Natural product biosynthesis by microorganisms and plants: A
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Amsterdam [u.a.]
Elsevier, Acad. Press
2012
|
| Ausgabe: | 1. ed. |
| Schriftenreihe: | Methods in enzymology
515 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | LV, 411 S., [9] Bl. Ill., graph. Darst. |
| ISBN: | 9780123942906 |
Internformat
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Datensatz im Suchindex
| _version_ | 1804149635756851200 |
|---|---|
| adam_text | CONTENTS
Contributors
xi
Preface
xv
Volumes in Series
xxi
Section
1
Terpenoids
1.
Steady-State Kinetic Characterization of Sesquiterpene Synthases
by Gas Chromatography-Mass Spectroscopy
3
Steven R. Garrett, Richard J. Morris, and Paul E. O Maille
1.
Introduction
4
2.
Experimental Components and Considerations
7
3.
Pilot Experiments
12
4.
Steady-State Kinetic Experiments
15
5.
Data Handling/Processing
16
6.
Summary
17
References
18
2.
Automating Gene Library Synthesis by Structure-Based
Combinatorial Protein Engineering: Examples from Plant
Sesquiterpene Synthases
21
Melissa Dokarry, Caroline Laurendon, and Paul E. O Maille
1.
Overview
22
2.
Plasmid Library Synthesis
24
3.
Optimization of SCOPE PCR Conditions
26
4.
Generic SCOPE Method
29
5.
Applications of SCOPE Synthesis
33
6.
Troubleshooting
39
7.
Conclusions
41
References
42
3.
In
Planta
Transient Expression Analysis of
Monoterpene
Synthases
43
Sol A. Green, Xiuyin Chen, and Adam J. Matich
1.
Introduction
44
2.
Plant Transformation Vector Construction
46
vi
Contents
3.
Agrobacterium-Mediated
Transient
Expression 49
4.
Agrobacterìum
Preparation for High-Throughput Analysis
51
5.
Product Identification
51
6.
Transient Expression of a Kiwifruit Linalool Synthase
52
7.
Conclusions
58
Acknowledgments
59
References
59
4.
Natural Rubber Biosynthesis in Plants: Rubber
Transferase
63
Katrina Cornish and Wenshuang Xie
1.
Introduction
64
2.
Preparing Samples for Assaying Rubber
Transferase
Activity
64
3.
The Rubber
Transferase
Assay
68
4.
Identification and Purification of Rubber
Transferase
71
5.
Qualitative Protein Analysis
77
6.
Protein Quantification
77
7.
Summary
79
Acknowledgments
80
References
80
5.
Discovery and Characterization of Terpenoid Biosynthetic
Pathways of Fungi
83
Grayson T.
Wawrzyn,
Sarah E. Bloch, and Claudia Schmidt-Dannert
1.
Introduction
84
2.
Identification, Cloning, and Characterization of
Terpene
Synthases
86
3.
Structural Characterization and Engineering of Fungal
Terpene
Synthase Activities
90
4.
Identification and Characterization of Biosynthetic Gene Clusters
92
5.
Genome Mining for Sesquiterpene Synthases
98
6.
Conclusions
101
Acknowledgments
102
References
102
6.
Menaquinone Biosyntheses in Microorganisms
107
Tohru Dairi
1.
Introduction
108
2.
Futalosine Pathway
109
Acknowledgments
121
References
121
Contents
vii
7.
Diversity and Analysis of Bacterial
Terpene
Syntheses
123
Yuuki Yamada, David
E. Cane,
and Haruo Ikeda
1.
Terpenoid Metabolites from Bacterial Cultures
124
2.
Bacterial
Terpene
Synthases
124
3.
Methods for the Study of Bacterial
Terpene
Synthases
129
References
159
8.
Platensimycin and Platencin Biosynthesis in Streptomyces platensis,
Showcasing Discovery and Characterization of Novel Bacterial
Diterpene
Synthases
163
Michael J. Smanski, Ryan M. Peterson, and Ben Shen
1.
Introduction
164
2.
Methods
168
3.
Conclusions
183
Acknowledgment
183
References
183
Section
2
Alkaloids and Glucosinolates
9.
Strategies for Engineering Plant Natural Products:
The Iridoid-Derived
Monoterpene Indole
Alkaloids of
Catharanthus roseus
189
Sarah E. O Connor
1.
Introduction
190
2.
Metabolic Engineering Strategies
193
3.
Conclusions and Future Directions
204
References
204
10.
Discovery and Functional Analysis of Monoterpenoid
Indole
Alkaloid Pathways in Plants
207
Vincenzo De Luca,
Vonný Salim,
Dylan Levac, Sayaka
Masada
Atsumi,
and Fang Yu
1.
Introduction
208
2.
Enzyme Assays for MIA Pathway Steps
212
3.
Methods for MIA Pathway Gene Discovery in
С
roseus
214
4.
Summary
226
Acknowledgments
226
References
227
vj¡¡
Contents
II.Biochemical Genomks
for
Gene
Discovery in Benzylisoquinoline
Alkaloid Biosynthesis in Opium Poppy and Related Species
231
Thu Thuy T. Dang, Akpevwe Onoyovwi, Scott
С
Farrow, and
Peter J.
Facchini
1.
Benzylisoquinoline Alkaloids
232
2.
