Characterization of porcine CLCA members with potential significance for cystic fibrosis: = Charakterisierung porziner CLCA-Mitglieder mit möglicher Bedeutung bei zystischer Fibrose
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
Berlin
Mensch-und-Buch-Verl.
2011 [erschienen] 2012
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | X, 100 S. Ill., graph. Darst. 21 cm |
| ISBN: | 9783863871338 |
Internformat
MARC
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| 245 | 1 | 0 | |a Characterization of porcine CLCA members with potential significance for cystic fibrosis |b = Charakterisierung porziner CLCA-Mitglieder mit möglicher Bedeutung bei zystischer Fibrose |c submitted by Stephanie Plog |
| 246 | 1 | 1 | |a Charakterisierung porziner CLCA-Mitglieder mit möglicher Bedeutung bei zystischer Fibrose |
| 264 | 1 | |a Berlin |b Mensch-und-Buch-Verl. |c 2011 [erschienen] 2012 | |
| 300 | |a X, 100 S. |b Ill., graph. Darst. |c 21 cm | ||
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| 502 | |a Berlin, Freie Univ., Diss., 2012 | ||
| 650 | 7 | |a animal models |2 cabt | |
| 650 | 7 | |a cystic fibrosis |2 cabt | |
| 650 | 7 | |a gene expression |2 cabt | |
| 650 | 7 | |a pigs |2 cabt | |
| 650 | 7 | |a ion transport |2 cabt | |
| 650 | 7 | |a modifier genes |2 cabt | |
| 650 | 7 | |a keratin |2 cabt | |
| 650 | 7 | |a polymerase chain reaction |2 cabt | |
| 650 | 7 | |a immunohistochemistry |2 cabt | |
| 650 | 7 | |a immunofluorescence |2 cabt | |
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Datensatz im Suchindex
| _version_ | 1804149594150404096 |
|---|---|
| adam_text | IMAGE 1
CONTENTS
LIST OF ABBREVIATIONS IX
1 INTRODUCTION 1
1.1 PORCINE MODELS OF HUMAN DISEASES 1
1.1.1 BACKGROUND 1
1.1.2 THE PIG IN CYSTIC FIBROSIS RESEARCH 1
1.1.2.1 THE DISEASE 1
1.1.2.2 THE ROLE OF MODIFIER GENES IN CYSTIC FIBROSIS 3
1.1.2.3 ANIMAL MODELS - ADVANTAGES AND DISADVANTAGES 4
1.1.2.4 THE NEW PORCINE MODEL 5
1.2 THE CLCA PROTEIN FAMILY 8
1.2.1 HISTORY OF THE DISCOVERY AND STRUCTURE OF CLCA PROTEINS 8
1.2.2 EXPRESSION PATTERNS IN MAMMALIAN SPECIES 10
1.2.3 CLCA AS MODIFIERS OF CYSTIC FIBROSIS AND OTHER PROPOSED FUNCTIONS
11
1.2.3.1 CLCA IN CYSTIC FIBROSIS 11
1.2.3.2 CLCA IN ASTHMA AND OTHER RESPIRATORY DISEASES 13
1.2.3.3 CLCA IN METASTASIS AND TUMOR CELL ADHESION 14
1.2.3.4 OTHER FUNCTIONS OF CLCA PROTEINS 15
1.2.4 THE CLCA FAMILY IN THE PIG 15
1.3 AIMS AND HYPOTHESES 18
2 RESEARCH PUBLICATIONS IN JOURNALS WITH PEER-REVIEW 20
2.1 TISSUE AND CELLULAR EXPRESSION PATTERNS OF PORCINE CFTR:
SIMILARITIES TO AND
DIFFERENCES FROM HUMAN CFTR 20
2.2 GENOMIC, TISSUE EXPRESSION, AND PROTEIN CHARACTERIZATION OF PCLCAL,
A PUTATIVE
MODULATOR OF CYSTIC FIBROSIS IN THE PIG 34
2.3 THE PORCINE CHLORIDE CHANNEL, CALCIUM-ACTIVATED FAMILY MEMBER
PCLCA4A
MIRRORS LUNG EXPRESSION OF THE HUMAN HCLCA4 48
3 DECLARATION OF OWN PORTION OF WORK IN THE RESEARCH PUBLICATIONS 61
3.1 TISSUE AND CELLULAR EXPRESSION PATTERNS OF PORCINE CFTR:
SIMILARITIES TO AND
DIFFERENCES FROM HUMAN CFTR 61
V I I
HTTP://D-NB.INFO/1021713163
IMAGE 2
CONTENTS
3.2 GENOMIC, TISSUE EXPRESSION, AND PROTEIN CHARACTERIZATION OF PCLCAL,
A PUTATIVE
MODULATOR OF CYSTIC FIBROSIS IN THE PIG 62
