Essentials of pharmaceutical chemistry:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
London [u.a.]
Pharmaceutical Press
2012
|
| Ausgabe: | 4. ed. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | VIII, 308 S. Ill., graph. Darst. |
| ISBN: | 9780853699798 |
Internformat
MARC
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| 100 | 1 | |a Cairns, Donald |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Essentials of pharmaceutical chemistry |c ed. by Donald Cairns |
| 250 | |a 4. ed. | ||
| 264 | 1 | |a London [u.a.] |b Pharmaceutical Press |c 2012 | |
| 300 | |a VIII, 308 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 4 | |a Chimie pharmaceutique | |
| 650 | 4 | |a Drug Stability | |
| 650 | 4 | |a Pharmaceutical Preparations |x analysis | |
| 650 | 4 | |a Pharmaceutical Preparations |x chemistry | |
| 650 | 4 | |a Pharmaceutical chemistry | |
| 650 | 4 | |a Structure-Activity Relationship | |
| 650 | 0 | 7 | |a Pharmazeutische Chemie |0 (DE-588)4132158-3 |2 gnd |9 rswk-swf |
| 655 | 7 | |0 (DE-588)4151278-9 |a Einführung |2 gnd-content | |
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| 999 | |a oai:aleph.bib-bvb.de:BVB01-025784232 | ||
Datensatz im Suchindex
| _version_ | 1804150143605276672 |
|---|---|
| adam_text | Contents
lx
Preface
to the fourth edition
χ
Acknowledgements
xi
About the author
1
Chemistry of acids and bases
1
Dissociation of weak acids and bases
3
Hydrolysis of salts
9
Amphiprotic salts
10
Buffer solutions
11
Buffer capacity
13
Biological buffers
15
Ionisation
of drugs
18
pACa values of drug molecules
19
pH
indicators
19
Tutorial examples
22
Problems
26
2
Partition coefficient and biopharmacy
29
Experimental measurement of the partition coefficient
32
Drua absorption, distribution and bioavailabitity
35
Passée
diffusion
38
The
pH
partition hypothesis
40
Active transport mechanisms
43
The action of local anaesthetics
44
Excretion and
reabsorption
of drugs
47
Food and drink
48
Tutorial examples
50
Problems
55
vi
I Contents
3
Physicochemical properties of drugs 5?
Γ
1
Carboxylic acids
Phenols 61
Warfarin 62
Phenylbutazone
^5
Indometacin
Barbiturates 65
Phenytoin
Sulfonamides °
Basic drugs 6
Basicity of heterocyclic compounds
Separation of mixtures 71
Tutorial examples
Problems 7/
4
Stereochemistry **1
Polarimetry
Biological systems ^
Fischer projections ^
Stereochemistry case study: thalidomide
95
Geometrical ¡somensm
^7
Tutorial examples
9
Problems 101
5
Drug metabolism 103
Metabolic pathways ^
Cytochromes P450
·
105
Enzyme induction and inhibition 1^
Drug conjugation reactions (Phase
2)
11 °
Stereochemistry 11 ^
Metabolic pathways for common drugs ^
Tutorial example !25
Problems 126
Volumetric analysis of drugs
Volumetric flask 13°
Pipette 130
Burettes 131
Units of concentration 131
Worked example ^
33
Concentration of active ingredients 13^
Contents
I
vii
Design
of an assay
134
Practical points
137
Back and blank titrations
140
Assay of unit-dose medicines
143
Non-aqueous titrations
144
REDOX
titrations
145
Compleximetric titrations
148
Argentimetric titrations
149
Limit tests
150
Problems
151
7
Analytical spectroscopy
155
Effect of
pH
on spectra
159
Instrumentation
163
Experimental measurement of absorbance
166
Dilutions
167
Quantitative aspects of spectroscopy
168
Beer s and Lambert s laws
168
Methods of drug assay
170
Derivative spectroscopy
172
Infrared spectroscopy
1 74
Fluonmetry
177
Structure elucidation
178
Tutorial examples
188
Problems
196
8 Chromatographie
methods of analysis
199
Definitions used in chromatography
199
Types of chromatography
200
Terms used in chromatography
211
Tutorial examples
214
Problems
216
9
Stability of drugs and medicines
217
Oxidation
217
Hydrolysis
228
Other mechanisms of degradation
233
Prodrugs
233
Tutorial examples
235
Problems
237
viii
I Contents
10
Kinetics of drug stability
239
Rate, order and moleculanty
239
Rate equations and first-order reactions
240
Half-life
243
Shelf-life
243
Second-order reactions
243
Zero-order reactions
245
Reaction rates and temperature 24b
Tutorial example
247
Problems
248
11
Licensing of drugs and the British Pharmacopoeia
249
Furopean licensing procedures
250
Applications for marketing authorisations
252
British Pharmacopoeia Commission
253
The British Pharmacopoeia
254
12
Medicinal chemistry: the science of rational drug design
259
flow do drugs work
259
Where do drugs come from?
266
Why do we need new drugs7
271
13
Answers to problems
277
Selected bibliography
293
Index
295
|
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| discipline | Chemie / Pharmazie Medizin |
| edition | 4. ed. |
| format | Book |
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| indexdate | 2024-07-10T00:34:14Z |
| institution | BVB |
| isbn | 9780853699798 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-025784232 |
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| physical | VIII, 308 S. Ill., graph. Darst. |
| publishDate | 2012 |
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| spelling | Cairns, Donald Verfasser aut Essentials of pharmaceutical chemistry ed. by Donald Cairns 4. ed. London [u.a.] Pharmaceutical Press 2012 VIII, 308 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Chimie pharmaceutique Drug Stability Pharmaceutical Preparations analysis Pharmaceutical Preparations chemistry Pharmaceutical chemistry Structure-Activity Relationship Pharmazeutische Chemie (DE-588)4132158-3 gnd rswk-swf (DE-588)4151278-9 Einführung gnd-content Pharmazeutische Chemie (DE-588)4132158-3 s DE-604 Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025784232&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Cairns, Donald Essentials of pharmaceutical chemistry Chimie pharmaceutique Drug Stability Pharmaceutical Preparations analysis Pharmaceutical Preparations chemistry Pharmaceutical chemistry Structure-Activity Relationship Pharmazeutische Chemie (DE-588)4132158-3 gnd |
| subject_GND | (DE-588)4132158-3 (DE-588)4151278-9 |
| title | Essentials of pharmaceutical chemistry |
| title_auth | Essentials of pharmaceutical chemistry |
| title_exact_search | Essentials of pharmaceutical chemistry |
| title_full | Essentials of pharmaceutical chemistry ed. by Donald Cairns |
| title_fullStr | Essentials of pharmaceutical chemistry ed. by Donald Cairns |
| title_full_unstemmed | Essentials of pharmaceutical chemistry ed. by Donald Cairns |
| title_short | Essentials of pharmaceutical chemistry |
| title_sort | essentials of pharmaceutical chemistry |
| topic | Chimie pharmaceutique Drug Stability Pharmaceutical Preparations analysis Pharmaceutical Preparations chemistry Pharmaceutical chemistry Structure-Activity Relationship Pharmazeutische Chemie (DE-588)4132158-3 gnd |
| topic_facet | Chimie pharmaceutique Drug Stability Pharmaceutical Preparations analysis Pharmaceutical Preparations chemistry Pharmaceutical chemistry Structure-Activity Relationship Pharmazeutische Chemie Einführung |
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