Early gastrointestinal cancers:
Gespeichert in:
| Weitere Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Heidelberg [u.a.]
Springer
2012
|
| Schriftenreihe: | Recent results in cancer research
196 |
| Schlagworte: | |
| Online-Zugang: | Inhaltstext Inhaltsverzeichnis |
| Beschreibung: | XII, 318 S. Ill., graph. Darst. 24 cm |
| ISBN: | 9783642316289 |
Internformat
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Datensatz im Suchindex
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|---|---|
| adam_text |
IMAGE 1
COUNTERS
PART I MULTIMODAL APPROACH TO COLORECTAL CANCER CLINICALLY RELEVANT
STUDY END POINTS IN RECTAL CANCER 3
1 INTRODUCTION 4
2 END POINTS IN PHASE I TRIALS 6
3 END POINTS IN PHASE II NEOADJUVANT RECTAL CANCER TRIALS 7
3.1 PATHOLOGICAL PARAMETERS O F RESPONSE 8
3.2 IMAGING RESPONSE 12
4 ENDPOINTS IN PHASE III TRIALS 13
4.1 DISEASE-FREE SURVIVAL AND LOCAL RECURRENCE 15
4.2 THE NEED FOR LONG-TERM FOLLOW-UP 15
5 DISCUSSION 16
REFERENCES 16
NEOADJUVANT TREATMENT IN RECTAL CANCER: DO W E ALWAYS NEED RADIOTHERAPY
OR CAN W E RISK ASSESS LOCALLY ADVANCED RECTAL CANCER BETTER? 21
1 INTRODUCTION 22
2 LATE EFFECTS OF RADIOTHERAPY 23
3 LOCAL RECURRENCE 24
3.1 IS NEOADJUVANT CHEMOTHERAPY AN ALTERNATIVE? 2 6
3.2 CAN RADIOTHERAPY BE OMITTED? 26
3.3 ARE THERE CLEARLY DISTINGUISHABLE GROUPS WHO DO NOT NEED RT? 26
4 CONCLUSION 32
REFERENCES 33
V
HTTP://D-NB.INFO/1023292114
IMAGE 2
VI C O N T E N T S
TREATMENT DILEMMAS IN PATIENTS WITH SYNCHRONOUS
COLORECTAL LIVER METASTASES 37
1 INTRODUCTION 38
2 PATIENTS WITH ASYMPTOMATIC CANCER OF THE COLON AND UNRESECTABLE
SYNCHRONOUS LIVER METASTASES 38
2.1 RESULTS OF INITIAL TREATMENT WITH CHEMOTHERAPY 39
2.2 RESULTS OF INITIAL RESECTION O F THE PRIMARY TUMOR 4 0
2.3 THE EFFECT O F TREATMENT STRATEGY ON OVERALL SURVIVAL 42
3 PATIENTS PRESENTING WITH RESECTABLE SYNCHRONOUS LIVER METASTASES AND
RECTAL CANCER 4 3
3.1 RESULTS O F STAGED OR SIMULTANEOUS RECTAL AND LIVER RESECTION
COMBINED WITH PERIOPERATIVE RADIOTHERAPY AND CHEMOTHERAPY 44
3.2 ENHANCING EFFICACY O F PERIOPERATIVE RADIOTHERAPY AND CHEMOTHERAPY
44
3.3 RESULTS OF THE LIVER-FIRST APPROACH 45
REFERENCES 4 6
PART II IMPROVING TREATMENT O F PANCREATIC CANCER
PANCREATIC SURGERY: BEYOND THE TRADITIONAL LIMITS 53
1 INTRODUCTION 54
2 PORTAL/MESENTERIC VEIN RESECTION 55
3 ARTERIAL RESECTION 56
4 EXTENDED LYMPHADENECTOMY 57
5 MULTIVISCERAL RESECTION 58
6 RESECTION FOR M1 PDAC 58
7 SURGERY FOR RECURRENT PDAC 59
8 PANCREATIC PARENCHYMA SPARING PROCEDURES 59
9 CONCLUSION 60
REFERENCES 61
ADJUVANT THERAPY FOR PANCREATIC CANCER 65
