Sodium calcium exchange: a growing spectrum of pathophysiological implications ; proceedings of the 6th International Conference on Sodium Calcium Exchange
Gespeichert in:
| Format: | Tagungsbericht Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York [u.a.]
Springer
2013
|
| Schriftenreihe: | Advances in experimental medicine and biology
961 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Klappentext |
| Beschreibung: | Conference proceedings |
| Beschreibung: | XXIV, 463 S. Ill., graph. Darst |
| ISBN: | 9781461447559 1461447550 9781461447566 |
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| 245 | 1 | 0 | |a Sodium calcium exchange |b a growing spectrum of pathophysiological implications ; proceedings of the 6th International Conference on Sodium Calcium Exchange |c Lucio Annunziato ed. |
| 264 | 1 | |a New York [u.a.] |b Springer |c 2013 | |
| 300 | |a XXIV, 463 S. |b Ill., graph. Darst | ||
| 336 | |b txt |2 rdacontent | ||
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| 653 | |a Sodium channels--Congresses. | ||
| 653 | |a Calcium channels--Congresses. | ||
| 653 | |a Sodium cotransport systems--Congresses. | ||
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Datensatz im Suchindex
| _version_ | 1804149988163321856 |
|---|---|
| adam_text | Contents
Part I Historical Perspective
1
Livin
with NCX and
Lovin
It: A
45
Year Romance
................ 3
Mordecai P.
Blaustein
2 20
Years from NCX Purification and Cloning:
Milestones
..................................................................................... 17
Debora A. Nicoli,
Michela
Ottolia, Joshua I. Goldhaber,
and Kenneth D. Philipson
Part II Structural and Functional Aspects of NCX
3
Ca2+ Regulation in the Na+/Ca2+ Exchanger Features
a Dual Electrostatic Switch Mechanism
..................................... 27
Mark Hilge
4
Molecular Determinants of AUosteric Regulation
in NCX Proteins
........................................................................... 35
Moshe
Giladi and Daniel Khananshvili
5
NCX1: Mechanism of Transport
................................................ 49
Michela
Ottolia and Kenneth D. Philipson
6
Structural Studies of the Ca2+ Regulatory Domain
of
Drosophila
Na7Ca2+ Exchanger CALX
................................. 55
Lei Zheng, Mousheng Wu, and Shuilong
Tong
7
Interplay of Ca2+ and Mg2+ in Sodium-Calcium
Exchanger and in Other Ca^-Binding Proteins:
Magnesium, Watchdog That Blocks Each Turn if Able
........... 65
Dmitri O. Levitsky and Masayuki Takahashi
Part III Structural and Functional Aspects of NCKX
8
Functional and Structural Properties of the NCKX2
Na+-Ca2VK+ Exchanger: A Comparison with the NCX1
Na+/Ca2+ Exchanger
..................................................................... 81
Haider F.
Altimimi,
Robert T.
Szerencsei,
and Paul P.M. Schnetkamp
Contents
9 NCKX5,
a Natural Regulator of Human Skin Colour
Variation, Regulates the Expression of Key Pigment
Genes MC1R and Alpha-MSH and Alters Cholesterol
Homeostasis in Normal Human Melanocytes
............................ 95
Stephen Wilson, Rebecca S. Ginger, Tony Dadd, David Gunn,
Fei-Ling Lim, Magdalena
Sawicka,
Melanie
Sandel,
Paul P.M. Schnetkamp, and Martin R. Green
10
Expression and Regulation of Sodium/Calcium
Exchangers, NCX and NCKX, in Reproductive Tissues:
Do They Play a Critical Role in Calcium Transport
for Reproduction and Development?
......................................... 109
Hyun Yang, Kyung-Chul Choi, Eui-Man Jung,
Beum-Soo An, Sang-Hwan Hyun, and Eui-Bae Jeung
Part IV Genetic and Epigenetic Regulation
11
Transcriptional Pathways and Potential Therapeutic
Targets in the Regulation of Ncxl Expression
in Cardiac Hypertrophy and Failure
......................................... 125
Donald R. Menick,
Mona
S.
Li,
Olga Chernysh,
Ludivine
Renaud, Denise Kimbrough,
Harinath Kasiganesan, and Santhosh K.
Mani
12 Transcriptional Regulation
of ncxl Gene in the Brain.............
