Natural product biosynthesis by microorganisms and plants: C
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Amsterdam [u.a.]
Elsevier, Acad. Press
2012
|
| Ausgabe: | 1. ed. |
| Schriftenreihe: | Methods in enzymology
517 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | LVIII, 449 S., [7] Bl. Ill., graph. Darst. |
| ISBN: | 9780124046344 |
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| 245 | 1 | 0 | |a Natural product biosynthesis by microorganisms and plants |n C |c ed. by David A. Hopwood |
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Datensatz im Suchindex
| _version_ | 1804149810193760256 |
|---|---|
| adam_text | CONTENTS
Contributors
xiii
Preface
xvii
Volumes in Series
xxiii
Section
1
Metabolites from Novel Sources
Ί.
Methods for the Study of Endophytic Microorganisms
from Traditional Chinese Medicine Plants
3
Li-Xing Zhao, Li-Hua Xu, and Cheng-Lin Jiang
1.
Introduction
4
2.
Experimental Methods
б
3.
Novel Bioactive Compounds from Endophytic Actinobacteria
10.
4.
Conclusion
14
Acknowledgment
16
References
1
б
2.
Cyanobacteria as a Source of Natural Products
23
Martin
Welker, Elke
Dittmann, and Hans
von Döhren
1.
Introduction
24
2.
Cyanobacteria as Starting Material for Natural Products
25
3.
Screening for New Compounds and Producers
31
4.
Genomic Mining of Cyanobacterial Natural Products
36
5.
Summary
41
References
41
3.
Isolating Antifungals from Fungus-Growing Ant Symbionts
Using a Genome-Guided Chemistry Approach
47
Ryan F. Seipke, Sabine Grüschow,
Rebecca J. M. Goss,
and Matthew I. Hutchings
1.
Introduction
48
2.
Strain Isolation and Genome Sequencing
50
3.
Identifying Antifungals made by Pseudonocardia PI
52
4.
Identifying Antifungals made by S. albus S4
57
5.
Summary and Perspectives
66
vi
Contents
Acknowledgments
67
References
68
4.
Gamma-Butyrolactone and
Furan
Signaling Systems
in Streptomyces
71
John D. Sidda and
Christophe
Corre
1.
Introduction
71
2.
AfsA-Like Enzymes and the Biosynthesis of Signaling Molecules
73
3.
Heterologous Expression of an AfsA-Like-Containing Mini-Cluster
Combined with Comparative Metabolic Profiling
80
4.
Genetic Disruption of mmfLHP and Chemical Complementation
Experiments
82
5.
Conclusion
84
Acknowledgment
85
References
85
5.
Old Meets New: Using
Interspecies
Interactions to
Detect Secondary Metabolite Production in
Actinomycetes
89
Mohammad R. Seyedsayamdost, Matthew F. Traxler, Jon Clardy,
and Roberto
Kolter
1.
Introduction
90
2.
Setting Up Binary Actinomycete Interactions
91
3.
Activity-Guided Fractionation for Amychelin Isolation
98
4.
Determining the Affinity of Amychelin for Fe
101
5.
Identifying the Amychelin Biosynthetic Gene Cluster
103
6.
Transcriptomic Analysis using Nanostring Technology
104
7.
Summary
106
Acknowledgments
107
References
107
Section
2
Analyzing Gene Clusters
6.
Finding and Analyzing Plant Metabolic Gene Clusters
113
Anne Osbourn, Kalliopi K. Papadopoulou, Xiaoquan Qi, Ben Field,
and Eva Wegel
1.
Introduction
114
2.
Discovery of Plant Metabolic Gene Clusters Through Genetic Analysis
115
3.
Mining Genomes for Secondary Metabolic Gene Clusters
119
Contents
vii
4.
Validating Candidate Metabolic Gene Clusters
123
5.
Imaging Gene Clusters
129
6.
Future Prospects
135
Acknowledgments
135
References
135
7.
Genomic Approaches for Interrogating the Biochemistry
of Medicinal Plant Species
139
Elsa Góngora-Castillo,
Greg Fedewa,
Yunsoo Yeo,
Joe Chappell,
Dean DellaPenna, and C. Robin Buell
1.
Introduction
140
2.
Plant Material Selection and Quality
141
3.
Isolation of
RNA
142
4.
Generation of Next-Generation whole
Transcriptome
Sequences
144
5.
Assembly of a Reference
Transcriptome
145
6.
Assessment of Expression Abundances
154
7.
