Gap junctions in the brain: physiological and pathological roles
Literaturangaben
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| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Amsterdam [u.a.]
Elsevier/AP
2013
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| Ausgabe: | 1. ed. |
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| Online-Zugang: | Inhaltsverzeichnis Klappentext |
| Zusammenfassung: | Literaturangaben |
| Beschreibung: | XIV, 290, [11] S. Ill., graph. Darst. |
| ISBN: | 9780124159013 |
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Datensatz im Suchindex
| _version_ | 1804150104453545984 |
|---|---|
| adam_text | Contents
About the Editor
xi
List of Contributors
xiii
I
THE PHYSIOLOGY OF GAP
JUNCTIONS IN THE BRAIN
Non-Channel Functions of Connexins
21
Expression Pattern of Glial Connexins in the Hippocampus:
Molecular, Subcellular and Cellular Heterogeneity
21
Heterocellular Coupling and Panglial Coupling
Compartments
23
Functions of Glial Gap Junctions: Controlling Neurogenesis
and
Neuronal
Activity
24
Acknowledgments
24
References
24
1.
Gap Junctions in the Brain
ARMIN ZLOMUZICA, SONJA
BINDER,
EKREM
DERE
Introduction
3
Structural Aspects of Gap Junctions
5
Types of Gap Junction
5
Cellular and Brain Regional Expression Patterns of Specific
Connexins
6
СоппехіпЗО
7
СоппехіпЗО. З
7
СоппехіпЗ І Л
7
Соппехіп32
7
СоппехіпЗб
7
Соппехіп43
8
Соппехіп45
8
Gap Junction Pharmacology
8
Synchronization and Rhythmic Oscillation of Neural Activity
9
Theta and Gamma Oscittations
9
High-Frequency Oscilfotions
10
Connexin45 and
Neuronal
Network
Oscilbtions 1
0
СоппехіпЗб
and Olivocerebettar Network Oscillations
10
Gap Junction-Related Human Diseases
11
Conclusion
12
Acknowledgments 1
3
References 1
3
2.
Physiology and Function of Glial Gap Junctions
in the Hippocampus
MARTIN THEIS, CHRISTIAN
STEINHÄUSER
The Connexin Gene Family
19
Intercellular Communication Mediated By Connexins
20
Hemichannel Functions of Connexins
20
II
GAP JUNCTIONS BETWEEN
ASTROCYTES, NEURONS, AND
GLIA-NEURON INTERACTIONS
3.
Pathophysiology of Gap Junctions
in the Brain
RIMA
HAMDAN,
MAISSÁ
YEHIA, RABIH
S. TALHOUK,
MARWAN E. EL-SABBAN
Introduction
31
Gap Junctions: Nomenclature and General Properties
32
Gap Junction Coupling in the Brain
33
Cell-Specific Expression of Connexins in
Brain Tissues
35
Connexin26
35
СоппехіпЗО
35
СоппехіпЗО. З
35
СоппехіпЗ
l.¡
36
СоппехіпЗб
36
Connexin43
36
Соппехіп45
37
ínnexms
and Pannexms
37
Modulation and Regulation of Electrical Synapses
38
Activity-Dependent Plasticity
38
pH
and [Ca^] Sensitivity
38
Neurotransmitter
Modulation and Connexin
Phosphorylation
38
Gap Junction-Related Neurological Diseases
39
СоппехіпЗО
39
Connexin32
39
Соппехіп43
39
VI
CONTENTS
Connexin47
42
Gap
Junctions and Behavior
42
Pharmacology of Gap Junctions
43
Conclusion
44
References
44
4-
Astroglial Calcium Signaling and Calcium
Waves
ALEXEI VERKHRATSKY, VLADIMIR PARPURA
Introduction
51
Glial Calcium Excitability
52
Astroglia: Homeostatic Cells of the Brain
52
Calcium Signaling in Astrocytes
53
Principles of Calcium Signaling
53
Glial Ca ^ Excitability: The Primary Role of the
Endoplasmic Reticulum Ca ^ Store
56
Control of Glial Function by the Endoplasmic
Reticulum Ca + Store
56
Store-Operated Ca ^ Entry: A Role for Canonical Transient
Receptor Potential Channels
57
lonotropic Ca2+ Permeable Receptors in Astrocytes
58
The Sodium/Cakium Exchanger in Astroglia
58
60
60
Mitochondria in Astroglial
Са +
Signaling
Voltage-Gated Ca2+ Channels in Astroglia
Astroglial Calcium Waves
60
Conclusion
62
Acknowledgments
62
References
62
5.