137
Valeria
Valsecchi, Giuseppe Pignataro, Rossana Sirabella,
Carmela
Matrone, Francesca Boscia, Antonella Scorziello,
Maria Jose Sisalli,
Elga Esposito,
Nicola Zambrano,
Mauro Cataldi, Gianfranco Di Renzo,
and Lucio Annunziato
Part
V Regulatory Mechanisms of NCX
13 Metabolie Regulation
of the Squid
Nerve Na+/Ca2+
Exchanger: Recent
Developments.............................................. 149
Luis
Beaugé, Reinaldo DiPolo, Mariana
Bollo,
Alexandra Cousido,
Graciela
Berberián,
and Alberto Podjarny
14
Regulation of Sodium-Calcium Exchanger Activity
by
Creatine
Kinase
....................................................................... 163
Ya-Chi Yang and Lung-Sen
Kao
15
Coordinated Regulation of Cardiac Na7Ca2+ Exchanger
and Na+-K+-ATPase by Phospholemman (FXYD1)
.................. 175
Joseph Y. Cheung, Xue-Qian Zhang, Jianliang Song,
Erhe
Gao,
Tung O. Chan, Joseph E. Rabinowitz, Walter J. Koch,
Arthur M. Feldman, and JuFang Wang
Contents
Part
VI Subcellular
Localization and Function of NCX
in Ca^-Storing Organelles and Mitochondria
16
Mitochondria Na+-Ca2+ Exchange in Cardiomyocytes
and Lymphocytes
......................................................................... 193
Bongju Kim, Ayako Takeuchi, One
Koga, Masaki
Hikida,
and Satoshi Matsuoka
17
New Insights in Mitochondrial Calcium Handling
by Sodium/Calcium Exchanger
.................................................. 203
Antonella Scorziello, Claudia
Savoia,
Agnese
Secondo,
Francesca Boscia, Maria Jose Sisalli, Alba Esposito,
Annalisa
Caducei, Pasquale
Molinaro,
Luca Lignitto,
Gianfranco Di Renzo, Antonio Feliciello,
and Lucio Armunziato
Part
VII NCX in Neurodegenerative
Diseases
18
Genetically Modified Mice as a Strategy to Unravel
the Role Played by the Na+/Ca2+ Exchanger in Brain Ischemia
and in Spatial Learning and Memory Deficits
.......................... 213
Pasquale
Molinaro,
Mauro Cataldi, Omelia
Cuomo,
Davide
Viggiano, Giuseppe Pignataro, Rossana Sirabella,
Agnese
Secondo,
Francesca Boscia. Anna Pannaccione,
Antonella Scorziello, Sophie Sokolow,
André
Herchuelz,
Gianfranco Di Renzo,
and
Lucio
Annunziato
19
NCX as a Key Player in the
Neuroprotection
Exerted
by
Ischemie
Preconditioning and Postconditioning
.................. 223
Giuseppe Pignataro,
Omelia
Cuomo, Antonio
Vinciguerra,
Rossana Sirabella,
Elga
Esposito, Francesca Boscia,
Gianfranco Di Renzo,
and
Lucio
Annunziato
20
The Role of the Mitochondrial NCX in the Mechanism
of Neurodegeneration in Parkinson s Disease
........................... 241
Alison Wood-Kaczmar, Emma
Deas,
Nicholas W. Wood,
and
Andrey Y. Abramov
21
The Contribution of the Sodium-Calcium Exchanger
(NCX) and Plasma Membrane Ca2+ ATPase (PMCA)
to Cerebellar Synapse Function
.................................................. 251
Chris J. Roome and Ruth M. Empson
Part
VIII
Emerging Role of NCX Activity in Immune
and Glial Cells
22
Sodium-Calcium Exchanger Modulates the L-Glutamate
Ca.2+ Signalling in
Туре
-l
Cerebellar Astrocy
tes
....................... 267
Hector
Rojas,
Claudia
Colina, Magaly
Ramos,
Gustavo Benaim, Erica Jaffe, Carlo
Caputo,
and
Reinaldo DiPolo
Contents
23 Immunosuppressive
Drugs, Immunophilins,
and Functional
Expression
of NCX Isoforms
............................ 275
Hannah Rahamimoff, Benayahu Elbaz, Michael Valitsky,
Mahdi Khatib, Marina Eskin-Schwartz, and Daniela Elmaz
24
Calcium Influx Through Reversed NCX Controls
Migration of Microglia
................................................................ 289
Mami
Noda, Masataka Ifuku, Yuki Mori,
and Alexei Verkhratsky
25
Sodium Fluxes and Astroglial Function
..................................... 295
Alexei Verkhratsky,
Mami
Noda, Vladimir Parpura,
and Sergei Kirischuk
26
New Roles of NCX in Glial Cells: Activation of Microglia
in Ischemia and Differentiation of Oligodendrocytes
............... 307
Francesca Boscia,
Carla D Avanzo,
Anna Pannaccione,
Agnese
Secondo,
Antonella
Casamassa,
Luigi Formisano,
Natascia
Guida,
Antonella Scorziello,
Gianfranco Di Renzo,
and Lucio Annunziato
27
Human
Macrophages
and Monocytes Express
Functional Na+/Ca2+ Exchangers
1
and
3................................... 317
Rosaria
I. Staiano,
Francescopaolo
Granata,
Agnese
Secondo,
Angelica Petraroli,
Stefania
Loffredo, Lucio Annunziato,
Massimo Triggiani,
