Extreme tissue engineering: concepts and strategies for tissue fabrication
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Chichester [u.a.]
Wiley-Blackwell
2013
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Includes bibliographical references and index |
| Beschreibung: | XIV, 252 S. Ill., graph. Darst. cm |
| ISBN: | 9780470974476 9780470974469 |
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| 100 | 1 | |a Brown, Robert A. |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Extreme tissue engineering |b concepts and strategies for tissue fabrication |c Robert A. Brown |
| 264 | 1 | |a Chichester [u.a.] |b Wiley-Blackwell |c 2013 | |
| 300 | |a XIV, 252 S. |b Ill., graph. Darst. |c cm | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 500 | |a Includes bibliographical references and index | ||
| 650 | 4 | |a Tissue Engineering | |
| 650 | 4 | |a Cell Culture Techniques | |
| 650 | 4 | |a Regenerative Medicine |x methods | |
| 650 | 4 | |a Tissue Scaffolds | |
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Datensatz im Suchindex
| _version_ | 1804149745752473600 |
|---|---|
| adam_text | Contents
Preface:
Extreme
Tissue
Engineering -
a User s Guide,
xi
1
Which Tissue Engineering Tribe Are You From?,
1
1.1
Why do we need to engineer tissues at all?,
1
7.7.7
Will the real tissue engineering and regenerative
medicine please stand up?,
2
1.1.2
Other people s definitions,
3
1.1.3
Defining our tissue engineering: fixing where we are on
the scale-hierarchy,
4
1.2
Bio-integration as a fundamental component of engineering
tissues,
7
7.2.7
Bio-scientists and physical scientists/engineers:
understanding diversity in TERM,
8
1.3
What are the tribes of tissue engineering?,
10
1.3.1
Special needs for special characteristics: why is
networking essential for TERM?,
13
1.4
Surprises from tissue engineering (Veselius to
Vacanti),
16
1.5
So, really, is there any difference between tissue engineering and
regenerative medicine?,
20
7.5.7
Questions never really asked: repair versus
regeneration?,
20
1.5.2
Understanding the full spectrum: tissue replacement,
repair and regeneration,
23
1.6
Conclusions,
27
1.7
Summarizing definitions,
28
Annex
1
Other people s definitions of tissue engineering,
29
Annex
2
Other people s definitions of regenerative medicine,
30
Further reading,
31
2
Checking Out the Tissue Groupings and the Small Print,
33
2.1
Checking the small print what did we agree to engineer?,
33
2.2
Identifying special tissue needs, problems and opportunities,
37
2.3
When is aiming high just over the top ?,
39
2.4
Opportunities, risks and problems,
41
2.4.7
Experimental model tissues (as
distină
from spare-parts
and fully regenerated tissues),
41
2.4.2
The pressing need for
3D
model tissues,
42
2.4.3
Tissue models can be useful spin-offs on the way to
implants,
42
vi
Contents
2.5
Special
needs for model tissues,
44
2.5.7
Cell
seleđion:
constancy versus correctness,
44
2.5.2
Support matrices
-
can synthetics fake it?,
45
2.5.3
Tissue dimensions: when size does matter!,
46
2.6
Opportunities and sub-divisions for engineering clinical implant
tissues,
46
2.6.1
Making physiological implants: spare parts or complete
replacement?,
47
2.6.2
Making pathological and aphysiological constructs:
inventing new parts and new uses,
47
2.6.3
Learning to use the plethora of tissue requirements as an
opportunity,
48
2.7
Overall summary,
49
Further reading,
49
What Cells
Неаґ
When We Say
30 , 51
3.1
Sensing your environment in three dimensions: seeing the cues,
51
3.2
What is this
3D
cell culture thing?,
54
3.3
Is
3D,
for cells, more than a stack of 2Ds?,
55
3.4
On, in and between tissues: what is it like to be a cell?,
58
3.5
Different forms of cell-space: 2D,
3D,
pseudo-SD and 4D cell
culture,
62
3.5.1
What has
3D
ever done for me?,
62
3.5.2
Introducing extracellular matrix,
63
3.5.3
Diffusion and mass transport,
65
3.5.4
Oxygen mass transport and gradients in
3D
engineered
tissues: scaling Mount Doom,
66
3.6
Matrix-rich, cell-rich and pseudo-SD cell cultures,
69
3.7
4D cultures
-
or cultures with a 4th dimension?,
71
3.8
Building our own personal understanding of cell position in its
3D
space,
73
3.9
Conclusion,
75
Further reading,
75
Making Support-Scaffolds Containing Living Cells,
77
4.1
Two in one: maintaining a synergy means keeping a good duet
together,
77
4.2
Choosing cells and support-scaffolds is like matching carriers with
cargo,
78
4.3
How like the real thing must a scaffold be to fool its resident
