Total synthesis of variecolortides A-C: studies towards the total synthesis of naphthomycin K and divergolides C and D ; synthesis of photochromic open channel blockers
Saved in:
| Main Author: | |
|---|---|
| Format: | Thesis Book |
| Language: | English |
| Published: |
München
Dr. Hut
2012
|
| Series: | Organische Chemie
|
| Subjects: | |
| Online Access: | https://nbn-resolving.org/urn:nbn:de:bvb:19-148284 kostenfrei Inhaltsverzeichnis |
| Physical Description: | 241 S. graph. Darst. |
| ISBN: | 9783843906005 |
Staff View
MARC
| LEADER | 00000nam a2200000 c 4500 | ||
|---|---|---|---|
| 001 | BV040502564 | ||
| 003 | DE-604 | ||
| 005 | 20130110 | ||
| 007 | t | ||
| 008 | 121024s2012 gw d||| m||| 00||| eng d | ||
| 016 | 7 | |a 102674234X |2 DE-101 | |
| 020 | |a 9783843906005 |c Pb. : EUR 48.00 (DE), EUR 49.40 (AT) |9 978-3-8439-0600-5 | ||
| 035 | |a (OCoLC)816313753 | ||
| 035 | |a (DE-599)DNB102674234X | ||
| 040 | |a DE-604 |b ger |e rakddb | ||
| 041 | 0 | |a eng | |
| 044 | |a gw |c XA-DE-BY | ||
| 049 | |a DE-384 |a DE-473 |a DE-703 |a DE-1051 |a DE-824 |a DE-29 |a DE-12 |a DE-91 |a DE-19 |a DE-1049 |a DE-92 |a DE-739 |a DE-898 |a DE-355 |a DE-706 |a DE-20 |a DE-1102 | ||
| 082 | 0 | |a 547.7 |2 22/ger | |
| 084 | |a 540 |2 sdnb | ||
| 100 | 1 | |a Kuttruff, Christian Andreas |d 1984- |e Verfasser |0 (DE-588)1026241677 |4 aut | |
| 245 | 1 | 0 | |a Total synthesis of variecolortides A-C |b studies towards the total synthesis of naphthomycin K and divergolides C and D ; synthesis of photochromic open channel blockers |c Christian A. Kuttruff |
| 264 | 1 | |a München |b Dr. Hut |c 2012 | |
| 300 | |a 241 S. |b graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 0 | |a Organische Chemie | |
| 502 | |a Zugl.: Ludwig-Maximilians-Universität München, Diss., 2012 | ||
| 650 | 0 | 7 | |a Chemische Synthese |0 (DE-588)4133806-6 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Bioaktive Verbindungen |0 (DE-588)4145589-7 |2 gnd |9 rswk-swf |
| 655 | 7 | |0 (DE-588)4113937-9 |a Hochschulschrift |2 gnd-content | |
| 689 | 0 | 0 | |a Bioaktive Verbindungen |0 (DE-588)4145589-7 |D s |
| 689 | 0 | 1 | |a Chemische Synthese |0 (DE-588)4133806-6 |D s |
| 689 | 0 | |5 DE-604 | |
| 776 | 0 | 8 | |i Erscheint auch als |n Online-Ausgabe |o urn:nbn:de:bvb:19-148284 |
| 856 | 4 | |u https://nbn-resolving.org/urn:nbn:de:bvb:19-148284 |x Resolving-System | |
| 856 | 4 | |u http://edoc.ub.uni-muenchen.de/14828/ |x Verlag |z kostenfrei | |
| 856 | 4 | 2 | |m DNB Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025349307&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 912 | |a ebook | ||
| 999 | |a oai:aleph.bib-bvb.de:BVB01-025349307 | ||
Record in the Search Index
| _version_ | 1804149577105801217 |
|---|---|
| adam_text | IMAGE 1
TABLE OF CONTENTS
PART I: TOTAL SYNTHESIS OF VARIECOLORTIDES A-C 1
1 INTRODUCTION 1
1.1 ISOLATION AND STRUCTURE 2
1.2 PROPOSED BIOSYNTHESIS 2
2 RESULTS 6
2.1 PUBLISHED RESULTS 6
2.1.1 CONCISETOTALSYNTHESESOFVARIECOLORTLDESAANDBTHROUGHANUNUSUAL 6
HETERO-DIELS-ALDER REACTION
2.12 EVOLUTION OF A SYNTHETIC STRATEGY FOR THE VARIECOLORTIDES 60
PART II: TOWARDS THETOTAL SYNTHESIS OF NAPHTHOMYDN K AND 89
DIVERGOLIDES C AND D 1 TOWARDS THE TOTAL SYNTHESIS OF NAPHTHOMYCIN K 89
1.1 INTRODUCTION AND BACKGROUND 89
1.1.1 ANSAMYCIN ANTIBIOTICS 89
1.1 J NAPHTHOMYCINSA-J 91
1.1.3 NAPHTHOMYCIN K 93
1.1.4 BIOSYNTHESIS O F THE NAPHTHOMYCINS 94
1.1.5 RETROSYNTHETLC ANALYSIS O F NAPHTHOMYCIN K 96
1.1.6 1 APPROACH TO THE NAPHTHALENE CORE 97
1.2 PUBLISHED RESULTS 99