1 INTRODUCTION 67
2 RATIONALE FOR ADJUVANT THERAPY 67
3 EVIDENCE FOR ADJUVANT CHEMOTHERAPY 68
3.1 SYSTEMIC CHEMOTHERAPY 68
3.2 REGIONAL CHEMOTHERAPY 72
4 EVIDENCE FOR ADJUVANT CHEMORADIOTHERAPY 73
4.1 INTRAOPERATIVE RADIOTHERAPY 73
4.2 POSTOPERATIVE CHEMORADIOTHERAPY 73
4.3 CHEMORADIOTHERAPY, AND FOLLOW ON CHEMOTHERAPY 7 4
IMAGE 3
CONTENTS VII
5 EVIDENCE FOR NEOADJUVANT THERAPY 79
5.1 PUBLISHED STUDIES 79
5.2 ONGOING STUDIES 80
6 EVIDENCE FROM META-ANALYSES 80
6.1 ADJUVANT THERAPY 80
6.2 NEOADJUVANT THERAPY 81
7 CONCLUSIONS 82
8 FUTURE DIRECTIONS 82
REFERENCES 82
RADIOTHERAPY O F THE PANCREAS: STATE O F THE ART IN 2012 89
1 THE ROLE O F RADIOTHERAPY IN THE THERAPEUTIC MANAGEMENT OF PANCREATIC
CANCER 9 0
1.1 ADJUVANT APPROACH 90
1.2 NEOADJUVANT APPROACH 92
1.3 APPROACH OF UNRESECTABLE PANCREATIC TUMORS 93
2 TECHNIQUES OF RADIATION THERAPY PLANNING AND DELIVERY 9 4
2.1 RADIATION DOSE ESCALATION 95
2.2 INTENSITY-MODULATED RADIATION THERAPY 95
2.3 IMAGE-GUIDED RADIATION THERAPY AND STEREOTACTIC BODY RADIATION
THERAPY 97
3 CONCLUSIONS 99
REFERENCES 99
PART III DIFFERENT CANCER TYPES IN THE OESOPHAGUS AND STOMACH
ADENOCARCINOMA O F THE GEJ: GASTRIC OR OESOPHAGEAL CANCER? 107 1
INTRODUCTION 108
2 CHALLENGES OF THE CURRENT BARRETT'S CONCEPT 108
2.1 EVIDENCE OF TWO PATHWAYS 108
2.2 EVIDENCE O F DIFFERENT TARGETS FOR THERAPY 110
2.3 EVIDENCE FOR SURVEILLANCE RECOMMENDATIONS I L L
REFERENCES 112
WHY IS THERE A CHANGE IN PATTERNS O F GE CANCER? 115
1 INTRODUCTION - 117
2 AN AGEING POPULATION 118
2.1 FACTORS LEADING TO IMPROVED LIFE EXPECTANCY 118
2.2 IMPLICATIONS O F AN AGEING POPULATION ON MANAGEMENT OF UPPER GI
CANCERS 118
IMAGE 4
VILI
C O N T E N T S
3 COLONISATION WITH HELICOBACTER PYLORI 119
3.1 MECHANISMS O F ONCOGENESIS 119
3.2 H. PYLORI ERADICATION AND DECLINE IN PREVALENCE 119
3.3 ASSOCIATION BETWEEN H. PYLORI AND OESOPHAGEAL CANCERS . . . . 120
4 THE ROLE OF OBESITY 120
5 BILE ACIDS AND DIETARY FAT 122
6 TOBACCO AND ALCOHOL 123
6.1 SMOKING AND GASTRIC CANCER 123
6.2 ALCOHOL, GORD AND OESOPHAGEAL CANCERS 123
7 GASTRIC POLYPS 124
7.1 EPIDEMIOLOGY OF GASTRIC POLYPS 124
7.2 ADENOMATOUS POLYPS AND RISK OF MALIGNANCY 124
7.3 HEREDITARY POLYPOSIS SYNDROMES 125
8 OTHER MEDICAL CONDITIONS 125
8.1 PERNICIOUS ANAEMIA 125
8.2 PARTIAL GASTRECTOMY 126
8.3 PLUMMER-VINSON SYNDROME 126
8.4 COELIAC DISEASE 127
8.5 OEOSPHAGEAL ACHALASIA 127
8.6 HEREDITARY TYLOSIS (FAMILIAL PALMOPLANTAR KERATOSIS) 128
9 ANTI-INFLAMMATORY DRUGS 128
10 FAMILY HISTORY 129
10.1 SPORADIC GASTRIC CANCER 129
10.2 INHERITED CANCER SYNDROMES 130
11 HAVING OTHER CANCERS 130
