The role of sphingolipids in cancer development and therapy:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Amsterdam [u.a.]
Elsevier
2013
|
| Ausgabe: | 1. ed. |
| Schriftenreihe: | Advances in cancer research
117 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Einzelaufn. für Zeitschr.-H. |
| Beschreibung: | XVII, 288 S. graph. Darst. |
| ISBN: | 9780123942746 |
Internformat
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| 100 | 1 | |a Norris, James S. |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a The role of sphingolipids in cancer development and therapy |c vol. ed.: James Norris |
| 250 | |a 1. ed. | ||
| 264 | 1 | |a Amsterdam [u.a.] |b Elsevier |c 2013 | |
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| 490 | 0 | |a Advances in cancer research |v 117 | |
| 500 | |a Einzelaufn. für Zeitschr.-H. | ||
| 650 | 4 | |a Cancer / Etiology | |
| 650 | 4 | |a Cancer / Chemotherapy | |
| 650 | 4 | |a Sphingolipids | |
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Datensatz im Suchindex
| _version_ | 1804149988709629952 |
|---|---|
| adam_text | Titel: The role of sphingolipids in cancer development and therapy
Autor: Norris, James S
Jahr: 2013
CONTENTS
Contributors ix
Preface xiii
1. Interdiction of Sphingolipid Metabolism to Improve Standard
Cancer Therapies 1
Thomas H. Beckham, Joseph C. Cheng, S. Tucker Marrison, James S. Norris,
and Xiang Liu
1. Introduction 2
2. Sphingolipids and Cytotoxic Chemotherapies 7
3. Sphingolipids and Radiation Therapy 13
4. Sphingolipids and Targeted Anticancer Agents 21
5. Concluding Remarks 26
References 27
2. Diverse Functions of Ceramide in Cancer Cell Death
and Proliferation 37
Sahar A. Saddoughi and Besim Ogretmen
1. Structure and Metabolism of Ceramide 38
2. Distinct Functions of CerSI-6 39
3. Novel Ceramide-Protein Interactions That Regulate Ceramide Metabolism
and Signaling 42
4. Clinical Relevance of Ceramide Metabolism and Signaling in Cancer
Pathogenesis, Therapy, or Drug Resistance 45
5. Ceramide/Sphingosine-Based Anticancer Therapeutics 47
6. Conclusions 51
Acknowledgments 52
References 52
3. Ceramide Glycosylation Catalyzed by Glucosylceramide
Synthase and Cancer Drug Resistance 59
Yong-Yu Liu, Ronald A. Hill, and Yu-Teh Li
1. Introduction 60
2. Ceramide Glycosylation and GEMs 62
3. Ceramide Glycosylation and Cancer Drug Resistance 69
4. Targeting Ceramide Glycosylation to Reverse Drug Resistance 77
vi Contents
5. Prospective 80
Acknowledgments 81
References 81
4. Use of Acid Sphingomyelinase for Cancer Therapy 91
Radoslav Savic and Edward H. Schuchman
1. Introduction 92
2. Involvement of ASM in Stress Response, Apoptosis, and
Cancer Cell Resistance 95
3. Use of Exogenous ASM as an Adjunct in Cancer Therapy 101
4. Conclusions and Future Directions 107
Acknowledgments 108
References 108
5. Hypoxia, Therapeutic Resistance, and Sphingosine 1-Phosphate 117
Olivier Cuvillier, Isabelle Ader, Pierre Bouquerel, Leyre Brizuela,
Cécile Gstalder, and Bernard Malavaud
1. The Hypoxia-inducible Factors Family: Regulation, Role in Cancer and
Therapeutic Implication 118
2. What Does Sphingosine 1-Phosphate Signaling Have to Do with Hypoxia? 121
3. Sphingosine 1-Phosphate Signaling as a Target for AntiHypoxic Strategy? 129
4. Concluding Remarks 131
Acknowledgments 132
References 132
6. Therapeutic Potential of Targeting SKI in Human Cancers 143
Heba Alshaker, Lysann Sauer, Danielle Monteil, Silvia Ottaviani,
Shyam Srivats, Torsten Böhler, and Dmitri Pchejetski
1. Introduction to Sphingolipid Metabolism 144
2. Sphingosine Kinase: A Regulator of the Sphingolipid Signaling 152
3. Role of SKI in Cancer Progression 161
4. Therapeutic Potential of SKI Inhibition 166
5. FTY720: A Novel Clinically Applicable SKI Inhibitor 171
6. Conclusions and Clinical Perspective 175
References 181
Contents
vii
7. Sphingosine Kinase 1 in Cancer 201
Linda A. Heffernan-Stroud and Lina M. Obeid
1. Introduction 202
2. SK1 is an oncogene 205
3. SK1/S1P signals for tumor growth and spread 220
4. Conclusion 224
Acknowledgments 224
References 224
8. Natural Products as Platforms for the Design of
Sphingolipid-Related Anticancer Agents 237
Antonio Delgado, Gemma Fabriàs, Josefina Casas, and José Luis Abad
1. The Role of Sphingolipids in Cancer 238
2. Fungal Metabolites as Inhibitors of SL Biosynthesis 243
3. Deoxysphingolipids of Marine Origin 256
4. Jaspine B, a Marine Heterocyclic Sphingoid 260
5. Other Heterocyclic Natural Sphingoids 262
6. oc-Galactosylceramides and Structural Modifications Thereof 264
7. Concluding Remarks 267
Acknowledgments 268
References 268
Index
283
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| series2 | Advances in cancer research |
| spelling | Norris, James S. Verfasser aut The role of sphingolipids in cancer development and therapy vol. ed.: James Norris 1. ed. Amsterdam [u.a.] Elsevier 2013 XVII, 288 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Advances in cancer research 117 Einzelaufn. für Zeitschr.-H. Cancer / Etiology Cancer / Chemotherapy Sphingolipids HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025671616&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Norris, James S. The role of sphingolipids in cancer development and therapy Cancer / Etiology Cancer / Chemotherapy Sphingolipids |
| title | The role of sphingolipids in cancer development and therapy |
| title_auth | The role of sphingolipids in cancer development and therapy |
| title_exact_search | The role of sphingolipids in cancer development and therapy |
| title_full | The role of sphingolipids in cancer development and therapy vol. ed.: James Norris |
| title_fullStr | The role of sphingolipids in cancer development and therapy vol. ed.: James Norris |
| title_full_unstemmed | The role of sphingolipids in cancer development and therapy vol. ed.: James Norris |
| title_short | The role of sphingolipids in cancer development and therapy |
| title_sort | the role of sphingolipids in cancer development and therapy |
| topic | Cancer / Etiology Cancer / Chemotherapy Sphingolipids |
| topic_facet | Cancer / Etiology Cancer / Chemotherapy Sphingolipids |
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