TRIM, RBCC proteins:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York, NY
Springer Science + Business Media, LLC
2012
|
| Schriftenreihe: | Advances in experimental medicine and biology
770 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Includes bibliographical references and index Genomics and evolution of the TRIM gene family / Germana Meroni -- The tripartite motif : structure and function / Lucia Micale ... [et al.] -- TRIM proteins as ring finger E3 ubiquitin ligases / Kazuhiro Ikeda and Satoshi Inoue -- PML nuclear bodies and other TRIM-defined subcellular compartments / Elizabeth C. Batty, Kirsten Jensen, and Paul S. Freemont -- TRIM involvement in transcriptional regulation / Florence Cammas ... [et al.] -- TRIM proteins in cancer / Valeria Cambiaghi ... [et al.] -- TRIM proteins and the innate immune response to viruses / Melvyn W. Yap and Jonathan P. Stoye -- The microtubule-associated C-I subfamily of TRIM proteins and the regulation of polarized cell responses / Timothy C. Cox -- MuRFS : specialized members of the TRIM/RBCC family with roles in the regulation of the trophic state of muscle and its metabolism / Olga Mayans and Siegfried Labeit -- Trim proteins in development / Francesca Petrera and Germana Meroni |
| Beschreibung: | XIX, 145 S. Ill., graph. Darst. |
| ISBN: | 9781461453970 1461453976 |
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| 490 | 1 | |a Advances in experimental medicine and biology |v 770 | |
| 500 | |a Includes bibliographical references and index | ||
| 500 | |a Genomics and evolution of the TRIM gene family / Germana Meroni -- The tripartite motif : structure and function / Lucia Micale ... [et al.] -- TRIM proteins as ring finger E3 ubiquitin ligases / Kazuhiro Ikeda and Satoshi Inoue -- PML nuclear bodies and other TRIM-defined subcellular compartments / Elizabeth C. Batty, Kirsten Jensen, and Paul S. Freemont -- TRIM involvement in transcriptional regulation / Florence Cammas ... [et al.] -- TRIM proteins in cancer / Valeria Cambiaghi ... [et al.] -- TRIM proteins and the innate immune response to viruses / Melvyn W. Yap and Jonathan P. Stoye -- The microtubule-associated C-I subfamily of TRIM proteins and the regulation of polarized cell responses / Timothy C. Cox -- MuRFS : specialized members of the TRIM/RBCC family with roles in the regulation of the trophic state of muscle and its metabolism / Olga Mayans and Siegfried Labeit -- Trim proteins in development / Francesca Petrera and Germana Meroni | ||
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Datensatz im Suchindex
| _version_ | 1804149988343676929 |
|---|---|
| adam_text | Titel: TRIM, RBCC proteins
Autor: Meroni, Germana
Jahr: 2012
CONTENTS
1. GENOMICS AND EVOLUTION OF THE TRIM GENE FAMILY...................1
Germana Meroni
Abstract.........................................................................................................................................1
Introduction..................................................................................................................................1
The Human TRIM Family..........................................................................................................2
TRIM Family Evolution..............................................................................................................6
Conclusion....................................................................................................................................8
2. THE TRIPARTITE MOTIF: STRUCTURE AND FUNCTION.......................11
Lucia Micale, Evelyne Chaignat, Carmela Fusco, Alexandre Reymond
and Giuseppe Merla
Abstract.......................................................................................................................................11
Introduction................................................................................................................................11
The Tripartite Motif...................................................................................................................12
C-Terminal Region.....................................................................................................................18
Conclusion..................................................................................................................................21
3. TRIM PROTEINS AS RING FINGER E3 UBIQUITIN LIGASES..................27
Kazuhiro Ikeda and Satoshi Inoue
Abstract.......................................................................................................................................27
Introduction................................................................................................................................27
TRIM Proteins Are Involved in Protein Modification Pathway by Ubiquitin.....................28
Efp/TRIM25 Functions as E3 Ligase for Both Ubiquitination and ISGylation...................29
E3 Ubiquitin Ligases in TRIM/RBCC Proteins......................................................................31
Conclusion..................................................................................................................................34
XV
xvi CONTENTS
4. PML NUCLEAR BODIES AND OTHER TRIM-DEFINED
SUBCELLULAR COMPARTMENTS.........................................................39
Elizabeth C. Batty, Kirsten Jensen and Paul S. Freemont
Abstract.......................................................................................................................................39