Distribution and Function of Gap
Junction Coupling in Cortical
GABAergic Neurons
DANIELE F.
CONDORELLI, GIUSEPPA
MUDÒ,
VINCENZA BARRESI,
NATALE BELLUARDO
Neuronal
Gap Junctions and Connexins
69
A Premise on Inferior Olive Excitatory Neurons: a
Privileged Site in the Study of
Neuronal
Gap Junctions
in Mammals
70
СоппехіпЗб,
Gap Junctions and Electrical Coupling
in Neocortical Gabaergic Neurons
71
СоппехіпЗб,
Gap Junctions and Electrical Coupling in
Hippocampal Gabaergic
Interneurons
75
Functional Properties of
СоппехіпЗб
and
СоппехіпЗб
-Based
Gap Junctions and their Role in Gabaergic
Interneuronal
Networks
77
Basic Properties of
Neuronal
Gap Junctions
77
Properties of
Neuronal
Gap Junctions
(Electrical Synapses) Integrated in
Neuronal
Cell Physiohgy
77
Properties of Simple Circuits Containing Electrical
Synapses as Modular Units of Larger
Neuronal
NetworL·
78
Emerging Properties of Complex
Neuronal
Networks Containing Electrical Synapses: Oscillator}
Activities
79
Modulation of Learning, Memory and Synaptic
Plasticity by
СоппехтЗб
-Basea1
Electrical
Synapses
79
References
79
____________
III
____________
THE ROLE OF GAP JUNCTIONS IN
BRAIN DEVELOPMENT
6.
Functions of Gap Junctions in the Developing
Neocortex
BERND SUTOR
Introduction
85
Gap Junctions, Connexons, Connexins and their
Distribution in Neocortical Neural Cell Types
87
Role of Gap Junctions in the Ventricular Zone
and during Migration of Neurons
88
Role of Gap Junctions in the Subplate
89
Gap Junctions between Neocortical Gabaergic Inhibitory
Interneurons
90
Gap Junctions between Immature Neocortical
Pyramidal Cells
91
Gap Junctions between Neocortical Glial Cells
93
Conclusion
94
References
95
IV
GAP JUNCTIONS AND
NEURONAL
SYNCHRONIZATION
7.
Involvement of Gap Junctions in the Generation
of the Hippocampal Formation Theta Rhythm
in Rats
JAN KONOPACKI,
RENATA
BOCIAN,
TOMASZ KOWALCZYK, PAULINA KAZMIERSKA
Introduction
101
Gap Junctions, Oscillations and Synchrony
102
Oscillations and Synchrony in the
Limbie
Cortex In Vivo
103
Oscillations and Synchrony in the
Limbie
Cortex
In Vitro
104
Gap Junctions and Theta Oscillations in Rat In Vitro
Hippocampal Formation Slices
104
CONTENTS
Vil
Gap Junctions and Theta Oscillations in Rat Ex Vivo
Hippocampal Formation Slices
108
Concluding Remarks on in Vitro and Ex Vivo Experiments
1
J O
Gap Junctions and Hippocampal Theta Oscillations
in Rat In Vivo Preparation
110
Mechanism of Trimethylamine Action on Gap Junction
Channels
¡20
Concluding Remarks on In Vivo Experiments
¡21
Conclusion
121
References
¡22
8.
Gap Junctions and
Neuronal
Synchronization
in the Olivocerebellar System
P. BAZZIGALUPPI, S.C. ISENIA, C.I.
DE ZEEUW, M.T.G.
DE JEU
Introduction
127
Gap Junctions Between Olivary Cells
130
Microscopic and Vltrastructural Anatomy
of Olivary Gap Junctions
130
Electrotonic Coupling between Olivary Neurons
¡32
Subthreshold Oscillation and Network Synchronization
і
34
Network Considerations
135
Gap Junctions Between Molecular
Interneurons
136
Microscopic and Vltrastructural Anatomy of
Molecular Layer
ínterneurons
і
36
Physiohgy of the Mohcuhr Layer
ínterneurons ¡
36
Electrotonic Coupling between Molecular Layer
¡ntemeurons
¡37
Gap Junctions Between Golgi Cells
138
Microscopic and Ultrastructural Anatomy of Golgi Cells
138
Physiohgy of Golgi Cells
¡38
Electrotonic Coupling of Golgi Cells
¡
39
Gap Junctions and Purkinje Cells
139
Gap Junctions in Cerebellar and
Vestibular
Nuclei
140
Conclusion
141
References
І4І
V
GAP JUNCTIONS AND
NEUROLOGICAL AND
NEUROPSYCHIATRIC DISEASES
9.
