Understanding periodontal research:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Heidelberg [u.a.]
Springer
2012
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XIII, 772 S. zahlr. Ill. |
| ISBN: | 9783642289224 3642289223 |
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| 245 | 1 | 0 | |a Understanding periodontal research |c Alexandrina L. Dumitrescu |
| 264 | 1 | |a Heidelberg [u.a.] |b Springer |c 2012 | |
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Datensatz im Suchindex
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| adam_text | IMAGE 1
1 EVIDENCE-BASED PERIODONTOLOGY 1
1.1 WHAT IS EVIDENCE-BASED MEDICINE? 1
1.2 WHAT IS EVIDENCE-BASED DENTISTRY? 6
1.3 WHAT IS EVIDENCE-BASED PERIODONTOLOGY? 6
1.4 EVIDENCE-BASED PERIODONTOLOGY VERSUS TRADITIONAL PERIODONTOLOGY 6
REFERENCES 6
2 ETHICAL CONSIDERATIONS IN PERIODONTAL RESEARCH 9
2.1 PROTECTION OF HUMAN STUDY PARTICIPANTS 9
2.2 RESPONSIBILITIES OF INVESTIGATORS 19
2.3 ETHICAL ISSUES SPECIFIC TO CERTAIN TYPES O F RESEARCH . . . . 22
REFERENCES 27
3 OVERVIEW O F CLINICAL RESEARCH DESIGN ARCHITECTURE 31
3.1 DEVELOPING A RESEARCH QUESTION 31
3.2 CLASSIFICATION O F TYPES OF CLINICAL RESEARCH 32
3.3 OBSERVATIONAL CLINICAL RESEARCH 34
3.4 EXPERIMENTAL STUDIES 64
3.5 SMALL CLINICAL TRIALS 78
3.6 SAMPLING METHODS 79
3.7 MEASUREMENT OF OUTCOMES 81
3.8 ARE THE FINDINGS VALID? 82
3.9 ASSESSING THE QUALITY OF PUBLISHED OBSERVATIONAL RESEARCH 82
REFERENCES 83
4 RANDOMIZED CONTROLLED CLINICAL TRIALS 89
4.1 CLINICAL TRIAL DESIGN 89
4.2 CLINICAL TRIAL IMPLEMENTATION 115
4.3 CONSOLIDATED STANDARDS O F REPORTING TRIALS (CONSORT) GUIDELINES 123
4.4 SPECIAL TYPES O F RCTS: COMPARATIVE RCTS 133
4.5 SPECIAL TYPES OF RCTS: CLUSTER (GROUP)-RANDOMIZED TRIALS 137
REFERENCES 138
I X
HTTP://D-NB.INFO/1019901365
IMAGE 2
X
5 BIAS IN PERIODONTAL RESEARCH 1 45
5.1 BIAS BEFORE A TRIAL BEGINS 145
5.2 BIAS DURING TRIAL EXECUTION 151
5.3 BIAS AFTER A TRIAL ENDS 153
5.4 OVERARCHING BIASES 154
5.5 THE EFFECT OF BIAS ON THE MAGNITUDE O F CLINICAL OUTCOMES IN
PERIODONTOLOGY 155
REFERENCES 156
6 MEASUREMENT RELIABILITY IN PERIODONTAL RESEARCH 159
6.1 BASIC TERMINOLOGY 159
6.2 SOURCES OF VARIABILITY FOR THE MEASUREMENT RELIABILITY . . 159 6.3
STANDARDIZATION VERSUS CALIBRATION 166
6.4 RELIABILITY MEASURES 167
6.5 INTER- VERSUS INTRA-EXAMINER VARIABILITY 172
6.6 INTRA-EXAMINER VARIABILITY IN PERIODONTAL STUDIES 173
REFERENCES 180
7 COMPLIANCE CONSIDERATIONS IN CLINICAL TRIAL DESIGN 185
7.1 COMPLIANCE IN PERIODONTAL ANTIMICROBIAL T R E A T M E N T . . . .
185 7.2 ENHANCING ADHERENCE IN CLINICAL RESEARCH 186