3.3 THE PORCINE CHLORIDE CHANNEL, CALCIUM-ACTIVATED FAMILY MEMBER
PCLCA4A
MIRRORS LUNG EXPRESSION OF THE HUMAN HCLCA4 6 3
4 CONCLUDING DISCUSSION 64
4.1 EXPRESSION OF PORCINE CFTR IN COMPARISON TO HUMAN CFTR 6 4
4.2 CHARACTERIZATION OF PORCINE CLCA MEMBERS IN COMPARISON TO THEIR
HUMAN AND
MURINE ORTHOLOGS 6 6
4.2.1 PCLCAL 67
4.2.2 PCLCA4A 69
4.3 PORCINE CLCA MEMBERS: MODULATORS IN THE CYSTIC FIBROSIS PIG MODEL?
70
4.4 CONCLUSION 74
4.5 OUTLOOK 75
5 SUMMARY 78
6 ZUSAMMENFASSUNG 80
7 REFERENCES 82
8 ORAL PRESENTATIONS AND POSTERS 97
9 ACKNOWLEDGEMENTS / DANKSAGUNG 98
SELBSTSTANDIGKEITSERKLARUNG 100
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|
| any_adam_object | 1 |
| author | Plog, Stephanie |
| author_GND | (DE-588)1023144565 |
| author_facet | Plog, Stephanie |
| author_role | aut |
| author_sort | Plog, Stephanie |
| author_variant | s p sp |
| building | Verbundindex |
| bvnumber | BV040515339 |
| classification_rvk | XX 4004 |
| ctrlnum | (OCoLC)918422325 (DE-599)DNB1021713163 |
| dewey-full | 616.372071 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
| dewey-raw | 616.372071 |
| dewey-search | 616.372071 |
| dewey-sort | 3616.372071 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| format | Thesis Book |
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| id | DE-604.BV040515339 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T00:25:30Z |
| institution | BVB |
| isbn | 9783863871338 |
| language | English |
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| physical | X, 100 S. Ill., graph. Darst. 21 cm |
| publishDate | 2011 |
| publishDateSearch | 2012 |
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| publisher | Mensch-und-Buch-Verl. |
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| spelling | Plog, Stephanie Verfasser (DE-588)1023144565 aut Characterization of porcine CLCA members with potential significance for cystic fibrosis = Charakterisierung porziner CLCA-Mitglieder mit möglicher Bedeutung bei zystischer Fibrose submitted by Stephanie Plog Charakterisierung porziner CLCA-Mitglieder mit möglicher Bedeutung bei zystischer Fibrose Berlin Mensch-und-Buch-Verl. 2011 [erschienen] 2012 X, 100 S. Ill., graph. Darst. 21 cm txt rdacontent n rdamedia nc rdacarrier Berlin, Freie Univ., Diss., 2012 animal models cabt cystic fibrosis cabt gene expression cabt pigs cabt ion transport cabt modifier genes cabt keratin cabt polymerase chain reaction cabt immunohistochemistry cabt immunofluorescence cabt Tiermodell (DE-588)4140660-6 gnd rswk-swf Schwein (DE-588)4053848-5 gnd rswk-swf Chloridkanal (DE-588)4291189-8 gnd rswk-swf Mukoviszidose (DE-588)4040669-6 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Mukoviszidose (DE-588)4040669-6 s Chloridkanal (DE-588)4291189-8 s Tiermodell (DE-588)4140660-6 s Schwein (DE-588)4053848-5 s DE-604 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025361767&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Plog, Stephanie Characterization of porcine CLCA members with potential significance for cystic fibrosis = Charakterisierung porziner CLCA-Mitglieder mit möglicher Bedeutung bei zystischer Fibrose animal models cabt cystic fibrosis cabt gene expression cabt pigs cabt ion transport cabt modifier genes cabt keratin cabt polymerase chain reaction cabt immunohistochemistry cabt immunofluorescence cabt Tiermodell (DE-588)4140660-6 gnd Schwein (DE-588)4053848-5 gnd Chloridkanal (DE-588)4291189-8 gnd Mukoviszidose (DE-588)4040669-6 gnd |