12 RADIATION EXPOSURE 131
13 REDUCED IMMUNITY 131
14 WORK CHEMICALS 132
15 HORMONE REPLACEMENT THERAPY 132
16 PHYSICAL ACTIVITY 133
17 CONCLUSION 133
REFERENCES 135
PART IV CHOOSING THE BEST TREATMENT FOR OESOPHAGEAL CANCER
ENDOSCOPIC TREATMENT FOR ESOPHAGEAL SQUAMOUS CELL CARCINOMA. . . . 143 1
INTRODUCTION 143
2 INDICATIONS O F ENDOSCOPIC RESECTION FOR ESOPHAGEAL SCC 144
2.1 ABSOLUTE INDICATION 144
2.2 RELATIVE INDICATIONS 144
3 ENDOSCOPIC MUCOSAL RESECTION 145
3.1 PROCEDURES 145
3.2 ADVANTAGE AND DISADVANTAGE O F EMR 145
IMAGE 5
CONTENTS IX
4 ENDOSCOPIC SUBMUCOSAL DISSECTION (ESD) 145
4.1 PROCEDURE 145
4.2 MARKING AND SUBMUCOSAL INJECTION 146
4.3 MUCOSAL INCISION 146
4.3 SUBMUCOSAL DISSECTION 148
4.5 HEMOSTASIS 150
4.6 PREVENTION OF BLEEDING 150
5 COMPLICATIONS O F ESOPHAGEAL EMR/ESD 151
REFERENCES 153
OPEN OR MINIMALLY INVASIVE RESECTION FOR OESOPHAGEAL CANCER? . . . . 155
1 INTRODUCTION 156
2 MIO TECHNIQUES 157
3 RESULTS 158
4 MIO LEARNING CURVE 163
5 COMMENTS AND FUTURE 164
REFERENCES 165
CHOOSING THE BEST TREATMENT FOR ESOPHAGEAL CANCER 169
1 INTRODUCTION 170
2 POSTOPERATIVE MORTALITY 170
3 RO-RESECTION 171
4 LYMPHADENECTOMY 171
5 MULTIMODAL TREATMENT 172
6 ADJUVANT THERAPY 172
7 NEOADJUVANT RADIOTHERAPY 172
8 NEOADJUVANT CHEMOTHERAPY OR RADIOCHEMOTHERAPY 173
9 RESPONSE PREDICTION 174
10 TARGETED DRUGS IN MULTIMODAL THERAPY 174
REFERENCES 175
PART V MULTIMODAL THERAPY O F GEJ CANCER
MULTIMODAL THERAPY O F GEJ CANCER: WHEN IS THE DEFINITIVE
RADIOCHEMOTHERAPY THE TREATMENT O F CHOICE? 181
1 INTRODUCTION 182
2 STANDARD TREATMENT OPTIONS IN LOCALIZED DISEASE 182
2.1 PERIOPERATIVE THERAPY 182
2.2 DEFINITIVE CHEMORADIOTHERAPY 182
3 CONCLUSION 184
REFERENCES 184
IMAGE 6
X
C O N T E N T S
RADIOTHERAPY O F GASTROESOPHAGEAL JUNCTION CANCER 187
1 BACKGROUND 188
2 DIAGNOSTIC WORKUP 189
3 EARLY STAGE DISEASE 189
4 LOCALLY ADVANCED DISEASE 189
5 NEOADJUVANT THERAPY 190
6 RESPONSE-GUIDED THERAPY 191
7 DEFINITIVE CHEMOIRRADIATION 193
8 ADJUVANT THERAPY 193
9 SALVAGE RADIOTHERAPY 194
10 PALLIATIVE RADIOTHERAPY 195
11 NEW RADIATION TECHNOLOGIES 195
12 NEW COMBINATION POSSIBILITIES 196
13 CONCLUSIONS 197
REFERENCES 197
OPTIMIZING NEOADJUVANT CHEMOTHERAPY THROUGH THE USE O F EARLY RESPONSE
EVALUATION BY POSITRON EMISSION TOMOGRAPHY 201
1 INTRODUCTION 202
2 PET TRACERS 203
3 PET FOR STAGING 203
4 PET AND PROGNOSIS 204
5 PET AND TREATMENT RESPONSE 205
5.1 POST-THERAPEUTIC RESPONSE ASSESSMENT 205
5.2 PRE-THERAPEUTIC ASSESSMENT 206
5.3 EARLY METABOLIC RESPONSE 207
6 CONCLUSIONS 208
REFERENCES 209
PART VI GASTRIC CANCER
