Sequential experimentation in clinical trials: design and analysis
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
New York, NY [u.a.]
Springer
2013
|
| Schriftenreihe: | Springer series in statistics
|
| Schlagworte: | |
| Online-Zugang: | BTU01 TUM01 UBA01 UBM01 UBT01 UBW01 UPA01 Volltext Inhaltsverzeichnis Abstract |
| Beschreibung: | 1 Online-Ressource |
| ISBN: | 9781461461135 9781461461142 |
| DOI: | 10.1007/978-1-4614-6114-2 |
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Datensatz im Suchindex
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| adam_text | SEQUENTIAL EXPERIMENTATION IN CLINICAL TRIALS
/ BARTROFF, JAY
: 2013
TABLE OF CONTENTS / INHALTSVERZEICHNIS
INTRODUCTION
NONLINEAR REGRESSION, EXPERIMENTAL DESIGN, AND PHASE I CLINICAL TRIALS
SEQUENTIAL TESTING THEORY AND STOCHASTIC OPTIMIZATION OVER TIME
GROUP SEQUENTIAL DESIGN OF PHASE II AND III TRIALS
SEQUENTIAL METHODS FOR VACCINE SAFETY EVALUATION AND SURVEILLANCE IN
PUBLIC HEALTH
TIME-SEQUENTIAL DESIGN OF CLINICAL TRIALS WITH FAILURE-TIME ENDPOINTS
CONFIDENCE INTERVALS AND P-VALUES
ADAPTIVE DESIGN OF CONFIRMATORY TRIALS
REFERENCES
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
SEQUENTIAL EXPERIMENTATION IN CLINICAL TRIALS
/ BARTROFF, JAY
: 2013
ABSTRACT / INHALTSTEXT
THIS BOOK PRESENTS AN INTEGRATED METHODOLOGY FOR SEQUENTIAL
EXPERIMENTATION IN CLINICAL TRIALS. THE METHODOLOGY ALLOWS SEQUENTIAL
LEARNING DURING THE COURSE OF A TRIAL TO IMPROVE THE EFFICIENCY OF THE
TRIAL DESIGN, WHICH OFTEN LACKS ADEQUATE INFORMATION AT THE PLANNING
STAGE. ADAPTATION VIA SEQUENTIAL LEARNING OF UNKNOWN PARAMETERS IS A
CENTRAL IDEA NOT ONLY IN ADAPTIVE DESIGNS OF CONFIRMATORY CLINICAL
TRIALS BUT ALSO IN THE THEORY OF OPTIMAL NONLINEAR EXPERIMENTAL DESIGN,
WHICH THE BOOK COVERS AS INTRODUCTORY MATERIAL. OTHER INTRODUCTORY
TOPICS FOR WHICH THE BOOK PROVIDES PREPARATORY BACKGROUND INCLUDE
SEQUENTIAL TESTING THEORY, DYNAMIC PROGRAMMING AND STOCHASTIC
OPTIMIZATION, SURVIVAL ANALYSIS AND RESAMPLING METHODS. IN THIS WAY, THE
BOOK GIVES A SELF-CONTAINED AND THOROUGH TREATMENT OF GROUP SEQUENTIAL
AND ADAPTIVE DESIGNS, TIME-SEQUENTIAL TRIALS WITH FAILURE-TIME
ENDPOINTS, AND STATISTICAL INFERENCE AT THE CONCLUSION OF THESE
TRIALS.THE BOOK CAN BE USED FOR GRADUATE COURSES IN SEQUENTIAL ANALYSIS,
CLINICAL TRIALS, AND BIOSTATISTICS, AND ALSO FOR SHORT COURSES ON
CLINICAL TRIALS AT PROFESSIONAL MEETINGS. EACH CHAPTER ENDS WITH
SUPPLEMENTS FOR THE READER TO EXPLORE RELATED CONCEPTS AND METHODS, AND
PROBLEMS WHICH CAN BE USED FOR EXERCISES IN GRADUATE COURSES. JAY
BARTROFF IS ASSOCIATE PROFESSOR OF MATHEMATICS AT THE UNIVERSITY OF
SOUTHERN CALIFORNIA WHERE HE IS A MEMBER OF THE LABORATORY OF APPLIED
PHARMACOKINETICS AT THE USC KECK SCHOOL OF MEDICINE. HE IS A LEADING
EXPERT ON GROUP SEQUENTIAL AND MULTISTAGE ADAPTIVE STATISTICAL
PROCEDURES AND THEIR APPLICATIONS TO CLINICAL TRIAL DESIGNS, AND HE IS A
SOUGHT-AFTER CONSULTANT IN ACADEMIA AND INDUSTRY.TZE LEUNG LAI IS
PROFESSOR OF STATISTICS, AND BY COURTESY, OF HEALTH RESEARCH AND POLICY
AND OF THE INSTITUTE OF COMPUTATIONAL AND MATHEMATICAL ENGINEERING AT
STANFORD UNIVERSITY, WHERE HE IS THE DIRECTOR OF THE FINANCIAL AND RISK
MODELING INSTITUTE AND CO-DIRECTOR OF THE BIOSTATISTICS CORE AT THE
