Verfügbarkeit: Prokaryotic toxin-antitoxins

Prokaryotic toxin-antitoxins:

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Bibliographische Detailangaben
Format:	Elektronisch E-Book
Sprache:	English
Veröffentlicht:	Berlin, Heidelberg Springer 2013
Schlagworte:	Biowissenschaften Life sciences Microbiology Cytology Microbial genetics Antitoxin Toxin Prokaryoten Gen Aufsatzsammlung
Online-Zugang:	FAN01 UBT01 Volltext Inhaltsverzeichnis Abstract
Beschreibung:	1 Online-Ressource
ISBN:	9783642332524 9783642332531
DOI:	10.1007/978-3-642-33253-1

Internformat

MARC


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Datensatz im Suchindex

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adam_text	PROKARYOTIC TOXIN-ANTITOXINS / : 2013 TABLE OF CONTENTS / INHALTSVERZEICHNIS INTRODUCTION TYPE I TOXIN – ANTITOXIN SYSTEMS: HOK/SOK AND FST NOVEL TYPE I TOXIN – ANTITOXIN SYSTEMS TYPE II TA LOCI: THE CCDAB AND PARDE FAMILIES TYPE II TA LOCI: THE RELBE FAMILY TYPE II TA LOCI: THE UNUSUAL MQSRA LOCUS TYPE II TA LOCI: THE MAZEF FAMILY TYPE II TA LOCI: VAPBC AND OTHER TA LOCI IN MYCOBACTERIA TYPE II TA LOCI: PHD DOC FAMILY TYPE II TA LOCI: THE FIC FAMILY TYPE II TA LOCI, HIPAB AND PERSISTERS TYPE II TA LOCI: ZETA/PEZT FAMILY TYPE II LOCI: PHYLOGENY TYPE III TA LOCI TA LOCI ENCODED BY PLASMIDS TA LOCI IN ARCHAEA TA LOCI IN MYCOBACTERIUM TUBERCULOSIS TA LOCI IN STREPTOCOCCUS PNEUMONIAE BIOTECHNOLOGICAL AND MEDICAL EXPLOITATIONS OF TA GENES AND THEIR COMPONENTS DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT. PROKARYOTIC TOXIN-ANTITOXINS / : 2013 ABSTRACT / INHALTSTEXT PROKARYOTIC TOXINS – ANTITOXINS PRESENTS THE FIRST COMPREHENSIVE OVERVIEW OF AN EXCITING AND RAPIDLY EXPANDING RESEARCH FIELD. TOXIN – ANTITOXIN (TA) GENES WERE FIRST IDENTIFIED ON PLASMIDS ALMOST 30 YEARS AGO. SINCE THEN IT HAS BECOME EVIDENT THAT TA GENES ARE HIGHLY ABUNDANT ON BOTH PLASMIDS AND CHROMOSOMES BELONGING TO THE BACTERIAL AND ARCHAEAL DOMAINS. TA GENES COME IN THREE VARIANTS, DEPENDING ON HOW THE ANTITOXIN WORKS. IN THE MOST COMMON TA GENES, CALLED TYPE II TA LOCI, THE ANTITOXINS ARE PROTEINS THAT COMBINE WITH AND NEUTRALIZE THE TOXINS. EVEN THOUGH THE TOXINS COME FROM AT LEAST 10 EVOLUTIONARY INDEPENDENT GENE FAMILIES THEY INHIBIT TRANSLATION AND INDUCE DORMANCY AND PERSISTENCE. THE TOXINS INHIBIT TRANSLATION USING DIFFERENT MOLECULAR MECHANISMS. FOR EXAMPLE, THE MOST COMMON TOXIN FAMILY, CALLED VAPC (VIRULENCE-ASSOCIATED PROTEIN), INHIBITS TRANSLATION BY CLEAVING INITIATOR TRNA.ANOTHER COMMON TOXIN FAMILY, CALLED RELE, INHIBITS TRANSLATION BY CLEAVING MESSENGER RNA POSITIONED AT THE RIBOSOME. RECENT DATABASE MINING REVEALED MORE THAN 10,000 SUCH TA LOCI IN 700 PROKARYOTIC ORGANISMS. REMARKABLY, IN SOME SPECIES, TA GENES HAVE UNDERGONE DRAMATIC EXPANSIONS. FOR EXAMPLE, THE HIGHLY PERSISTENT MAJOR HUMAN PATHOGEN MYCOBACTERIUM TUBERCULOSIS HAS ALMOST 100 TA LOCI BELONGING TO DIFFERENT GENE FAMILIES, WHEREAS ITS CLOSE RELATIVE M. LEPRAE HAS NONE. ALL SEQUENCED ARCHAEAL GENOMES TO DATE HAVE AT LEAST TWO TA LOCI AND THE THERMOPHILIC ARCHAEON SULFOLOBUS TOKODAII HAS 40 