OPTIMAL SURGERY FOR GASTRIC CANCER: IS MORE ALWAYS BETTER? 215
1 INTRODUCTION 216
2 SURGICAL ANATOMY 216
3 CHARACTERISTICS OF THE PRIMARY TUMOUR 218
3.1 T1 DISEASE 219
3.2 T2 AND T3 DISEASE 221
3.3 T4 DISEASE 222
3.4 EXTENDED LYMPHADENECTOMY 223
3.5 METASTATIC DISEASE 224
4 PATIENT FACTORS 225
5 CONCLUSIONS 225
REFERENCES 226
IMAGE 7
CONTENTS XI
CAN ADJUVANT CHEMORADIOTHERAPY REPLACE EXTENDED LYMPH
NODE DISSECTION IN GASTRIC CANCER? 229
1 INTRODUCTION 230
2 SURGERY 230
3 CHEMOTHERAPY 231
4 CHEMORADIOTHERAPY 233
5 R1-RESECTION 235
6 CONCLUSION 236
REFERENCES 237
PREDICTING THE RESPONSE TO CHEMOTHERAPY IN GASTRIC ADENOCARCINOMA: WHO
BENEFITS FROM NEOADJUVANT CHEMOTHERAPY? 241
1 INTRODUCTION 242
2 HISTOLOGICAL RESPONSE EVALUATION 243
3 HISTOLOGICAL TUMOUR CHARACTERISTICS AS A PREDICTIVE MARKER OF
CHEMOTHERAPY RESPONSE 243
3.1 EFFICACY OF NEOADJUVANT TREATMENT IN SRC GASTRIC CANCER. . . 244 3.2
CHEMORESISTANCE SRC GASTRIC CANCER: POSTULATED MECHANISMS 245
4 IMAGING AS A PREDICTIVE BIOMARKER O F CHEMOTHERAPY RESPONSE 245
4.1 RESPONSE EVALUATION: EUS AND C T 246
4.2 18-F-FLUORO-2-DEOXYGLUCOSE POSITRON EMISSION TOMOGRAPHY: FDG-PET 246
4.3 IS RESPONSE PREDICTION IMPROVED WITH OTHER RADIOTRACERS? FLT-PET 249
5 MOLECULAR MARKERS: PREDICTING RESPONSE TO CHEMOTHERAPY AND TARGETING
TREATMENT 250
5.1 THYMIDYLATE SYNTHASE 250
5.2 THYMIDINE PHOSPHORYLASE AND DIHYDROPYRIMIDINE DEHYDROGENASE 252
5.3 GLUTATHIONE S-TRANSFERASE 253
5.4 P53 255
5.5 BCL-2 255
5.6 SURVIVIN 257
5.7 MICROSATELLITE INSTABILITY 257
5.8 INHIBITION OF ANGIOGENESIS: VASCULAR ENDOTHELIAL DERIVED GROWTH
FACTOR 258
6 TARGETED THERAPIES IN GASTRIC CANCER: SIGNS O F FUTURE PROMISE 258
6.1 TYROSINE KINASE INHIBITORS 258
6.2 MONOCLONAL ANTIBODIES AGAINST VEGF 259
6.3 HER FAMILY 259
7 CONCLUSIONS AND FUTURE DIRECTIONS 261
REFERENCES 262
IMAGE 8
XII C O N T E N T S
PREDICTION O F RESPONSE AND PROGNOSIS BY A SCORE INCLUDING
ONLY PRETHERAPEUTIC PARAMETERS IN 410 NEOADJUVANT TREATED GASTRIC CANCER
PATIENTS 269
1 CHAPTER 1 270
1.1 BACKGROUND 270
1.2 PROGNOSTIC BIOMARKERS IN GASTRIC CANCER 271
1.3 AIMS OF THE STUDY 272
2 CHAPTER 2 272
2.1 PATIENTS 272
2.2 CLINICAL STAGING 273
2.3 SURGERY 273
2.4 HISTOPATHOLOGICAL WORK-UP AND RESPONSE EVALUATION 273
2.5 STATISTICAL ANALYSIS 274
3 CHAPTER 3 274
3.1 RESULTS 274
3.2 PROGNOSTIC INDEX AND RISK GROUPS 278
4 CHAPTER 4 280
4.1 CONCLUSIONS 280
4.2 FUTURE DIRECTIONS 284
REFERENCES 285
ADJUVANT CHEMOTHERAPY: A N OPTION FOR ASIAN PATIENTS ONLY? 291 1
INTRODUCTION 292
2 SURGERY 293
2.1 EXTENT OF LYMPHADENECTOMY 293
2.2 EPIDEMIOLOGY 296
2.3 MARUYAMA INDEX 296
