Cell polarity and cancer:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
London
Portland Press
2012
|
| Series: | Essays in biochemistry
53 |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XXII, 172 S. Ill., graph. Darst. |
| ISBN: | 9781855781894 |
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Record in the Search Index
| _version_ | 1804150136127881216 |
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| adam_text | Titel: Cell polarity and cancer
Autor: Chalmers, Andrew D
Jahr: 2012
Contents
Preface.....................................................................................................................xi
Authors.................................................................................................................xiii
Abbreviations....................................................................................................xix
Cell polarity and asymmetric cell division: the
G elegans early embryo
Anna Noatynska and Monica Gotta
Abstract............................................................................................................I
Introduction.....................................................................................................I
Early development of the C. elegans embryo...........................................2
PAR proteins: major polarity players.........................................................4
Polarity establishment...................................................................................5
Polarity maintenance.....................................................................................7
PAR protein downstream effectors...........................................................8
Positioning of the mitotic spindle and unequal cell division.................9
Conclusions..................................................................................................10
Summary........................................................................................................10
References.....................................................................................................11
Phosphoinositide lipids and cell polarity: linking the plasma
membrane to the cytocortex
Michael P. Krahn and Andreas Wodarz
Abstract.........................................................................................................IS
Introduction..................................................................................................16
Phosphoinositides as components of biological membranes............17
Recruitment of cytosolic proteins to biological membranes by
direct binding to phosphoinositide head groups...............................19
Proteins mediating downstream effects of phosphoinositides..........20
Phosphoinositides control the polarity of migrating cells..................20
Phosphoinositides control the polarity of non-migratory cells........21
Interactions between phosphoinositides and PAR (PARtitioning
defective) proteins....................................................................................22
Manipulation of phosphoinositide signalling by bacterial
pathogens....................................................................................................24
v
Contents © 2012 Biochemical Society
Conclusion....................................................................................................24
Summary........................................................................................................24
References.....................................................................................................25
The role of secretory and endocytic pathways in the
maintenance of cell polarity
Su Fen Ang and Heike Fölsch
Abstract.........................................................................................................29
Introduction..................................................................................................30
Sorting to the apical membrane...............................................................31
Sorting to endosomes and the basolateral membrane.......................32
Transcytosis..................................................................................................34
Sorting into primary cilia...........................................................................35
Conclusions..................................................................................................36
Note added in proof...................................................................................36
Summary........................................................................................................37
References.....................................................................................................37
Continuous endocytic recycling of tight junction proteins:
how and why?
Andrew D. Chalmers and Paul Whitley
Abstract.........................................................................................................41
An introduction to tight junctions...........................................................41
The dynamic nature of tight junctions....................................................43
Is continuous recycling of tight junction proteins a common
feature of epithelial cells?........................................................................43
How is endocytosis of tight junction proteins mediated?..................45
Regulation of recycling and junctional remodelling.............................47
Post-endocytic sorting and trafficking of tight junction proteins.....48
Why do cells continuously recycle tight junction proteins?..............49
Conclusions..................................................................................................50
Summary........................................................................................................50
References.....................................................................................................50
Crucial polarity regulators in axon specification
Giovanna Lalli
Abstract.........................................................................................................55
Introduction..................................................................................................56
vi
© 2012 Biochemical Society Contents
The cytoskeleton.........................................................................................57
Intracellular signalling..................................................................................60
Conclusion....................................................................................................64
Summary........................................................................................................65
References.....................................................................................................65
Cell wars: regulation of cell survival and proliferation
by cell competition
Silvia Vivarelli, Laura Wagstaff and Eugenia Piddini
Abstract.........................................................................................................69
Introduction..................................................................................................70
Pathways of cell competition....................................................................70
Sensing cellular fitness................................................................................72
Elimination of loser cells............................................................................73
Tissue colonization by winner cells.........................................................76
Cell competition and disease....................................................................76