1.2.1 AN APPROACH TO AMINONAPHTHOQUINONEANSAMYCINS USING A MODIFIED 99
DANISHEFSKY DIENE
13 UNPUBLISHED RESULTS 135
1.3.1 ATTEMPTS TO THE SYNTHESIS O F 2.17 135
1.3.2 2* APPROACH TO THE NAPHTHALENE CORE 136
13.2.1 SYNTHESIS OF ACETYL-PROTECTED BROMONAPHTHALENE 237 137 13.2.2
SYNTHESIS OF BOC-PROTECTED BROMONAPHTHALENE 2.38 139 13.2.3 SYNTHESIS OF
(Z)-VINYL IODIDE 2.22 140
2 TOWARDS THE TOTAL SYNTHESIS OF DIVERGOLIDES C AND D 143
2.1 ISOLATION, STRUCTURE AND BIOLOGICAL ACTIVITIES 143
2.2 BIOSYNTHESIS 144
2.3 RETROSYNTHETIC ANALYSIS 145
2.4 UNPUBLISHED RESULTS 146
3 EXPERIMENTAL PART 149
3.1 GENERAL EXPERIMENTAL DETAILS 149
3.2 INSTRUMENTATION 149
33 SYNTHETIC PROCEDURES 150
3.3.1 NAPHTHOMYCIN K PROJECT 150
33.2 DIVERGOLIDES C AND D PROJECT 164
HTTP://D-NB.INFO/102674234X
IMAGE 2
3.4 NMR SPECTRA 172
3.4.1 NAPHTHOMYCIN K PROJECT 172
3.4J DIVERGOLIDES C AND D PROJECT 192
3.5 CRYSTAL STRUCTURES 201
PART III: SYNTHESIS OF PHOTOCHROME OPEN CHANNEL BLOCKERS 203
1 INTRODUCTION 203
1.1 OPTOCHEMICAL GENETICS 203
1.2 THE AZOBENZENE SCAFFOLD 204
13 QAQ 205
2 RESULTS 207
2.1 PUBLISHED RESULTS 207
2.1.1 EXPLORING THE PHARMACOLOGY AND ACTION-SPECTRA O F PHOTOCHROMIC 207
OPEN- CHANNEL BLOCKERS
|
| any_adam_object | 1 |
| author | Kuttruff, Christian Andreas 1984- |
| author_GND | (DE-588)1026241677 |
| author_facet | Kuttruff, Christian Andreas 1984- |
| author_role | aut |
| author_sort | Kuttruff, Christian Andreas 1984- |
| author_variant | c a k ca cak |
| building | Verbundindex |
| bvnumber | BV040502564 |
| collection | ebook |
| ctrlnum | (OCoLC)816313753 (DE-599)DNB102674234X |
| dewey-full | 547.7 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 547 - Organic chemistry |
| dewey-raw | 547.7 |
| dewey-search | 547.7 |
| dewey-sort | 3547.7 |
| dewey-tens | 540 - Chemistry and allied sciences |
| discipline | Chemie / Pharmazie |
| format | Thesis Book |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>02126nam a2200457 c 4500</leader><controlfield tag="001">BV040502564</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">20130110 </controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">121024s2012 gw d||| m||| 00||| eng d</controlfield><datafield tag="016" ind1="7" ind2=" "><subfield code="a">102674234X</subfield><subfield code="2">DE-101</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9783843906005</subfield><subfield code="c">Pb. : EUR 48.00 (DE), EUR 49.40 (AT)</subfield><subfield code="9">978-3-8439-0600-5</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)816313753</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DNB102674234X</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rakddb</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="044" ind1=" " ind2=" "><subfield code="a">gw</subfield><subfield code="c">XA-DE-BY</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-384</subfield><subfield code="a">DE-473</subfield><subfield code="a">DE-703</subfield><subfield code="a">DE-1051</subfield><subfield code="a">DE-824</subfield><subfield code="a">DE-29</subfield><subfield code="a">DE-12</subfield><subfield code="a">DE-91</subfield><subfield code="a">DE-19</subfield><subfield code="a">DE-1049</subfield><subfield code="a">DE-92</subfield><subfield code="a">DE-739</subfield><subfield code="a">DE-898</subfield><subfield code="a">DE-355</subfield><subfield code="a">DE-706</subfield><subfield code="a">DE-20</subfield><subfield code="a">DE-1102</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">547.7</subfield><subfield