cells?,
80
4.4
Tissue prosthetics and cell prosthetics
-
what does it matter?,
83
4.5
Types of cell support material for tissue engineering
-
composition
or architecture?,
85
4.5.1
Surface or bulk
-
what does it mean to the cells?,
85
4.5.2
Bulk material breakdown and the local cell economy ,
85
Contents
vii
4.6
Three generic types of bulk composition for support materials,
86
4.6.1
Synthetic materials for cell supports,
88
4.6.2
Natural, native polymer materials for cell supports,
90
4.6.3
Hybrids: composite cell support materials having
synthetic and natural components,
98
4.7
Conclusions,
100
Further reading,
101
Making the Shapes for Cells in Support-Scaffolds,
103
5.1 3D
shape and the size hierarchy of support materials,
104
5.2
What do we think substrate shape might control?,
106
5.3
How we fabricate tissue structures affects what we get out in the
end: bottom up or top down?,
107
5.4
What shall we seed into our cell-support materials?,
110
5.4.7
Cell loading: guiding the willing, bribing the reludant or
trapping the unwary?,
111
5.4.2
Getting cells onto/into
pre-
fabricated
construas
(the
willing and the reludant),
114
5.4.3
Trapping the unwary: Seeding cells into self-assembling,
gel-forming materials,
115
5.5
Acquiring our cells: recruiting the enthusiastic or press-ganging
the resistant,
118
5.5.1
From cell expansion to selection and differentiation,
121
5.6
Cargo, crew or stowaway?,
124
5.6.1
Crew-type cells: helping with the journey,
124
5.6.2
Cargo-type cells: building the bulk tissue,
125
5.6.3
Stowaway or ballast-type cells,
128
5.7
Chapter summary,
128
Further reading,
129
Asymmetry:
3D
Complexity and Layer Engineering
-
Worth the Hassle?,
131
6.1
Degrees of tissue asymmetry,
133
6.2
Making simple anisotropic/asymmetrical structures,
134
6.3
Thinking asymmetrically,
137
6.4
How do we know which scale to engineer first?,
140
6.5
Making a virtue of hierarchical complexity: because we have to,
144
6.6
Cell-layering and matrix-layering,
147
6.7
No such thing as too many layers: theory and practice of tissue
layer engineering,
151
6.7.7
Examples of layer engineering,
7 53
6.8
Other forms of tissue fabrication in layers and zones,
158
6.8.7
Section summary,
158
6.9
Familiar asymmetrical construction components: everyday layer
engineering ,
159
6.10
Summary,
160
Further reading,
160
viii Contents
Other Ways to Grow Tissues?,
163
7.1
General philosophies for repair, replacement and regeneration,
163
7.7.7
What does reconstrudive surgery have to teach us?,
165
7.7.2
Clues from the natural growth of tissues,
166
7.2
What part of grow do we not understand?,
167
7.2.1
Childhood growth of son connective tissues: a good
focus?,
169
7.2.2
Mechanically induced growth of tissues in children,
170
7.2.3
Mechanically induced growth of adult tissue,
171
7.2.4
Growth has a mirror image
-
ungrowth or
shrinkage-remodelling,
172
7.3
If growth and ungrowth maintain
a tensional homeostasis,
what
are its controls?,
173
7.3.7
Tension-driven growth and
tensional
homeostasis
-
the
cell s perspective?,
174
7.3.2
Mechanically reatiive collagen remodelling
-
the
constant tailor theory,
177
7.4
Can we already generate tension-driven growth in in vivo tissue
engineering?,
178
7.4.1
Mechanical loading of existing tissues,
178
7.5
Conclusions: what can we learn from engineered growth?,
179
Appendix to Chapter
7,179
Further reading,
182
Bioreactors and All That Bio-Engineering Jazz,
185
8.1
What are tissue bioreactors and why do we need them?,
186
8.7.7
Rumblings of unease in the smaller communities,
186
8.1.2
Hunting for special cells or special cues,
187
8.1.3
Farming
-
culture or engineered fabrication,
188
8.2
Bioreactors: origins of tissue bioreactor logic, and its problems,
190
8.2.1
What have
üssue
engineers ever done for bioreactor
technology?,
190
8.2.2
The
3D
caveat,
191
8.2.3
Fundamental difference between biochemical and tissue
bioreactors:
3D
solid material fabrication,
193
8.2.4
Why should a little thing like matrix change so much?,
194
8.2.5
The place of tissue bioreactors in tissue engineering
logic: what happened to all the good analogies?,
795
8.3
Current strategies for tissue bioreactor process control: views of
Christmas past and present,
199
8.3.7
В
toreador enabling factors,
200
8.3.2
Cell and architecture control,
203
Contents
їх
8.4 Extreme
tissue engineering
solutions
to the tissue bioreactor
paradox: a view of Christmas future?,
209
8.4.1
In vivo versus in vitro tissue bioreactors: the new nature