REFERENCES 189
8 PERFORMING SYSTEMATIC REVIEWS AND META-ANALYSES 191
8.1 INTRODUCTION 191
8.2 STEPS IN CONDUCTING A SYSTEMATIC REVIEW 195
8.3 REPORTING OF SYSTEMATIC REVIEWS AND META-ANALYSIS OF OBSERVATIONAL
STUDIES 232
8.4 REPORTING OF SYSTEMATIC REVIEWS AND META-ANALYSIS OF RANDOMIZED
CONTROLLED TRIALS 232
8.5 ASSESSING THE QUALITY O F SYSTEMATIC REVIEWS 234
8.6 PITFALLS IN SYSTEMATIC REVIEWS 238
8.7 WHEN CAN A META-ANALYSIS MISLEAD? 242
8.8 PARTICULAR TYPES OF SYSTEMATIC REVIEWS AND META-ANALYSIS 242
8.9 IMPROVING AND UPDATING REVIEWS 246
REFERENCES 250
9 STATISTICAL VERSUS CLINICAL SIGNIFICANCE IN PERIODONTAL RESEARCH 257
9.1 THE MATTER OF STATISTICAL SIGNIFICANCE 257
9.2 DEFINITION OF CLINICAL SIGNIFICANCE 259
9.3 METHODS AND CRITERIA TO EVALUATE CLINICAL RELEVANCE . . . 260 9.4
THE NUMBER NEEDED TO TREAT (NNT) 262
9.5 CLINICAL SIGNIFICANCE OF PERIODONTAL THERAPIES 266
REFERENCES 268
10 CLINICAL PRACTICE GUIDELINES IN PERIODONTOLOGY 27 1
10.1 BENEFITS OF CLINICAL GUIDELINES 271
10.2 LIMITS OF CLINICAL GUIDELINES 272
10.3 DEVELOPMENT OF CLINICAL PRACTICE GUIDELINES AND CLINICAL GUIDANCE
STATEMENTS 274
IMAGE 3
X I
10.4 CLINICAL PRACTICE GUIDELINES UPDATE PROCESS 290
10.5 CLINICAL GUIDELINES THAT SUPPORT COMMON DENTAL PROCEDURES 291
REFERENCES 294
11 MULTILEVEL MODELLING IN PERIODONTAL RESEARCH 297
11.1 SITE-BASED, TOOTH-BASED, AND SUBJECT-BASED PERIODONTAL EVALUATION
297
11.2 PRINCIPLES OF MULTILEVEL MODELLING (MLM) 298
11.3 THE MLWIN SOFTWARE 300
11.4 THE APPLICATION OF MULTILEVEL MODELLING TO CROSS-SECTIONAL
PERIODONTAL DATA 300
11.5 THE APPLICATION OF MULTILEVEL MODELLING TO LONGITUDINAL PERIODONTAL
DATA 302
11.6 THE APPLICATION O F MULTILEVEL MODELLING TO PERIODONTAL TREATMENT
RESPONSE DATA 305
REFERENCES 312
12 CONTEMPORARY CONCEPTS IN THE DIAGNOSIS O F PERIODONTAL DISEASE 315
12.1 CLINICAL METHODS FOR PERIODONTAL DIAGNOSIS 315
12.2 RADIOGRAPHIC ASSESSMENT OF PERIODONTAL DISEASE 325
12.3 NEWLY EMERGING METHODS FOR PERIODONTAL DIAGNOSIS . . . 330 12.4
ADVANCES IN MICROBIOLOGIC ANALYSIS 346
12.5 BIOCHEMICAL ANALYSIS AS PART OF PERIODONTAL DIAGNOSIS. . 370
REFERENCES 404
13 A GUIDE TO DIAGNOSTIC ACCURACY STUDIES IN PERIODONTOLOGY 423
13.1 TYPES OF DIAGNOSTIC EVALUATION STUDIES 423
13.2 USED TERMINOLOGY 424
13.3 THE DIFFERENCES BETWEEN STUDIES OF DIAGNOSIS AND THERAPY 426
13.4 DEFINING AND INTERPRETING THE ACCURACY DIAGNOSTIC TEST. . . 427
13.5 GUIDE FOR REPORTING STUDIES OF DIAGNOSTIC TESTS: THE STARD
INITIATIVE 430
13.6 CHECKLISTS FOR ASSESSING STUDIES ON DIAGNOSTIC TEST ACCURACY 432
