Holdings: Antimicrobial peptides

Antimicrobial peptides:

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Bibliographic Details
Main Authors:	Phoenix, David A. (Author), Dennison, Sarah R. (Author), Harris, Frederick M. (Author)
Format:	Book
Language:	English
Published:	Weinheim Wiley-VCH 2013
Subjects:	Peptide Antimikrobieller Wirkstoff Lehrbuch
Online Access:	Inhaltstext Inhaltsverzeichnis
Physical Description:	XV, 231 S. Ill., graph. Darst. 240 mm x 170 mm
ISBN:	9783527332632 3527332634

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MARC


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Record in the Search Index

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adam_text	IMAGE 1 CONTENTS PREFACE I X LIST O F ABBREVIATIONS X I I I 1 ANTIMICROBIAL PEPTIDES: THEIR HISTORY, EVOLUTION, AND FUNCTIONAL PROMISCUITY 1 SUMMARY 1 1.1 INTRODUCTION: THE HISTORY O F ANTIMICROBIAL PEPTIDES 1 1.2 AMPS: EVOLUTIONARILY ANCIENT MOLECULES 4 1.3 AMPS: MULTIFUNCTIONAL MOLECULES 11 1.3.1 DEFENSINS AS EFFECTORS O F IMMUNITY 12 1.3.2 DEFENSINS AND WOUND HEALING 16 1.3.3 DEFENSINS AND CANINE COAT COLOR 17 1.4 DISCUSSION 17 REFERENCES 19 2 CATIONIC ANTIMICROBIAL PEPTIDES 39 SUMMARY 39 2.1 INTRODUCTION 39 2.2 CAMPS AND THEIR ANTIMICROBIAL ACTION 42 2.3 CAMPS THAT ADOPT AN A-HELICAL STRUCTURE 43 2.4 CAMPS THAT ADOPT A P-SHEET STRUCTURE 51 2.5 CAMPS THAT ADOPT EXTENDED STRUCTURES RICH IN SPECIFIC RESIDUES 55 2.6 DISCUSSION 60 REFERENCES 62 3 ANIONIC ANTIMICROBIAL PEPTIDES 83 SUMMARY 83 3.1 INTRODUCTION 83 3.2 AAMPS IN THE RESPIRATORY TRACT 85 3.3 AAMPS IN THE BRAIN 87 3.4 AAMPS IN THE EPIDERMIS 91 3.5 AAMPS IN THE EPIDIDYMIS 94 HTTP://D-NB.INFO/1026137349 IMAGE 2 V I \| CONTENTS 3.6 AAMPS IN BLOOD COMPONENTS 96 3.7 AAMPS IN THE GASTROINTESTINAL TRACT AND FOOD PROTEINS 97 3.8 AAMPS AND THEIR STRUCTURE-FUNCTION RELATIONSHIPS 99 3.9 DISCUSSION 101 REFERENCES 102 4 GRAPHICAL TECHNIQUES TO VISUALIZE THE AMPHIPHILIC STRUCTURES OF ANTIMICROBIAL PEPTIDES 115 SUMMARY 115 4.1 INTRODUCTION 115 4.2 AMPHIPHILIC STRUCTURES ADOPTED BY AMPS 116 4.3 QUALITATIVE METHODS FOR IDENTIFYING AMPHIPHILIC STRUCTURE 118 4.4 QUANTITATIVE TECHNIQUES FOR ANALYZING AMPHIPHILIC STRUCTURE 121 4.4.1 TECHNIQUES BASED ON HYDROPATHY PLOT ANALYSIS 121 4.4.2 TECHNIQUES BASED ON FOURIER TRANSFORMS 123 4.4.3 AMPHIPATHIC INDEX 124 4.4.4 HYDROPHOBIC MOMENT ANALYSIS 124 4.4.4.1 CHOICE O F HYDROPHOBICITY SCALES 125 4.4.4.2 EFFECT O F SEQUENCE LENGTH ON AMPHIPHILICITY 126 4.4.5 CLASSIFICATION O F AMPHIPHILIC A-HELICES USING THE APPROACH OF SEGREST 127 4.4.6 AMPHIPHILICITY PROFILING ANALYSIS O F TILTED A-HELICES 129 4.4.7 EXTENDED HYDROPHOBIC MOMENT PLOT ANALYSIS O F TILTED A-HELICES 130 4.4.8 AMPHIPHILICITY QUANTIFIED USING THE APPROACH O F KELLER 130 4.4.9 AMPHIPHILICITY QUANTIFIED USING THE APPROACH O F BRASSEUR 132 4.5 DISCUSSION 133 REFERENCES 135 5 MODELS FOR THE MEMBRANE INTERACTIONS O F ANTIMICROBIAL PEPTIDES 145 SUMMARY 145 5.1 INTRODUCTION 145 5.2 CM-ASSOCIATED FACTORS THAT AFFECT THE ANTIMICROBIAL ACTION OF A-CAMPS 149 5.3 MECHANISMS USED BY CAMPS FOR MICROBIAL MEMBRANE INTERACTION 154 5.4 ESTABLISHED MODELS FOR THE MEMBRANE INTERACTIONS O F A-AMPS 155 5.4.1 BARREL-STAVE AND