Gap Junctions in the Basal Ganglia
MARIE VANDECASTEELE, LAURENT VENANCE
Introduction
149
Distribution of Gap Junctions in Basal Ganglia Nuclei
150
Striami
Output Neurons
¡5¡
Fast-Spiking Striatal
ínterneurons ¡5¡
Dopaminergic Neurons of the
Substantia
Nigra
Pars
Compacta
¡51
GABAergic Neurons of the Ventral Tegmenta! Area
] 55
Putative Roles of Gap Junctions in Basal Ganglia
Neuronal
Networks
156
Rok
of Electrical Coupling between Striatal Output
Neurons
J
56
Role of Electrical Coupling between Fast-Spiking
ínterneurons
¡57
Role of Electrical Coupling between Dopaminergic
Neurons of the
Substantia
Nigra
і
58
Role
of Electrical Coupling between GABAergic
Neurons of the Ventral Tegmental Area
J
58
Gap Junctional Communication in Basal Ganglia
Pathologies
159
Conclusion
159
References
і
60
10.
Connexin Mutations in Pelizaeus—Merzbacher-
Like Disease, Oculodentodigital Dysplasia
and Related Diseases
CHARLES K. ABRAMS, JENNIFER ORTHMANN-MURPHY
Introduction
165
Disease Manifestations of GJC2 Mutations
166
Pefeaeus—Merzbacher-Like Disease
J
166
Hereditary Spastic Paresis
¡66
Hereditary Lymphedema
i C i
66
Disease Manifestations of GJAi Mutations
168
Oculodentodigital Dysplasia
168
Hallermann—Streiff
Syndrome
169
Connexins Expressed by Astrocytes and Oligodendrocytes
169
Distribution and Coupling
(69
Roles of Glial Connexins in Central Nervous System
Glia
170
Studies on Genetically Modified Mice Lacking One or More
Connexin
і
70
P/iysioÍogical Roles
of Glial Connexins
¡7¡
Pathogenesis of
Connexin47-Associated
Diseases
172
Pathogenesis of
Соппех^З-АѕѕосЈаг^
Diseases
175
Conclusion
182
Acknowledgments
і
82
References
182
11.
Gap Junctions in Cerebellar Development
and Pathology
BÉATRICE
VERNET-DER GARABEDIAN, JEAN
MARIANI
Introduction
189
A Brief Primer on Anatomical and Developmental
Aspects of the Cerebellum
190
Anatomy of the Cerebellum
190
Development
of the Cerebellum
f
90
Gap Junctions in the Cerebellum
192
Connexin and Pannexin Expression in the Cerebellum
J
92
Vlil
CONTENTS
Cerebettar
Phenotypes of Genetically Engineered
Connexin Mice
192
Connexin-Linked Cerebellar Pathologies
196
Cerebeüar
Anomalies in Pelizaeus—Merzbacher-Like
Disease
196
Dandy—Walker Malformation Associated with
Keratitis—
lchthyosis—Deafness Syndrome
196
Cerebeüar
Neuropathy Associated with X-Linked
Charcot—Marie—Tooth Disease
Í96
Mouse Models of Central Nervous System
Connexin-Linked Human Diseases
198
Conclusion
198
References
Í99
12.
Charcot—Marie—Tooth Disease
KLEOPAS A. KLEOPA
Introduction
201
Clinical and Pathological Features of X-Linked
Charcot—Marie—Tooth Disease
201
Clinical Manifestations of CMT1X Neuropathy
201
Central Nervous System Phenotypes
in CMTIX Patients
202
ElectrophysioL·gical
Findings in Patients with CMTJX
203
Pathological Features of CMT¡X Neuropathy
203
Genetics and Neurobiology of X-Linked
Charcot—Marie—Tooth Disease
204
GJB1/CX32 Mutations Cause
СМТІХ
204
Role of Connexin32 in My
elinating
Cells
205
Modeh of CMTIX and Molecuhr Mechanisms
of Connexin32 Mutants
207
Axoruzl Involvement in CMTIX
208
Therapeutic Challenges and Perspectives in X-Linked
Charcot—Marie—Tooth Disease
209
Current Management of CMT
í X
209
Research on Future CMTJX Treatments
209
Further Questions on CMTIX Pathogenesis
210
Acknowledgments
210
References
211
13.
