Antimicrobial peptides:
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Weinheim
Wiley-VCH
2013
|
| Schlagworte: | |
| Online-Zugang: | Inhaltstext Inhaltsverzeichnis |
| Beschreibung: | XV, 231 S. Ill., graph. Darst. 240 mm x 170 mm |
| ISBN: | 9783527332632 3527332634 |
Internformat
MARC
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| 300 | |a XV, 231 S. |b Ill., graph. Darst. |c 240 mm x 170 mm | ||
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Datensatz im Suchindex
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IMAGE 1
CONTENTS
PREFACE I X
LIST O F ABBREVIATIONS X I I I
1 ANTIMICROBIAL PEPTIDES: THEIR HISTORY, EVOLUTION, AND FUNCTIONAL
PROMISCUITY 1 SUMMARY 1
1.1 INTRODUCTION: THE HISTORY O F ANTIMICROBIAL PEPTIDES 1 1.2 AMPS:
EVOLUTIONARILY ANCIENT MOLECULES 4 1.3 AMPS: MULTIFUNCTIONAL MOLECULES
11 1.3.1 DEFENSINS AS EFFECTORS O F IMMUNITY 12 1.3.2 DEFENSINS AND
WOUND HEALING 16 1.3.3 DEFENSINS AND CANINE COAT COLOR 17 1.4 DISCUSSION
17
REFERENCES 19
2 CATIONIC ANTIMICROBIAL PEPTIDES 39
SUMMARY 39
2.1 INTRODUCTION 39
2.2 CAMPS AND THEIR ANTIMICROBIAL ACTION 42 2.3 CAMPS THAT ADOPT AN
A-HELICAL STRUCTURE 43 2.4 CAMPS THAT ADOPT A P-SHEET STRUCTURE 51 2.5
CAMPS THAT ADOPT EXTENDED STRUCTURES RICH IN SPECIFIC RESIDUES 55 2.6
DISCUSSION 60
REFERENCES 62
3 ANIONIC ANTIMICROBIAL PEPTIDES 83
SUMMARY 83
3.1 INTRODUCTION 83
3.2 AAMPS IN THE RESPIRATORY TRACT 85
3.3 AAMPS IN THE BRAIN 87
3.4 AAMPS IN THE EPIDERMIS 91
3.5 AAMPS IN THE EPIDIDYMIS 94
HTTP://D-NB.INFO/1026137349
IMAGE 2
V I | CONTENTS
3.6 AAMPS IN BLOOD COMPONENTS 96
3.7 AAMPS IN THE GASTROINTESTINAL TRACT AND FOOD PROTEINS 97 3.8 AAMPS
AND THEIR STRUCTURE-FUNCTION RELATIONSHIPS 99 3.9 DISCUSSION 101
REFERENCES 102
4 GRAPHICAL TECHNIQUES TO VISUALIZE THE AMPHIPHILIC STRUCTURES OF
ANTIMICROBIAL PEPTIDES 115 SUMMARY 115 4.1 INTRODUCTION 115
4.2 AMPHIPHILIC STRUCTURES ADOPTED BY AMPS 116 4.3 QUALITATIVE METHODS
FOR IDENTIFYING AMPHIPHILIC STRUCTURE 118 4.4 QUANTITATIVE TECHNIQUES
FOR ANALYZING AMPHIPHILIC STRUCTURE 121 4.4.1 TECHNIQUES BASED ON
HYDROPATHY PLOT ANALYSIS 121 4.4.2 TECHNIQUES BASED ON FOURIER
TRANSFORMS 123 4.4.3 AMPHIPATHIC INDEX 124 4.4.4 HYDROPHOBIC MOMENT
ANALYSIS 124 4.4.4.1 CHOICE O F HYDROPHOBICITY SCALES 125 4.4.4.2 EFFECT
O F SEQUENCE LENGTH ON AMPHIPHILICITY 126 4.4.5 CLASSIFICATION O F
AMPHIPHILIC A-HELICES USING THE APPROACH OF
SEGREST 127
4.4.6 AMPHIPHILICITY PROFILING ANALYSIS O F TILTED A-HELICES 129 4.4.7
EXTENDED HYDROPHOBIC MOMENT PLOT ANALYSIS O F TILTED A-HELICES 130 4.4.8
AMPHIPHILICITY QUANTIFIED USING THE APPROACH O F KELLER 130
4.4.9 AMPHIPHILICITY QUANTIFIED USING THE APPROACH O F BRASSEUR 132 4.5
DISCUSSION 133
REFERENCES 135
5 MODELS FOR THE MEMBRANE INTERACTIONS O F ANTIMICROBIAL PEPTIDES 145
SUMMARY 145 5.1 INTRODUCTION 145
5.2 CM-ASSOCIATED FACTORS THAT AFFECT THE ANTIMICROBIAL ACTION OF
A-CAMPS 149 5.3 MECHANISMS USED BY CAMPS FOR MICROBIAL MEMBRANE
INTERACTION 154
5.4 ESTABLISHED MODELS FOR THE MEMBRANE INTERACTIONS O F A-AMPS 155
5.4.1 BARREL-STAVE AND TOROIDAL PORE MODELS 155 5.4.2 CARPET MECHANISM
AND THE SHAI-HUANG-MATSAZUKI MODEL 158 5.5 RECENT NOVEL MODELS FOR THE
MEMBRANE INTERACTIONS OF
A-AMPS 159
5.6 TILTED PEPTIDE MECHANISM 161
5.7 AMYLOIDOGENIC MECHANISMS 163 5.8 DISCUSSION 166