Transcriptomics
236
3.
Proteomics
246
4.
Metabolomics
250
5.
Integrated Functional Genomics
255
Acknowledgments
262
References
263
12.
Analysis and Modification of Ergot Alkaloid Profiles in Fungi
267
Daniel G. Panaccione,
Katy
L
Ryan, Christopher
L. Schardl,
and
Simona
Florea
1.
Introduction
268
2.
Extraction of Ergot Alkaloids from Biological Sources
269
3.
Analysis of Ergot Alkaloids by HPLC
272
4.
Identification of Candidate Genes via Comparative Genomics
279
5.
Modification of Ergot Alkaloid Pathways via Transformation
282
6.
Summary
286
Acknowledgment
287
References
287
13.
Engineering of Glucosinolate Biosynthesis: Candidate
Gene Identification and Validation
291
Morten E. Moldrup, Bo Salomonsen, and Barbara A. Halkier
1.
Introduction
292
2.
Pathway Elucidation and Candidate Identification In Silico
293
3.
Metabolic Engineering of Glucosinolates in
N.
benthamiana
295
4.
Metabolic Engineering of Glucosinolates in
5.
cerevistae
303
5.
Conclusion
310
Acknowledgments
311
References
311
Contents ix
Section
З
Type III PKSs
14.
Structure-Function Analyses of Plant Type III
Polyketide Synthases
317
Jing-Ke Weng and Joseph P. Noel
1.
Introduction
318
2.
Bioinformatic Analyses of Type III PKSs
319
3.
In Vivo Biochemical Function of Type III PKSs
322
4.
Expression of Type III PKSs
324
5.
Structural Analyses of Type III PKSs
327
6.
Kinetic Analyses of Type III PKSs
329
7.
Mutagenic Exploration of Type III
PKS
Function and Adaptive Evolution
331
Acknowledgments
332
References
332
15.
Engineering of Plant Type III Polyketide Synthases
337
Toshiyuki Wakimoto, Hiroyuki Morita, and Ikuro Abe
1.
Introduction
337
2.
Benzalacetone Synthase
339
3.
Pentaketide Chromon Synthase
343
4.
Octaketide Synthase
346
5.
Polyketide Synthase
1 348
6.
Practical Considerations
351
7.
Summary and Future Prospects
354
Acknowledgments
355
References
355
16.
Type III Polyketide Synthases in Microorganisms
359
Yohei Katsuyama and Yasuo Ohnishi
1.
Introduction
359
2.
Methods of Study
363
References
374
Author Index
379
Subject Index
399
|
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| indexdate | 2024-07-10T00:26:10Z |
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| isbn | 9780123942906 |
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| spelling | Natural product biosynthesis by microorganisms and plants A ed. by David A. Hopwood 1. ed. Amsterdam [u.a.] Elsevier, Acad. Press 2012 LV, 411 S., [9] Bl. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Methods in enzymology 515 Methods in enzymology ... Mikroorganismus (DE-588)4039226-0 gnd rswk-swf Pflanzen (DE-588)4045539-7 gnd rswk-swf Biochemische Methode (DE-588)4319880-6 gnd rswk-swf Biosynthese (DE-588)4006902-3 gnd rswk-swf Naturstoff (DE-588)4041418-8 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Naturstoff (DE-588)4041418-8 s Biosynthese (DE-588)4006902-3 s Mikroorganismus (DE-588)4039226-0 s Biochemische Methode (DE-588)4319880-6 s DE-604 Pflanzen (DE-588)4045539-7 s b DE-604 Hopwood, David A. Sonstige oth (DE-604)BV040543707 1 Methods in enzymology 515 (DE-604)BV000000938 515 Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025389563&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Natural product biosynthesis by microorganisms and plants Methods in enzymology Mikroorganismus (DE-588)4039226-0 gnd Pflanzen (DE-588)4045539-7 gnd Biochemische Methode (DE-588)4319880-6 gnd Biosynthese (DE-588)4006902-3 gnd Naturstoff (DE-588)4041418-8 gnd |
| subject_GND | (DE-588)4039226-0 (DE-588)4045539-7 (DE-588)4319880-6 (DE-588)4006902-3 (DE-588)4041418-8 (DE-588)4143413-4 |
| title | Natural product biosynthesis by microorganisms and plants |
| title_auth | Natural product biosynthesis by microorganisms and plants |
| title_exact_search | Natural product biosynthesis by microorganisms and plants |
| title_full | Natural product biosynthesis by microorganisms and plants A ed. by David A. Hopwood |
| title_fullStr | Natural product biosynthesis by microorganisms and plants A ed. by David A. Hopwood |
| title_full_unstemmed | Natural product biosynthesis by microorganisms and plants A ed. by David A. Hopwood |
| title_short | Natural product biosynthesis by microorganisms and plants |
| title_sort | natural product biosynthesis by microorganisms and plants |
| topic | Mikroorganismus (DE-588)4039226-0 gnd Pflanzen (DE-588)4045539-7 gnd Biochemische Methode (DE-588)4319880-6 gnd Biosynthese (DE-588)4006902-3 gnd Naturstoff (DE-588)4041418-8 gnd |
| topic_facet | Mikroorganismus Pflanzen Biochemische Methode Biosynthese Naturstoff Aufsatzsammlung |
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