Phosphoinositides and disease:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Dordrecht [u.a.]
Springer
2012
|
| Schriftenreihe: | Current topics in microbiology and immunology
362 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Klappentext |
| Beschreibung: | VI, 318 S. Ill., graph. Darst. |
| ISBN: | 9789400750241 9789400750258 |
Internformat
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Datensatz im Suchindex
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Current Topics in Microbiology and Immunology
362
Marco Falasca Editor
Phosphoinositides and Disease
Phosphoinositides
(
Pis) are minor components of cellular membranes that play critical
regulatory roles in several intracellular functions. This book describes the main enzymes
regulating the turnover of each of the seven Pis in mammalian cells, some of their
intracellular functions and some evidence
oí
their involvement in human diseases. Due
to the complex inter-relation between the distinct Pis and the plethora of functions that
they can regulate inside a cell, this book is not meant to be a comprehensive coverage of
all aspects of Pis signalling but rather an overview on the current state of the field and
where it could go from here.
Phosphoinositide and inositol phosphates interact with and modulate the recruitment
and activation of key regulatory proteins and in doing so control diverse functions
including cell growth and proliferation, apoptosis, cytoskeletal dynamics, insulin action,
vesicle trafficking and nuclear function. Initially, inositide signaling was limited to the
PLC pathway; however, it is now clear that all the seven phosphoinositides and more
than
30
different inositol phosphates likely have specific signaling functions. Moreover
there is a growing list of proteins that are regulated by inositol signaling. This has raised
the question as to how inositol signaling can control diverse processes and yet maintain
signaling specificity. Controlling the levels of inositol signaling molecules and their
subcellular compart
mentalisation
is likely to be critical. 'Phis meeting will bring together
scientists from different backgrounds to discuss how understanding inositol signaling
may be used to target complex human diseases that manifest themselves when inositol
sitţnalina
is deregulated.
Contents
1 An
Introduction
to
Phosphoinositides. 1
Tania
Mafťucci
2
Phosphoinositides
and Cardiovascular Diseases.
43
Alessandra Ghigo, Alessia
Perino
and
Emilio
Hirsch
3 Phnsphoinositides
iu
Insulin
Action and Diabetes
. 61
Dave Bridges and Alan R. Saltiel
4
Phosphoinositides in Neuroexocytosis and
Neuronal
Diseases
. 87
Peter J. Wen. Shona L. Osborne and Frederic
A. Meunier
5
Effects of Phosphoinositides and Their Derivatives
on Membrane Morphology and Function
. 99
Banafshé
Larijani and Dominic L. Poccia
6
Molecular Analysis of Protein-Phosphoinositide Interactions
. 1
11
Tatiana
G.
Kutateladze
7
PIKfyve and its
Lipid
Products in Health and in Sickness
. 127
Assia Shisheva
8
Class I Phosphoinositide 3-Kinases in Normal
and Pathologic Hematopoietic Cells
. 163
François Vergez.
Christian Recher and Bernard Payrastre
9
The Diverse Functions of Phosphatidylinositol
Transfer Proteins
.
і
85
Shamshad Cockcroft
vi
Contents
10 Myotubularin Phosphoinositide Phosphatases
in Human
Diseases
. 209
Leonela Amoasii,
Karím
Hnia and Jocelyn Laporte
11
Nuclear PI-PLC
ßl
and Myelodysplastic Syndromes:
From Bench to Clinics
. 235
Sara Mongiorgi,
Matilde
Y.
Follo,
Cristina Clissa, Roberto
Giardino,
Milena
Fini, Lucia Manzoli, Giulia Ramazzotti,
Roberta
Fiume,
Carlo Finelli and Lucio Cocco
12
Inositol Polyphosphate Phosphatases in
Human Disease.
247
Sandra Hakim,
Micka
С.
Bertucci,
Sarah E.
Conduit,
David
L.
Vuong and Christina A. Mitchell
Index
. 315 |
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| discipline | Biologie |
| format | Book |
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| illustrated | Illustrated |
| indexdate | 2024-08-14T00:53:25Z |
| institution | BVB |
| isbn | 9789400750241 9789400750258 |
| language | English |
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| physical | VI, 318 S. Ill., graph. Darst. |
| publishDate | 2012 |
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| publisher | Springer |
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| series | Current topics in microbiology and immunology |
| series2 | Current topics in microbiology and immunology |
| spelling | Phosphoinositides and disease Marco Falasca, ed. Dordrecht [u.a.] Springer 2012 VI, 318 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Current topics in microbiology and immunology 362 Phosphoinositide (DE-588)4346034-3 gnd rswk-swf Krankheit (DE-588)4032844-2 gnd rswk-swf Phosphoinositide (DE-588)4346034-3 s Krankheit (DE-588)4032844-2 s b DE-604 Falasca, Marco Sonstige oth Current topics in microbiology and immunology 362 (DE-604)BV002527248 362 Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025429559&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025429559&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
| spellingShingle | Phosphoinositides and disease Current topics in microbiology and immunology Phosphoinositide (DE-588)4346034-3 gnd Krankheit (DE-588)4032844-2 gnd |
| subject_GND | (DE-588)4346034-3 (DE-588)4032844-2 |
| title | Phosphoinositides and disease |
| title_auth | Phosphoinositides and disease |
| title_exact_search | Phosphoinositides and disease |
| title_full | Phosphoinositides and disease Marco Falasca, ed. |
| title_fullStr | Phosphoinositides and disease Marco Falasca, ed. |
| title_full_unstemmed | Phosphoinositides and disease Marco Falasca, ed. |
| title_short | Phosphoinositides and disease |
| title_sort | phosphoinositides and disease |
| topic | Phosphoinositide (DE-588)4346034-3 gnd Krankheit (DE-588)4032844-2 gnd |
| topic_facet | Phosphoinositide Krankheit |
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