TA LOCI. THE CONSIDERABLE EXPANSION OF THE TA GENES IS A BIOLOGICAL MYSTERY BUT MAY BE RELATED TO THE BIOLOGICAL FUNCTION(S) OF TA GENES, A TOPIC THAT IS STILL HOTLY DEBATED. THE GENETIC ANALYSIS OF TA GENES IS HAMPERED BY THE MULTITUDE OF SEEMINGLY SIMILAR GENES WITHIN ONE PARTICULAR GENOME. HOWEVER, RECENT ANALYSIS WITH THE MODEL ORGANISM E.COLI REVEALED A BREAKTHROUGH INDICATING THAT TA GENES CONTRIBUTE CUMULATIVELY TO BACTERIAL PERSISTENCE. ALL KNOWN FREE-LIVING BACTERIA THAT FORM PERSISTERS, CELLS THAT SURVIVE ANTIBIOTICS AND OTHER ENVIRONMENTAL THREATS, CONTAIN TA GENES. TOGETHER, THESE GROUNDBREAKING OBSERVATIONS HAVE RAISED THE EXCITING POSSIBILITY THAT TA GENES ARE INVOLVED IN THE PERSISTENCE OF MANY BACTERIA, INCLUDING MAJOR HUMAN PATHOGENS SUCH AS M. TUBERCULOSIS. THE EXPANDING TA FIELD HAS AN EXCITING FUTURE AHEAD OF IT DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
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spelling	Prokaryotic toxin-antitoxins Kenn Gerdes, ed. Berlin, Heidelberg Springer 2013 1 Online-Ressource txt rdacontent c rdamedia cr rdacarrier Biowissenschaften Life sciences Microbiology Cytology Microbial genetics Antitoxin (DE-588)4336552-8 gnd rswk-swf Toxin (DE-588)4127018-6 gnd rswk-swf Prokaryoten (DE-588)4201051-2 gnd rswk-swf Gen (DE-588)4128987-0 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Prokaryoten (DE-588)4201051-2 s Toxin (DE-588)4127018-6 s Antitoxin (DE-588)4336552-8 s Gen (DE-588)4128987-0 s DE-604 Gerdes, Kenn Sonstige oth https://doi.org/10.1007/978-3-642-33253-1 Verlag Volltext Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025725732&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025725732&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Abstract
spellingShingle	Prokaryotic toxin-antitoxins Biowissenschaften Life sciences Microbiology Cytology Microbial genetics Antitoxin (DE-588)4336552-8 gnd Toxin (DE-588)4127018-6 gnd Prokaryoten (DE-588)4201051-2 gnd Gen (DE-588)4128987-0 gnd
subject_GND	(DE-588)4336552-8 (DE-588)4127018-6 (DE-588)4201051-2 (DE-588)4128987-0 (DE-588)4143413-4
title	Prokaryotic toxin-antitoxins
title_auth	Prokaryotic toxin-antitoxins
title_exact_search	Prokaryotic toxin-antitoxins
title_full	Prokaryotic toxin-antitoxins Kenn Gerdes, ed.
title_fullStr	Prokaryotic toxin-antitoxins Kenn Gerdes, ed.
title_full_unstemmed	Prokaryotic toxin-antitoxins Kenn Gerdes, ed.
title_short	Prokaryotic toxin-antitoxins
title_sort	prokaryotic toxin antitoxins
topic	Biowissenschaften Life sciences Microbiology Cytology Microbial genetics Antitoxin (DE-588)4336552-8 gnd Toxin (DE-588)4127018-6 gnd Prokaryoten (DE-588)4201051-2 gnd Gen (DE-588)4128987-0 gnd
topic_facet	Biowissenschaften Life sciences Microbiology Cytology Microbial genetics Antitoxin Toxin Prokaryoten Gen Aufsatzsammlung
url	https://doi.org/10.1007/978-3-642-33253-1 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025725732&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025725732&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA
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