TOROIDAL PORE MODELS 155 5.4.2 CARPET MECHANISM AND THE SHAI-HUANG-MATSAZUKI MODEL 158 5.5 RECENT NOVEL MODELS FOR THE MEMBRANE INTERACTIONS OF A-AMPS 159 5.6 TILTED PEPTIDE MECHANISM 161 5.7 AMYLOIDOGENIC MECHANISMS 163 5.8 DISCUSSION 166 REFERENCES 168 IMAGE 3 CONTENTS \| V I I 6 SELECTIVITY AND TOXICITY O F ONCOLYTIC ANTIMICROBIAL PEPTIDES 181 SUMMARY 181 6.1 INTRODUCTION 181 6.2 PEPTIDE-BASED FACTORS THAT CONTRIBUTE TO THE ANTICANCER ACTION OF ANTICANCER PEPTIDES 183 6.2.1 SEQUENCE LENGTH 187 6.2.2 NET POSITIVE CHARGE 187 6.2.3 HYDROPHOBICITY 191 6.2.4 AMPHIPHILICITY 195 6.3 MEMBRANE-BASED FACTORS THAT CONTRIBUTE TO THE ANTICANCER ACTION OF ACPS 196 6.3.1 MEMBRANE RECEPTORS 199 6.3.2 CHOLESTEROL 199 6.3.3 ANIONIC MEMBRANE COMPONENTS 200 6.3.4 GLYCOPROTEINS AND GLYCOLIPIDS 201 6.3.5 PROTEOGLYCANS 202 6.3.6 PHOSPHOLIPIDS 203 6.4 DISCUSSION 205 REFERENCES 207 INDEX 223
any_adam_object	1
author	Phoenix, David A. Dennison, Sarah R. Harris, Frederick M.
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dewey-sort	3547.7
dewey-tens	540 - Chemistry and allied sciences 610 - Medicine and health
discipline	Chemie / Pharmazie Biologie Chemie Medizin
format	Book
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physical	XV, 231 S. Ill., graph. Darst. 240 mm x 170 mm
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spelling	Phoenix, David A. Verfasser aut Antimicrobial peptides David A. Phoenix ; Sarah R. Dennison ; Frederick Harris Weinheim Wiley-VCH 2013 XV, 231 S. Ill., graph. Darst. 240 mm x 170 mm txt rdacontent n rdamedia nc rdacarrier Peptide (DE-588)4045125-2 gnd rswk-swf Antimikrobieller Wirkstoff (DE-588)4142688-5 gnd rswk-swf (DE-588)4123623-3 Lehrbuch gnd-content Peptide (DE-588)4045125-2 s Antimikrobieller Wirkstoff (DE-588)4142688-5 s DE-604 Dennison, Sarah R. Verfasser (DE-588)1032210656 aut Harris, Frederick M. Verfasser aut X:MVB text/html http://deposit.dnb.de/cgi-bin/dokserv?id=4126141&prov=M&dok_var=1&dok_ext=htm Inhaltstext DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025877985&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis
spellingShingle	Phoenix, David A. Dennison, Sarah R. Harris, Frederick M. Antimicrobial peptides Peptide (DE-588)4045125-2 gnd Antimikrobieller Wirkstoff (DE-588)4142688-5 gnd
subject_GND	(DE-588)4045125-2 (DE-588)4142688-5 (DE-588)4123623-3
title	Antimicrobial peptides
title_auth	Antimicrobial peptides
title_exact_search	Antimicrobial peptides
title_full	Antimicrobial peptides David A. Phoenix ; Sarah R. Dennison ; Frederick Harris
title_fullStr	Antimicrobial peptides David A. Phoenix ; Sarah R. Dennison ; Frederick Harris
title_full_unstemmed	Antimicrobial peptides David A. Phoenix ; Sarah R. Dennison ; Frederick Harris
title_short	Antimicrobial peptides
title_sort	antimicrobial peptides
topic	Peptide (DE-588)4045125-2 gnd Antimikrobieller Wirkstoff (DE-588)4142688-5 gnd
topic_facet	Peptide Antimikrobieller Wirkstoff Lehrbuch
url	http://deposit.dnb.de/cgi-bin/dokserv?id=4126141&prov=M&dok_var=1&dok_ext=htm http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025877985&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
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