versus nurture question?,
209
8.4.2
Do we need tissue bioreactors at all?,
210
8.5
Overall summary
-
how can bioreactors help us in the future?,
212
Further reading,
214
9
Towards 4D Fabrication: Time, Monitoring, Function and Process
Dynamics,
217
9.1
Controlling the dynamics of what we make: what can we
control?,
218
9.2
Can we make tissue bioreactor processes work
-
another way
forward?,
222
9.2.1
Blending the process systems: balancing the Yin and the
Yang,
224
9.2.2
Making the most of hybrid strategies: refining the timing
and sequence,
226
9.2.3
A real example of making tissues directly,
230
9.3
The 4th dimension applied to bioreactor design,
232
9.3.7
Change, change, change!,
232
9.3.2
For bioreactor monitoring, what are we really talking
about?,
233
9.3.3
Monitoring and processes
-
chickens and eggs: which
come first?,
234
9.4
What sort of monitoring: how do we do it?,
238
9.4.1
Selecting parameters to be monitored,
238
9.4.2
What is so special about our particular glass slipper ?,
241
9.5
The take-home message,
245
Further reading,
246
10
Epilogue: Where Can Extreme Tissue Engineering Go Next?,
247
10.1
So where can extreme tissue engineering go next?,
247
Index,
249
|
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| dewey-sort | 3612 228 |
| dewey-tens | 610 - Medicine and health |
| discipline | Biologie Medizin |
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| id | DE-604.BV040633711 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T00:27:55Z |
| institution | BVB |
| isbn | 9780470974476 9780470974469 |
| language | English |
| lccn | 2012009774 |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-025460923 |
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| owner_facet | DE-355 DE-BY-UBR DE-29 DE-20 DE-634 |
| physical | XIV, 252 S. Ill., graph. Darst. cm |
| publishDate | 2013 |
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| publisher | Wiley-Blackwell |
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| spelling | Brown, Robert A. Verfasser aut Extreme tissue engineering concepts and strategies for tissue fabrication Robert A. Brown Chichester [u.a.] Wiley-Blackwell 2013 XIV, 252 S. Ill., graph. Darst. cm txt rdacontent n rdamedia nc rdacarrier Includes bibliographical references and index Tissue Engineering Cell Culture Techniques Regenerative Medicine methods Tissue Scaffolds Gewebekultur (DE-588)4157245-2 gnd rswk-swf Regenerative Medizin (DE-588)7652075-4 gnd rswk-swf Zellkultur (DE-588)4067547-6 gnd rswk-swf Zellkultur (DE-588)4067547-6 s Regenerative Medizin (DE-588)7652075-4 s DE-604 Gewebekultur (DE-588)4157245-2 s b DE-604 Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025460923&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Brown, Robert A. Extreme tissue engineering concepts and strategies for tissue fabrication Tissue Engineering Cell Culture Techniques Regenerative Medicine methods Tissue Scaffolds Gewebekultur (DE-588)4157245-2 gnd Regenerative Medizin (DE-588)7652075-4 gnd Zellkultur (DE-588)4067547-6 gnd |
| subject_GND | (DE-588)4157245-2 (DE-588)7652075-4 (DE-588)4067547-6 |
| title | Extreme tissue engineering concepts and strategies for tissue fabrication |
| title_auth | Extreme tissue engineering concepts and strategies for tissue fabrication |
| title_exact_search | Extreme tissue engineering concepts and strategies for tissue fabrication |
| title_full | Extreme tissue engineering concepts and strategies for tissue fabrication Robert A. Brown |
| title_fullStr | Extreme tissue engineering concepts and strategies for tissue fabrication Robert A. Brown |
| title_full_unstemmed | Extreme tissue engineering concepts and strategies for tissue fabrication Robert A. Brown |
| title_short | Extreme tissue engineering |
| title_sort | extreme tissue engineering concepts and strategies for tissue fabrication |
| title_sub | concepts and strategies for tissue fabrication |
| topic | Tissue Engineering Cell Culture Techniques Regenerative Medicine methods Tissue Scaffolds Gewebekultur (DE-588)4157245-2 gnd Regenerative Medizin (DE-588)7652075-4 gnd Zellkultur (DE-588)4067547-6 gnd |
| topic_facet | Tissue Engineering Cell Culture Techniques Regenerative Medicine methods Tissue Scaffolds Gewebekultur Regenerative Medizin Zellkultur |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025460923&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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