code="2">22/ger</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">540</subfield><subfield code="2">sdnb</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Kuttruff, Christian Andreas</subfield><subfield code="d">1984-</subfield><subfield code="e">Verfasser</subfield><subfield code="0">(DE-588)1026241677</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Total synthesis of variecolortides A-C</subfield><subfield code="b">studies towards the total synthesis of naphthomycin K and divergolides C and D ; synthesis of photochromic open channel blockers</subfield><subfield code="c">Christian A. Kuttruff</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">München</subfield><subfield code="b">Dr. Hut</subfield><subfield code="c">2012</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">241 S.</subfield><subfield code="b">graph. Darst.</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="490" ind1="0" ind2=" "><subfield code="a">Organische Chemie</subfield></datafield><datafield tag="502" ind1=" " ind2=" "><subfield code="a">Zugl.: Ludwig-Maximilians-Universität München, Diss., 2012</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Chemische Synthese</subfield><subfield code="0">(DE-588)4133806-6</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Bioaktive Verbindungen</subfield><subfield code="0">(DE-588)4145589-7</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="655" ind1=" " ind2="7"><subfield code="0">(DE-588)4113937-9</subfield><subfield code="a">Hochschulschrift</subfield><subfield code="2">gnd-content</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">Bioaktive Verbindungen</subfield><subfield code="0">(DE-588)4145589-7</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="1"><subfield code="a">Chemische Synthese</subfield><subfield code="0">(DE-588)4133806-6</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="776" ind1="0" ind2="8"><subfield code="i">Erscheint auch als</subfield><subfield code="n">Online-Ausgabe</subfield><subfield code="o">urn:nbn:de:bvb:19-148284</subfield></datafield><datafield tag="856" ind1="4" ind2=" "><subfield code="u">https://nbn-resolving.org/urn:nbn:de:bvb:19-148284</subfield><subfield code="x">Resolving-System</subfield></datafield><datafield tag="856" ind1="4" ind2=" "><subfield code="u">http://edoc.ub.uni-muenchen.de/14828/</subfield><subfield code="x">Verlag</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">DNB Datenaustausch</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025349307&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ebook</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-025349307</subfield></datafield></record></collection> |
| genre | (DE-588)4113937-9 Hochschulschrift gnd-content |
| genre_facet | Hochschulschrift |
| id | DE-604.BV040502564 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T00:25:08Z |
| institution | BVB |
| isbn | 9783843906005 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-025349307 |
| oclc_num | 816313753 |
| open_access_boolean | 1 |
| owner | DE-384 DE-473 DE-BY-UBG DE-703 DE-1051 DE-824 DE-29 DE-12 DE-91 DE-BY-TUM DE-19 DE-BY-UBM DE-1049 DE-92 DE-739 DE-898 DE-BY-UBR DE-355 DE-BY-UBR DE-706 DE-20 DE-1102 |
| owner_facet | DE-384 DE-473 DE-BY-UBG DE-703 DE-1051 DE-824 DE-29 DE-12 DE-91 DE-BY-TUM DE-19 DE-BY-UBM DE-1049 DE-92 DE-739 DE-898 DE-BY-UBR DE-355 DE-BY-UBR DE-706 DE-20 DE-1102 |
| physical | 241 S. graph. Darst. |
| psigel | ebook |
| publishDate | 2012 |
| publishDateSearch | 2012 |
| publishDateSort | 2012 |
