Computational neuroscience: simulated demyelinating neuropathies and neuronopathies
"Preface Preface v vi Computational Neuroscience Simulated Demyelinating Neuropathies and Neuronopathies (PISD) are specifi c indicators for CIDP and its subtypes; (3) the severe focal demyelinations, each of them internodal and paranodal, paranodalinternodal (IFD and PFD, PIFD), are specifi c...
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Boaca Raton [u.a.]
Taylor and Francis
2013
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Zusammenfassung: | "Preface Preface v vi Computational Neuroscience Simulated Demyelinating Neuropathies and Neuronopathies (PISD) are specifi c indicators for CIDP and its subtypes; (3) the severe focal demyelinations, each of them internodal and paranodal, paranodalinternodal (IFD and PFD, PIFD), are specifi c indicators for acquired demyelinating neuropathies such as GBS and MMN; (4) the simulated progressively greater degrees of axonal dysfunctions termed ALS1, ALS2 and ALS3 are specifi c indicators for the motor neuron disease ALS Type1, Tape2 and Type3; and (5) the obtained excitability properties in the simulated demyelinating neuropathies are quite different from those in the simulated ALS subtypes, because of the different fi bre electrogenesis. The results show that the abnormalities in the axonal excitability properties in the ALS1 subtype are near normal. The results also show that in the simulated hereditary, chronic and acquired demyelinating neuropathies, the slowing of action potential propagation, based on the myelin sheath dysfunctions, is larger than this, based on the progressively increased uniform axonal dysfunctions in the simulated ALS2 and ALS3 subtypes. Conversely, the abnormalities in the accommodative and adaptive processes are larger in the ALS2 and ALS3 subtypes than in the demyelinating neuropathies. The increased axonal superexcitability in the ALS2 and ALS3 subtypes leads to repetitive discharges (action potential generation) in the nodal and internodal axolemma beneath the myelin sheath along the fi bre length in response to the applied long-duration subthreshold polarizing current stimuli (accommodative processes) and to the applied long-duration suprathreshold depolarizing current stimuli (adaptive processes)"-- |
| Beschreibung: | Includes bibliographical references (pages 115-133) and index |
| Beschreibung: | x, 136 S. 24 cm |
| ISBN: | 9781466578326 |
Internformat
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| 100 | 1 | |a Stephanova, Diana I. |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Computational neuroscience |b simulated demyelinating neuropathies and neuronopathies |c Diana I. Stephanova ; Bozhidar Dimitrov |
| 264 | 1 | |a Boaca Raton [u.a.] |b Taylor and Francis |c 2013 | |
| 300 | |a x, 136 S. |c 24 cm | ||
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| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 500 | |a Includes bibliographical references (pages 115-133) and index | ||
| 520 | |a "Preface Preface v vi Computational Neuroscience Simulated Demyelinating Neuropathies and Neuronopathies (PISD) are specifi c indicators for CIDP and its subtypes; (3) the severe focal demyelinations, each of them internodal and paranodal, paranodalinternodal (IFD and PFD, PIFD), are specifi c indicators for acquired demyelinating neuropathies such as GBS and MMN; (4) the simulated progressively greater degrees of axonal dysfunctions termed ALS1, ALS2 and ALS3 are specifi c indicators for the motor neuron disease ALS Type1, Tape2 and Type3; and (5) the obtained excitability properties in the simulated demyelinating neuropathies are quite different from those in the simulated ALS subtypes, because of the different fi bre electrogenesis. The results show that the abnormalities in the axonal excitability properties in the ALS1 subtype are near normal. The results also show that in the simulated hereditary, chronic and acquired demyelinating neuropathies, the slowing of action potential propagation, based on the myelin sheath dysfunctions, is larger than this, based on the progressively increased uniform axonal dysfunctions in the simulated ALS2 and ALS3 subtypes. Conversely, the abnormalities in the accommodative and adaptive processes are larger in the ALS2 and ALS3 subtypes than in the demyelinating neuropathies. The increased axonal superexcitability in the ALS2 and ALS3 subtypes leads to repetitive discharges (action potential generation) in the nodal and internodal axolemma beneath the myelin sheath along the fi bre length in response to the applied long-duration subthreshold polarizing current stimuli (accommodative processes) and to the applied long-duration suprathreshold depolarizing current stimuli (adaptive processes)"-- | ||
| 650 | 4 | |a Computational neuroscience | |
| 650 | 4 | |a Neurogenetics / Computer simulation | |
| 650 | 7 | |a MEDICAL / Neurology |2 bisacsh | |
| 650 | 7 | |a SCIENCE / Life Sciences / Biology / General |2 bisacsh | |
| 650 | 7 | |a SCIENCE / Life Sciences / Neuroscience |2 bisacsh | |
| 650 | 4 | |a Medizin | |
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| 999 | |a oai:aleph.bib-bvb.de:BVB01-025775875 | ||
Datensatz im Suchindex
| _version_ | 1804150131019218944 |
|---|---|
| adam_text | Contents
Preface
v
Abbreviations
xi
I. Nerve Fibres
1
Myelinated
Axons
1
Demyelinating Neuropathies
7
Charcot-Marie-Tooth Diseases (CMT) and Type
IA (CMT1A)
8
Chronic Inflammatory Demyelinating Polyneuropathy
9
(CIDP) and its Subtypes
Guillain-Barré
Syndrome (GBS) and Multifocal Motor
10
Neuropathy (MMN)
Neuronopathies
11
Amyotrophic Lateral Sclerosis
(ALS) 11
Axonal Excitability
12
Mathematical Modeling of Nerve Fibres
14
II
.