REFERENCES 168
IMAGE 3
CONTENTS | V I I
6 SELECTIVITY AND TOXICITY O F ONCOLYTIC ANTIMICROBIAL PEPTIDES 181
SUMMARY 181
6.1 INTRODUCTION 181
6.2 PEPTIDE-BASED FACTORS THAT CONTRIBUTE TO THE ANTICANCER ACTION OF
ANTICANCER PEPTIDES 183 6.2.1 SEQUENCE LENGTH 187
6.2.2 NET POSITIVE CHARGE 187
6.2.3 HYDROPHOBICITY 191 6.2.4 AMPHIPHILICITY 195 6.3 MEMBRANE-BASED
FACTORS THAT CONTRIBUTE TO THE ANTICANCER ACTION OF ACPS 196
6.3.1 MEMBRANE RECEPTORS 199 6.3.2 CHOLESTEROL 199
6.3.3 ANIONIC MEMBRANE COMPONENTS 200 6.3.4 GLYCOPROTEINS AND
GLYCOLIPIDS 201 6.3.5 PROTEOGLYCANS 202
6.3.6 PHOSPHOLIPIDS 203
6.4 DISCUSSION 205
REFERENCES 207
INDEX 223 |
| any_adam_object | 1 |
| author | Phoenix, David A. Dennison, Sarah R. Harris, Frederick M. |
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| dewey-full | 547.7 615.792 |
| dewey-hundreds | 500 - Natural sciences and mathematics 600 - Technology (Applied sciences) |
| dewey-ones | 547 - Organic chemistry 615 - Pharmacology and therapeutics |
| dewey-raw | 547.7 615.792 |
| dewey-search | 547.7 615.792 |
| dewey-sort | 3547.7 |
| dewey-tens | 540 - Chemistry and allied sciences 610 - Medicine and health |
| discipline | Chemie / Pharmazie Biologie Chemie Medizin |
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| isbn | 9783527332632 3527332634 |
| language | English |
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| physical | XV, 231 S. Ill., graph. Darst. 240 mm x 170 mm |
| publishDate | 2013 |
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| spelling | Phoenix, David A. Verfasser aut Antimicrobial peptides David A. Phoenix ; Sarah R. Dennison ; Frederick Harris Weinheim Wiley-VCH 2013 XV, 231 S. Ill., graph. Darst. 240 mm x 170 mm txt rdacontent n rdamedia nc rdacarrier Peptide (DE-588)4045125-2 gnd rswk-swf Antimikrobieller Wirkstoff (DE-588)4142688-5 gnd rswk-swf (DE-588)4123623-3 Lehrbuch gnd-content Peptide (DE-588)4045125-2 s Antimikrobieller Wirkstoff (DE-588)4142688-5 s DE-604 Dennison, Sarah R. Verfasser (DE-588)1032210656 aut Harris, Frederick M. Verfasser aut X:MVB text/html http://deposit.dnb.de/cgi-bin/dokserv?id=4126141&prov=M&dok_var=1&dok_ext=htm Inhaltstext DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025877985&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Phoenix, David A. Dennison, Sarah R. Harris, Frederick M. Antimicrobial peptides Peptide (DE-588)4045125-2 gnd Antimikrobieller Wirkstoff (DE-588)4142688-5 gnd |
| subject_GND | (DE-588)4045125-2 (DE-588)4142688-5 (DE-588)4123623-3 |
| title | Antimicrobial peptides |
| title_auth | Antimicrobial peptides |
| title_exact_search | Antimicrobial peptides |
| title_full | Antimicrobial peptides David A. Phoenix ; Sarah R. Dennison ; Frederick Harris |
| title_fullStr | Antimicrobial peptides David A. Phoenix ; Sarah R. Dennison ; Frederick Harris |
| title_full_unstemmed | Antimicrobial peptides David A. Phoenix ; Sarah R. Dennison ; Frederick Harris |
| title_short | Antimicrobial peptides |
| title_sort | antimicrobial peptides |
| topic | Peptide (DE-588)4045125-2 gnd Antimikrobieller Wirkstoff (DE-588)4142688-5 gnd |
| topic_facet | Peptide Antimikrobieller Wirkstoff Lehrbuch |
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