3 POST/PERIOPERATIVE THERAPY 297
3.1 ADJUVANT CHEMOTHERAPY 297
3.2 POSTOPERATIVE CHEMORADIOTHERAPY 301
3.3 PERIOPERATIVE CHEMOTHERAPY 302
4 CONCLUSIONS 303
REFERENCES 304
SELECTING THE BEST TREATMENT FOR AN INDIVIDUAL PATIENT 307
1 INTRODUCTION 308
2 TREATMENT O F EARLY GASTRIC CANCER 309
2.1 ADJUVANT SETTING 309
2.2 PERI-OPERATIVE SETTING 311
3 PHARMACOGENOMICS 314
3.1 ADJUVANT SETTING 314
3.2 PERI-OPERATIVE SETTING 315
4 CONCLUSIONS 316
REFERENCES 316 |
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| indexdate | 2024-08-21T00:21:39Z |
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| language | English |
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| series | Recent results in cancer research |
| series2 | Recent results in cancer research |
| spelling | Early gastrointestinal cancers Florian Otto ... ed. Heidelberg [u.a.] Springer 2012 XII, 318 S. Ill., graph. Darst. 24 cm txt rdacontent n rdamedia nc rdacarrier Recent results in cancer research 196 Gastrointestinaler Krebs (DE-588)4525888-0 gnd rswk-swf (DE-588)1071861417 Konferenzschrift 2012 Sankt Gallen gnd-content Gastrointestinaler Krebs (DE-588)4525888-0 s DE-604 Otto, Florian edt Erscheint auch als Online-Ausgabe 978-3-642-31629-6 Recent results in cancer research 196 (DE-604)BV000000043 196 X:MVB text/html http://deposit.dnb.de/cgi-bin/dokserv?id=4056598&prov=M&dok%5Fvar=1&dok%5Fext=htm Inhaltstext DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025420647&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Early gastrointestinal cancers Recent results in cancer research Gastrointestinaler Krebs (DE-588)4525888-0 gnd |
| subject_GND | (DE-588)4525888-0 (DE-588)1071861417 |
| title | Early gastrointestinal cancers |
| title_auth | Early gastrointestinal cancers |
| title_exact_search | Early gastrointestinal cancers |
| title_full | Early gastrointestinal cancers Florian Otto ... ed. |
| title_fullStr | Early gastrointestinal cancers Florian Otto ... ed. |
| title_full_unstemmed | Early gastrointestinal cancers Florian Otto ... ed. |
| title_short | Early gastrointestinal cancers |
| title_sort | early gastrointestinal cancers |
| topic | Gastrointestinaler Krebs (DE-588)4525888-0 gnd |
| topic_facet | Gastrointestinaler Krebs Konferenzschrift 2012 Sankt Gallen |
| url | http://deposit.dnb.de/cgi-bin/dokserv?id=4056598&prov=M&dok%5Fvar=1&dok%5Fext=htm http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025420647&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000000043 |
| work_keys_str_mv | AT ottoflorian earlygastrointestinalcancers |