Summary
157
8.
Useful Links
157
Acknowledgments
158
References
158
8.
Phylogenetic Approaches to Natural Product
Structure Prediction
161
Nadine
Ziemert and Paul R. Jensen
1.
Introduction
162
2.
Working with Sequence Data
169
3.
NaPDoS
176
4.
Conclusions and Future Directions
177
Acknowledgments
178
References
178
Section
3
Heterologous Expression of Pathways
9.
Using a Virus-Derived System to Manipulate Plant
Natural Product Biosynthetic Pathways
185
Frank Sainsbury, Pooja Saxena,
Katrin Geisler, Anne
Osbourn,
and George P. Lomonossoff
1.
Introduction
186
2.
Deleted Vectors Based on Cowpea Mosaic Virus
186
viii Contents
3. Expression
of Enzymes in Plants Using pEAQ Vectors
196
4.
Conclusions and Perspectives
200
Acknowledgments
201
References
201
10. DNA
Assembler: A Synthetic Biology Tool for Characterizing
and Engineering Natural Product Gene Clusters
203
Zengyi Shao and Huimin Zhao
1.
Introduction
204
2.
General Guidelines for Construct Design
205
3.
Heterologous Expression and Fine Modification of Natural Product Gene
Clusters
207
4.
Characterization of Natural Product Gene Clusters
217
5.
Construction of Artificial Gene Clusters
221
Acknowledgments
223
References
223
11.
Reassembly of Functionally Intact Environmental
DNA-Derived Biosynthetic Gene Clusters
225
Dimitris Kallifidas and Sean F. Brady
1.
Introduction
226
2.
Protocol for Constructing,
Arraying, and
Screening Environmental Libraries
227
3.
Use of TAR to Reassemble
Overlapping
Clones into Complete
Biosynthetic Pathways
231
4.
Downstream Analysis
236
5.
Example
237
Acknowledgment
238
References
238
12.
A Toolkit for Heterologous Expression of Metabolic Pathways in
Aspergillus oryzae
241
Khomaizon A. K. Pahirulzaman,
Katherine
Williams, and Colin M. Lazarus
1.
Introduction
242
2.
Fundamental Aspects of Vector Development
244
3.
Heterologous Expression of a Fungal Natural Product Pathway in A. oryzae
246
4.
Methods
250
5.
Summary
256
Acknowledgments
257
References
257
Contents
13. De
Novo
Synthesis of High-Value Plant Sesquiterpenoids
,
in Yeast
261
Trinh-Don Nguyen, Gillian MacNevin, and Dae-Kyun Ro
1.
Introduction
262
2.
Yeast Culture and Metabolite Analysis
■ 264
3.
Expression Plasmid Construct and Transformation
268
4.
De Novo
Production of Sesquiterpenes
271
5.
De Novo
Production of Hydroxylated Sesquiterpene
272
6.
General Discussion
274
Acknowledgments
276
References
276
yA.Streptomyces coelicolor as an Expression Host for Heterologous
Gene Clusters
279
Juan Pablo Gomez-Escribano and Mervyn J. Bibb
·
1.
Introduction
280
2.
S. coelicolor Strains for Heterologous Expression
281
3.
Cloning of Secondary Metabolite Gene Clusters
286
4.
Introduction and Propagation of Cloned Gene Clusters in
S. coelicolor Hosts
■ 288
5.
Preservation of Selected Clones
290
6.
Growth in Liquid Culture for Metabolite Analysis
291
7.
Comparative Metabolic Profiling
293
Acknowledgments
297
References
■ 297
Section
4
Waking Up Silent Genes
15.
Toward Awakening Cryptic Secondary Metabolite Gene
Clusters in Filamentous Fungi
303
Fang Yun
Lim,
James F. Sanchez, Clay
С. С.
Wang, and Nancy P. Keller
1.
Introduction
304
2.
Activation Handles of Fungal Secondary Metabolite Gene Clusters
305
3.
Mining for Novel Compounds and Their Biosynthetic Genes
307
4.
Genetic Manipulation of Biosynthetic and Regulatory Genes
309
5.
Secondary Metabolite Analysis
316
Acknowledgments
322
References
322
x
Contents
16.
Regulatory Cross Talk and Microbial Induction
of Fungal Secondary Metabolite Gene Clusters
325
Hans-Wilhelm Nützmann, Volker
Schroeckh, and Axel
A. Brakhage
1.
Introduction
326
2.