Gap Junctions Regulate Seizure Activity
-
But in Unexpected Ways
LOGAN
]. VOSS,
JAMES W. SLEIGH
Introduction
217
Gap Junction Structure and Distribution of Connexin
Subtypes
218
Gap Junction Expression in the Cortex
and Hippocampus
218
Experimental Studies Investigating Gap Junction
Regulation of Seizure Activity
219
Background and Experimental Approaches
219
Pharmacological Approaches
219
Genetic Approaches
219
Gap Junction-Linked Intemeuronal Networks
220
Gap Junction-Unked Astrocytic Networks
222
Mathematical Models of Gap Junction Effects
223
Background to Mathematical Modeling of Seizure Activity
223
Neuron-by-Neuron Models
224
Mean-Field Models
224
Conclusion
226
Acknowledgments
227
References
227
14.
Gap Junction-Mediated
Neuroprotection
MICHAEL G. KOZORIZ, CHRISTIAN
С
NAUS
Introduction
231
Are Gap Junctions Protective or Destructive?
231
Gap Junction Proteins and Cellular Protection
232
Gap Junction Proteins and Cellular Destruction
233
Channel Mechanisms of
Neuroprotection
or
Neuronal
Injury
235
Intercelular
Communication: Gap Junction
Channels
235
Connexin HemichanneL·
236
Pannexins
236
Non-Channel Mechanisms
237
Connexin Interacting Proteins
237
Mitochondria
238
Cellular Mechanisms
239
Gliosis
239
Microglia
240
Conclusion
241
Acknowledgments
242
References
242
VI
GAP JUNCTIONS AND BEHAVIOR
15.
Possible Actions of Gap Junctional Coupling in
Reward-Seeking Behaviors
JOSE LUIS PEREZ VELAZQUEZ
Introduction
249
Changes in Gap Junctional Communication Associated with
Changes in Nervous System Activity
250
Changes in Gap Junctional Communication Associated with
Changes in Behavior
251
Changes in Gap Junctional Communication
Associated with Changes in Reward-Seeking
and Addictive Behaviors
252
From Correlations to Mechanisms
255
Conclusion
256
References
257
16.
Behavioral Pharmacology of Gap Junctions
GRZEGORZ
R.
JUSZCZAK,
ARTUR
H.
SWIERGIEL
Properties of Gap Junction
Blockers 261
CONTENTS
ЇХ
Physiological Effects of Gap Junction
Blockers
Relevant to Behavior
263
Behavioral Effects of Gap Junction
Blockers 265
Sleep
265
Cognitive Effects
266
Emotions, Mood and Reward
268
Effect of Gap Junctions on the Effect of Alcohol
269
Effect of Gap Junction
Blockers
on Movement
Generation
269
Seizures
271
Pain
271
Other Effects
271
Conclusion
272
Acknowledgments
272
References
272
17.
Behavioral Genetics of Gap Junctions
ARMIN
ZLOMUZICA, HASAN X. AVCI, EKREM
DERE
Introduction
277
Learning and Memory
277
Motor Function
279
Emotional Behavior
280
Addictive Behavior
280
Conclusion
281
Acknowledgment
281
References
282
Index
285
Gap Junctions
in the Brain
Edited by
Ekrem
Dere
Université
Pierre
et
Marie Curie, Paris, France and
АР
-HP
Hôpital
Charles Foix, Centre
de
Recherche
et Développement,
Ivry-sur-Seine, France
It has been long thought that inter-cellular communication in the adult mammalian brain is exclusively mediated
by
neurotransmission
at chemical synapses. However, evidence from molecular, biological, electrophysiological,
pharmacological, and genetic approaches has accumulated indicating that electrical synapses (or gap junctions)
in the adult brain also contribute to inter-cellular communication by the direct electrotonic and metabolic coupling
of the cytosolic compartments of adjacent cells. Moreover, it has been discovered that gap junctions are important
modulators of chemical
neurotransmission
and
neuronal
excitability.
Gap junctions between glial cells or neurons are ubiquitously expressed in the mammalian brain and play a role in brain
development including cell differentiation, cell migration and survival, and tissue homeostasis, as well as in human
diseases including hearing loss, neuropathies, epilepsy, brain trauma, and cardiovascular disease. Furthermore,
gap junctions are involved in the synchronization and rhythmic oscillation of hippocampal and neocortical
neuronal
ensembles, which may be important for memory formation and consolidation. Moreover, the behavioral phenotyping of
gap junction mutant mice has demonstrated the importance of gap junctions in the brain for various behaviors including
motor behavior and memory performance. Further analysis of the molecular structural features of gap junctions may
pave the way for the development of more selective pharmacological tools to modulate specific gap junctions, and
ideally this will stimulate the development of novel gap junction-related treatments for human disease conditions.