Conclusions..................................................................................................79
Summary........................................................................................................79
References.....................................................................................................80
The control of gene expression and cell proliferation
by the epithelial apical junctional complex
Domenica Spadaro, Rocio Tapia, Pamela Pulimeno
and Sandra Citi
Abstract.........................................................................................................83
Introduction..................................................................................................84
AJ proteins and nucleo-cytoplasmic signalling......................................84
The role of ZO proteins, symplekin and ZONAB
(ZO-1 -associated nucleic acid-binding protein) in the control
of gene expression and cell proliferation............................................86
YAP, a regulator of cell growth, is controlled by
junctional proteins....................................................................................88
RhoA-dependent control of gene expression: interplay with
junctional proteins?...................................................................................89
Conclusions..................................................................................................90
Summary........................................................................................................91
References.....................................................................................................91
vii
Contents
©2012 Biochemical Society
8
10
Apicobasal polarity and cell proliferation
during development
Nitin Sabherwal and Nancy Papalopulu
Abstract.........................................................................................................95
Introduction: apicobasal polarity and cell proliferation......................95
Model systems for studying polarity in conjunction with
cell proliferation........................................................................................97
Evidence that polarity and proliferation are linked...........................101
Mechanisms linking polarity and proliferation in
Drosophila models....................................................................................101
Mechanisms linking polarity and proliferation in the vertebrate
neuroepithelium......................................................................................104
Conclusions and unanswered questions..............................................105
Summary......................................................................................................106
References...................................................................................................106
The Hippo pathway: key interaction and catalytic
domains in organ growth control, stem cell self-renewal
and tissue regeneration
Claire Cherrett, Makoto Furutani-Seiki and Stefan Bagby
Abstract.......................................................................................................111
Introduction................................................................................................112
The Hippo pathway and its role in organ growth control...............112
Hippo pathway components..................................................................112
Organ growth control and tumorigenesis...........................................114
Integration of multi-pathway signalling.................................................114
Key Hippo pathway domains..................................................................118
Conclusions................................................................................................123
Summary......................................................................................................123
References...................................................................................................124
Epithelial cell polarity: what flies can teach us about cancer
Daniel T Bergstralh and Daniel St Johnston
Abstract.......................................................................................................129
Introduction................................................................................................130
Apical signalling factors............................................................................131
Basolateral signalling factors...................................................................133
The low-energy polarity pathway..........................................................135
viii
© 2012 Biochemical Society
Contents
Conclusion..................................................................................................137
Summary......................................................................................................138
References...................................................................................................138
The Scribble-Dlg-Lgl polarity module in development and
cancer: from flies to man
Imogen Elsum, Laura Yates, Patrick O. Humbert
and Helena E. Richardson
Abstract.......................................................................................................141
Introduction................................................................................................142
The Scribble polarity module is highly conserved in evolution......143
Biological processes regulated by Scrib, Dig and Lgl.........................145
The mechanism of Scrib/Dlg/Lgl function............................................146
Role of Scrib/Dlg/Lgl in cancer progression and metastasis............157
Conclusions and future perspectives....................................................158
Summary......................................................................................................159
References...................................................................................................159
Index.....................................................................................................................169
ix
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| id | DE-604.BV040799055 |
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| institution | BVB |
| isbn | 9781855781894 |
| language | English |
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| physical | XXII, 172 S. Ill., graph. Darst. |
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| publisher | Portland Press |
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| series | Essays in biochemistry |
| series2 | Essays in biochemistry |
| spelling | Cell polarity and cancer ed. by Andrew D. Chalmers ... London Portland Press 2012 XXII, 172 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Essays in biochemistry 53 Chalmers, Andrew Sonstige oth Essays in biochemistry 53 (DE-604)BV026536280 53 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025779194&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Cell polarity and cancer Essays in biochemistry |
| title | Cell polarity and cancer |
| title_auth | Cell polarity and cancer |
| title_exact_search | Cell polarity and cancer |
| title_full | Cell polarity and cancer ed. by Andrew D. Chalmers ... |
| title_fullStr | Cell polarity and cancer ed. by Andrew D. Chalmers ... |
| title_full_unstemmed | Cell polarity and cancer ed. by Andrew D. Chalmers ... |
| title_short | Cell polarity and cancer |
| title_sort | cell polarity and cancer |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025779194&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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