Production of Secondary Metabolites by Overexpression of
Pathway-Specific Regulatory Genes
327
3.
Genetic Manipulation of Signal Transduction Cascades
330
4.
Microbial Induction of Fungal Secondary Metabolite Gene Clusters
333
Acknowledgments
338
References
338
17.
Waking up Streptomyces Secondary Metabolism by
Constitutive Expression of Activators or Genetic
Disruption of Repressors
343
Bertrand Aigle
and
Christophe
Corre
1.
Introduction
344
2.
Awakening Cryptic Gene Clusters with Pathway-Specific Activators
347
3.
Awakening Cryptic Gene Clusters Using Transcriptional
Repressor
Disruptions
355
4.
Comparative Metabolic Profiling to Identify Novel Metabolites
in the Engineered Strains
359
5.
Conclusion/Perspectives
361
References
362
18.
Use and Discovery of Chemical Elicitors That Stimulate
Biosynthetic Gene Clusters in Streptomyces Bacteria
367
Jane M. Moore, Elizabeth Bradshaw, Ryan F. Seipke, Matthew I. Hutchings,
and Michael McArthur
1.
Introduction
368
2.
Role of HDAC-Like Acetyltransferases in Controlling the
Expression of Biosynthetic Pathways
369
3.
Use of HDAC Inhibitors to Stimulate Expression of Secondary
Metabolic Genes
376
4.
Screening for HDAC Inhibitors from Streptomyces Bacteria
381
5.
Conclusion
383
References
383
Contents_________________________________________________________________________x|
19.
Persister
Eradication: Lessons from the World
of Natural Products
387
Iris Keren, Lawrence R. Mulcahy, and Kim Lewis
1.
Persisters
and Infectious Disease
388
2.
Mechanisms of
Persister
Formation
391
3.
Persister
Eradication
397
References
401
Author Index
407
Subject Index
437
|
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| id | DE-604.BV040679083 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T00:28:56Z |
| institution | BVB |
| isbn | 9780124046344 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-025505518 |
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| spelling | Natural product biosynthesis by microorganisms and plants C ed. by David A. Hopwood 1. ed. Amsterdam [u.a.] Elsevier, Acad. Press 2012 LVIII, 449 S., [7] Bl. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Methods in enzymology 517 Methods in enzymology ... Biochemische Methode (DE-588)4319880-6 gnd rswk-swf Naturstoff (DE-588)4041418-8 gnd rswk-swf Mikroorganismus (DE-588)4039226-0 gnd rswk-swf Biosynthese (DE-588)4006902-3 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Naturstoff (DE-588)4041418-8 s Biosynthese (DE-588)4006902-3 s Mikroorganismus (DE-588)4039226-0 s Biochemische Methode (DE-588)4319880-6 s DE-604 Hopwood, David A. Sonstige oth (DE-604)BV040543707 3 Methods in enzymology 517 (DE-604)BV000000938 517 Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025505518&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Natural product biosynthesis by microorganisms and plants Methods in enzymology Biochemische Methode (DE-588)4319880-6 gnd Naturstoff (DE-588)4041418-8 gnd Mikroorganismus (DE-588)4039226-0 gnd Biosynthese (DE-588)4006902-3 gnd |
| subject_GND | (DE-588)4319880-6 (DE-588)4041418-8 (DE-588)4039226-0 (DE-588)4006902-3 (DE-588)4143413-4 |
| title | Natural product biosynthesis by microorganisms and plants |
| title_auth | Natural product biosynthesis by microorganisms and plants |
| title_exact_search | Natural product biosynthesis by microorganisms and plants |
| title_full | Natural product biosynthesis by microorganisms and plants C ed. by David A. Hopwood |
| title_fullStr | Natural product biosynthesis by microorganisms and plants C ed. by David A. Hopwood |
| title_full_unstemmed | Natural product biosynthesis by microorganisms and plants C ed. by David A. Hopwood |
| title_short | Natural product biosynthesis by microorganisms and plants |
| title_sort | natural product biosynthesis by microorganisms and plants |
| topic | Biochemische Methode (DE-588)4319880-6 gnd Naturstoff (DE-588)4041418-8 gnd Mikroorganismus (DE-588)4039226-0 gnd Biosynthese (DE-588)4006902-3 gnd |
| topic_facet | Biochemische Methode Naturstoff Mikroorganismus Biosynthese Aufsatzsammlung |
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| volume_link | (DE-604)BV040543707 (DE-604)BV000000938 |
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