and Gianni
Marone
Part IX
NCX in
the Heart and Vascular Smooth Muscle
28
New Insights into the Contribution of Arterial NCX
to the Regulation of Myogenic Tone and Blood Pressure
......... 329
Jin Zhang
29
Toward an Understanding of the Complete NCX1
Lifetime in the Cardiac Sarcolemma
......................................... 345
Donald W. Hilgemann,
Mei-
Jung Lin, Michael Fine,
Gary Frazier, and Hao-Ran Wang
Part X NCX Role in Hypertension, Heart Failure,
Ischemia-
Reperfusion,
Arrhythmias and Diabetes
30
Cardiac Sodium-Calcium Exchange and Efficient
Excitation-Contraction Coupling: Implications
for Heart Disease
.......................................................................... 355
Joshua I. Goldhaber and Kenneth D. Philipson
31
Cross Talk Between Plasma Membrane NaVCa2+
Exchanger-1 and TRPC/Orai-Containing Channels:
Key Players in Arterial Hypertension
........................................ 365
Maria V. Pulina, A. Zulian, Sergey G. Baryshnikov,
Cristina
I.
Linde,
Eiji Karashima, John M. Hamlyn,
Patrizia
Ferrari, Mordecai P.
Blaustein,
and
Vera A. Golovina
Contents
32 T-Tubule
Remodelling and Ryanodine Receptor
Organization Modulate Sodium-Calcium Exchange
................ 375
Karin
R.
Sipido,
Karoly
Acsai,
Gudrun Antoons,
Virginie
Bito,
and Niall Macquaide
33
Na+/Ca2+ Exchange and the Plasma Membrane
Ca2+-ATPase in
ß-Cell
Function and Diabetes
........................... 385
André Herchuelz, Evrard Nguidjoe,
Lin Jiang,
and Nathalie
Pacherà
Part XI NCX Partners in Ionic Homeostasis: ASIC, NMDA,
NHE and TRPC
34
The Na+/H+ Exchanger NHE5 Is Sorted to Discrete
Intracellular Vesicles in the Central and Peripheral
Nervous Systems
........................................................................... 397
Viktoria
Lukashova, Tushare Jinadasa,
Alina
Hie,
David Verbich, Ellis Cooper, and John Orlowski
35
The Role of NaVH+ Exchanger
Isoform 1
in Inflammatory Responses: Maintaining H+ Homeostasis
of Immune Cells
........................................................................... 411
Yejie Shi, Dong Kim, Marie Caldwell, and
Dandan
Sun
36
Acid-Sensing Ion Channels in Pathological Conditions
........... 419
Xiang-Ping
Chu
and Zhi-Gang Xiong
37
Nonselective Cation Channels and Links to Hippocampal
Ischemia, Aging, and Dementia
.................................................. 433
John F. MacDonald, Julian C. Belrose, Yu-Feng Xie,
and Michael F. Jackson
List of Participants
............................................................................... 449
Author Index
........................................................................................ 451
Subject Index
........................................................................................ 455
Advances in Experimental Medicine and Biology
961
Lucio Anntmziato
Editor
Sodium Calcium Exchange: A Growing Spectrum
of Pathophysiological Implications
Proceedings of the 6th International Conference on Sodium Calcium Exchange
This book reports the text of the lectures of the 6th International Conference on Sodium
Calcium Exchange held in
Lacco Ameno in
the Island of Ischia in the Gulf of Naples,
Italy, from October
ι
to October
5,2011.
The present book uncovers the most striking new findings on NCX that emerged since
the previous Conference on Sodium Calcium Exchange, such as the structural
dissection of the molecular determinants of
Саг+
sensitivity of the exchanger, the
epigenetic regulation of ncxi gene, the molecular identification of the mitochondrial
Sodium Calcium Exchanger, and the discovery of NCX in unexpected anatomical
locations such as the female reproductive tract.
The book is organized into
π
parts covering NCX structural aspects, genetic and
epigenetic regulation, regulatory mechanisms, subcellular localization in mitochondria,
involvement in
neurodegenerative
diseases and in immune regulation, and the role
of the cardiovascular and endocrine systems, as well as diabetes in physiology and
pathophysiology. Selected chapters of the book are also devoted to the interaction of
NCKX and other ion channels and transporters with NCX, like ASICs, TRPM, and NHE.
Lucio Annunziato
is Professor of Pharmacology and chairman of the Department of
Neuroscience
in the School of Medicine at the
Federico
П
University of Naples, Italy.
