The malaria genome projects: promise, progress, and prospects
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
London [u.a.]
Imperial College Press
2012
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Klappentext |
| Beschreibung: | XV, 372 S. |
| ISBN: | 9781848169036 1848169035 |
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Datensatz im Suchindex
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|---|---|
| adam_text | Contents
Preface
xi
Chapter
1.
Introduction
1
Plasmodium
discovered
2
Plasmodium
transmitted
10
Plasmodium in
hiding
19
Chapter
2.
Réspice:
Before the Genome Project
23
Chapter
3.
The Nature of
Plasmoãium falciparum
and its Genome
41
A home for the genome
43
Location, location, location
47
The malaria genome capers
49
Chapter
4.
Chipping Away at the Genome
63
Turning on, turning off
71
Evasion
77
Chapter
5.
The Importance of Import
85
Chapter
6.
Remodeling the Genome s Home
103
Chapter
7.
Getting on the Inside 111
Chapter
8.
The Great Escape
125
vii
viii The Malaria
Genome Projects: Promise, Progress, and Prospects
Chapter
9.
The Neglected Malaria, Plasmodium vivax
133
Resistance
135
Secrets hidden in the genome
141
Chapter
10.
The Anopheles Genome and Transmission
Control
145
Making mosquitoes immune
147
Making mosquitoes insecticide resistant
150
Replacement and/or reduction
150
Chapter
11.
The Monkey s Tale
155
Chapter
12.
A Not So Sweet Solution
171
Isoenzymes,
the Achilles heels of Plasmodium
178
Tackling the
Krebs
cycle
181
Chapter
13.
To Search and Find
187
Rapid diagnostic tests
188
Nucleic acid-based tests
189
Loop-mediated isothermal amplification
193
Chapter
14.
The Elusive Vaccines
195
Antigens before the genome
196
Two blood-stage vaccine candidates
217
The road to merozoite surface protein
218
The road to apical membrane antigen
1 222
A failed promise, SPf66
224
Transmission-blocking vaccines
227
The sporozoite vaccine revisited
233
Development of the pre-blood-stage
vaccine,
RTS, S
242
Back
to
the future
249
Learning from the liver
253
Contents
ix
Vaccine approaches before sequencing
the genome
261
Vaccine approaches after sequencing
the genome
264
Chapter
15.
New Medicines, Old Problems
269
The old problem of resistance
273
Chloroquine
275
Resistance to anti-folate drugs
281
Mefloquine and multidrug resistance
284
The fall of mefloquine
288
Atovaquone
289
Artemisia to artemisinins
293
Chapter
16.
Prospice: Looking to the Future
301
References
305
Index
359
THE
MALARIA
GENOME
PROJECTS
Promise, Progress, and Prospects
The year
2012
marks the tenth anniversary of the announcement of
the genome sequence of the human malaria parasite Plasmodium
falciparum and that of its mosquito vector Anopheles. The genome
sequences were a result of the Plasmodium falciparum Genome Project.
This book covers in detail the biology of malaria parasites and the
mosquitoes that transmit the disease, how the Genome Projects
came into being, the people who created them, and the cadre of
scientists who are attempting to see the promise of the Projects
realized. The promise was: a more complete understanding of the
genes of the parasite (and its vector) would provide a rational basis
for the development of antimalariai drugs and vaccines, allow a better
understanding of the regulation of the complex life cycle in the red
blood and liver ceils of the human, identify the genes the parasite
uses to thwart the host immune response and the ways in which
the parasite evades cure by drug treatments, as well as leading to
more effective measures of
contro!
transmission. The hope was that
cracking the genetic code of Plasmodium and Anopheles would reveal
the biochemical Achilles heel of the parasite and its vector, leading
to the development of novel drugs and better methods of control,
and by finding the targets of protective immunity could result in the
manufacture of effective vaccines.
Through a historic approach, this book will allow for those new to the
field, or those with insufficient background in the sciences, to have
an easier entry point. Even scientists already working in the field may
better appreciate how discoveries made in the past can impact the
direction of future research.
|
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| id | DE-604.BV040754853 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-10T00:33:13Z |
| institution | BVB |
| isbn | 9781848169036 1848169035 |
| language | English |
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| spelling | Sherman, Irwin W. Verfasser aut The malaria genome projects promise, progress, and prospects Irwin W. Sherman London [u.a.] Imperial College Press 2012 XV, 372 S. txt rdacontent n rdamedia nc rdacarrier Malariamücke (DE-588)4168696-2 gnd rswk-swf Genomprojekt (DE-588)4324732-5 gnd rswk-swf Plasmodium vivax (DE-588)4725933-4 gnd rswk-swf Plasmodium falciparum (DE-588)4250521-5 gnd rswk-swf Plasmodium falciparum (DE-588)4250521-5 s Plasmodium vivax (DE-588)4725933-4 s Malariamücke (DE-588)4168696-2 s Genomprojekt (DE-588)4324732-5 s DE-604 Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025734541&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025734541&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
| spellingShingle | Sherman, Irwin W. The malaria genome projects promise, progress, and prospects Malariamücke (DE-588)4168696-2 gnd Genomprojekt (DE-588)4324732-5 gnd Plasmodium vivax (DE-588)4725933-4 gnd Plasmodium falciparum (DE-588)4250521-5 gnd |
| subject_GND | (DE-588)4168696-2 (DE-588)4324732-5 (DE-588)4725933-4 (DE-588)4250521-5 |
| title | The malaria genome projects promise, progress, and prospects |
| title_auth | The malaria genome projects promise, progress, and prospects |
| title_exact_search | The malaria genome projects promise, progress, and prospects |
| title_full | The malaria genome projects promise, progress, and prospects Irwin W. Sherman |
| title_fullStr | The malaria genome projects promise, progress, and prospects Irwin W. Sherman |
| title_full_unstemmed | The malaria genome projects promise, progress, and prospects Irwin W. Sherman |
| title_short | The malaria genome projects |
| title_sort | the malaria genome projects promise progress and prospects |
| title_sub | promise, progress, and prospects |
| topic | Malariamücke (DE-588)4168696-2 gnd Genomprojekt (DE-588)4324732-5 gnd Plasmodium vivax (DE-588)4725933-4 gnd Plasmodium falciparum (DE-588)4250521-5 gnd |
| topic_facet | Malariamücke Genomprojekt Plasmodium vivax Plasmodium falciparum |
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