The immunological barriers to regenerative medicine:
Gespeichert in:
| Format: | Elektronisch E-Book |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York, NY
Springer
2013
|
| Schriftenreihe: | Stem cell biology and regenerative medicine
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| Schlagworte: | |
| Online-Zugang: | FAN01 UBT01 Volltext Inhaltsverzeichnis Abstract |
| Beschreibung: | 1 Online-Ressource |
| ISBN: | 9781461454793 9781461454809 |
| DOI: | 10.1007/978-1-4614-5480-9 |
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Datensatz im Suchindex
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| adam_text | THE IMMUNOLOGICAL BARRIERS TO REGENERATIVE MEDICINE
/
: 2013
TABLE OF CONTENTS / INHALTSVERZEICHNIS
MECHANISMS OF IMMUNE REJECTION OF STEM CELL-DERIVED TISSUES: INSIGHTS
FROM ORGAN TRANSPLANTATION
THE IMMUNOGENICITY OF ES CELLS AND THEIR PROGENY
INTERACTION OF EMBRYONIC STEM CELLS WITH THE IMMUNE SYSTEM
THE ROLE OF NK CELLS AND T CELLS IN THE REJECTION OF EMBRYONIC STEM
CELL-DERIVED TISSUES
MITIGATING THE RISKS OF IMMUNOGENICITY IN THE PURSUIT OF INDUCED
PLURIPOTENCY
THYMIC INVOLUTION: A BARRIER OR OPPORTUNITY FOR CELL REPLACEMENT
THERAPY?
CONSTRUCTION OF STEM CELL BANKS: PROSPECTS FOR TISSUE MATCHING
GENERATION OF HISTOCOMPATIBLE TISSUES VIA PARTHENOGENESIS
PROSPECTS FOR DESIGNING ‘UNIVERSAL’ STEM CELL LINES
THE IMMUNOSUPPRESSIVE PROPERTIES OF ADULT STEM CELLS: MSC AS A CASE
STUDY
THE IMMUNOGENICITY OF STEM CELLS AND THYMUS-BASED STRATEGIES TO MINIMISE
IMMUNE REJECTION
THE INDUCTION OF MIXED CHIMERISM USING ES CELL-DERIVED HEMATOPOIETIC
STEM CELLS
PROSPECTS FOR THE INDUCTION OF TRANSPLANT TOLERANCE USING DENDRITIC
CELLS
STRATEGIES FOR THE INDUCTION OF TOLERANCE WITH MONOCLONAL ANTIBODIES
INDUCTION OF IMMUNOLOGICAL TOLERANCE TO TRANSGENE PRODUCTS
ADDRESSING THE CHALLENGE OF AUTOIMMUNITY IN THE TREATMENT OF DIABETES
WITH STEM CELLS
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
THE IMMUNOLOGICAL BARRIERS TO REGENERATIVE MEDICINE
/
: 2013
ABSTRACT / INHALTSTEXT
RECENT YEARS HAVE WITNESSED NUMEROUS ADVANCES IN STEM CELL RESEARCH THAT
HAVE SUGGESTED NOVEL STRATEGIES FOR THE TREATMENT OF THE CHRONIC AND
REGENERATIVE DISEASES THAT POSE A GROWING CHALLENGE TO THE PROVISION OF
HEALTHCARE IN THE 21ST CENTURY. NEVERTHELESS, THERE IS LITTLE DOUBT
THAT RELATED DISCIPLINES HAVE FAILED TO KEEP PACE WITH SUCH
DEVELOPMENTS, OF WHICH THE IMMUNOLOGY OF TRANSPLANT REJECTION IS PERHAPS
THE MOST RELEVANT TO THE NASCENT FIELD OF REGENERATIVE MEDICINE.
INDEED, GIVEN THAT AFTER DECADES OF RESEARCH INTO THE MECHANISMS OF
ORGAN ALLOGRAFT REJECTION, WE REMAIN WHOLLY DEPENDENT ON IMMUNE
SUPPRESSION TO ENSURE ACCEPTANCE OF FOREIGN TISSUES, WE MIGHT
LEGITIMATELY ASK WHETHER THERE IS ANY REASON WHY TISSUES DIFFERENTIATED
FROM STEM CELLS MIGHT NOT SUFFER THE SAME FATE. THIS VOLUME SEEKS TO
ADDRESS THIS ISSUE BY DRAWING ON THE PRINCIPLES OF ALLOANTIGEN
RECOGNITION TO ASSESS THE VALIDITY OF EARLY CONVICTIONS THAT EMBRYONIC
STEM CELL-DERIVED TISSUES MAY PROVE INVISIBLE TO THE IMMUNE SYSTEM OF
THE HOST AND THE MORE RECENT BELIEF THAT INDUCED PLURIPOTENT STEM CELLS,
DERIVED IN A FULLY AUTOLOGOUS MANNER, WILL CIRCUMVENT THE ISSUE OF
IMMUNOGENICITY. HAVING DEBUNKED SUCH ASSUMPTIONS AND ESTABLISHED THE
MAGNITUDE OF THE IMMUNOLOGICAL BARRIERS TO BE OVERCOME, THIS BOOK THEN
DRAWS ON THE EXPERTISE OF INTERNATIONALLY-RECOGNISED LABORATORIES AROUND
THE WORLD TO PROVIDE A CRITICAL ASSESSMENT OF THE LIKELY SUCCESS OF
APPLYING STRATEGIES SUCH AS STEM CELL BANKING, SILENCING OF GENES THAT
CONFER IMMUNOGENICITY, AND THE INDUCTION OF TRANSPLANTATION TOLERANCE TO
OVERCOMING THE IMMUNOLOGICAL BARRIERS IN THE FUTURE. INDEED, IT IS
ONLY THROUGH REACHING A CONSENSUS IN THE FIELD THAT ENDURING SOLUTIONS
TO SUCH AN INTRACTABLE PROBLEM MAY ULTIMATELY EMERGE
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
|
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| series2 | Stem cell biology and regenerative medicine |
| spelling | The immunological barriers to regenerative medicine Paul J. Fairchild, ed. New York, NY Springer 2013 1 Online-Ressource txt rdacontent c rdamedia cr rdacarrier Stem cell biology and regenerative medicine Biowissenschaften Life sciences Immunology Biotechnology Cytology Stem cells Fairchild, Paul J. Sonstige oth https://doi.org/10.1007/978-1-4614-5480-9 Verlag Volltext Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025725437&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025725437&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Abstract |
| spellingShingle | The immunological barriers to regenerative medicine Biowissenschaften Life sciences Immunology Biotechnology Cytology Stem cells |
| title | The immunological barriers to regenerative medicine |
| title_auth | The immunological barriers to regenerative medicine |
| title_exact_search | The immunological barriers to regenerative medicine |
| title_full | The immunological barriers to regenerative medicine Paul J. Fairchild, ed. |
| title_fullStr | The immunological barriers to regenerative medicine Paul J. Fairchild, ed. |
| title_full_unstemmed | The immunological barriers to regenerative medicine Paul J. Fairchild, ed. |
| title_short | The immunological barriers to regenerative medicine |
| title_sort | the immunological barriers to regenerative medicine |
| topic | Biowissenschaften Life sciences Immunology Biotechnology Cytology Stem cells |
| topic_facet | Biowissenschaften Life sciences Immunology Biotechnology Cytology Stem cells |
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