Verfügbarkeit: Botulinum neurotoxins

Botulinum neurotoxins:

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Bibliographische Detailangaben
Format:	Elektronisch E-Book
Sprache:	English
Veröffentlicht:	Heidelberg [u.a.] Springer 2012
Schriftenreihe:	Current topics in microbiology and immunology 364
Schlagworte:	Botulinustoxin Arzneimittel Aufsatzsammlung
Online-Zugang:	FAN01 UBT01 Volltext Inhaltsverzeichnis Abstract
Beschreibung:	1 Online-Ressource
ISBN:	9783642335709
DOI:	10.1007/978-3-642-33570-9

Internformat

MARC


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Datensatz im Suchindex

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adam_text	BOTULINUM NEUROTOXINS / : 2013 TABLE OF CONTENTS / INHALTSVERZEICHNIS GENETIC DIVERSITY WITHIN CLOSTRIDIUM BOTULINUM SEROTYPES, BOTULINUM NEUROTOXIN GENE CLUSTERS AND TOXIN SUBTYPES ASSEMBLY AND FUNCTION OF THE BOTULINUM NEUROTOXIN PROGENITOR COMPLEX UPTAKE OF BOTULINUM NEUROTOXIN IN THE INTESTINE DOUBLE RECEPTOR ANCHORAGE OF BOTULINUM NEUROTOXINS ACCOUNTS FOR THEIR EXQUISITE NEUROSPECIFICITY THE ELUSIVE COMPASS OF CLOSTRIDIAL NEUROTOXINS: DECIDING WHEN AND WHERE TO GO? SYNCHRONIZED CHAPERONE FUNCTION OF BOTULINUM NEUROTOXIN DOMAINS MEDIATES LIGHT CHAIN TRANSLOCATION INTO NEURONS CLOSTRIDIAL NEUROTOXIN LIGHT CHAINS: DEVICES FOR SNARE CLEAVAGE MEDIATED BLOCKADE OF NEUROTRANSMISSION SYNAPTIC VESICLE PROTEINS: TARGETS AND ROUTES FOR BOTULINUM NEUROTOXINS PERSISTENCE OF BOTULINUM NEUROTOXIN INACTIVATION OF NERVE FUNCTION STRUCTURE-BASED DRUG DISCOVERY FOR BOTULINUM NEUROTOXINS COMPLEXITY OF BOTULINUM NEUROTOXINS: CHALLENGES FOR DETECTION TECHNOLOGY PROGRESS IN CELL BASED ASSAYS FOR BOTULINUM NEUROTOXIN DETECTION TRANSFORMING THE DOMAIN STRUCTURE OF BOTULINUM NEUROTOXINS INTO NOVEL THERAPEUTICS BOTULINUM TOXIN: APPLICATION, SAFETY, AND LIMITATIONS DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT. BOTULINUM NEUROTOXINS / : 2013 ABSTRACT / INHALTSTEXT BOTULINUM NEUROTOXINS ARE THE MOST TOXIC NATURAL SUBSTANCES AND REPRESENT A MAJOR THREAT TO THE POPULATION WHEN INTENTIONALLY RELEASED IN BIOTERRORIST ATTACKS. ON THE OTHER HAND, DURING THE PAST TWO DECADES BOTULINUM NEUROTOXINS HAVE BECOME ESTABLISHED AS INDISPENSABLE DRUGS FOR THE TREATMENT OF A VARIETY OF SEVERE NEUROLOGICAL DISORDERS. THE NEED FOR EFFICIENT COUNTERMEASURES AS WELL AS THE EXPANSION INTO ADDITIONAL FIELDS OF THERAPEUTIC APPLICATION, CALL FOR COMPREHENSIVE INFORMATION ON THE BOTULINUM NEUROTOXIN MOLECULES AND THEIR MODE OF ACTION. OUR KNOWLEDGE OF THIS SUBJECT HAS MADE GREAT STRIDES IN RECENT YEARS, SETTING THE STAGE FOR THE DEVELOPMENT OF NEW BOTULINUM NEUROTOXIN-BASED MOLECULES AND NOVEL APPLICATIONS. THIS BOOK REVIEWS THE CURRENT STATUS OF BASIC BOTULINUM NEUROTOXIN RESEARCH. THE FIRST PART DESCRIBES THE GENETIC VARIABILITY OF THE TOXIN-PRODUCING BACTERIA, AND SHEDS LIGHT ON EACH STEP FROM TOXIN INGESTION TO THE ABROGATION OF SYNAPTIC SIGNALING INCLUDING THE INTESTINAL PASSAGE AND ABSORPTION, NERVE CELL BINDING AND ENTRY, AND INTRACELLULAR SUBSTRATE CLEAVAGE. THE REMAINING CHAPTERS DETAIL PROGRESS MADE IN DETECTION METHODS FOR BOTULINUM NEUROTOXINS, THE DEVELOPMENT OF BOTULINUM NEUROTOXIN INHIBITORS, AND STRATEGIES TO REFINE THE NEUROTOXINS FOR FURTHER MEDICINAL APPLICATIONS BY MEANS OF RECOMBINANT TECHNOLOGIES DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
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spelling	Botulinum neurotoxins Andreas Rummel ... eds. Heidelberg [u.a.] Springer 2012 1 Online-Ressource txt rdacontent c rdamedia cr rdacarrier Current topics in microbiology and immunology 364 Botulinustoxin (DE-588)4273044-2 gnd rswk-swf Arzneimittel (DE-588)4003115-9 gnd rswk-swf 1\p (DE-588)4143413-4 Aufsatzsammlung gnd-content Botulinustoxin (DE-588)4273044-2 s Arzneimittel (DE-588)4003115-9 s 2\p DE-604 Rummel, Andreas 1973- Sonstige (DE-588)13200285X oth Erscheint auch als Druckausgabe 978-3-642-33569-3 Current topics in microbiology and immunology 364 (DE-604)BV022782309 364 https://doi.org/10.1007/978-3-642-33570-9 Verlag Volltext Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025732471&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025732471&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Abstract 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 2\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk
spellingShingle	Botulinum neurotoxins Current topics in microbiology and immunology Botulinustoxin (DE-588)4273044-2 gnd Arzneimittel (DE-588)4003115-9 gnd
subject_GND	(DE-588)4273044-2 (DE-588)4003115-9 (DE-588)4143413-4
title	Botulinum neurotoxins
title_auth	Botulinum neurotoxins
title_exact_search	Botulinum neurotoxins
title_full	Botulinum neurotoxins Andreas Rummel ... eds.
title_fullStr	Botulinum neurotoxins Andreas Rummel ... eds.
title_full_unstemmed	Botulinum neurotoxins Andreas Rummel ... eds.
title_short	Botulinum neurotoxins
title_sort	botulinum neurotoxins
topic	Botulinustoxin (DE-588)4273044-2 gnd Arzneimittel (DE-588)4003115-9 gnd
topic_facet	Botulinustoxin Arzneimittel Aufsatzsammlung
url	https://doi.org/10.1007/978-3-642-33570-9 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025732471&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025732471&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA
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