Introduction........----------------................___________________......._____________.............----------------...........------...39
PML Nuclear Bodies and Associated Proteins........................................................................42
The Tripartite Motif in PML.....................................................................................................43
The Formation and Dissolution of PML Nuclear Bodies.......................................................44
PML Nuclear Body Dynamics—Number, Movement and Morphology...............................44
Isoforms of PML Protein...........................................................................................................46
PML Nuclear Bodies and Disease.............................................................................................47
Nuclear Compartments Sharing Associations with PML Nuclear Bodies............................48
TRIM Proteins That Localise to PML Nuclear Bodies...........................................................50
Other TRIM-Defined Subcellular Compartments..................................................................52
Conclusion..................................................................................................................................53
5. TRIM INVOLVEMENT IN TRANSCRIPTIONAL REGULATION...............59
Florence Cammas, Konstantin Khetchoumian, Pierre Chambon
and Régine Losson
Abstract.......................................................................................................................................59
Introduction................................................................................................................................59
The TIFI Family Proteins in Gene-Specific Regulation.........................................................60
PML/TRIM19 in the Control of Transcription.......................................................................65
RFP/TRIM27 in the Control of Transcription........................................................................67
Other TRIM Family Members in Transcriptional Regulation..............................................71
Conclusion..................................................................................................................................72
6. TRIM PROTEINS IN CANCER...........................................................................77
Valeria Cambiaghi, Virginia Giuliani, Sara Lombardi, Cristiano Marinelli,
Francesca Toffalorio and Pier Giuseppe Pelicci
Abstract.......................................................................................................................................77
Introduction................................................................................................................................77
TRIM Proteins in Chromosomal Translocations....................................................................78
TRIM Proteins as E3-Ub Ligases.............................................................................................84
TRIM Proteins with Tumour Suppressor Functions or Involvement
in p53 Pathways..................................................................................................................86
Conclusion..................................................................................................................................87
7. TRIM PROTEINS AND THE INNATE IMMUNE
RESPONSE TO VIRUSES.............................................................................93
Melvyn W. Yap and Jonathan P. Stoye
Abstract.......................................................................................................................................93
Introduction................................................................................................................................93
CONTENTS xvii
TRIM25 and Interferon ß Induction........................................................................................94
TRIM22 and Inhibition of HIV-1 Production.........................................................................95
TRIM 28 and Retroviral Silencing...........................................................................................96
TRIM5 and Retroviral Restriction...........................................................................................97
Other TRIMs Associated with Viral Resistance......................................................................98
TRIM Proteins That Negatively Regulate the Innate Immune Response............................98
Discussion and Conclusion........................................................................................................99
8. THE MICROTUBULE-ASSOCIATED C-I SUBFAMILY
OF TRIM PROTEINS AND THE REGULATION
OF POLARIZED CELL RESPONSES......................................................105
Timothy C. Cox
Abstract.....................................................................................................................................105
Introduction..............................................................................................................................105
MID1/TRIM18.........................................................................................................................106
MID2/TRIM1...........................................................................................................................107
TRIM9.......................................................................................................................................112
