Host range determinants for canine distemper virus:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
Berlin
mbv
2012
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | 125 S. Ill., graph. Darst. |
| ISBN: | 9783863871208 |
Internformat
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| 100 | 1 | |a Nikolin, Veljko M. |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Host range determinants for canine distemper virus |c by Veljko M. Nikolin |
| 264 | 1 | |a Berlin |b mbv |c 2012 | |
| 300 | |a 125 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
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| 338 | |b nc |2 rdacarrier | ||
| 502 | |a Berlin, Freie Univ., Diss., 2011 | ||
| 650 | 7 | |a morbillivirus |2 cabt | |
| 650 | 7 | |a canine distemper virus |2 cabt | |
| 650 | 7 | |a dogs |2 cabt | |
| 650 | 7 | |a lions |2 cabt | |
| 650 | 7 | |a host parasite relationship |2 cabt | |
| 650 | 7 | |a host range |2 cabt | |
| 650 | 7 | |a molecular epidemiology |2 cabt | |
| 650 | 7 | |a Tanzania |2 cabt | |
| 650 | 0 | 7 | |a Staupevirus |0 (DE-588)4349365-8 |2 gnd |9 rswk-swf |
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| 650 | 0 | 7 | |a Raubtiere |0 (DE-588)4177019-5 |2 gnd |9 rswk-swf |
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Datensatz im Suchindex
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|---|---|
| adam_text | IMAGE 1
CONTENT
CHAPTER 1 G E N E R A L INTRODUCTION AND THESIS OUTLINE 8
1.1 PATHOGENESIS AND PROTECTIVE IMMUNITY 9
1.2 VIRUS STRUCTURE AND GENOME ORGANISATION 11
1.3 MOLECULAR EPIDEMIOLOGY O F CDV 14
1.3.1 MOLECULAR EPIDEMIOLOGY IN EUROPE 15
1.3.2 MOLECULAR EPIDEMIOLOGY IN EASTERN AFRICA 16
1.4 CANINE DISTEMPER VIRUS HOST RANGE 17
1.5 OUTLINE O F STUDY AIMS 20
1.5.1 SUSCEPTIBILITY OF CARNIVORE HOSTS TO STRAINS O F CANINE DISTEMPER
VIRUS FROM
DISTINCT GENETIC LINEAGES 20
1.5.2 EVIDENCE FOR SPECIALIST AND GENERALIST STRAINS IN A MULTI-HOST
VIRUS 21
1.5.3 A UNIQUE MUTATION WITHIN THE HAEMAGGLUTININ GENE OF CANINE
DISTEMPER
STRAINS FROM SERENGETI NATIONAL PARK PLAYS A KEY ROLE IN HIGHER
EFFICIENCY OF THE
VIRUS ENTRY INTO FELID CELLS 2 4
1.6 LITERATURE CITED 26
CHAPTER 2: SUSCEPTIBILITY O F CARNIVORE HOSTS TO STRAINS O F CANINE
DISTEMPER VIRUS
FROM DISTINCT GENETIC LINEAGES 32
ABSTRACT 32
2.1 INTRODUCTION 32
2.2 MATERIALS AND METHODS 34
2.2.1 WILDLIFE STRAINS FROM NORTHEAST GERMANY 34
2.2.2 RT-PCR, SEQUENCING AND PHYLOGENETIC ANALYSIS 34
2.2.3 STATISTICAL ANALYSIS OF AMINO ACID SITES 35
2.3 RESULTS 36
2.4 DISCUSSION 41
2.5 CONCLUSION 4 4
2.6 LITERATURE CITED 4 4
CHAPTER 3: EVIDENCE FOR SPECIALIST AND GENERALIST STRAINS IN A
MULTI-HOST VIRUS 47
ABSTRACT 47
3.1 INTRODUCTION 4 7
3.2 MATERIAL AND METHODS 51
3.2.1 CELL LINES AND VIRUSES 51
3.2.2 CONSTRUCTION OF PROTEIN EXPRESSION VECTOR EXPRESSING HA AND F
PROTEINS OF
5
HTTP://D-NB.INFO/1021240435
IMAGE 2
CDV STRAINS 52
3.2.3 SEQUENCING AND PHYLOGENETIC ANALYSIS OF SLAM 52
3.2.4 CONSTRUCTION OF PROTEIN EXPRESSION VECTOR EXPRESSING SLAM
RECEPTORS AND
GENERATION OF SLAM EXPRESSING CELL LINES 53
3.2.5 GENERATION O F SLAM EXPRESSING CELL LINES 5 3
3.2.6 FUSION ASSAY 54
3.2.7 VIRUS GROWTH 55
3.2.8 STATISTICAL ANALYSIS 55
3.3 RESULTS 56
3.3.1 SLAM SEQUENCE ANALYSIS 5 6
3.3.2 SYNCYTIA FORMATION 56
3.3.3 VIRUS PRODUCTION 59
3.4 DISCUSSION 61
3.5 LITERATURE CITED 65
CHAPTER 4: A UNIQUE MUTATION WITHIN THE HAEMAGGLUTININ GENE O F CANINE
DISTEMPER
STRAINS FROM SERENGETI NATIONAL PARK PLAYS A KEY ROLE IN HIGHER
EFFICIENCY O F THE VIRUS
ENTRY INTO FELID CELLS 70
ABSTRACT 70
4.1 INTRODUCTION 71
4.2 MATERIALS AND METHODS 7 4
4.2.1. WILDLIFE CDV STRAINS FROM THE SERENGETI ECOSYSTEM 74
4.2.2 RT-PCR, SEQUENCING AND PHYLOGENETIC ANALYSIS 74
4.2.3 CODON SELECTION ANALYSIS 75
4.2.4 CONSTRUCTION OF EXPRESSION PLASMIDS AND FUSION ASSAY 7 6
4.2.5 FUSION ASSAY 7 6
4.2.6 STATISTICAL ANALYSIS O F THE EXTENT O F SYNCYTIUM FORMATION 7 7
4.3 RESULTS 7 8
4.3.1 PHYLOGENETIC ANALYSIS OF CDV STRAINS FROM THE SERENGETI ECOSYSTEM
BETWEEN 1994 AND 2011 7 8
4.3.2 CDV GENOTYPES DEFINED BY CODONS 519 AND 549 WITHIN THE SLAM
BINDING
REGION OF HA GENES 80
4.3.3 THE EFFECTS OF RESIDUES 5191 AND 549H AND THEIR SYNERGY ON IN
VITRO
SYNCYTIA FORMATION IN CELLS EXPRESSING DIFFERENT SLAM RECEPTORS 82
