Theoretical perspectives on signal transduction pathways depending on regulated proteolysis:
Gespeichert in:
| 1. Verfasser: | |
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| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
Berlin
Logos Verl.
2013
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| Schlagworte: | |
| Online-Zugang: | Inhaltstext Inhaltsverzeichnis |
| Beschreibung: | IV, 238 S. Ill., graph. Darst. |
| ISBN: | 9783832533373 3832533370 |
Internformat
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Datensatz im Suchindex
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IMAGE 1
CONTENTS
ZUSAMMENFASSUNG I
1 INTRODUCTION 3
2 T H E CANONICAL WNT/P-CATENIN SIGNALLING P A T H W A Y 9
2.1 INTRODUCTION O F CANONICAL WNT/P-CATENIN SIGNALLING 9
2.1.1 BIOLOGICAL B A C K G R O U N D 9
2.1.2 MATHEMATICAL M O D E L L I N G O F THE CANONICAL WNT/P-CATENIN P A
T H W A Y 12
2.1.3 SCOPE O F THIS THESIS 1 9
2.2 ANALYSIS O F THE EFFECTS O F INHIBITIONS 2 1
2.2.1 M O D E L A N D M E T H O D 21
2.2.2 A N A L Y S E S O F THE WILD-TYPE MODEL 2 5
2.2.3 EFFECTS O F INHIBITIONS O F PROCESSES IN T H E PRESENCE O F A P C
MUTATIONS 2 9
2.2.4 DISCUSSION 4 2
2.3 EFFECTS O F THE COEXISTENCE O F WILD-TYPE A N D MUTATED P-CATENIN O
N T H E
SIGNALLING PROPERTIES O F THE P A T H W A Y 4 9
2.3.1 M O D E L INCLUDING M U T A T E D P-CATENIN 50
2.3.2 EFFECT O F M U T A T E D P-CATENIN O N THE UNSTIMULATED STEADY
STATE
CONCENTRATION O F WILD-TYPE P-CATENIN 5 2
2.3.3 STIMULATED SYSTEM 5 4
2.3.4 SENSITIVITY ANALYSIS 5 9
2.3.5 MINIMAL M O D E L 6 6
2.3.6 DISCUSSION 7 5
2.4 A N A L Y S E S O F THE EFFECTS O F CELLULAR E-CADHERIN LEVELS A N D
THE AXIN-2 FEEDBACK
O N THE D Y N A M I C S O F P-CATENIN SIGNALLING 7 9
2.4.1 EXPERIMENTAL DATA 8 0
2.4.2 M O D E L INCLUDING E-CADLIERIN A N D THE F E E D B A C K LOOP V I
A AXIN-2 85
2.4.3 EFFECTS O F THE SINGLE M O D E L EXTENSIONS 8 7
2.4.4 EFFECTS O F E-CADHERIN, A P C A N D AXIN-2 FEEDBACK 8 9
2.4.5 COMBINATION O F EXPERIMENTS A N D SIMULATIONS 9 8
2.4.6 SENSITIVITY ANALYSIS 106
2.4.7 EFFECTS O F A P C MUTATIONS 122
2.4.8 DISCUSSION 129
HTTP://D-NB.INFO/1031259368
IMAGE 2
3 M O D E L L I N G T H E NON-CANONICAL N F - K B P A T H W A Y 1 3 7
3 . 1 I N T R O D U C T I O N IN N F - K B S I G N A L L I N G 1 3 7
3.2 D E V E L O P M E N T A N D ANALYSES O F A MATHEMATICAL M O D E L O
F THE NON-CANONICAL
N F - K B S I G N A L L I N G P A T H W A Y 1 4 1
3.2.1 T H E MATHEMATICAL M O D E L 141
3.2.2 EXPERIMENTAL D A T A A N D SIMULATED T I M E COURSES 146
3.2.3 FITTED PARAMETERS 154
3.2.4 MODEL PREDICTIONS 156
3.2.5 MODELLING MUTATIONS 160
3 . 2 . 6 SENSITIVITY ANALYSIS O F THE M O D E L O F NON-CANONICAL N F -
K B S I G N A L L I N G 1 6 3
3.2.7 DISCUSSION 168
3.2.8 O U T L O O K 170
4 CONCLUSIONS A N D OUTLOOK 177
APPENDICES 181
A T H E WILD-TYPE M O D E L O F WNT/P-CATENIN SIGNALLING 181
A. 1 ILLUSTRATION O F P A T H W A Y M O D U L E S 181
A . 2 MODEL EQUATIONS A N D PARAMETERS 182
B WNT/P-CATENIN MODEL INCLUDING MUTATED P-CATENIN 188
B . L MODEL EQUATIONS A N D PARAMETERS 188
B.2 M O D E L EQUATIONS AND PARAMETERS O F THE M I N I M A L M O D E L
190
B.3 EFFECTS O F MUTATED P-CATENIN O N THE FOLD-CHANGE O F WILD-TYPE