Models and Methods for Investigation of the Human
18
Motor Nerve Fibre
Multi-Layered and Double Cable Models
18
Line-Source Model
28
Methods of Stimulation and Calculation of the Potentials
30
(Action, Electrotonic and Extracellular)
Methods for Calculation of the Strength-Duration Time
32
Constants, Rheobasic Currents and Recovery Cycles
III. Simulated Demyelinating Neuropathies and
33
Neuronopathies
Simulation of CMT1A, CIDP, CIDP Subtypes, GBS, MMN
33
and
ALS
Abnormalities in the Potentials
36
Action Potentials
36
χ
Computaţional
Neurosáence:
Simulated
Demyelinating
Neuropathies and Neurmopathies
Mechanisms Defining the Action Potential Abnormalities
39
in Simulated CMT1A, CIDP and
СЮР
Subtypes
Mechanisms Defining the Action Potential Abnormalities
42
in Simulated GBS and MMN
Mechanisms Defining the Action Potential Abnormalities
43
in Simulated
ALS
Electrotonic Potentials
46
Mechanisms Defining Abnormalities of the Polarizing
49
Electrotonic Potentials in Simulated CMT1A, CIDP
and CIDP Subtypes
Mechanisms Defining Abnormalities of the Polarizing
55
Electrotonic Potentials in Simulated GBS and MMN
Mechanisms Defining Abnormalities of the Polarizing
Ы
Electrotonic Potentials in Simulated
ALS
Homogeneity or Heterogeneity of Membrane Polarization in
71
Simulated Demyelinating Neuropathies without or with
Conduction Block
Abnormalities in the Extracellular Potentials and their
77
Mechanisms
Abnormalities in the Strength-Duration Time Constants,
81
Rheobasic Currents and their Mechanisms
Abnormalities in the Recovery Cycles and their Mechanisms
87
IV. Effect of
Myelin
Sheath Aqueous Layers on the
94
Excitability Properties of Simulated Hereditary
and Chronic Demyelinating Neuropathies
Simulation of CMT1A, CIDP and CIDP Subtypes with
94
Aqueous Layers within the
Myelin
Sheath
Effect of
Myelin
Sheath Aqueous Layers on the Potentials
98
Effect of
Myelin
Sheath Aqueous Layers on the
105
Strength-Duration
Tíme
Constants, Rheobasic Currents
and Recovery Cycles
References
115
Index
135
|
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| author | Stephanova, Diana I. |
| author_facet | Stephanova, Diana I. |
| author_role | aut |
| author_sort | Stephanova, Diana I. |
| author_variant | d i s di dis |
| building | Verbundindex |
| bvnumber | BV040795670 |
| classification_rvk | ST 640 |
| ctrlnum | (OCoLC)835326211 (DE-599)BVBBV040795670 |
| discipline | Informatik |
| format | Book |
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| id | DE-604.BV040795670 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-10T00:34:02Z |
| institution | BVB |
| isbn | 9781466578326 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-025775875 |
| oclc_num | 835326211 |
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| owner_facet | DE-473 DE-BY-UBG |
| physical | x, 136 S. 24 cm |
| publishDate | 2013 |
| publishDateSearch | 2013 |
| publishDateSort | 2013 |
| publisher | Taylor and Francis |
| record_format | marc |
| spelling | Stephanova, Diana I. Verfasser aut Computational neuroscience simulated demyelinating neuropathies and neuronopathies Diana I. Stephanova ; Bozhidar Dimitrov Boaca Raton [u.a.] Taylor and Francis 2013 x, 136 S. 24 cm txt rdacontent n rdamedia nc rdacarrier Includes bibliographical references (pages 115-133) and index "Preface Preface v vi Computational Neuroscience Simulated Demyelinating Neuropathies and Neuronopathies (PISD) are specifi c indicators for CIDP and its subtypes; (3) the severe focal demyelinations, each of them internodal and paranodal, paranodalinternodal (IFD and PFD, PIFD), are specifi c indicators for acquired demyelinating neuropathies such as GBS and MMN; (4) the simulated progressively greater degrees of axonal dysfunctions termed ALS1, ALS2 and ALS3 are specifi c indicators for the motor neuron disease ALS Type1, Tape2 and Type3; and (5) the obtained excitability properties in the simulated demyelinating neuropathies are quite different from those in the simulated ALS subtypes, because of the different fi bre electrogenesis. The results show that the abnormalities in the axonal excitability properties in the ALS1 subtype are near normal. The results also show that in the simulated hereditary, chronic and acquired demyelinating neuropathies, the slowing of action potential propagation, based on the myelin sheath dysfunctions, is larger than this, based on the progressively increased uniform axonal dysfunctions in the simulated ALS2 and ALS3 subtypes. Conversely, the abnormalities in the accommodative and adaptive processes are larger in the ALS2 and ALS3 subtypes than in the demyelinating neuropathies. The increased axonal superexcitability in the ALS2 and ALS3 subtypes leads to repetitive discharges (action potential generation) in the nodal and internodal axolemma beneath the myelin sheath along the fi bre length in response to the applied long-duration subthreshold polarizing current stimuli (accommodative processes) and to the applied long-duration suprathreshold depolarizing current stimuli (adaptive processes)"-- Computational neuroscience Neurogenetics / Computer simulation MEDICAL / Neurology bisacsh SCIENCE / Life Sciences / Biology / General bisacsh SCIENCE / Life Sciences / Neuroscience bisacsh Medizin Neurowissenschaften (DE-588)7555119-6 gnd rswk-swf Computersimulation (DE-588)4148259-1 gnd rswk-swf Neurowissenschaften (DE-588)7555119-6 s Computersimulation (DE-588)4148259-1 s DE-604 Dimitrov, Bozhidar Sonstige oth Digitalisierung UB Bamberg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025775875&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Stephanova, Diana I. Computational neuroscience simulated demyelinating neuropathies and neuronopathies Computational neuroscience Neurogenetics / Computer simulation MEDICAL / Neurology bisacsh SCIENCE / Life Sciences / Biology / General bisacsh SCIENCE / Life Sciences / Neuroscience bisacsh Medizin Neurowissenschaften (DE-588)7555119-6 gnd Computersimulation (DE-588)4148259-1 gnd |
| subject_GND | (DE-588)7555119-6 (DE-588)4148259-1 |
| title | Computational neuroscience simulated demyelinating neuropathies and neuronopathies |
| title_auth | Computational neuroscience simulated demyelinating neuropathies and neuronopathies |
| title_exact_search | Computational neuroscience simulated demyelinating neuropathies and neuronopathies |
| title_full | Computational neuroscience simulated demyelinating neuropathies and neuronopathies Diana I. Stephanova ; Bozhidar Dimitrov |
| title_fullStr | Computational neuroscience simulated demyelinating neuropathies and neuronopathies Diana I. Stephanova ; Bozhidar Dimitrov |
| title_full_unstemmed | Computational neuroscience simulated demyelinating neuropathies and neuronopathies Diana I. Stephanova ; Bozhidar Dimitrov |
| title_short | Computational neuroscience |
| title_sort | computational neuroscience simulated demyelinating neuropathies and neuronopathies |
| title_sub | simulated demyelinating neuropathies and neuronopathies |
| topic | Computational neuroscience Neurogenetics / Computer simulation MEDICAL / Neurology bisacsh SCIENCE / Life Sciences / Biology / General bisacsh SCIENCE / Life Sciences / Neuroscience bisacsh Medizin Neurowissenschaften (DE-588)7555119-6 gnd Computersimulation (DE-588)4148259-1 gnd |
| topic_facet | Computational neuroscience Neurogenetics / Computer simulation MEDICAL / Neurology SCIENCE / Life Sciences / Biology / General SCIENCE / Life Sciences / Neuroscience Medizin Neurowissenschaften Computersimulation |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025775875&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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