TRIM36/Haprin.......................................................................................................................114
TRIFIC7TRIM46 and TNL/TRIM67.....................................................................................115
Conclusion................................................................................................................................115
9. MuRFS: SPECIALIZED MEMBERS OF THE TRIM/RBCC FAMILY
WITH ROLES IN THE REGULATION OF THE TROPHIC
STATE OF MUSCLE AND ITS METABOLISM......................................119
Olga Mayans and Siegfried Laheit
Abstract.....................................................................................................................................119
Introduction: Skeletal Muscle Plasticity and MuRFs...........................................................119
Discovery and Conserved Features of the MuRF Gene Family..........................................120
The Molecular Structure of MuRFs.......................................................................................122
Physiological Roles and Cellular Targets of MuRFl............................................................124
Outlook: Emerging Concepts on the Regulation of the Tïopic State of Myocytes
and Their Metabolism by Ubiquitin Ligases.................................................................126
Conclusion................................................................................................................................128
10. TRIM PROTEINS IN DEVELOPMENT.........................................................131
Francesca Petrera and Germana Meroni
Abstract.....................................................................................................................................131
Introduction..............................................................................................................................131
The TRIM-NHL Protein Group.............................................................................................132
The TRIM-FN3 Protein Group...............................................................................................135
Other TRIM Proteins Involved in Developmental Processes...............................................138
Conclusion................................................................................................................................138
INDEX,
143
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| genre_facet | Aufsatzsammlung |
| id | DE-604.BV040690600 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T00:31:46Z |
| institution | BVB |
| isbn | 9781461453970 1461453976 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-025671377 |
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| physical | XIX, 145 S. Ill., graph. Darst. |
| publishDate | 2012 |
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| publisher | Springer Science + Business Media, LLC |
| record_format | marc |
| series | Advances in experimental medicine and biology |
| series2 | Advances in experimental medicine and biology |
| spelling | TRIM, RBCC proteins ed. by Germana Meroni New York, NY Springer Science + Business Media, LLC 2012 XIX, 145 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Advances in experimental medicine and biology 770 Includes bibliographical references and index Genomics and evolution of the TRIM gene family / Germana Meroni -- The tripartite motif : structure and function / Lucia Micale ... [et al.] -- TRIM proteins as ring finger E3 ubiquitin ligases / Kazuhiro Ikeda and Satoshi Inoue -- PML nuclear bodies and other TRIM-defined subcellular compartments / Elizabeth C. Batty, Kirsten Jensen, and Paul S. Freemont -- TRIM involvement in transcriptional regulation / Florence Cammas ... [et al.] -- TRIM proteins in cancer / Valeria Cambiaghi ... [et al.] -- TRIM proteins and the innate immune response to viruses / Melvyn W. Yap and Jonathan P. Stoye -- The microtubule-associated C-I subfamily of TRIM proteins and the regulation of polarized cell responses / Timothy C. Cox -- MuRFS : specialized members of the TRIM/RBCC family with roles in the regulation of the trophic state of muscle and its metabolism / Olga Mayans and Siegfried Labeit -- Trim proteins in development / Francesca Petrera and Germana Meroni Carrier Proteins Carrier-Proteine (DE-588)4213127-3 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Carrier-Proteine (DE-588)4213127-3 s b DE-604 Meroni, Germana Sonstige oth Advances in experimental medicine and biology 770 (DE-604)BV000003102 770 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025671377&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | TRIM, RBCC proteins Advances in experimental medicine and biology Carrier Proteins Carrier-Proteine (DE-588)4213127-3 gnd |
| subject_GND | (DE-588)4213127-3 (DE-588)4143413-4 |
| title | TRIM, RBCC proteins |
| title_auth | TRIM, RBCC proteins |
| title_exact_search | TRIM, RBCC proteins |
| title_full | TRIM, RBCC proteins ed. by Germana Meroni |
| title_fullStr | TRIM, RBCC proteins ed. by Germana Meroni |
| title_full_unstemmed | TRIM, RBCC proteins ed. by Germana Meroni |
| title_short | TRIM, RBCC proteins |
| title_sort | trim rbcc proteins |
| topic | Carrier Proteins Carrier-Proteine (DE-588)4213127-3 gnd |
| topic_facet | Carrier Proteins Carrier-Proteine Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025671377&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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