The Prirnacy of Meiosis 606
Promoting Longevity 587 B SIDELIGHTS SPECULATIONS Big Decisions:
Mitosis or Meiosis? Egg or Sperm? 608
CHAPTER 17 Gamete Maturation 610
The Saga Of the Germ Line 591 Maturation ofthe oocytes in frogs 610
Conserved Molecular Components 591 Meroistic oogenesis in insects 613
Germ Cell Specification 592 Gametogenesis in Mammals 614
Germ cell determination in nematodes 592 Spermatogenese 616
Germ cell determination in insects 594 Oogenesis in mammals 619
Coda 623
PART FOUR SYSTEMS BIOLOGY
Expanding Developmental Biology to Medicine,
Ecology, and Evolution 627
Pragmatic Systems Biology: From Gene to Level-Specific Properties and Emergence 631
System 627 Heterogeneous Causation 632
Systems Theory Biology: From System to Integration 632
Gene 630
Context-Dependent Properties 631
Modules and Robustness 632
Homeorhesis 633
CHAPTER 18 DES as an endocrine disruptor 647
Birth Defects, Endocrine Disruptors, ¦ sidelights speculations Testicuiar
and Cancer 635 Dysgenesis Syndrome 649
Bisphenol A (BPA) 652
The Role of Chance 635 Endocrine disruptors as obesogens 654
Genetic Errors of Human Development 636 Transgenerational Inheritance of Developmental
The nature of human Syndromes 637 Disorders 654
Genetic and phenotypic heterogeneity 637 Cancer as a Disease of Development 655
Teratogenesis: Environmental Assaults on Human Context-dependent tumors 656
Development 638 Cancer stem cells and the epithelial-mesechymal
Alcohol as a teratogen 640 transition 658
Retinoic acid as a teratogen 642 Cancer and epigenetic gene regulation 659
Other teratogenic agents 643 Developmental therapies for cancer 659
Endocrine Disruptors: The Embryonic Origins of Coda 660
Adult Disease 644
¦ SIDELIGHTS SPECULATIONS Developmental
Origins of Adult-Onset Disease 645
Contents xv
CHAPTER 19 CHAPTER 20
Ecological Developmental Biology Developmental Mechanisms of
Biotic, Abiotic, and Symbiotic Regulation of Evolutionary Change 689
Development 663 Descent with Modification: Why Animals Are Alike
The Environment as a Normal Agent in Producing anc Different 689
Phenotypes 663 ¦ SIDELIGHTS SPECULATIONS Development,
Diet-induced polyphenisms 665 Multicellularity, and the Origin of the Metazoa 690
Predator-induced polyphenisms 667 Preconditions for Evolution: The Developmental
Temperature as an environmental agent 669 Structure of the Genome 690
Environmental Induction of Behavioral Modularity: Divergence through dissociation 691
Phenotypes 671 Molecular parsimony: Gene duplication and
Adult anxiery and environmentally regulated DNA divergence 694
methylation 671 Deep Homology 698
Learning: The Developmentally Plastic Nervous Mechanisms of Evolutionary Change 699
System 672 Heterotopy 699
Experiential changes in mammalian Visual Heterochrony 701
pathways 673 Heterometry 702
Life Cycles and Polyphenisms 674
Diapause 674
Larval settlement 675
Heterotypy 705
SIDELIGHTS SPECULATIONS Transposable DNA
Elements and the Origins of Pregnancy 706
SIDELIGHTS SPECULATIONS Life Cycle Choices: Developmental Constraints on Evolution 708
D/cryoSfe/«vm 676 physical constraints 708
The hard life of spadefoot toads 679 Morphogenetic constraints 708
Developmental Symbioses 680
Mechanisms of developmental symbiosis: Getting the
partners together 680
The Euprymna-Vibrio symbiosis 682
Obligate developmental mutualism 682
Phyletic constraints 708
¦ SIDELIGHTS SPECULATIONS Reaction-Diffusion
Kinetics and the Evolution of Mammalian Teeth 709
Selectable Epigenetic Variation 711
Genetic assimilation 713
Developmental symbiosis in the mammalian
intestine 684 Fixation of environmentally induced phenotypes 715
Coda 686 ¦ SIDELIGHTS SPECULATIONS Hsp90 and Genetic
Assimilation 716
Coda 716
GLOSSARY G-1
CHAPTER-OPENING SOURCE CREDITS C-1
AUTHOR INDEX AI-1
SUBJECT INDEX SI-1
|
| any_adam_object | 1 |
| author | Gilbert, Scott F. 1949- |
| author_GND | (DE-588)133098559 |