4.3.4 THE EFFECT OF INDIVIDUAL STRAINS ON IN VITRO SYNCYTIA FORMATION IN
CELLS
6
IMAGE 3
EXPRESSING DIFFERENT SLAM RECEPTORS 85
4.4 DISCUSSION 87
4.5 LITERATURE CITED 93
CHAPTER 5: GENERAL DISCUSSION 98
5.1 SUSCEPTIBILITY O F CARNIVORE HOSTS TO STRAINS OF CANINE DISTEMPER
VIRUS FROM
DISTINCT GENETIC LINEAGES 102
5.2 EVIDENCE FOR SPECIALIST AND GENERALIST STRAINS IN A MULTI-HOST VIRUS
104
5.3 A UNIQUE MUTATION WITHIN THE HAEMAGGLUTININ GENE OF CANINE DISTEMPER
STRAINS
FROM SERENGETI NATIONAL PARK PLAYS A KEY ROLE IN HIGHER EFFICIENCY O F
THE VIRUS ENTRY
INTO FELID CELLS 107
5.4 CONCLUDING REMARKS 110
5.5 LITERATURE CITED 113
SUMMARY 117
ZUSAMMENFASSUNG 120
ACKNOWLEDGMENTS 123
7
|
| any_adam_object | 1 |
| author | Nikolin, Veljko M. |
| author_facet | Nikolin, Veljko M. |
| author_role | aut |
| author_sort | Nikolin, Veljko M. |
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| building | Verbundindex |
| bvnumber | BV040504732 |
| ctrlnum | (OCoLC)809068088 (DE-599)DNB1021240435 |
| dewey-full | 636.7089691801 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 636 - Animal husbandry |
| dewey-raw | 636.7089691801 |
| dewey-search | 636.7089691801 |
| dewey-sort | 3636.7089691801 |
| dewey-tens | 630 - Agriculture and related technologies |
| discipline | Agrar-/Forst-/Ernährungs-/Haushaltswissenschaft / Gartenbau |
| format | Thesis Book |
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| id | DE-604.BV040504732 |
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| indexdate | 2024-07-10T00:25:16Z |
| institution | BVB |
| isbn | 9783863871208 |
| language | English |
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| physical | 125 S. Ill., graph. Darst. |
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| spelling | Nikolin, Veljko M. Verfasser aut Host range determinants for canine distemper virus by Veljko M. Nikolin Berlin mbv 2012 125 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Berlin, Freie Univ., Diss., 2011 morbillivirus cabt canine distemper virus cabt dogs cabt lions cabt host parasite relationship cabt host range cabt molecular epidemiology cabt Tanzania cabt Staupevirus (DE-588)4349365-8 gnd rswk-swf Wirtstiere (DE-588)4717292-7 gnd rswk-swf Raubtiere (DE-588)4177019-5 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Staupevirus (DE-588)4349365-8 s Wirtstiere (DE-588)4717292-7 s Raubtiere (DE-588)4177019-5 s DE-604 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025351394&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Nikolin, Veljko M. Host range determinants for canine distemper virus morbillivirus cabt canine distemper virus cabt dogs cabt lions cabt host parasite relationship cabt host range cabt molecular epidemiology cabt Tanzania cabt Staupevirus (DE-588)4349365-8 gnd Wirtstiere (DE-588)4717292-7 gnd Raubtiere (DE-588)4177019-5 gnd |
| subject_GND | (DE-588)4349365-8 (DE-588)4717292-7 (DE-588)4177019-5 (DE-588)4113937-9 |
| title | Host range determinants for canine distemper virus |
| title_auth | Host range determinants for canine distemper virus |
| title_exact_search | Host range determinants for canine distemper virus |
| title_full | Host range determinants for canine distemper virus by Veljko M. Nikolin |
| title_fullStr | Host range determinants for canine distemper virus by Veljko M. Nikolin |
| title_full_unstemmed | Host range determinants for canine distemper virus by Veljko M. Nikolin |
| title_short | Host range determinants for canine distemper virus |
| title_sort | host range determinants for canine distemper virus |
| topic | morbillivirus cabt canine distemper virus cabt dogs cabt lions cabt host parasite relationship cabt host range cabt molecular epidemiology cabt Tanzania cabt Staupevirus (DE-588)4349365-8 gnd Wirtstiere (DE-588)4717292-7 gnd Raubtiere (DE-588)4177019-5 gnd |
| topic_facet | morbillivirus canine distemper virus dogs lions host parasite relationship host range molecular epidemiology Tanzania Staupevirus Wirtstiere Raubtiere Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025351394&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT nikolinveljkom hostrangedeterminantsforcaninedistempervirus |