13.7 SYSTEMATIC REVIEWS AND META-ANALYSIS OF DIAGNOSTIC STUDIES 434
13.8 APPLICATION O F GRADE: MAKING EVIDENCE-BASED RECOMMENDATIONS ABOUT
DIAGNOSTIC TESTS IN CLINICAL PRACTICE GUIDELINES 438
REFERENCES 440
14 CLINICAL TRIALS PRINCIPLES FOR EVALUATION O F ANTIMICROBIAL DRUGS IN
PERIODONTAL DISEASE TREATMENT 441
14.1 STUDIES IN VITRO 442
14.2 STUDIES IN VIVO 443
14.3 CLASS OR TRIAL TYPE 452
REFERENCES 453
IMAGE 4
X I I
15 THE HAWTHORNE EFFECT 459
15.1 TERMINOLOGY 459
15.2 THE PLACEBO EFFECT 459
15.3 THE HAWTHORNE EFFECT 460
REFERENCES 462
16 CLINICAL TRIAL PRINCIPLES FOR EVALUATION O F PRODUCTS USED IN THE
MANAGEMENT O F ORAL MALODOUR 465
16.1 ETIOPATHOGENESIS O F ORAL MALODOUR 465
16.2 ASSESSMENT METHODS O F ORAL MALODOUR 467
16.3 TREATMENT OF ORAL MALODOUR 469
16.4 GUIDELINES FOR INVESTIGATING SUBJECTS WITH HALITOSIS . . . . 470
16.5 THE ADA GUIDELINES ON ORAL MALODOUR PRODUCTS 473
REFERENCES 475
17 CHALLENGES IN PERIODONTAL GENETICS RESEARCH 477
17.1 PERIODONTITIS IS A COMPLEX DISEASE 477
17.2 POLYGENETIC MODEL FOR PERIODONTITIS 482
17.3 EPIGENETICS AND PERIODONTAL DISEASE 485
17.4 CHALLENGES FOR PERIODONTITIS GENETICS STUDIES 487
17.5 LIMITATIONS O F GENETIC ASSOCIATION STUDIES 503
REFERENCES 505
18 QUANTIFICATION O F GINGIVAL, PERIODONTAL, AND ORAL HYGIENE STATUS IN
PERIODONTAL RESEARCH ENVIRONMENT 507 18.1 EVALUATION OF INFLAMMATORY
CHANGES OF THE GINGIVA . . . . 507 18.2 INDICES FOR MEASURING
PERIODONTITIS 525
18.3 ORAL HYGIENE INDICES 540
18.4 MISCELLANEOUS INDICES 563
18.5 TREATMENT NEEDS INDICES 564
REFERENCES 568
19 ASPECTS OF THE RESEARCH METHODOLOGY FOR PERIODONTAL DISEASE
ASSESSMENT IN EPIDEMIOLOGICAL SURVEYS 575
19.1 INTRODUCTION 575
19.2 EPIDEMIOLOGICAL STUDY DESIGNS 575
19.3 ISSUES OF STUDY DESIGN 577
19.4 DEFINITIONS O F PERIODONTITIS AND METHODS THAT HAVE BEEN USED TO
IDENTIFY THIS DISEASE IN EPIDEMIOLOGICAL STUDIES 589
19.5 PERIODONTAL DISEASE PROGRESSION 619
19.6 MONITORING AND QUALITY CONTROL 621
19.7 SELF-REPORTED PERIODONTAL DISEASE 626
19.8 USING ADMINISTRATIVE DATA FOR EPIDEMIOLOGICAL RESEARCH 634
19.9 RISK FACTORS OF PERIODONTAL DISEASE 635
REFERENCES 637
IMAGE 5
X I I I
20 ASSESSING CONFOUNDING AND EFFECT MODIFICATION
O F PERIODONTITIS-SYSTEMIC DISEASE ASSOCIATIONS 645
20.1 CONFOUNDING 645
20.2 CONTROLLING FOR CONFOUNDING 649
20.3 EFFECT MODIFICATION 652
REFERENCES 653
21 ANIMAL MODELS IN PERIODONTAL RESEARCH 655
21.1 ANIMAL MODELS USED IN PERIODONTAL RESEARCH 655
21.2 SELECTION O F AN EXPERIMENTAL ANIMAL MODEL 655
21.3 EXPERIMENTAL PERIODONTAL DEFECTS 657
21.4 NONHUMAN PRIMATES 670
21.5 DOGS 676
21.6 MINIATURE PIGS 692
21.7 RATS 696