| subject_GND | (DE-588)4140660-6 (DE-588)4053848-5 (DE-588)4291189-8 (DE-588)4040669-6 (DE-588)4113937-9 |
| title | Characterization of porcine CLCA members with potential significance for cystic fibrosis = Charakterisierung porziner CLCA-Mitglieder mit möglicher Bedeutung bei zystischer Fibrose |
| title_alt | Charakterisierung porziner CLCA-Mitglieder mit möglicher Bedeutung bei zystischer Fibrose |
| title_auth | Characterization of porcine CLCA members with potential significance for cystic fibrosis = Charakterisierung porziner CLCA-Mitglieder mit möglicher Bedeutung bei zystischer Fibrose |
| title_exact_search | Characterization of porcine CLCA members with potential significance for cystic fibrosis = Charakterisierung porziner CLCA-Mitglieder mit möglicher Bedeutung bei zystischer Fibrose |
| title_full | Characterization of porcine CLCA members with potential significance for cystic fibrosis = Charakterisierung porziner CLCA-Mitglieder mit möglicher Bedeutung bei zystischer Fibrose submitted by Stephanie Plog |
| title_fullStr | Characterization of porcine CLCA members with potential significance for cystic fibrosis = Charakterisierung porziner CLCA-Mitglieder mit möglicher Bedeutung bei zystischer Fibrose submitted by Stephanie Plog |
| title_full_unstemmed | Characterization of porcine CLCA members with potential significance for cystic fibrosis = Charakterisierung porziner CLCA-Mitglieder mit möglicher Bedeutung bei zystischer Fibrose submitted by Stephanie Plog |
| title_short | Characterization of porcine CLCA members with potential significance for cystic fibrosis |
| title_sort | characterization of porcine clca members with potential significance for cystic fibrosis charakterisierung porziner clca mitglieder mit moglicher bedeutung bei zystischer fibrose |
| title_sub | = Charakterisierung porziner CLCA-Mitglieder mit möglicher Bedeutung bei zystischer Fibrose |
| topic | animal models cabt cystic fibrosis cabt gene expression cabt pigs cabt ion transport cabt modifier genes cabt keratin cabt polymerase chain reaction cabt immunohistochemistry cabt immunofluorescence cabt Tiermodell (DE-588)4140660-6 gnd Schwein (DE-588)4053848-5 gnd Chloridkanal (DE-588)4291189-8 gnd Mukoviszidose (DE-588)4040669-6 gnd |
| topic_facet | animal models cystic fibrosis gene expression pigs ion transport modifier genes keratin polymerase chain reaction immunohistochemistry immunofluorescence Tiermodell Schwein Chloridkanal Mukoviszidose Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025361767&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT plogstephanie characterizationofporcineclcamemberswithpotentialsignificanceforcysticfibrosischarakterisierungporzinerclcamitgliedermitmoglicherbedeutungbeizystischerfibrose AT plogstephanie charakterisierungporzinerclcamitgliedermitmoglicherbedeutungbeizystischerfibrose |