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siRNA design: methods and protocols

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Bibliographische Detailangaben
Format:	Buch
Sprache:	English
Veröffentlicht:	New York [u.a.] Humana Press, Springer 2013
Schriftenreihe:	Methods in molecular biology 942
Schlagworte:	Small interfering RNA RNA, Small Interfering > genetics > Laboratory Manuals Gene Silencing > Laboratory Manuals Gene Targeting > methods > Laboratory Manuals Silencer Molekulardesign RNS-Interferenz Methode Laboratory Manuals
Online-Zugang:	Inhaltsverzeichnis
Beschreibung:	Includes bibliographical references and index
Beschreibung:	XIII, 392 S. Ill., graph. Darst.
ISBN:	9781627031189

Internformat

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Datensatz im Suchindex

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adam_text	Titel: siRNA design Autor: Taxman, Debra J Jahr: 2013 Contents Preface.............................................................. v Contributors.......................................................... xi 1 What Parameters to Consider and Which Software Tools to Use for Target Selection and Molecular Design of Small Interfering RNAs....... 1 Olga Matveeva 2 Methods for Selecting Effective siRNA Target Sequences Using a Variety of Statistical and Analytical Techniques....................... 17 Shigeru Takasaki 3 Designing Functional siRNA with Reduced Off-Target Effects............ 57 Tuki Naito and Kumiko Ui-Tei 4 Design and Screening of siRNAs Against Highly Structured RNA Targets......................................... 69 Neda Nasheri, John Paul Pezacki, and Selena M. Sagan 5 Engineering Small Interfering RNAs by Strategic Chemical Modification.......................................... 87 Jesper B. Bramsen andj$rgen Kjems 6 The Design, Selection, and Evaluation of Highly Specific and Functional siRNA Incorporating Unlocked Nucleobase Analogs........ Ill Narendra Vaish and Pinky Agarwal 7 The Design, Preparation, and Evaluation of Asymmetric Small Interfering RNA for Specific Gene Silencing in Mammalian Cells.......... 135 Chanil Chang, Sun Woo Hong, Pooja Dua, Soyoun Kim, and Dong-ki Lee 8 Design of Nuclease-Resistant Fork-Like Small Interfering RNA (fsiRNA)................................................ 153 Elena L. Chemolovskaya and Marina A. Zenkova 9 Designing Dual-Targeting siRNA Duplexes Having Two Active Strands that Combine siRNA and MicroRNA-Like Targeting............. 169 Pal S trom 10 Strategies for Designing and Validating Immunostimulatory siRNAs........ 179 Michael P. Gantier 11 Designing Efficient and Specific Endoribonuclease-Prepared siRNAs........ 193 Vineeth Surendranath, Mirko Theis, Bianca H Habermann, and Frank Buchholz 12 Short Hairpin RNA-Mediated Gene Silencing......................... 205 Luke S. Lambeth and Craig A. Smith IX x Contents 13 Design of Lentivirally Expressed siRNAs............................. 233 Ting Poi Liu and Ben Berkhout 14 Bifunctional Short Hairpin RNA (bi-shRNA): Design and Pathway to Clinical Application........................................... 259 Donald D. Rao, Neil Senzer, Zhaohui Wang, Padmasini Kumar, Chris M. Jay, and John Nemunaitis 15 Design and Chemical Modification of Synthetic Short shRNAs as Potent RNAi Triggers......................................... 279 Anne Dallas and Brian H. Johnston 16 Production and Application of Long dsRNAin Mammalian Cells.......... 291 Katerina Chalupnikova, Jana Nejepinska, and Petr Svoboda 17 Design of RNAi Reagents for Invertebrate Model Organisms and Human Disease Vectors...................................... 315 Thomas Horn and Michael Boutros 18 Construction of shRNA Expression Plasmids for Silkworm Cell Lines Using Single-Stranded DNA and JSxtDNA Polymerase.............. 347 Hiromitsu Tanaka 19 Designing Effective amiRNA and Multimeric amiRNA Against Plant Viruses.................................... 357 Muhammad Fahim and Philip J. Larkin 20 Downregulation of Plant Genes with miRNA-Induced Gene Silencing...... 379 Felipe Fenselau de Felippes Index........................................................... 389
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spelling	siRNA design methods and protocols ed. by Debra J. Taxman New York [u.a.] Humana Press, Springer 2013 XIII, 392 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Methods in molecular biology 942 Springer protocols Includes bibliographical references and index Small interfering RNA RNA, Small Interfering genetics Laboratory Manuals Gene Silencing Laboratory Manuals Gene Targeting methods Laboratory Manuals Silencer (DE-588)4378881-6 gnd rswk-swf Molekulardesign (DE-588)4265444-0 gnd rswk-swf RNS-Interferenz (DE-588)4802706-6 gnd rswk-swf Methode (DE-588)4038971-6 gnd rswk-swf Laboratory Manuals RNS-Interferenz (DE-588)4802706-6 s Silencer (DE-588)4378881-6 s Molekulardesign (DE-588)4265444-0 s Methode (DE-588)4038971-6 s b DE-604 Taxman, Debra J. Sonstige oth Erscheint auch als Online-Ausgabe 978-1-62703-119-6 Methods in molecular biology 942 (DE-604)BV035362695 942 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025681866&sequence=000004&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis
spellingShingle	siRNA design methods and protocols Methods in molecular biology Small interfering RNA RNA, Small Interfering genetics Laboratory Manuals Gene Silencing Laboratory Manuals Gene Targeting methods Laboratory Manuals Silencer (DE-588)4378881-6 gnd Molekulardesign (DE-588)4265444-0 gnd RNS-Interferenz (DE-588)4802706-6 gnd Methode (DE-588)4038971-6 gnd
subject_GND	(DE-588)4378881-6 (DE-588)4265444-0 (DE-588)4802706-6 (DE-588)4038971-6
title	siRNA design methods and protocols
title_auth	siRNA design methods and protocols
title_exact_search	siRNA design methods and protocols
title_full	siRNA design methods and protocols ed. by Debra J. Taxman
title_fullStr	siRNA design methods and protocols ed. by Debra J. Taxman
title_full_unstemmed	siRNA design methods and protocols ed. by Debra J. Taxman
title_short	siRNA design
title_sort	sirna design methods and protocols
title_sub	methods and protocols
topic	Small interfering RNA RNA, Small Interfering genetics Laboratory Manuals Gene Silencing Laboratory Manuals Gene Targeting methods Laboratory Manuals Silencer (DE-588)4378881-6 gnd Molekulardesign (DE-588)4265444-0 gnd RNS-Interferenz (DE-588)4802706-6 gnd Methode (DE-588)4038971-6 gnd
topic_facet	Small interfering RNA RNA, Small Interfering genetics Laboratory Manuals Gene Silencing Laboratory Manuals Gene Targeting methods Laboratory Manuals Silencer Molekulardesign RNS-Interferenz Methode
url	http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025681866&sequence=000004&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
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