P-CATENIN 192
B.4 PROOFS 197
C T H E CELLULAR M O D E L O F WNT/P-CATENIN SIGNALLING 2 0 2
C . L M O D E L EQUATIONS A N D PARAMETERS 2 0 2
C.2 ADDITIONAL ANALYSES O F THE CELLULAR M O D E L 2 0 5
D M O D E L O F THE NON-CANONICAL N F - K B S I G N A L L I N G P A T H
W A Y 2 1 0
D . L M O D E L EQUATIONS 2 1 0
D . 2 SENSITIVITY ANALYSIS 2 1 2
D . 3 DETAILED MODEL O F THE N I K - T R A F - R E G U L A T I O N M O D
U L E 2 1 4
ABBREVIATIONS 2 1 9
BIBLIOGRAPHY 221
D A N K S A G U N G 2 3 7 |
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| isbn | 9783832533373 3832533370 |
| language | English |
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| spelling | Kofahl, Bente 1978- Verfasser (DE-588)1032154578 aut Theoretical perspectives on signal transduction pathways depending on regulated proteolysis von Bente Kofahl Berlin Logos Verl. 2013 IV, 238 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Zugl.: Berlin, Humboldt-Univ., Diss., 2012 Catenine (DE-588)4380415-9 gnd rswk-swf Mathematisches Modell (DE-588)4114528-8 gnd rswk-swf Nuklearfaktor Kappa B (DE-588)4348985-0 gnd rswk-swf Signaltransduktion (DE-588)4318717-1 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Signaltransduktion (DE-588)4318717-1 s Catenine (DE-588)4380415-9 s Nuklearfaktor Kappa B (DE-588)4348985-0 s Mathematisches Modell (DE-588)4114528-8 s DE-604 X:MVB text/html http://deposit.dnb.de/cgi-bin/dokserv?id=4254101&prov=M&dok_var=1&dok_ext=htm Inhaltstext DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025788638&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Kofahl, Bente 1978- Theoretical perspectives on signal transduction pathways depending on regulated proteolysis Catenine (DE-588)4380415-9 gnd Mathematisches Modell (DE-588)4114528-8 gnd Nuklearfaktor Kappa B (DE-588)4348985-0 gnd Signaltransduktion (DE-588)4318717-1 gnd |
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| title | Theoretical perspectives on signal transduction pathways depending on regulated proteolysis |
| title_auth | Theoretical perspectives on signal transduction pathways depending on regulated proteolysis |
| title_exact_search | Theoretical perspectives on signal transduction pathways depending on regulated proteolysis |
| title_full | Theoretical perspectives on signal transduction pathways depending on regulated proteolysis von Bente Kofahl |
| title_fullStr | Theoretical perspectives on signal transduction pathways depending on regulated proteolysis von Bente Kofahl |
| title_full_unstemmed | Theoretical perspectives on signal transduction pathways depending on regulated proteolysis von Bente Kofahl |
| title_short | Theoretical perspectives on signal transduction pathways depending on regulated proteolysis |
| title_sort | theoretical perspectives on signal transduction pathways depending on regulated proteolysis |
| topic | Catenine (DE-588)4380415-9 gnd Mathematisches Modell (DE-588)4114528-8 gnd Nuklearfaktor Kappa B (DE-588)4348985-0 gnd Signaltransduktion (DE-588)4318717-1 gnd |
| topic_facet | Catenine Mathematisches Modell Nuklearfaktor Kappa B Signaltransduktion Hochschulschrift |
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