21.8 HAMSTER 714
21.9 MICE 714
21.10 SHREW ( SUNCUS MURINUS) 727
21.11 RABBIT 727
21.12 SHEEP MODEL 728
21.13 FERRETS 730
21.14 CAT 731
21.15 ANIMAL MODELS OF PERIODONTITIS-ASSOCIATED SYSTEMIC DISEASE 731
21.16 IMPROVING THE REPORTING OF ANIMAL EXPERIMENTS: THE ARRIVE
GUIDELINES 741
21.17 METHODOLOGICAL QUALITY OF SYSTEMATIC REVIEWS OF ANIMAL STUDIES 744
21.18 COMPARISON O F TREATMENT EFFECTS BETWEEN ANIMAL EXPERIMENTS AND
CLINICAL TRIALS 745
REFERENCES 747
INDEX 765
|
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| author | Dumitrescu, Alexandrina L. |
| author_facet | Dumitrescu, Alexandrina L. |
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| dewey-ones | 617 - Surgery & related medical specialties |
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| dewey-tens | 610 - Medicine and health |
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| language | English |
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| spelling | Dumitrescu, Alexandrina L. Verfasser aut Understanding periodontal research Alexandrina L. Dumitrescu Heidelberg [u.a.] Springer 2012 XIII, 772 S. zahlr. Ill. txt rdacontent n rdamedia nc rdacarrier Forschung (DE-588)4017894-8 gnd rswk-swf Evidenz-basierte Medizin (DE-588)4543414-1 gnd rswk-swf Parodontitis (DE-588)4322079-4 gnd rswk-swf Periodontics--Research--Methodology. Parodontitis (DE-588)4322079-4 s Forschung (DE-588)4017894-8 s Evidenz-basierte Medizin (DE-588)4543414-1 s DE-604 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025454183&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Dumitrescu, Alexandrina L. Understanding periodontal research Forschung (DE-588)4017894-8 gnd Evidenz-basierte Medizin (DE-588)4543414-1 gnd Parodontitis (DE-588)4322079-4 gnd |
| subject_GND | (DE-588)4017894-8 (DE-588)4543414-1 (DE-588)4322079-4 |
| title | Understanding periodontal research |
| title_auth | Understanding periodontal research |
| title_exact_search | Understanding periodontal research |
| title_full | Understanding periodontal research Alexandrina L. Dumitrescu |
| title_fullStr | Understanding periodontal research Alexandrina L. Dumitrescu |
| title_full_unstemmed | Understanding periodontal research Alexandrina L. Dumitrescu |
| title_short | Understanding periodontal research |
| title_sort | understanding periodontal research |
| topic | Forschung (DE-588)4017894-8 gnd Evidenz-basierte Medizin (DE-588)4543414-1 gnd Parodontitis (DE-588)4322079-4 gnd |
| topic_facet | Forschung Evidenz-basierte Medizin Parodontitis |
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