| publisher | Dr. Hut |
| record_format | marc |
| series2 | Organische Chemie |
| spelling | Kuttruff, Christian Andreas 1984- Verfasser (DE-588)1026241677 aut Total synthesis of variecolortides A-C studies towards the total synthesis of naphthomycin K and divergolides C and D ; synthesis of photochromic open channel blockers Christian A. Kuttruff München Dr. Hut 2012 241 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Organische Chemie Zugl.: Ludwig-Maximilians-Universität München, Diss., 2012 Chemische Synthese (DE-588)4133806-6 gnd rswk-swf Bioaktive Verbindungen (DE-588)4145589-7 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Bioaktive Verbindungen (DE-588)4145589-7 s Chemische Synthese (DE-588)4133806-6 s DE-604 Erscheint auch als Online-Ausgabe urn:nbn:de:bvb:19-148284 https://nbn-resolving.org/urn:nbn:de:bvb:19-148284 Resolving-System http://edoc.ub.uni-muenchen.de/14828/ Verlag kostenfrei DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025349307&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Kuttruff, Christian Andreas 1984- Total synthesis of variecolortides A-C studies towards the total synthesis of naphthomycin K and divergolides C and D ; synthesis of photochromic open channel blockers Chemische Synthese (DE-588)4133806-6 gnd Bioaktive Verbindungen (DE-588)4145589-7 gnd |
| subject_GND | (DE-588)4133806-6 (DE-588)4145589-7 (DE-588)4113937-9 |
| title | Total synthesis of variecolortides A-C studies towards the total synthesis of naphthomycin K and divergolides C and D ; synthesis of photochromic open channel blockers |
| title_auth | Total synthesis of variecolortides A-C studies towards the total synthesis of naphthomycin K and divergolides C and D ; synthesis of photochromic open channel blockers |
| title_exact_search | Total synthesis of variecolortides A-C studies towards the total synthesis of naphthomycin K and divergolides C and D ; synthesis of photochromic open channel blockers |
| title_full | Total synthesis of variecolortides A-C studies towards the total synthesis of naphthomycin K and divergolides C and D ; synthesis of photochromic open channel blockers Christian A. Kuttruff |
| title_fullStr | Total synthesis of variecolortides A-C studies towards the total synthesis of naphthomycin K and divergolides C and D ; synthesis of photochromic open channel blockers Christian A. Kuttruff |
| title_full_unstemmed | Total synthesis of variecolortides A-C studies towards the total synthesis of naphthomycin K and divergolides C and D ; synthesis of photochromic open channel blockers Christian A. Kuttruff |
| title_short | Total synthesis of variecolortides A-C |
| title_sort | total synthesis of variecolortides a c studies towards the total synthesis of naphthomycin k and divergolides c and d synthesis of photochromic open channel blockers |
| title_sub | studies towards the total synthesis of naphthomycin K and divergolides C and D ; synthesis of photochromic open channel blockers |
| topic | Chemische Synthese (DE-588)4133806-6 gnd Bioaktive Verbindungen (DE-588)4145589-7 gnd |
| topic_facet | Chemische Synthese Bioaktive Verbindungen Hochschulschrift |
| url | https://nbn-resolving.org/urn:nbn:de:bvb:19-148284 http://edoc.ub.uni-muenchen.de/14828/ http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025349307&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT kuttruffchristianandreas totalsynthesisofvariecolortidesacstudiestowardsthetotalsynthesisofnaphthomycinkanddivergolidescanddsynthesisofphotochromicopenchannelblockers |