Key Features:
1
Most current and comprehensive reference available covering the physiological, behavioral, and
pathophysiologicai roies of gap junctions in the brain, geared for use by researchers, clinicians, and students.
•
Chapters summarize knowledge of the basic physiology of gap junctions in the brain, as well as of human disease
conditions associated with mutations in single gap junction connexin genes.
•
Includes reviews of pharmacological studies with gap junction biockers and openers, summarizing information
obtained from phenotyping gap junctions mouse mutants.
ISBN
978-0-12-415901-3
ELSFVIER
ACADEMIC PRESS
An imprint of
Elsevier
store, elsevier.com
|
| any_adam_object | 1 |
| author2 | Dere, Ekrem |
| author2_role | edt |
| author2_variant | e d ed |
| author_GND | (DE-588)128623489 |
| author_facet | Dere, Ekrem |
| building | Verbundindex |
| bvnumber | BV040773980 |
| classification_rvk | WE 5340 WW 2400 |
| ctrlnum | (OCoLC)835302974 (DE-599)OBVAC09591213 |
| discipline | Biologie |
| edition | 1. ed. |
| format | Book |
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| id | DE-604.BV040773980 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T00:33:37Z |
| institution | BVB |
| isbn | 9780124159013 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-025752338 |
| oclc_num | 835302974 |
| open_access_boolean | |
| owner | DE-703 |
| owner_facet | DE-703 |
| physical | XIV, 290, [11] S. Ill., graph. Darst. |
| publishDate | 2013 |
| publishDateSearch | 2013 |
| publishDateSort | 2013 |
| publisher | Elsevier/AP |
| record_format | marc |
| spelling | Gap junctions in the brain physiological and pathological roles ed. by Ekrem Dere 1. ed. Amsterdam [u.a.] Elsevier/AP 2013 XIV, 290, [11] S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Literaturangaben Säugetiere (DE-588)4051253-8 gnd rswk-swf Gap junction (DE-588)4197886-9 gnd rswk-swf Connexin (DE-588)4307065-6 gnd rswk-swf Pathologie (DE-588)4044893-9 gnd rswk-swf Physiologie (DE-588)4045981-0 gnd rswk-swf Säugetiere (DE-588)4051253-8 s Gap junction (DE-588)4197886-9 s Connexin (DE-588)4307065-6 s Physiologie (DE-588)4045981-0 s Pathologie (DE-588)4044893-9 s DE-604 Dere, Ekrem (DE-588)128623489 edt Digitalisierung UB Bayreuth application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025752338&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Bayreuth application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025752338&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
| spellingShingle | Gap junctions in the brain physiological and pathological roles Säugetiere (DE-588)4051253-8 gnd Gap junction (DE-588)4197886-9 gnd Connexin (DE-588)4307065-6 gnd Pathologie (DE-588)4044893-9 gnd Physiologie (DE-588)4045981-0 gnd |
| subject_GND | (DE-588)4051253-8 (DE-588)4197886-9 (DE-588)4307065-6 (DE-588)4044893-9 (DE-588)4045981-0 |
| title | Gap junctions in the brain physiological and pathological roles |
| title_auth | Gap junctions in the brain physiological and pathological roles |
| title_exact_search | Gap junctions in the brain physiological and pathological roles |
| title_full | Gap junctions in the brain physiological and pathological roles ed. by Ekrem Dere |
| title_fullStr | Gap junctions in the brain physiological and pathological roles ed. by Ekrem Dere |
| title_full_unstemmed | Gap junctions in the brain physiological and pathological roles ed. by Ekrem Dere |
| title_short | Gap junctions in the brain |
| title_sort | gap junctions in the brain physiological and pathological roles |
| title_sub | physiological and pathological roles |
| topic | Säugetiere (DE-588)4051253-8 gnd Gap junction (DE-588)4197886-9 gnd Connexin (DE-588)4307065-6 gnd Pathologie (DE-588)4044893-9 gnd Physiologie (DE-588)4045981-0 gnd |
| topic_facet | Säugetiere Gap junction Connexin Pathologie Physiologie |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025752338&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025752338&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT dereekrem gapjunctionsinthebrainphysiologicalandpathologicalroles |