He is coordinator of the University s
Neuroscience
Ph.D. program. He is also past-
president of the Italian Society for
Neuroscience.
Dr. Annunziato has authored more
that
190
full papers in peer reviewed international journals in the field of
neuroscience
and molecular pharmacology ot plasmamembrane transporters and ionic channels
involved in the pathophysiology of stroke and other
neurodegenerative
diseases.
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| genre | (DE-588)1071861417 Konferenzschrift 2011 Lacco Ameno gnd-content |
| genre_facet | Konferenzschrift 2011 Lacco Ameno |
| id | DE-604.BV040690510 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T00:31:46Z |
| institution | BVB |
| institution_GND | (DE-588)102982682X |
| isbn | 9781461447559 1461447550 9781461447566 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-025671270 |
| oclc_num | 826601412 |
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| owner | DE-12 DE-355 DE-BY-UBR |
| owner_facet | DE-12 DE-355 DE-BY-UBR |
| physical | XXIV, 463 S. Ill., graph. Darst |
| publishDate | 2013 |
| publishDateSearch | 2013 |
| publishDateSort | 2013 |
| publisher | Springer |
| record_format | marc |
| series | Advances in experimental medicine and biology |
| series2 | Advances in experimental medicine and biology |
| spelling | Sodium calcium exchange a growing spectrum of pathophysiological implications ; proceedings of the 6th International Conference on Sodium Calcium Exchange Lucio Annunziato ed. New York [u.a.] Springer 2013 XXIV, 463 S. Ill., graph. Darst txt rdacontent n rdamedia nc rdacarrier Advances in experimental medicine and biology 961 Conference proceedings Natrium-Calcium-Austauscher (DE-588)4734212-2 gnd rswk-swf Pathophysiologie (DE-588)4044898-8 gnd rswk-swf Sodium channels--Congresses. Calcium channels--Congresses. Sodium cotransport systems--Congresses. (DE-588)1071861417 Konferenzschrift 2011 Lacco Ameno gnd-content Natrium-Calcium-Austauscher (DE-588)4734212-2 s Pathophysiologie (DE-588)4044898-8 s DE-604 Annunziato, Lucio Sonstige (DE-588)14000467X oth International Conference on Sodium Calcium Exchange 6 2011 Lacco Ameno Sonstige (DE-588)102982682X oth Erscheint auch als Online-Ausgabe Annunziato, Lucio Sodium calciume xchange: a growing spectrum of pathophysiological implications Advances in experimental medicine and biology 961 (DE-604)BV000003102 961 Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025671270&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025671270&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
| spellingShingle | Sodium calcium exchange a growing spectrum of pathophysiological implications ; proceedings of the 6th International Conference on Sodium Calcium Exchange Advances in experimental medicine and biology Natrium-Calcium-Austauscher (DE-588)4734212-2 gnd Pathophysiologie (DE-588)4044898-8 gnd |
| subject_GND | (DE-588)4734212-2 (DE-588)4044898-8 (DE-588)1071861417 |
| title | Sodium calcium exchange a growing spectrum of pathophysiological implications ; proceedings of the 6th International Conference on Sodium Calcium Exchange |
| title_auth | Sodium calcium exchange a growing spectrum of pathophysiological implications ; proceedings of the 6th International Conference on Sodium Calcium Exchange |
| title_exact_search | Sodium calcium exchange a growing spectrum of pathophysiological implications ; proceedings of the 6th International Conference on Sodium Calcium Exchange |
| title_full | Sodium calcium exchange a growing spectrum of pathophysiological implications ; proceedings of the 6th International Conference on Sodium Calcium Exchange Lucio Annunziato ed. |
| title_fullStr | Sodium calcium exchange a growing spectrum of pathophysiological implications ; proceedings of the 6th International Conference on Sodium Calcium Exchange Lucio Annunziato ed. |
| title_full_unstemmed | Sodium calcium exchange a growing spectrum of pathophysiological implications ; proceedings of the 6th International Conference on Sodium Calcium Exchange Lucio Annunziato ed. |
| title_short | Sodium calcium exchange |
| title_sort | sodium calcium exchange a growing spectrum of pathophysiological implications proceedings of the 6th international conference on sodium calcium exchange |
| title_sub | a growing spectrum of pathophysiological implications ; proceedings of the 6th International Conference on Sodium Calcium Exchange |
| topic | Natrium-Calcium-Austauscher (DE-588)4734212-2 gnd Pathophysiologie (DE-588)4044898-8 gnd |
| topic_facet | Natrium-Calcium-Austauscher Pathophysiologie Konferenzschrift 2011 Lacco Ameno |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025671270&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025671270&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000003102 |
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