RNA interference from biology to therapeutics:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York [u.a.]
Springer
2013
|
| Schriftenreihe: | Advances in delivery science and technology
|
| Schlagworte: | |
| Online-Zugang: | https://doi.org/10.1007/978-1-4614-4744-3 Inhaltsverzeichnis Klappentext |
| Beschreibung: | XV, 337 p. 46 illus., 35 illus. in color Ill., graph. Darst. |
| ISBN: | 9781461447436 |
| DOI: | 10.1007/978-1-4614-4744-3 |
Internformat
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| 245 | 1 | 0 | |a RNA interference from biology to therapeutics |c Kenneth A. Howard, ed. |
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Datensatz im Suchindex
| _version_ | 1804150010835632128 |
|---|---|
| adam_text | Contents
1
RNA
Interference Pathways and Therapeutic Exploitation
............... 1
Jesper B.
Bramsen and Thomas B.
Hansen
2
Synthetic Dicer-Substrate siRNAs as Triggers
of
RNA
Interference
................................................................................ 31
Scott D. Rose and Mark A. Behlke
3
The Role of MicroRNAs in Natural Tissue Development
and Application in Regenerative Medicine
........................................... 57
Morten 0stergaard Andersen,
Philipp Dillschneider,
and J0rgen Kjems
4
Intracellular Delivery Considerations for RNAi
Therapeutics
............................................................................................ 79
Yu Zhu, Jing Li, and David
Oupický
5
Mucosal Delivery of RNAi Therapeutics
.............................................. 97
Borja
Bailarín González,
Ebbe Bech Nielsen,
Troeis
Bo Thomsen, and Kenneth A. Howard
6
Nanomedicines for Systemic Delivery of RNAi Therapeutics
............ 127
Dan Peer
7
Lipidoids: A Combinatorial Approach to siRN A Delivery
.................. 143
Michael Goldberg
8
Polymeric Micelles for siRNA Delivery
................................................. 161
Frederico
Pittella
and Kazunori Kataoka
9
RNAi Therapeutic Delivery by Exosomes
............................................ 185
Samira Lakhal, Samir El Andaloussi, Aisling J. O Loughlin,
Jinghuan Li, and Matthew M.J. Wood
10
Aptamer-Mediated siRN A Targeting
.................................................... 207
Jiehua Zhou and John J. Rossi
xii
Contents
11
RNAi as Antiviral Therapy: The HIV-1 Case
....................................... 221
Ben
Berkhout
and Julia
J.M. Eekels
12
Genome-Wide RNAi Screening to Identify Human
Host Factors Crucial for Influenza Virus Replication
......................... 243
Katharina
Ahrens and Alexander Karlas
13
The Application of MicroRNAs in Cancer Diagnostics
....................... 259
Karina
D.
S0rensen, Marie S.
Ostenfeld,
Dennis K. Jeppesen,
Helle Kristensen, Christa
Haldrup, and
Torben F.
0rntoft
14
Therapeutic Application of MicroRNAs in Cancer
............................. 299
Nobuyoshi
Kosáka,
Fumitaka Takeshita, Yusuke Yoshioka,
and Takahiro Ochiya
15
Preclinical and Clinical Studies Employing
RNA
Interference as a Therapeutic for Respiratory Syncytial
Virus
(RSV)
Infection in the Lung
........................................................ 315
Amy R. Simon,
Verena Karsten,
Rachel Meyers, Jeff Cehelsky,
Jared Gollob, Akshay Vaishnaw, and Sara Nochur
About the Editor
............................................................................................. 329
Index
................................................................................................................. 331
Advances in Delivery Science and Technology
Series Editor: Michael Rathbone
Kenneth A. Howard Editor
RNÄ
Interference from Biology to Therapeutics
The Nobel Prize winning discovery that small interfering
RNA
can be utilised to control
cellular gene expression has propelled the field of
RNA
interference (RNAi) to the
forefront of
biomedical
science as a potential molecular medicine set to revolutionalise
disease treatment.
Harnessing the molecular mechanisms of RNAi and development of delivery technologies
is crucial for its transformation into a therapeutic modality, this dependency is the focus
of R A
Interference
from Biology to Therapeutics that gives a comprehensive overview
of RNAi biology and state-of-the-art delivery methods relevant to clinical translation
of RNAi therapeutics.
Key players and shapers in the fields of RNAi and delivery science have been assembled
in a single volume to produce a truly unique interdisciplinary text, making it a must-
read for both students and experts in, and at the interface of, RNAi, pharmaceutical
science and medicine. An attractive feature is the future perspectives section within
each chapter that allows global leaders the opportunity to express their views on the
direction the field is moving. Topics covered in the book include miRNA biology and
therapeutic exploitation, exosome delivery and clinical translation.
RNA
Interference from Biology to Therapeutics is an up-to-the-minute, highly informative
and invaluable text for those actively involved or interested in this fascinating and
high-impact field.
Kenneth Alan Howard is an Associate Professor and Group Leader at the Department
of Molecular Biology at the Interdisciplinary Nanoscience Center
(¡NANO),
Aarhus
University, Denmark. His team is based in a highly interdisciplinary setting with
research and teaching activities focused on advanced drug delivery, nanomedicine,
RNA
interference, and inflammation.
Dr
Howard is CEO ot an Aarhus University spin-out
company that provides delivery solutions
for RNA
interference-based therapeutics.
Kenneth Alan Howard received a PhD in Pharmaceutical Science
trom
the University
of Nottingham, UK in
1995,
and has held postdoctoral positions at the
CRC
institute for
Cancer Studies,
Universit}
of Birmi ngham, UK and the School of Pharmacy, University
of London.
Dr
Howard is an active member of the Controlled Release Society serving
on the Board of Scientific Advisors (chair). Nominations Committee and organizer of
a CRS Educational workshop
RNA
Interference Biology and Therapeutics .
|
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| language | English |
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| physical | XV, 337 p. 46 illus., 35 illus. in color Ill., graph. Darst. |
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| series2 | Advances in delivery science and technology |
| spelling | RNA interference from biology to therapeutics Kenneth A. Howard, ed. New York [u.a.] Springer 2013 XV, 337 p. 46 illus., 35 illus. in color Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Advances in delivery science and technology Medizin Medicine Pharmaceutical technology RNS-Interferenz (DE-588)4802706-6 gnd rswk-swf RNS-Interferenz (DE-588)4802706-6 s b DE-604 Howard, Kenneth A. Sonstige oth Erscheint auch als Online-Ausgabe 978-1-4614-4744-3 https://doi.org/10.1007/978-1-4614-4744-3 Resolving-System Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025686492&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025686492&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
| spellingShingle | RNA interference from biology to therapeutics Medizin Medicine Pharmaceutical technology RNS-Interferenz (DE-588)4802706-6 gnd |
| subject_GND | (DE-588)4802706-6 |
| title | RNA interference from biology to therapeutics |
| title_auth | RNA interference from biology to therapeutics |
| title_exact_search | RNA interference from biology to therapeutics |
| title_full | RNA interference from biology to therapeutics Kenneth A. Howard, ed. |
| title_fullStr | RNA interference from biology to therapeutics Kenneth A. Howard, ed. |
| title_full_unstemmed | RNA interference from biology to therapeutics Kenneth A. Howard, ed. |
| title_short | RNA interference from biology to therapeutics |
| title_sort | rna interference from biology to therapeutics |
| topic | Medizin Medicine Pharmaceutical technology RNS-Interferenz (DE-588)4802706-6 gnd |
| topic_facet | Medizin Medicine Pharmaceutical technology RNS-Interferenz |
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