| author_facet | Gilbert, Scott F. 1949- |
| author_role | aut |
| author_sort | Gilbert, Scott F. 1949- |
| author_variant | s f g sf sfg |
| building | Verbundindex |
| bvnumber | BV040946892 |
| callnumber-first | Q - Science |
| callnumber-label | QL955 |
| callnumber-raw | QL955 |
| callnumber-search | QL955 |
| callnumber-sort | QL 3955 |
| callnumber-subject | QL - Zoology |
| classification_rvk | WX 6000 WX 6004 |
| ctrlnum | (OCoLC)856796055 (DE-599)BVBBV040946892 |
| dewey-full | 571.8 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 571 - Physiology & related subjects |
| dewey-raw | 571.8 |
| dewey-search | 571.8 |
| dewey-sort | 3571.8 |
| dewey-tens | 570 - Biology |
| discipline | Biologie |
| edition | 10. ed. |
| format | Book |
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| genre | (DE-588)4123623-3 Lehrbuch gnd-content |
| genre_facet | Lehrbuch |
| id | DE-604.BV040946892 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T00:35:57Z |
| institution | BVB |
| isbn | 9781605351735 9780878939787 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-025925507 |
| oclc_num | 856796055 |
| open_access_boolean | |
| owner | DE-20 DE-19 DE-BY-UBM DE-29T DE-29 DE-188 DE-M49 DE-BY-TUM DE-11 |
| owner_facet | DE-20 DE-19 DE-BY-UBM DE-29T DE-29 DE-188 DE-M49 DE-BY-TUM DE-11 |
| physical | Getr. Zählung zahlr. Ill., graph. Darst. |
| publishDate | 2014 |
| publishDateSearch | 2014 |
| publishDateSort | 2014 |
| publisher | Sinauer |
| record_format | marc |
| spelling | Gilbert, Scott F. 1949- Verfasser (DE-588)133098559 aut Developmental biology Scott F. Gilbert 10. ed. Sunderland, MA Sinauer 2014 Getr. Zählung zahlr. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Hier auch später erschienene, unveränderte Nachdrucke Embryology Developmental biology Ontogenie (DE-588)4043565-9 gnd rswk-swf Morphogenese (DE-588)4132460-2 gnd rswk-swf Embryonalentwicklung (DE-588)4070792-1 gnd rswk-swf Entwicklungsbiologie (DE-588)4152440-8 gnd rswk-swf Entwicklungsphysiologie (DE-588)4152449-4 gnd rswk-swf Embryologie (DE-588)4014562-1 gnd rswk-swf (DE-588)4123623-3 Lehrbuch gnd-content Entwicklungsbiologie (DE-588)4152440-8 s Morphogenese (DE-588)4132460-2 s Entwicklungsphysiologie (DE-588)4152449-4 s Embryologie (DE-588)4014562-1 s Ontogenie (DE-588)4043565-9 s DE-188 Embryonalentwicklung (DE-588)4070792-1 s 1\p DE-604 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025925507&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Gilbert, Scott F. 1949- Developmental biology Embryology Developmental biology Ontogenie (DE-588)4043565-9 gnd Morphogenese (DE-588)4132460-2 gnd Embryonalentwicklung (DE-588)4070792-1 gnd Entwicklungsbiologie (DE-588)4152440-8 gnd Entwicklungsphysiologie (DE-588)4152449-4 gnd Embryologie (DE-588)4014562-1 gnd |
| subject_GND | (DE-588)4043565-9 (DE-588)4132460-2 (DE-588)4070792-1 (DE-588)4152440-8 (DE-588)4152449-4 (DE-588)4014562-1 (DE-588)4123623-3 |
| title | Developmental biology |
| title_auth | Developmental biology |
| title_exact_search | Developmental biology |
| title_full | Developmental biology Scott F. Gilbert |
| title_fullStr | Developmental biology Scott F. Gilbert |
| title_full_unstemmed | Developmental biology Scott F. Gilbert |
| title_short | Developmental biology |
| title_sort | developmental biology |
| topic | Embryology Developmental biology Ontogenie (DE-588)4043565-9 gnd Morphogenese (DE-588)4132460-2 gnd Embryonalentwicklung (DE-588)4070792-1 gnd Entwicklungsbiologie (DE-588)4152440-8 gnd Entwicklungsphysiologie (DE-588)4152449-4 gnd Embryologie (DE-588)4014562-1 gnd |
| topic_facet | Embryology Developmental biology Ontogenie Morphogenese Embryonalentwicklung Entwicklungsbiologie Entwicklungsphysiologie Embryologie Lehrbuch |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025925507&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT gilbertscottf developmentalbiology |