STANFORD CANCER INSTITUTE AND OF THE CENTER FOR INNOVATIVE STUDY DESIGN
AT THE SCHOOL OF MEDICINE. HE MADE SEMINAL CONTRIBUTIONS TO SEQUENTIAL
ANALYSIS, INNOVATIVE CLINICAL TRIAL DESIGNS, ADAPTIVE METHODS, SURVIVAL
ANALYSIS, NONLINEAR AND GENERALIZED MIXED MODELS, HYBRID RESAMPLING
METHODS, AND RECEIVED THE COMMITTEE OF PRESIDENTS OF STATISTICAL
SOCIETIES (COPSS) AWARD IN 1983. MEI-CHIUNG SHIH IS ASSISTANT PROFESSOR
OF BIOSTATISTICS AND A MEMBER OF THE STANFORD CANCER INSTITUTE AND OF
THE CENTER FOR INNOVATIVE STUDY DESIGN AT THE SCHOOL OF MEDICINE AT
STANFORD UNIVERSITY.SHE IS ALSO ASSOCIATE DIRECTOR FOR SCIENTIFIC AND
TECHNICAL OPERATIONS AT THE DEPARTMENT OF VETERANS AFFAIRS (VA)
COOPERATIVE STUDIES PROGRAM COORDINATING CENTER AT PALO ALTO HEALTH CARE
SYSTEM. SHE IS A LEADING EXPERT ON GROUP SEQUENTIAL AND ADAPTIVE DESIGNS
AND INFERENCE OF CLINICAL TRIALS, LONGITUDINAL AND SURVIVAL DATA
ANALYSIS, AND HAS BEEN LEADING THE DESIGN, CONDUCT AND ANALYSIS OF
SEVERAL LARGE TRIALS AT THE VA.
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
|
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| spelling | Bartroff, Jay Verfasser (DE-588)1031522433 aut Sequential experimentation in clinical trials design and analysis Jay Bartroff ; Tze Leung Lai ; Mei-Chiung Shih New York, NY [u.a.] Springer 2013 1 Online-Ressource txt rdacontent c rdamedia cr rdacarrier Springer series in statistics Sequentialanalyse (DE-588)4128461-6 gnd rswk-swf Klinisches Experiment (DE-588)4164223-5 gnd rswk-swf Klinisches Experiment (DE-588)4164223-5 s Sequentialanalyse (DE-588)4128461-6 s 1\p DE-604 Lai, Tze Leung 1945- Verfasser (DE-588)135683971 aut Shih, Mei-Chiung Verfasser (DE-588)1031536752 aut https://doi.org/10.1007/978-1-4614-6114-2 Verlag Volltext Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025746076&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025746076&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Abstract 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Bartroff, Jay Lai, Tze Leung 1945- Shih, Mei-Chiung Sequential experimentation in clinical trials design and analysis Sequentialanalyse (DE-588)4128461-6 gnd Klinisches Experiment (DE-588)4164223-5 gnd |
| subject_GND | (DE-588)4128461-6 (DE-588)4164223-5 |
| title | Sequential experimentation in clinical trials design and analysis |
| title_auth | Sequential experimentation in clinical trials design and analysis |
| title_exact_search | Sequential experimentation in clinical trials design and analysis |
| title_full | Sequential experimentation in clinical trials design and analysis Jay Bartroff ; Tze Leung Lai ; Mei-Chiung Shih |
| title_fullStr | Sequential experimentation in clinical trials design and analysis Jay Bartroff ; Tze Leung Lai ; Mei-Chiung Shih |
| title_full_unstemmed | Sequential experimentation in clinical trials design and analysis Jay Bartroff ; Tze Leung Lai ; Mei-Chiung Shih |
| title_short | Sequential experimentation in clinical trials |
| title_sort | sequential experimentation in clinical trials design and analysis |
| title_sub | design and analysis |
| topic | Sequentialanalyse (DE-588)4128461-6 gnd Klinisches Experiment (DE-588)4164223-5 gnd |
| topic_facet | Sequentialanalyse Klinisches Experiment |
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